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sarcoma de tejidos blandos

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Mecanismo <strong>de</strong> Acción Acci<br />

•Única en su capacidad <strong>de</strong> unirse covalentemente a la gruta menor <strong>de</strong>l DNA<br />

•Dobla el la Doble Hélice hacia el surco mayor<br />

•Inhibe activación transcripcional <strong>de</strong> algunos genes inducibles<br />

•Induce arresto <strong>de</strong>l ciclo celular en G2/M y apoptosis a través <strong>de</strong> un<br />

mecanismo in<strong>de</strong>pendiente <strong>de</strong> p53

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