Farmakoepi-Nyt - Dansk Selskab for FarmakoEpidemiologi

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Side 6 Marts 2010 mængde af danskere der dagligt tager medicinen. Overordnet konkluderer afhandlingen, at nogle NSAID er forbundet med øget risiko for kardiovaskulær mortalitet og morbiditet blandt raske mennesker. Især de selektive COX-2 hæmmere og det mere traditionelle præparat diclofenac var forbundet med en øget kardiovaskulær risiko. Fordi at disse lægemidler anvendes i så stort antal og fordi nogle af dem er tilgængelige i håndkøb peger dette PhD-studie på, at disse lægemidler poserer en fare for folkesundheden. Faren forbundet med disse præparater bør gøres klar for forbrugerne og risici ved behandlingen bør altid tages med i overvejelserne når en behandling med NSAID startes – hvilket gøres bedst af en læge. Vejledere: Christian Torp-Pedersen, Gunnar H. Gislason og Lars Køber. Opponenter: Jesper Hallas, Gorm Bøje Jensen og Susana Perez-Gutthann. Kopi af afhandlingen kan rekvireres hos forfatteren på e-mail: elf@heart.dk AUTOREFERATER Ph.d.-afhandling Lars Hougaard Nielsen Department of Biostatistics, Institute of Public Health, University of Copenhagen, forsvarede sin ph.d.-afhandling den 19. februar 2010: Describing episodes of postmenopausal hormone therapy using prescription data Supervisors: Niels Keiding, Department of Biostatistics, University of Copenhagen Ellen Løkkegaard, Obstetric and Gynecological Department, Hillerød Hospital Opponents: Mette Madsen, Institute of Public Health, University of Copenhagen Jesper Hallas, Department of Clinical Pharmacology, University of Southern Denmark Garnet Anderson, School of Public Health, University of Washington The Department of Biostatistics would like to invite you to a reception afterwards in room 5.2.46, CSS, University of Copenhagen, Øster Farimagsgade 5, Copenhagen. Abstract: The Danish prescription registry contains information on prescriptions dispensed at all Danish pharmacies since 1995. Such registries are an enormous resource for studying drug therapy in large populations, in particular in Denmark (and the other Scandinavian countries), since in this case the registry covers an entire country. From a methodological point of view, the largest limitation with respect to research applications of such registries has to do with the fact that prescription registries provide information on drug purchase, whereas applications most often concern maintenance of drugs. Using prescription data as proxies for drug exposure induce measurement error in the exposure variable, and the main focus of this Ph.D. thesis has been to study the importance of this measurement error in different applications involving postmenopausal hormone therapy (HT). Treatment episodes are essentially made up of two types of (possibly recurrent) events (i) treatment initiation and (ii) treatment discontinuation. While initiation often can be expected to occur around the time of the first prescription subsequent discontinuation is less connected to the data available from prescription registries. In the thesis, we present a method for assessing the validity of treatment discontinuation assessed from prescriptions and investigate the case of postmenopausal hormone therapy. The presented methodology is formulated as a multi state model and estimation involves investigation of backwards recurrence times. In conclusion we found high validity of HT exposure defined from prescription data, although the exact time point of HT discontinuation was difficult to estimate from prescription data.
Side 7 Marts 2010 MØDER, KURSER og STILLINGER Danmark: Det Farmaceutiske Fakultet, Københavns Universitet udbyder følgende enkeltkurser: Pharmacology, 17.-21. maj 2010. (Ansøgningsfrist 1. marts 2010) Kommunikation, rådgivning og information om lægemiddelanvendelse, 19.-21. maj + 23.- 25. august 2010. (Ansøgningsfrist 19. marts 2010) Non-Clinical Safety and Toxicology, 11.-15. oktober 2010. (Ansøgningsfrist 1. august 2010) Evidensbaseret lægemiddelanvendelse i praksis, 15.-17. november 2010 + 18.-20. januar 2011. (Ansøgningsfrist 1. september 2010) Drug Formulation and Delivery, 6.-10. december 2010. (Ansøgningsfrist 1. oktober 2010). Nærmere oplysninger: www.farma.ku.dk/enkeltkurser www.farma.ku.dk/kursuskatalog Udlandet: 26th ICPE: International Conference on Pharmacoepidemiology & Therapeutic Risk Management August 19-22, 2010 Hilton Brighton Metropole Brighton, England, UK Nærmere oplysninger: www.pharmacoepi.org
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Farmakoepi-Nyt - Dansk Selskab for FarmakoEpidemiologi

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