Karen Amaral Tavares Pinheiro - Universidade Católica de Pelotas

109
In the whole group the mean BDNF level was 2.26 ± 1.32 ng/ml, in PPAD group was
2.08 ± 1.32 ng/ml, of suicidality was 1.56 ± 1.36 ng/ml and the mean of BDNF levels in
women without suicide risk were 2.33 ±1.30 ng/ml. Women with PPAD and suicidality had
mean BDNF levels of 1.50 ±1.38 ng/ml. Mothers who experienced two or less SLEs had
mean serum BDNF levels of 2.33 ± 1.30 ng/ml and those who experienced three or more
SLEs of 1.64 ± 1.43 ng/ml (table 1).
In bivariate analysis there is no association between PPAD subjects without suicide
risk and BDNF levels (2.14 ± 1.40 ng/ml; F=0.44. p=0.506). Lower BDNF levels were
associated with suicide risk (p=0.02). The serum BDNF levels in those women with PPADs
presenting suicide risk (n=14) were significantly lower than in those women without suicide
risk (F=5.02, p=0.02) (Figure 1A). The serum BDNF levels in PPAD and with suicide risk
and depression, mania and mixed episodes were 1.68 ± 1.50 ng/ml, 1.46 ± 1.67 ng/ml and
1.39 ± 1.65 ng/ml, respectively (Figure 1B).
There were no significant differences in the serum BDNF levels in women with
PPADs presenting suicide risk according to their particular episodes (F= 0.101, P= 0.75).
There is not association between the serum BDNF levels in women with only anxiety
disorders and suicide risk (p=0.28).
Serum BDNF levels were significantly lower in subjects with three or more SLEs
(90th percentile) (1.64 ± 1.43 ng/ml) compared to those with two or less SLEs (2.33 ± 1.30
ng/ml, F= 5.64, p= 0.019) (Figure 1C).
Table 2 shows Multivariate Analysis of data obtained from the Linear and Poisson
regression analysis. Both the linear and Poisson regression analyses, adjusted for previous
psychiatry treatment and SLEs, showed similar p-values.
We performed a regression analysis to determine which variables have the most
impact on the BDNF level. After adjustment in Linear regression, for previous psychiatry