XMAS Special

PELONEWS<br />

WITH FOCUS ON X-MAS<br />

PELOBiotech Newsletter Dec. 2018<br />

“CFO asks<br />

CEO, “What<br />

happens if we<br />

invest in developing<br />

our people<br />

and then<br />

they leave<br />

us?”<br />

CEO: “What<br />

happens if we<br />

don’t, and they<br />

stay?”<br />

~Peter Baeklund,<br />

Leadership<br />

Coach~<br />

Dear Scientist,<br />

a sincere thank you for your confidence in<br />

us and your interest in our products and services.<br />

Wishing you, your staff and your loved ones<br />

a reflective and restful Christmas season and<br />

a happy and healthy New Year, bringing success<br />

in your personal endeavors and business<br />

ventures.<br />

Yours,<br />

Lothar, Peter and the PELOBiotech-Team<br />

Please note due to the holiday season<br />

our delivery times:<br />

last deliveries<br />

CW 51 (Dec 19, 2018; based upon stock)<br />

No deliveries CW52:<br />

Please contact us in between in urgent<br />

matters, we are here to help.<br />

Content<br />

Delivery Dates<br />

NEW Name: Native<br />

Coat<br />

CoSeedis<br />

Featured Fields<br />

<br />

<br />

<br />

3D<br />

ECM<br />

Cancer

---

PELONews<br />

One happy<br />

family after<br />

the talk:<br />

John O<br />

Neill (4th<br />

from the<br />

right) next<br />

to Tony<br />

Curro,<br />

Richard<br />

Nguyen (1<br />

left)<br />

We have talked: New Generation of ECM Organotypic ECM<br />

To a talk about applied 3D cell culture PELOBiotech GmbH and its US partner EastRiver BioSolutions<br />

from New York invited to the Sky-Room at the IZB End of November 2018,. Around 30 scientists from<br />

Munich biotech companies, the LMU, the Klinikum rechts der Isar, the Helmholtz Centre and the Hochschule<br />

Munich discussed with<br />

Dr. John O´Neill, CSO East River, the importance of the right physiological environment for cell growth.<br />

Guests came from Switzerland and the University of Dublin, Ireland, Prof. Günther Eissner, too.<br />

In his lecture on Native Organotypic ECM (Extracellular Matrix) for Coatings, Hydrogels and Scaffolds<br />

John made it very clear how the targeted use of native coatings not only proliferates the cells but also<br />

improves the adhesion of the cells. "You have to imagine if your cells are in a room with only brick walls.<br />

It's not very comfortable, is it?", John O´Neill explains the functionality of his organspecific product line<br />

compared to competitors such as Matrigel. Those offer often a cocktail disease-associated physiological<br />

factors such as collagens. This convinced the scientists:<br />

"The future of today's research is clearly moving in the direction of 3D," says one of the talk participants.<br />

"The right environment for the cells is becoming increasingly important in my field," she says. Possible<br />

applications include stem cells, tissue engineering, 3D cell culture and cancer research.<br />

Another participant hopes to receive support for his drug screening project from the novel organoid<br />

ECMs: "International research on pancreas organoid models is still in its infancy anyway.”<br />

CSO John O´Neill also had a delicacy for his audience: "Very soon we will be able to offer ECMs not only<br />

of animated but also of human origin". His colleagues Dr. Richard Nguyen, Business Development, and<br />

EastRiver Board Member Anthony A. Curro were particularly impressed by the IZB: “The event<br />

was a great success for us," said Anthony, who is also CEO the Biotech-company Immplacate: “It's<br />

like old times in New York, Alexandria Biotech Center. The audience, a great campus, great people, great<br />

atmosphere.” They will be back – soon, and then EastRiver has a new name: XYLYX Bio.<br />

Want to know more? Browse www.pelobiotech.com or info@pelobiotech.com

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EastRiver BioSolutions is now Xylyx Bio<br />

Our partner East River Bio has rebranded! Recognizing the importance of the native cell microenvironment,<br />

Xylyx Bio, formerly ER Bio, is harnessing the power of tissue-specific extracellular<br />

matrix for both drug discovery and tissue regeneration.<br />

NativeCoat and TissueSpec® ECM substrates represent the complexity of natural extracellular<br />

matrices and thus provide the essential cues that underlie cell function to enable cell models that<br />

are significantly more predictive of human physiology.<br />

Your advantages:<br />

<br />

<br />

<br />

Improved cell attachment<br />

Increased cell viability and proliferation<br />

Enhanced function<br />

<br />

Activation of signaling pathways<br />

Formerly...<br />

is now

---

PELONews<br />

Did you know?<br />

The new 3D<br />

CoSeedis Micro-<br />

Tumour System –<br />

WiDr offers fully validated<br />

protocols and includes<br />

all required components<br />

to successfully<br />

grow tumour cells into<br />

3D spheroids. It is ideally<br />

suited to establish the<br />

3D CoSeedis technology<br />

in your lab and provides<br />

easy-to-follow<br />

SOPs for:<br />

Pic : abc biopply<br />

3D CoSeedis: Valuable 3D Data<br />

in Radiation Therapy Response<br />

A recent publication in Translational Oncology (Vol. 11, No. 6, 2018;<br />

1307 – 1322), has shown the importance of proteome studies in the investigation<br />

of carcinoma responsiveness (pancreatic ductal adenocarcinoma,<br />

PDAC) to chemoradiation. Important evidence was provided by<br />

addressing the radiation resistance of A37-treated MiaPaCa-2 3D cell<br />

aggregates in 3D CoSeedis. The publication is available under:<br />

[10.1016/j.tranon.2018.08.001];<br />

or contact us for further information on 3D CoSeedis and its wide range<br />

of applications.<br />

3D aggregate formation<br />

Maintenance of aggregates<br />

for up to 10<br />

weeks<br />

Harvest of grown<br />

spheroids<br />

The system allows to<br />

monitor tumour growth in<br />

real-time and to accurately<br />

measure growthrelated<br />

effects of treatments.<br />

Furthermore, the system<br />

is fully compatible with<br />

abc biopply’s organoid<br />

histology system.<br />

How to reach us:<br />

If you need any further assistance or if you like what you see, tell us:<br />

PELOBiotech GmbH<br />

Klopferspitz 19 82152 Planegg | Germany<br />

Tel.: +49 89 517286 59 0 | info@pelobiotech.com | www.pelobiotech.com<br />

Dr.Peter Frost HRB 197203<br />

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