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danarTi #

danarTi #3brZaneba #84/o01.02.2011artoqsaniARTOXANpreparatis samedicino gamoyenebis instruqciasavaWro dasaxelebaartoqsani, ArtoxansaerTaSoriso arapatentirebuli dasaxelebatenoqsikami, Tenoxicamwamlis formareqtaluri supozitoriebi.aRweriloba: wagrZelebuli formis supozitoriebi, erTgvarovani, yviTeliferis, susti suniT.Semadgenlobareqtaluri supozitoria Seicavsaqtiuri nivTiereba: tenoqsikami 20 mg.daxmare nivTiereba: vitepsoli H 15.preparatis aTq kodi: M01AC02farmakoTerapiuli jgufianTebis sawinaaRmdego arasteroiduli preparatebi. oqsikamebi.farmakologiuri Tvisebebiartoqsani – efeqturi anTebis sawinaaRmdego arasteroiduli preparati (aass)Zlieri anTebis sawinaaRmdego, analgeziuri da naklebad gamoxatuli sicxisdamwevi moqmedebiT. preparatis Tvisebebi ganpirobebulia fermentciklooqsigenazas orive izoformis inhibirebiT, rac iwvevs araqidonis mJavasmetabolizmis darRvevas da prostalgandinebis sinTezis blokadas.artoqsanis anTebis sawinaaRmdego efeqti ganpirobebulia kapilarebisganvladobis SemcirebiT (zRudavs eqsudacias), lizosomuri membranebisstabilizebiT (xels uSlis qsovilebis damazianebeli lizosomurifermentebis gamoTavisuflebas), anTebis mediatorebis (prostalgandinebi,histamini, bradikinini, limfokinebi, komplementis faqtorebi) sinTezisdaTrgunviT an inaqtivaciiT. preparati anTebis keraSi amcirebs Tavisufaliradikalebis raodenobas, amcirebs qemotaqsiss da fagocitozs; aferxebsanTebis proliferaciuli fazis ganviTarebas; amcirebs qsovilebispostanTebiT sklerozirebas; axasiaTebs qondroproteqtoruli moqmedeba.preparati amcirebs tkivilis SegrZnebas anTebis keraSi da moqmedebs tkivilisTalamur centrebze, gaaCnia madesensibilizebeli moqmedeba (xangrZlivigamoyenebisas). revmatiuli daavadebebis dros amcirebs saxsrebis tkivils,rogorc mosvenebul mdgomareobaSi aseve moZraobisas, amcirebs dilisSeboWilobas da saxsrebis SeSupebas, aumjobesebs maT funqcias da zrdismoZraobis diapazons.farmakokinetikareqtaluri gamoyenebisas bioSeRwevadoba Seadgens 80%. C max miiRweva 2 saaTSi.sisxlis cilebs ukavSirdeba 99%-iT. 20-40 mg-is erTjeradi peroraruli


miRebis Semdeg, plazmaSi miiRweva maqsimaluri plazmuri koncentracia 2-4mg/l. 20 mg tenoqsikamis yoveldRuri miRebis Semdeg (erTjer dReSi), 10-12dReSi miiRweva daaxloebiT Tanabari mdgradi plazmuri koncentracia 11mg/l.ganawilebis moculoba Seadgens 0,15l/kg, naxevargamoyofis periodi 60-75saaTs.miRebuli dozis 2/3 gamoiyofa SardiT, 1/3 - fekaliebiT.tenoqsikami advilad aRwevs osteoarTritiT da revmatoiduli arTritiTdaavadebuli pacientebis sinoviur siTxeSi. dasturdeba RviZlSitransformacia araaqtiur metabolitebad. erT-erTi maTgani (5-hidroqsipiridili) gamoiyofa SardiT, danarCeni gamoiyofa naRveliTglukuronis koniugatebis saxiT.gamoyenebis Cvenebebisayrden-mamoZravebeli aparatis anTebiT-degeneraciuli daavadebebi, Tanmxlebitkivilis sindromiT:- saxsrovani sindromi podagris, revmatiuli arTritis, osteoarTrozis,maankilozebeli spondilitis, osteoqondrozis, revmatizmis saxsrovaniformis (periarTriti, tendiniti, bursiti, mioziti) dros, podagra;- tkivili xerxemlSi, nevralgia, mialgia, iSialgia, lumbago;- algodismenorea;- tramvebisas, damwvrobis dros.ukuCvenebebi- momatebuli mgrZnobeloba tenoqsikamis an sxva aass-ebis mimarT;- saWmlis momnelebeli sistemis eroziul-wylulovani dazianebebi;- sisxldena kuW-nawlavis traqtidan;- aspirinuli triada (bronquli asTmis TanxlebiT);- RviZlis da Tirkmelebis gamoxatuli darRvevebi;- Saqriani diabeti;- arteriuli hipertenzia, gulis ukmarisoba, SeSupeba;- orsuloba, laqtaciis periodi;- sisxlis daavadebebi.gverdiTi moqmedebakuW-nawlavis traqtis mxriv: dispefsia, (gulisreva, Rebineba, gulZmarva,diarea, meteorizmi), tkivili da usiamovno SegrZneba mucelSi, stomatiti,anoreqsia; maRal dozebSi xangrZlivi gamoyenebisas kuW-nawlavis eroziulwylulovanigarTulebebi.nervuli sistemis da grZnobaTa organoebis mxriv: Tavis tkivili,Tavbrusxveva, depresia, momatebuli agznebadoba.alergiuli reaqciebi: WinWris cieba, qavili, eriTema, stivens-jonsisa dalailis sindromebi.sxva: Tirkmlebis funqciis darRveva, plazmaSi kreatininis, azotis,Sardovanas, bilirubinis koncentraciis momateba, RviZlis transaminazebisaqtivobis momateba, sisxldenis drois gaxangrZliveba. sanTlebisgamoyenebisas SesaZlebelia adgilobrivi gaRizianea, mtkivneuli defekacia.gamoyenebis wesi da dozebigamoiyeneba reqtalurad. Cveulebriv iniSneba doziT 20 mg erTjer dRe-RameSierTsadaimave dros.mwvave podagruli arTritis dros iniSneba 40 mg erTjer dRe-RameSi 2 dRisganmavlobaSi, Semdeg 20 mg dReSi erTjer 5 dRis ganmavlobaSi.


Warbi dozadozis gadaWarbebis SemTxvevebi ar dafiqsirebula.urTierTqmedeba sxva samkurnalo saSualebebTanartoqsani aZlierebs liTiumis prepratebis (m. S. toqsikurobas), arapirdapiriantikoagulantebis, perolaruli hipoglikemiuri saSualebebis(sulfanilSardovanas warmoebulebi) efeqts.sxva aass-ebi amaRleben gverdiTi efeqtebis ganviTarebis risks, gansakuTrebiTkuW-nawlavis mxriv.mielotoqsiuri samkurnalo saSualebebi aZliereben hematotqsikurobas.gansakuTrebuli miTiTebebisifrTxiliT gamoiyeneba mkurnalobisaTvis asakovan pacientebSi,diuretikebis, nefrotoqsiuri preparatebis miRebisas, uSualod qirurgiuliCarevis Semdgom. qirurgiul Carevamde ramdenime dRiT adre artoqsanis miRebaunda Sewydes.xangrZlivi mkurnalobis procesSi saWiroa RviZlisa da Tirkmlis funqciis,sisxlSi proTrombinuli indeqsis, sisxlSi glukozis Semcvelobis kontroli.mkurnalobis fonze kuw-nawlavis traqtis eroziul- wylulovani dazianebisan sisxldenis SemTxvevaSi aucilebelia preparatis miRebis Sewyveta daSesabamisi mkurnalobis daniSvna.zegavlena avtomobilisa da sxva meqanizmebis marTvis unarzemkurnalobis periodSi avtomobilis marTvisa da sxva potenciurad saSiSisaqmianobis Sesrulebisas, romlebic saWiroeben yuradRebis momatebulkoncentraciasa da fsiqomotoruli reaqciebis siswrafes, aucileblad undadavicvaT sifrTxilegamoyeneba orsulobisa da laqtaciis periodSiorsulobis dros preparati ukunaCvenebia. laqtaciis periodSi daniSvnisaucileblobisas sakiTxi unda gadawydes ZuZuTi kvebis Sewyvetis Sesaxeb.gamoyeneba pediatriaSibavSvebSi gamoyenebis usafrTxoeba dadgenili ar aris.gamoSvebis forma5 reqtaluri supozitoria stripSi.1 stripi muyaos kolofSi gamoyenebis instruqciasTan erTad.Senaxvis pirobebiinaxeba sinaTlisagan dacul, bavSvebisaTvis miuwvdomel adgilas arumetes25 ° C temperaturaze.vargisianobis vada3 weli warmoebis TariRidan.ar gamoiyeneba vargisianobis vadis gasvlis Semdeg.gacemis pirobebifarmacevtuli produqtis jgufi II (gacemis reJimi: receptiT).mwarmoebelisavaWro markisa da registraciis sertifikatis mflobelia


kompania “rotafarmi”, didi britaneTi(“ROTAPHARM” Great Britain).damzadebulia“global napi farmaceutikalsi”-s mier.me-2 samrewvelo zona, #40, quCa #18, siqs ov oqtober siTi, giza, egvipte.(“Global Napi Pharmaceuticals”2 nd Industrial Zone, No.40, Street no.18, 6 th of October City, Giza, Egypt).

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