Журнал "Нирки" том 11, №1

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Ñòîð³íêà ðåäàêòîðàEditor’s PageDOI: https://doi.org/10.22141/2307-1257.11.1.2022.352Øàíîâí³ äðóç³ ³ êîëåãè!Слоган цього номера: «Щоденнийподвиг найбільш виснажливий». І цедо нього цитата із «Голосу України»(http://www.golos.com.ua/rus/article/303020):«У житті є речі незбагненні. Хтось здійснюєподвиг миттєвий — і увічнюється. Ахтось вершить щоденний подвиг, і людийого не помічають. Але минає час, і стаєзрозуміло, хто від нас пішов, кого нам невистачає, до кого звертатимемося черезроки».(Оригінальний текст: «В жизни есть вещи непостижимые. Ктотосовершает подвиг мгновенный — и увековечивается. А кто-товершит подвиг ежедневный, и люди его не замечают. Но проходитвремя, и становится понятно, кто от нас ушел, кого нам не хватает,к кому будем обращаться спустя годы»).З повагою, Дмитро ІвановÒîì 11, ¹ 1, 2022www.mif-ua.com, http://kidneys.zaslavsky.com.ua 5
Îðèã³íàëüí³ ñòàòò³Original ArticlesUDC 616.611-091.8DOI: https://doi.org/10.22141/2307-1257.11.1.2022.353Fateme ShamekhiImam Khomeini Hospital Complex, National Tehran Medical College, National Tehran of University MedicalSciences, Tehran, IranEffect of FN1 mutation on outcomesof fibronectin glomerulopathy in a systematicreview and meta-analysisAbstract. Background. Fibronectin glomerulopathy is an inherited kidney disease that is characterizedwith extensive depositions of fibronectin in mesangium and subendothelial space. The aim of study is toassess effect of fibronectin gene on decreased renal function and likeliness of recurrence of the diseaseafter kidney transplantation. Materials and methods. In retrospective descriptive studies, fifty-seven patientswith fibronectin glomerulopathy were enrolled in this research. Relative risk and Odds ratio for assessingeffect measures of risk factor on outcomes of disease were used. Results. Of fifty-seven patients withfibronectin glomerulopathy, thirty-six patients (36/57, 63.1 %) were male and twenty-one patients werefemale (21/57, 36.8 %). Relative risk and Odds ratio of end-stage kidney disease (ESKD) in nephrotic-rangeproteinuria versus non-nephrotic range proteinuria were assessed 1.33 and 1.39, respectively. Relative riskand Odds ratio of end-stage kidney disease with kidney replacement therapy (KRT) in patients with positiveFN1 gene (as risk or contributing factor) versus patients with negative FN1 gene was assessed 0.66 and0.50, respectively. Risk of recurrence after kidney transplant with nephrotic-range proteinuria was assessed0.83 (95% confidence interval of 0.1213 to 5.7244) and odds ratio of recurrence after kidney transplant withnephrotic proteinuria versus non-nephrotic range proteinuria was assessed 0.75 (95% confidence intervalof 0.03757 to 14.9733) in the current research. Conclusions. Relative risk and odds ratio of end-stage kidneydisease in nephrotic-range proteinuria versus non-nephrotic range proteinuria were assessed 1.33 and1.39, respectively. Therefore, it appears risk of fibronectin gene 1 on end-stage kidney disease with kidneyreplacement therapy be low.Keywords: fibronectin; fibronectin glomerulopathy; kidney failure; lobular appearanceIntroductionFibronectin glomerulopathy (FNG) or glomerulopathywith fibronectin deposits (GFND) is a rare hereditary conditionwith an autosomal dominant inheritance. Burgin etal described this disease for the first time in 1980 year [1].The main features of this glomerulopathy is immunoreactivityof glomerulus with a monoclonal immunoglobulinon serum fibronectin. Fibronectin glomerulopathy is diagnosedand confirmed with kidney biopsy. The depositsof fibronectin at first are deposited in the mesangium andthen in subendothelial area. They are red with trichromestain and stain intensely with the period acid Schiff (PAS)stain. The deposits are negative with the congo red T andS stains. The deposits are made of granular to occasionalfibrillary material, with and thioflavins fibrils measuring 14to 16 nm in diameter. Mutations of fibronectin gene (FN1)are located in 1q32 chromosome and timely diagnosis preventsthis disease in the next probands. Progression to endstagerenal disease may be done slowly in some patients.Recurrence of disease after kidney transplantation hasbeen documented [2]. The aim of this research is to assesseffect of FN1 gene mutation as risk factor on progressivekidney failure. Confirmation by genetic analysis helps tothe better recognition of the entity in the next probandsand prevention of disease. Today’s science moves towardgenomics detection of diseases.© «Нирки» / «Kidneys» ( ), 2022© Видавець Заславський О.Ю. / Publisher Zaslavsky O.Yu., 2022For correspondence: Fateme Shamekhi Amiri, Unrecorded Academic member of Nephrology, Imam Khomeini Hospital Complex, National Tehran Medical College, National Tehran of University MedicalSciences, Tehran, Iran; contact phone: +98911 311 1780; e-mail: fa.shamekhi@gmail.comFull list of author information is available at the end of the article.6 Íèðêè, ISSN 2307-1257 (print), ISSN 2307-1265 (online) Òîì 11, ¹ 1, 2022
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Журнал "Нирки" том 11, №1

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