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3 years ago

Karen Amaral Tavares Pinheiro - Universidade Católica de Pelotas

Karen Amaral Tavares Pinheiro - Universidade Católica de Pelotas

120 Artigo 2: Serum NGF,

120 Artigo 2: Serum NGF, BDNF and IL-6 levels in postpartum mothers as predictors of infant neurobiological development: the influence of affective disorders Revista: Biological Psychiatry Serum NGF, BDNF and IL-6 levels in postpartum mothers as predictors of infant neurobiological development: the influence of affective disorders ABSTRACT Background: Early adverse experiences are associated with increased risk of developing psychiatric disorders, although little is known about the neurobiological mediators involved. The mechanisms by which early environmental influences may mediate vulnerability in the development of offspring await further investigation. The present study correlated the Neurotrophic Growth Factor (NGF), Brain Derived Neurothofic Factor (BDNF), Interleukin-6 (IL-6) and cortisol levels of mothers with postpartum affective disorders (PPAD) with infant neurobiological development. Methods: A longitudinal study was performed with 152 pregnant women and their infants. Between 60 and 120 days after delivery, women were interviewed and provided biological samples for biochemical analysis, and the infants were examined for neurobiological-motor development. Results: Overall, the mothers’ history of affective disorders, PPAD and anxiety disorder were associated with infant motor development. Using an adjusted linear regression analysis, history of affective disorder (p=0.147), PPAD (p=0.049), maternal anxiety disorder (p=0.043), NGF level (p=0.034) and infant cortisol level (p=0.013) were associated with infant motor development. Using a factorial analysis of primary components, two components were restrained. The psychological factor was characterized by a positive loading of a history

121 of affective disorder, PPAD and anxiety disorder. For the biological factor, infant cortisol adhered negatively with infant motor development, but NGF was positively associated. The psychological factor had a negative association, but the biological factor had a positive association with infant motor development. Conclusions: There are few studies that have focused on the relationship of biomarkers and infant neurodevelopment. Taken together, the biological and psychological components of the effects observed in this study show how these complex processes affect infant development, considering that these factors are only a single part of the developmental context. KEY WORDS Postpartum affective disorder, NGF, BDNF, cortisol, infant neuromotor development.

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