Plantes à Alcaloïdes et produits apparentés - Master VRV ...

!"##$%!&"#'()*+&+,-."#'"/'-.+(",/-+!"#
PLANTES A ALCALOIDES
ET PRODUITS APPARENTES
Bernard Weniger
Pharmacognosie et Molécules Naturelles Bioactives
UMR 7200, Lab. d’Innovation Thérapeutique
Faculté de Pharmacie - Université de Strasbourg
PLAN DU COURS
1. Généralités sur les alcaloïdes
!"#$%$&$'%
!$(&)$*+&$'%,
!$(&)$*+&$'%,- "&.&,%.&+)/0
1$'(2%&34(/,/&,&25/(,(&)+6&+).+7
8.).6&")$(&$9+/( 8.).6&")$(&$9+/(,532($6' 532($6' 532($6'-63$:$9+/( 63$:$9+/(
;7&).6&$'%
2. Monographies de plantes

Relations biogénétiques entre les différents types
de métabolites secondaires
GÉNÉRALITÉS - DÉFINITION
>.):$,0/(,:"&.*'0$&/(,(/6'%D.$)/(@,.06.0'CD/(,/&,
3"&")'($D/(,6'%(&$&+/%&,0/(,5)$%6$5/(,.6&$#(,:.P/+)(,
/%,&3").5/+&$9+/,

GÉNÉRALITÉS - DÉFINITION
>)'&' >)'&'--.06.0'CD/(,'+,5(/+D'
.06.0'CD/(,'+,5(/+D'-.06.0'CD/(,F,
.06.0'CD/(,F,
.0c20.:$%/(,/&,.)20.:$%/(,
D/,0.)H/,D$(&)$*+&$'%
*"&.0.C%/(
5/5&$D/(,/&,.6G,.:$%"(
.:$D/(
5')532)$%/(,GG
PSEUDOALCALOÏDE : CAPSAÏCINE
8.5(.C6$%/,/&,D")$?"(F,.((/e,
('0+*0/(,D.%(,/.+,/&,3+$0/
E%.0H"($9+/(,&'5$9+/(@,
D"(/%($*$0$(.%&,)"6/5&/+)(,
D'+0/+)(@ D'+0/+)(@,)+*"#$.%&(@, )+*"#$.%&(@
D$.53')"&$9+/(
f)$H$%/,*$'(2%&3"&$9+/,:$7&/,F,
53"%205)'5.%/,d,*).%63/:/%&,
63.g%/,.0253.&$9+/
PSEUDOALCALOÏDE : BÉTALAÏNES
>$H:/%&(,.e'&"(,)/&)'+?"(,D.%(,6/)&.$%/(,
#.:$00/(,*'&.%$9+/(,K)/:50.6/%&,.%&3'62.%/(M
>)'5)$"&"(,.%&$'7$D.%&/(
0123456547

GÉNÉRALITÉS - DÉFINITION
E06.0'CD/(,%/,6'%&/%.%&,5.(,D_'72H4%/,F
0$9+$D/(,=,&/:5").&+)/,')D$%.$)/
?'0.&$0(@,/%&).g%.*0/(,=,0.,?.5/+),D_/.+,
%$6'&$%/ (5.)&"$%/
ALCALOÏDES
Distribution -état état naturel
SX, SX, 1.6&")$/(,K 1.6&")$/(,KPseudomonas
PseudomonasM
83.:5$H%'%(,K5($0'62*/@,.:.%$&/@,/)H'&M
Y2:%'(5/):/(,K
Y2:%'(5/):/(,KTaxus, Taxus, Ephedra EphedraM, M,
ALCALOÏDES
Distribution -état état naturel
Rh,X,D/(,.06.0'CD/(,(/,)/&)'+?/%&,63/e,0/(,,
!$6'&20"D'%/(,,
U%/,9+$%e.$%/,D/,#.:$00/(,('%&,5.)&$6+0$4)/:/%&
)$63/(,/%,50.%&/(,=,.06.0'CD/(
i/(,50+(,$:5')&.%&/(,('%&,0/(,(+$?.%&/(,F
E%%'%.6"/(@,E5'62%.6"/(@,i.+).6"/(@,
i'H.%$.6"/(@,.5.?/).6"/(@,j+*$.6"/(@,B'0.%.6"/(L
Y0'*.0/:/%&,F,\O
Y0'*.0/:/%&,F,\O-\W,X,D/(,E%H$'(5/):/(,,,
\W,X,D/(,E%H$'(5/):/(,,,
6'%&$/%%/%&,D/(,
6'%&$/%%/%&,D/(,.06.0'CD/(,/%,9+.%&$&",%'&.*0/(
.06.0'CD/(,/%,9+.%&$&",%'&.*0/(

ALCALOÏDES
Distribution -état état naturel
k.*$&+/00/:/%&,=,0l"&.&,D/,(/0(,D.%(,0.,50.%&/F,:.0.&/@
6$&).&/@,&.)&).&/,.$%($,9+_,/%,6':*$%.$('%,.?/6,0/(,&.%$%(
i'6.0$(.&$'%,
i'6.0$(.&$'%, &$((+(,5")$53")$9+/(
j"5.)&$&$'%,D$?/)($#$"/,F
0.)H/,F,6.#"$%/@,)"&$6+0$%/
)/(&)/$%&/,F,32'(6$.:$%/,KB'0.%.6"/(M@,:')53$%/,K
)/(&)/$%&/,F,32'(6$.:$%/,KB'0.%.6"/(M@,:')53$%/,KPapaver PapaverM, M,
('+?/%&,:"0.%H/,6':50/7/,D_')$H$%/,*$'(2%&3"&$9+/,6'::+%/,
]/%/+),F,
?.)$/,D.%(,D/,0.)H/(,0$:$&/(,F,"&.&,D/,&).6/(,
?.)$/,D.%(,D/,0.)H/(,0$:$&/(,F,"&.&,D/,&).6/(, \N, \N,X,K9+$%9+$%.M
X,K9+$%9+$%.M
?.)$.*$0$&",$:5')&.%&/,K/%?$)'%%/:/%&@,(.$('%@,3/+)/M
V'%6&$'%(,D.%(,0.,50.%&/,0.)H/:/%&,:"6'%%+/(,F,
5)'D+$&(,D_/76)"&$'%,D+,:"&.*'0$(:/,.e'&"
)"(/)?/,D_.e'&/@,D"#/%(/,6'%&)/,0/(,5)"D.&/+)(,LG
BIOSYNTHÈSE ET TYPES STRUCTURAUX
BIOSYNTHÈSE ET TYPES STRUCTURAUX

CARACTÉRISTIQUES PHYSICO-CHIMIQUES
PHYSICO CHIMIQUES
B'0+*$0$&",D/(,.06.0'CD/(,(/0'%,0/,5k,F
CH 3 COO
N
N
H +
5k,.06.0$%,F,
9+$%'0"$%/, 9+$%'0"$%/,*.(/, *.(/, ('0+*0/,,,
D.%( D.%(,('0?.%&(,')H.%$9+/(,
D.%(,('0?.%&(,')H.%$9+/(,/&,
('0?.%&( ')H.%$9+/( /& /&,
0/(, 0/(,.06''0( .06''0(
5k,.6$D/,K/7F,.6G,.6"&$9+/M,F
.6"&.&/,D/,9+$%'0"$%/, ('0+*0/
D.%(,0_/.+,/&,0/(,.06''0(
CARACTÉRISTIQUES PHYSICO-CHIMIQUES
PHYSICO CHIMIQUES
E+&)/,/7/:50/
E+&)/,/7/:50/F,6'6.C%/,*.(/,/&,630')32D).&/,D/,6'6.C%/,
F,6'6.C%/,*.(/,/&,630')32D).&/,D/,6'6.C%/,

CARACTÉRISTIQUES PHYSICO-CHIMIQUES
PHYSICO CHIMIQUES
B'0+*$0$&",D/(,(/0(,D.%(,0J/.+,F
630'32D).&/(,m,(+0#.&/(,m,&.)&).&/(
B'0+*$0$&",D.%(,0_.06''0,F,
*.(/(,/&,(/0(,('%&,('0+*0/(,D.%(,0/(,.06''0(
*.(/( *.(/(,/&,(/0(,('%&,('0+*0/(,D.%(,0/(,.06''0(
/& (/0( ('%& ('0+*0/( D.%( 0/( .06''0(
B'0+*$0$&",D$##")/%&/,($,5+),'+,/%,:"0.%H/,F
5)"(/%6/,D/,(.5'%'($D/(,
5)"(/%6/,D/,(.5'%'($D/(, :'D$#$/,('0+*$0$&",
/7 F,/7&).6&$'%,D/(,.06.0'CD/(,D/,
F,/7&).6&$'%,D/(,.06.0'CD/(,D/,Catharanthus
Catharanthus
roseus K.P:.0$6$%/M
EXTRACTION DES ALCALOIDES
+$(, >+$(,5+)$#$6.&$'%,5.),/7&).6&$'%,0$9+$D/,
5+)$#$6.&$'%,5.),/7&).6&$'%,0$9+$D/,- 0$9+$D/,
K('0?.%&(, K('0?.%&(,%'%, %'%,:$(6$*0/(M,.5)4(,63.%H/:/%&,D/,5k
:$(6$*0/(M,.5)4(,63.%H/:/%&,D/,5k

éé
éé
EXTRACTION DES ALCALOIDES
E)&"#.6&( D_/7&).6&$'%,
D_/7&).6&$'%,/%,5)"(/%6/,D_.6$D/,#')&,
/%,5)"(/%6/,D_.6$D/,#')&,
'+,D/,*.(/,#')&/,F
;7/:50/,D/(,$)$D'CD/(,K(o")'($D/,D/,0.,H/%&$.%/M,
($,/7&).6&$'%,/%,5)"(/%6/,D_.::'%$.9+/,6'%6/%&)"/,
H/%&$.%$%/,p,.06.0'CD/,.)&"#.6&
Glucose
O
O
O
EXTRACTION DES ALCALOIDES
8.(,D/(, 8.(,D/(,.06.0'CD/(,#.$*0/:/%&,*.($9+/(,
.06.0'CD/(,#.$*0/:/%&,*.($9+/(,F, F,
/7/:50/,D/,0.,6.#"$%/,/&,D/(,.+&)/(,7.%&3$%/(,
KD"0'6.0$(.&$'%,D/(,"0/6&)'%(M
/7&).6&$'%,5'(($*0/,D/(,.06.0'CD/(,*.(/,5.),0_/.+,63.+D/,
CH 3 N
O
O
NCH 3
NCH 3
N
CH 3 N
O
O
NCH 3
H
N
N
HN
NCH 3
NCH 3
O
O
N

EXTRACTION DES ALCALOIDES
E06.0'CD/(,9+.&/)%.$)/(,F
;7,F,*/)*")$%/@,32D).(&$%/GG
n/,5/+?/%&,5.(,^&)/,,,
/7&).$&(,(/0'%,0.,:"&3'D/,
D/,B&.( D/,B&.(-f&&' f&&'
/7&).$&(,(/0'%,0.,:"&3'D/, N +
N
O
#'):/,*.(/,
#'):/,*.(/,F,fk F,fk- /&, /&, #'):/,(/0, #'):/,(/0,F,80 F,80- kd &'+P'+)(, &'+P'+)(,D$(('6$"(, D$(('6$"(,
&'+P'+)(,('0+*0/(,D.%(,0_/.+,
/&,$%('0+*0/(,D.%(,0/(,('0?.%&(,')H.%$9+/(
EXTRACTION DES ALCALOIDES
E06.0'CD/(,53"%'0$9+/(,
E06.0'CD/(,53"%'0$9+/(,K,:')53$%/,M,F
K,:')53$%/,M,F
V'):.&$'%,D/,53"%.&/,/%,
5
:$0$/+,.06.0$%,
:$0$/+,.06.0$%, 5.((.H/,/%,
53.(/,.9+/+(/,
53.(/,.9+/+(/,.+&)/(, .+&)/(,
.06.0'CD/(,D/,0_'5$+:
O
HO
HO
NCH 3
OMe
OMe
n/,5/+?/%&,5.(,^&)/,/7&).$&,(/0'%,0.,:"&3'D/,D/,B&.(
n/,5/+?/%&,5.(,^&)/,/7&).$&,(/0'%,0.,:"&3'D/,D/,B&.(-f&&' f&&'
EXTRACTION DES ALCALOIDES
;7&).6&$'%,$%D+(&)$/00/,F
U&$0$(.&$'%(,D/,)".6&/+)(,D/,H).%D/,&.$00/
8/)&.$%(,('0?.%&(,$%&/)D$&(,K&'7$6$&"@,#0.::.*$0$&"@
D.%H/) D.%H/),D/750'($'%M
D.%H/) D.%H/),D/750'($'%M
DJ/750'($'%M
8'%D$&$'%(,"6'%':$9+/(,/&,5).&$9+/(,D"&/):$%.%&/(
j/63/)63/,D/,5)'6"D"(,5.)&$6+0$/)(,F,)".6&$'%(,
D.%(,0/,:$0$/+@,5)"6$5$&.&$'%(,("0/6&$?/(,LG
O

EXTRACTION DES ALCALOIDES
;7&).6&$'%,D/,0J.P:.0$6$%/,
;7&).6&$'%,D/,0J.P:.0$6$%/,D/(,).6$%/(,D/,
D/(,).6$%/(,D/,
Rauwolfia serpentina Ki.*G,>$/))/,V.*)/M,F
NMe
OH
N
OH
C 2 H 5
EP:.0$6$%/,K,p,).+*.($%/,M,
EP:.0$6$%/,K,p,).+*.($%/,M, .6&$#,%$?/.+,?.(6+0.$)/,6")"*).0
6&$#,%$?/.+,?.(6+0.$)/,6")"*).0
>)"(/%&/,/%,:"0.%H/,.?/6,.06.0'CD/(,%'%,$%&")/((.%&(,F
(/)5/%&$%/,K,*.(/,#')&/,M@,)"(/)5$%/@,*.(/(,#.$*0/(,GG,
EXTRACTION DES ALCALOIDES
N
H
N
N -
MeOOC
N +
MeOOC
OMe
O
COO OMe
OMe
OMe
EXTRACTION DE L'AJMALICINE DES
RACINES DE CATHARANTHUS ROSEUS
11

MISE EN ÉVIDENCE DES ALCALOIDES
j".6&$'%(,D/,6':50/7.&$'%,
j".6&$'%(,D/,6':50/7.&$'%,F
K5)"6$5$&.&$'%@,6'0').&$'%M
5)"6$5$&.&$'%@,6'0').&$'%M
1.("/(,(+),6.5.6$&",D/,6':*$%.$('%,.?/6,:"&.+7,/&,
:"&.0'CD/(,F,1$@,kH@,q@,[
]'+P'+)(,/%,:$0$/+,.9+/+7,.6$D/ P 9
F
;Y@,(.5'%$%/( (.5'%$%/(
DOSAGE PHARMACOPEE
!'(.H/,D/(,.06.0'CD/(,&'&.+7,F
.?'&@,'5$+:,/&,:')53$%/
'5$+: /& :')53$%/
ZG A+$%9+$%.,/&,9+$%$%/
NG B'0.%.6"/(,=,.06.0'CD/(,&)'5.%$9+/(
WG >0.%&/(,=,.06.0'CD/(,.%&$&+:').+7

Matières premières à caféine
CAFE ET CAFEINE
U%/,6'+)&/,3$(&'$)/,D+,6.#",,,,
8.#"$/),%.&$#,D/,0_E#)$9+/,D/,0_/(&,K(5G,
8.#"$/),%.&$#,D/,0_E#)$9+/,D/,0_/(&,K(5G,arabica arabicaM,/&,*.(($% M,/&,*.(($%
D+,8'%H',K(5G,
D+,8'%H',K(5G,canephora canephoraM
]'))"#$6.&$'%,/&,5)"5.).&$'%,D+,*)/+?.H/,D_')$H$%/,,,
.).*/ ;+)'5/ = 0. #$% D+

ASPECTS BOTANIQUES
U%/,6/%&.$%/,D_/(546/(,D/,
U%/,6/%&.$%/,D_/(546/(,D/,Coffea Coffea Kj+*$.6"/(M,,,
%.&$?/(,5'+),0.,50+5.)&,D_E#)$9+/@,5'+((.%&,D.%(,
D/(,3.*$&.&(,&)'5$6.+7,'+,(+*
D/(,3.*$&.&(,&)'5$6.+7,'+,(+*-&)'5$6.+7 &)'5$6.+7
A+.&)/,/(546/(,$:5')&.%&/(,D_+%,5'$%&,D/,?+/,,
6'::/)6$.0
6'::/)6$.0,F
Coffea Coffea arabica iG, iG, SW,X,5)'D+6&$'%,:'%D$.0/
S, S,- h,:'$(,/%&)/,0.,#0').$('%,/&,0.,:.&+).&$'%
D/+7,('+( D/+7,('+(-/(546/(,F, /(546/(,F,
?.)G, ?.)G,arabica arabica F,1)"($0@,E#)$9+/,D/,0_/(&@,E($/
?.)G, ?.)G,bourbon bourbon F,6.#",D_.0&$&+D/,Ki.,j"+%$'%M
ASPECTS BOTANIQUES
Coffea canephora >$/))/, >$/))/, .55/0", .55/0",6.#", 6.#",robusta robusta
u ZO,X,D/,0.,5)'D+6&$'%,:'%D$.0/,K$%(&.%&.%"M
u b, b,- \\,:'$(,D/,0.,#0').$('%,=,0.,:.&+).&$'%
u 6.#",D/,v*.((/,&/))/w,KE#)$9+/,"9+.&')$.0/M
u ?$H'+)/+7@,)"($(&.%&,.+7,:.0.D$/(@,6.#"$%/,
?$H'+)/+7@,)"($(&.%&,.+7,:.0.D$/(@,6.#"$%/,
u .)x:/,/&,H'y&,$%#")$/+)(,=,
.)x:/,/&,H'y&,$%#")$/+)(,=,C. C. arabica
C. excelsa EG,83/?G
u ?$H'+)/+7@,)"($(&.%&,.+7,:.0.D$/(,/&,("63/)/((/
C. liberica qG,1+00G,;7,k$/)%
u \N,:'$(,D/,0.,#0').$('%,=,0.,:.&+).&$'%
u H).$%(,D/,H).%D/,&.$00/,
u \X,D/,0.,5)'D+6&$'%,:'%D$.0/
Répartition des espèces

&$&,.)*)/,F
LA PLANTE
V/+$00/(,/%&$4)/(,5/)($(&.%&/(@,
6')$.6/(@,0+$(.%&/(
V0/+)(,*0.%63/(,'D').%&/(,/%
?/)&$6$00/(
!)+5/,6':5')&.%&,Q,H).$%/(,
.66'0"/(,?/)&/,
.66'0"/(,?/)&/, )'+H/,=,
:.&+)$&"
Caféier en fleur
Drupe en voie de maturation

LA RECOLTE DU CAFE
LA DROGUE VÉGÉTALE
LA DROGUE VÉGÉTALE
f*&/%&$'%,D+,6.#",v/%,H).$%w,F,
K,:"&3'D/(,3+:$D/,'+,(463/,M
!"5+05.H/,
!"5+05.H/,F,"0$:$%.&$'%,/7'6.)5/,
F,"0$:$%.&$'%,/7'6.)5/,
)'+H/,/&,:"('6.)5/,63.)%+
!"5.)63.H/ !"5.)63.H/,
!"5.)63.H/,F,"0$:$%.&$'%,/%D'6.)5/,
F"0$:$%.&$'%/%D'6.)5/
F,"0$:$%.&$'%,/%D'6.)5/,
(60")$#$", (60")$#$", v#4?/w,p,H).$%/,D/,6.#"
i.,H).$%/,K6.#",?/)&M,F
'?.0/@,6'%?/7/,(+),#.6/,D')(.0/@
.50.&$/,(+),#.6/,?/%&).0/
($00'%,0'%H$&+D$%.0,p,3$0/
D+)/,/&,?/)Ds&)/@,$%'D')/
Structure du fruit et de la graine
du caféier :
\F,($00'%,6/%&).0,
QF,H).$%,D/,6.#",K/%D'(5/):/M,
ZF,5/.+,D+,H).$%,K&"H+:/%&M,
NF,5.)63/,K/%D'6.)5/M,
WF,6'+63/,D/,:+6$0.H/(,
SF,5+05/,K:"('6.)5/M,
RF,5/.+,D+,#)+$&,K/7'6.)5/M,
Drupes de café
«fève fève » avant torréfaction

arabica
Café vert :
robusta
CARACTÈRES CHIMIQUES
WO,X, WO,X,H0+6$D/( H0+6$D/( K(+6)/(,d,5'02(.663.)$D/(M,
\\,X, \\,X,5)'&"$%/( 5)'&"$%/(
\O \O, \O \O,- \W \W,X, \W,X,0$5$D/( X 0$5$D/( K(&")'0( K(&")'0(@,&'6'53")'0(@,.06''0(,
&'6'53")'0( .06''0(
D$&/)5"%$9+/(,0$*)/(,/&,/(&")$#$"(M
W, W,- hX,/%?$)'%,D_
hX,/%?$)'%,D_.6$D/(,53"%'0(,
.6$D/(,53"%'0(,/&,D")$?"(, /&,D")$?"(,
K630')'H"%$9+/@,6.#"$9+/M
O@S, O@S,- Z,X,D/, Z,X,D/,6.#"$%/ 6.#"$%/ (/0'%,?.)$"&"(,d,&).6/(,D/,
&3"'*)':$%/

CARACTÈRES SENSORIELS
DU CAFÉ VERT MARCHAND
i/(,&/%/+)(,/%,.6$D/(,53"%'0(,/&,6.#"$%/ )/%(/$H%/%&,
(+),0_.:/)&+:/,D+,6.#",?/)&,F,
0.,&/%/+),/%,.6$D/(,630')'H"%$9+/(,D'$&,(/,($&+/),
/%&)/,R,/&,h,X,
0. 0.,&/%/+),/%,6.#"$%/@,5'+),+%,arabica@,D'$&,^&)/,z,\@NO,X
&/%/+) /% 6.#"$%/ 5'+) +% arabica D'$& ^&)/ z \ NO X
/)&/,D_3+:$D$&",/&,)".6&$'%(,D/,/)&/,D_3+:$D$&",/&,)".6&$'%(,D/,

LA DÉCAFEINISATION DU CAFÉ
i/,6.#",?/)&,D"6.#"$%",D'$&,6'%&/%$),z,O@Ob,X,D/,,
6.#"$%/,/&,0/,6.#",&'))"#$",D"6.#"$%",,O@\,X,D/,,
6.#"$%/,/&,0/,6.#",&'))"#$",D"6.#"$%",,O@\,X,D/,,
6.#"$%/, 6.#"$%/,K%'):/,#).%t.$(/M
K%'):/,#).%t.$(/M
U%/,&.((/,D/,6.#",D"6.#"$%",6'%&$/%&,\W,#'$(,:'$%(
D/,6.#"$%/,9+_+%/,&.((/,D_
D/,6.#"$%/,9+_+%/,&.((/,D_arabica arabica
i., i.,D"6.#"$%.&$'%
D"6.#"$%.&$'% (/,#.$&,&'+P'+)(,
(/,#.$&,&'+P'+)(,(+),0/,6.#",?/)&,
(+),0/,6.#",?/)&,6.), 6.),
'%,('+3.$&/,F
)/&$)/),(/+0/:/%&,0.,6.#"$%/,/&,0/,:'$%(,5'(($*0/,D/,
6':5'("(,?'0.&$0/(,.)':.&$9+/(
*"%"#$6$/),D/,0.,63.0/+),D/,0.,&'))"#.6&$'%,5'+),("63/),
0/,6.#",3+:$D$#$",5.),0.,D"6.#"$%.&$'%,
LA DECAFEINISATION DU CAFE
[0,/7$(&/,&)'$(,:"&3'D/(,F
!"6.#"$%.&$'%,=,0_/.+,F,
i/(($?.H/,=,63.+D,D/(,H).$%(,?/)&(,('+(,5)/(($'%
>+$(,("63.H/,=,0_.$),63.+D,/&,&'))"#$6.&$'%
!"6.#"$%.&$'%,5.),('0?.%&,630')",K8k
!"6.#"$%.&$'%,5.),('0?.%&,630')",K8kQ80 80QM i/(($?.H/,5.),('0?.%&(,630')"(,D/(,H).$%(,?/)&(,5)"
i/(($?.H/,5.),('0?.%&(,630')"(,D/(,H).$%(,?/)&(,5)"-3+:$D$#$"( 3+:$D$#$"(
;0$:$%.&$'%,D+,('0?.%&,5.),"?.5').&$'%@,5+$(,5.),/%&).g%/:/%&,=,
0.,?.5/+)@,("63.H/,D/(,H).$%(,=,0_.$),63.+D@,5+$(,&'))"#$6.&$'%
!"6.#"$%.&$'%,.+,8f
!"6.#"$%.&$'%,.+,8fQ (+5/)6)$&$9+/
B+),D/(,H).$%(,?/)&(,5)".0.*0/:/%&,3+:$D$#$"(
LE CAFÉ SOLUBLE
[0,(/,5)"5.)/,$%D+(&)$/00/:/%&,=,5.)&$),D/,6.#",
:'+0+@,5.),/7&).6&$'%,('0$D/|0$9+$D/,
:'+0+@,5.),/7&).6&$'%,('0$D/|0$9+$D/, 6'%#/6&$'%,
D_+%,/7&).$&,.9+/+7,&)4(,6'%6/%&)"@,D_.(5/6&,
($)+5/+7,
8/& 8/&,/7&).$&,/(&,/%(+$&/,6':504&/:/%&,D"(32D).&"@,
/7&).$& /(& /%(+$&/ 6':504&/:/%& D"(32D).&"
('$&,5.),.&':$(.&$'%@,('$&,5.),02'53$0$(.&$'%,F
5.),.&':$(.&$'%,
5.),.&':$(.&$'%,F,5+0?")$(.&$'%,K:$6)'H'+&&/0/&&/(M,
F,5+0?")$(.&$'%,K:$6)'H'+&&/0/&&/(M,
D.%(,+%,6'+).%&,D_.$),63.+D,
D.%(,+%,6'+).%&,D_.$),63.+D, H).%+0"(@,D/,5'&/%&$/0,
.)':.&$9+/,$%#")$/+)
5.),02'53$0$(.&$'%,
5.),02'53$0$(.&$'%,F,(+*0$:.&$'%,D/(,5.$00/&&/(,D/,
F,(+*0$:.&$'%,D/(,5.$00/&&/(,D/,
0_/7&).$&,D/,6.#",6'%H/0"

PRODUCTION MONDIALE DE CAFE
ASPECTS PHARMACOLOGIQUES
E6&$?$&"(,D":'%&)"/(,0$"/(,
=,0.,5)"(/%6/,D/,6.#"$%/,F
.%&.H'%$(&/(,D/(,)"6/5&/+)(,E\,/&,D/,
6/)&.$%(,)"6/5&/+)(,EQ,D/,0J.D"%'($%/
$%3$*/,0/(,53'(53'D$/(&").(/(,.$%($,9+/,0.,
0$*").&$'%,DJ3$(&.:$%/,5.),0/(,:.(&'62&/(
.6&$'%,(&$:+0.%&/,(+),0/(,(2(&4:/(,6.)D$'-
?.(6+0.$)/,/&,)/(5$).&'$)/@,/&,(+),0.,D$+)4(/
#.?')$(/,6'%6/%&).&$'%,/&,:":')$(.&$'%
.+H:/%&/,0.,D"5/%(/,"%/)H"&$9+/,
0$5'02&$9+/,5.),?'$/,/7&/)%/
U%/,9+.).%&.$%/,D/,(5"6$.0$&"(,53.):.6/+&$9+/(,/%,
V).%6/,K,.(('6$.&$'%,.?/6,.%&.0H$9+/(@,0$5'02&$9+/(,0'6.+7,M
8
k Z
f
n
f
n
8k Z
caféine
ASPECTS PHARMACEUTIQUES
n
n
8k Z

DOMAINE PHARMACEUTIQUE
Monographie analytique du café vert
>3.):.6'5"/,#).%t.$(/,} 4:/ 4:/ "DG
!)'H+/, !)'H+/,F,H).$%/,5)$?"/,D+,&"H+:/%&,/&,("63"/,D/,
F,H).$%/,5)$?"/,D+,&"H+:/%&,/&,("63"/,D/,Coffea Coffea arabica
iG@,D/, iG@,D/,Coffea Coffea canephora >$/))/,/7,V)'/3%/),/&,0/+)(,?.)$"&"(,
i/,6.#",?/)&,6'%&$/%&,
i/,6.#",?/)&,6'%&$/%&,.+,:$%$:+:,\@O,5'+),6/%&,D/,6.#"$%/,
.+,:$%$:+:,\@O,5'+),6/%&,D/,6.#"$%/,
6.06+0",5.),).55')&,=,0.,D)'H+/,D/(("63"/,
,
!'(.H/,D/,0.,6.#"$%/,5.),8ik>,K:'D$#$6.&$'%,:'%'H).53$/,/%,
K:'D$#$6.&$'%,:'%'H).53$/,/%,6'+)(,F 6'+)(,F
6' 6'-$%P/6&$'%, $%P/6&$'%,D_"5$6.&"63'0,5'+),?")$#$/),0.,6'%#'):$&",D+,(2(&4:/M,,,,
D_"5$6.&"63'0,5'+),?")$#$/),0.,6'%#'):$&",D+,(2(&4:/M,,,,
LE THEIER : Camellia sinensis (L.) Kuntze
U%/,6'+)&/,3$(&'$)/,D+,&3",
[0,.+).$&,"&",D"6'+?/)&,5.),0J;:5/)/+),B3^%
[0,.+).$&,"&",D"6'+?/)&,5.),0J;:5/)/+),B3^%-n+%H, n+%H,
KQROO,.?.%&, G8GM,F,6/,D/)%$/),(/,#$&,.55')&/),+%/,
&.((/,DJ/.+,*'+$00.%&/,/&@,.(($(,=,0J':*)/,DJ+%,&3"$/)@,
$0,(J.(('+5$&G,>/%D.%&,('%,('::/$0@,50+($/+)(,#/+$00/(
(/ (/,D"&.634)/%&,5'+),.00/),(/,5'(/),D.%(,0J/.+,*)y0.%&/
D"&.634)/%& 5'+) .00/) (/ 5'(/) D.%( 0J/.+ *)y0.%&/
0/,&3","&.$&,%"
i/,&3"$/),.55.)&$/%&,=,0.,#.:$00/,D/(,]/)%(&)'/:$.6"/(
K]3".6"/(M
f%,D$(&$%H+/,D/+7,?.)$"&"(,5)$%6$5.0/(,F
Camellia Camellia sinensis sinensis K,83$%/@, .5'%@,j+(($/@,[).%@]+)9+$/
Camellia Camellia sinensis assamica K,%')D K,%')D-/(&,D/,0J[%D/,M
/(&,D/,0J[%D/,M
LE THEIER : Camellia sinensis
8+0&$?",D.%(,0/(,5.2(,D+,
8+0&$?",D.%(,0/(,5.2(,D+,(+D (+D-/(&,.($.&$9+/,
/(&,.($.&$9+/,
:.$(,.+(($,(+),0/,6'%&$%/%&,.#)$6.$%@,/%,
]+)9+$/,'+,/%6')/,/%,E)H/%&$%/
>/&$&,.)*)/,).:/+7
>/&$&,.)*)/,).:/+7@,=,#/+$00/(,5/)($(&.%&/(@
@,=,#/+$00/(,5/)($(&.%&/(@
:'00/(,/&,D+?/&/+(/(,0')(9+J/00/(,('%&,
P/+%/( P/+%/(@,6')$.6/(,/&,5)/(9+/,H0.*)/(,
6')$.6/( /& 5)/(9+/ H0.*)/(
0')(9+J/00/(,('%&,sH"/(,K(60")$&/(M
;%,6+0&+)/@,0/(,&3"$/)(,('%&,
;%,6+0&+)/@,0/(,&3"$/)(,('%&,&.$00"( &.$00"( &)4(,
)"H+0$4)/:/%&,5'+),#.6$0$&/),0.,)"6'0&/
n"6/(($&/,+%,
n"6/(($&/,+%,/%('0/$00/:/%&
/%('0/$00/:/%& D/,W,3/+)/(,
:$%G,5.),P'+)@,3+:$D$&",D/,0J.$),KRO,
:$%G,5.),P'+)@,3+:$D$&",D/,0J.$),KRO,- bOXM,
/&,D/(,50+$/(,.*'%D.%&/(,K,/76/5&$'%,5'+),
0/(,&3"(,D_.0&$&+D/,M

LA RECOLTE DES FEUILLES DE THE
k.*$&+/00/:/%&@,'%,%/,6+/$00/,9+/,0/,
*'+)H/'% =,0_/7&)":$&",D/,0.,*).%63/,/&,
0/(,D/+7,#/+$00/(,(+$?.%&/(,0/(,50+(,P/+%/(,
)4H0/,D/(,` &o',0/.?/(,.%D,.,*+D a
;%,E#)$9+/@,'%,+&$0$(/,5.)#'$(,D/(,:.63$%/(@,
:.$(,.+,B)$,i.%c.,/&,/%,[%D/@,0/,&3",/(&,
$ B $ i c & [ D 0 &3" &
/%6')/,6+/$00$,=,0.,:.$%, :/$00/+)/,9+.0$&",
6.),0/(,6+/$00/+)(,0.$((/%&,D/,6x&",0/(,
5'+((/(,$%(+##$(.::/%&,:y)/(
E,*.((/,.0&$&+D/@,0/,&3",/(&,)"6'0&",P+(9+_=,
ZO,#'$(,5.),.%@,D.%(,0/(,3.+&/+)(@,
` (/+0/:/%& a,\W,#'$(@,6.),$0,5'+((/,50+(,
0/%&/:/%&
LE THEIER : CAMELLIA SINENSIS
8'::/)6$.0/:/%&@,'%,D$(&$%H+/,
(+)&'+&,,F
]3",*0.%6, ]3",*0.%6,F,(&.*$0$(",=,0.,?.5/+),,/&,("63"
F,(&.*$0$(",=,0.,?.5/+),,/&,("63"
]3",?/)& ]3",?/)&@,#s%",5+$(,(&.*$0$(",5.),0.,63.0/+)
@,#s%",5+$(,(&.*$0$(",5.),0.,63.0/+)
(463/,'+,5.),0.,?.5/+)@,)'+0"@,("63",,
5 5 @ @
).5$D/:/%&,/&,50+(,'+,:'$%(,&'))"#$"@,
K(+)&'+&,6'%('::",/%,83$%/,/&,.+, .5'%@
:.$(,0_+(.H/,(/,D"?/0'55/,/%,;+)'5/M
]3",%'$) ]3",%'$)@,#s%",+%/,?$%H&.$%/,DJ3/+)/(@,
@,#s%",+%/,?$%H&.$%/,DJ3/+)/(@,
)'+0"@,#/):/%&",/%,.&:'(534)/,3+:$D/,
5+$(,("63",=,0J.$),63.+D@,
5+$(,("63",=,0J.$),63.+D@,)/5)"(/%&.%&,
)/5)"(/%&.%&,
hO,X,D+,:.)63",:'%D$.0
]3",''0'%H,
]3",''0'%H,F,0"H4)/:/%&,#/):/%&"
F,0"H4)/:/%&,#/):/%&"
Thé vert
Thé noir
LE THEIER : CAMELLIA SINENSIS
]3"(,6'::/)6$.+7 F
~.)$"&"(,*'&.%$9+/(
?.)G, ?.)G,sinensis sinensis@, @,assamica assamica GG
EH/,D/(,#/+$00/(,
~.)$"&" ~.)$"&",D/(,&).$&/:/%&(F
D/( &).$&/:/%&(F
?/)&@,(/:$ ?/)&@,(/:$-'72D"(@,'72D"(@,.)':.&$("(,GG
'72D"(@,'72D"(@,.)':.&$("(,GG
f)$H$%/,H"'H).53$9+/
8/20.%,KB)$,i.%c.M
E((.:@,!.)P//0$%H,/&,B$cc$:,K[%D/M,
E%3+$,Kr//:+%M,/&,Ä+%%.%,K83$%/M
]3"(,D_E#)$9+/,Kr"%2.@,jo.%D.M
]3"(,D+,

VARIÉTÉS SELON LA TAILLE DES FEUILLES
`V0'o/)2,f).%H/,>/c'/a,KVf>MF
0.,#$%/,#/+$00/,D+,*'+)H/'%,=,#/+$00/(
`f).%H/,>/c'/a,Kf>M /(&,0.,
5)/:$4)/,#/+$00/,&/%D)/,/%&$4)/:/%&,
'+?/)&/ '+?/)&/,9+$,(/,)/#'):/,=,63.9+/,
9+$ (/ )/#'):/ = 63.9+/
53.(/,D/,6)'$((.%6/,D+,&3"$/)G,
B'%,H'y&,/(&,50+(,#')&,9+/,Vf>G,
`>/c'/a,K>M,D"($H%/,0.,D/+7$4:/,
#/+$00/,.5)4(,0/,*'+)H/'%,=,#/+$00/( F,
/00/,D'%%/,+%,H'y&,:.)9+",/&,+%/,
$%#+($'%,#')&/:/%&,6'0')"/
Dérivés flavaniques du thé vert
Flavanol
ASPECTS CHIMIQUES DU THE VERT
>)'&"$%/(@,.6$D/(,.:$%"(@,H0+6$D/(@,6.)'&4%/(
E6$D/,.(6')*$9+/,/&,?$&.:$%/(,D+,H)'+5/,1,
1.(/(,7.%&3$9+/(,
1.(/(,7.%&3$9+/(,5)$%6$5.0/:/%&,)/5)"(/%&"/(,5.),0.,
5)$%6$5.0/:/%&,)/5)"(/%&"/(,5.),0.,
6.#"$%/,KQ, 6.#"$%/,KQ,- N,X,(/0'%,?.)$"&"(,/&,#/+$00/(,6'%6/)%"/(M,d,
#.$*0/(,9+.%&$&"(,D/,&3"'53200$%/,/&,&3"'*)':$%/
k"&")'($D/( k"&")'($D/(,D.06''0(,&/)5"%$9+/(@,D'%&,0 k"&")'($D/( DJ.06''0( &/)5"%$9+/( D'%& 0J32D)'02(/ 32D)'02(/,0$*4)/, 0$*4)/
D/(,6'%(&$&+.%&(,9+$,6'%&)$*+/%&,=,0J.)x:/,D/,0J$%#+($'%
8':5'("(,53"%'0$9+/(,
8':5'("(,53"%'0$9+/(,KP+(9+J=, KP+(9+J=,ZO, ZO,X, X,D/, D/,0.,:.((/,(463/M,
0.,:.((/,(463/M,
:.$(,D'%&,0.,&/%/+),?.)$/,(/0'%,0.,?.)$"&"@,0JsH/,D/,0.,#/+$00/,
K0/(,50+(,P/+%/(,('%&,0/(,50+(,)$63/(M,/&,0.,(.$('%,
K0/(,50+(,P/+%/(,('%&,0/(,50+(,)$63/(M,/&,0.,(.$('%,K"&"M, "&"M,F
D")$?"(,#0.?.%$9+/(,F,H.00.&/,
D")$?"(,#0.?.%$9+/(,F,H.00.&/,D_"5$H.00'6.&"63'0,
D_"5$H.00'6.&"63'0,K;Y8YMF, K;Y8YMF,W-\Q,XM \Q,XM
.6$D/(,53"%'0(,
#0.?'%'CD/(,
5)'.%&3'62.%$D'0(

ASPECTS CHIMIQUES DU THE NOIR
i.,9+.%&$&",D/,
i.,9+.%&$&",D/,*.(/(,7.%&3$9+/(,
*.(/(,7.%&3$9+/(,5)"(/%&/,"?'0+/,5/+
5)"(/%&/,"?'0+/,5/+
!"?/0'55/:/%&,D/,0_.)x:/,5.),#'):.&$'%,D/,
!"?/0'55/:/%&,D/,0_.)x:/,5.),#'):.&$'%,D/,5)'D+$&(,?'0.&$0(
5)'D+$&(,?'0.&$0( F
D")$?"(,6"&'%$9+/(,5.),D"H).D.&$'%,D/(,6.)'&4%/(
3/7"%.0,5.),'72D.&$'%,D_.6$D/(,H).(,$%(.&+)"(
)".)).%H/:/%&,D/(,&/)54%/(
f72D.&$'%,D/(,
f72D.&$'%,D/(,5'0253"%'0(
5'0253"%'0( ?$($*0/,K63.%H/:/%&,D/,6'+0/+)M,,F
V'):.&$'%, '):.&$'%,D/,&)'5'0'%/(,F,&3".#0.?$%/@,&3".#0.H.0$%/@,
D/,&)'5'0'%/(,F,&3".#0.?$%/@,&3".#0.H.0$%/@,"5$&3".#0.H.0$%/
"5$&3".#0.H.0$%/
V')&/,D$:$%+&$'%,D/,0.,&/%/+),/%,D")$?"(,#0.?.%$9+/(,K6.&"63$%/(M
ACTIVITES BIOLOGIQUES
DES CONSTITUANTS DU THE
E6&$?$&"(,0$"/(,.+7,*.(/(,7.%&3$9+/(,K6.#"$%/M,
.6&$?$&",(&$:+0.%&/,:'$%(,$%&/%(/,:.$(,50+(,
5)'0'%H"/,9+/,0/,6.#",K6.#"$%/,0$"/,.+7,5'0253"%'0(M,
>'0253"%'0( K%'% K%'%,5'02:")$("(,D+,&3",?/)&M,F
5'02:")$("( D+ &3" ?/)&M F
)"D+6&$'%,D/(,6.%6/)(,D$H/(&$#(,/&,5)"?/%&$'%,D+,,
6.%6/),6'0')/6&.0,K,"&+D/(,"5$D":$'0'H$9+/(,M,
.6&$?$&"(,.%&$'72D.%&/(
.6&$?$&"(,.%&$*.6&")$/%%/(,K,6.)$/(@,(2(&4:/,D$H/(&$#,M
.6&$?$&",.%&$?$).0/
EVOLUTION DE LA PRODUCTION DE THÉ
AU NIVEAU MONDIAL

EVOLUTION DE LA PRODUCTION DE THÉ
AU NIVEAU MONDIAL
DOMAINE PHARMACEUTIQUE
Monographies analytiques du thé
Q,:'%'H).53$/(,=,0.,>3.):.6'5"/,#).%t.$(/,
THÉ VERT KCamelliae Camelliae sinensis non fermentata folia foliaM
V/+$00/@,P/+%/@,%'%,#/):/%&"/@,('+:$(/,=,+%/,D/(($66.&$'%,).5$D/,=,
63.+D@,5+$(,("63"/@,D/,
63.+D@,5+$(,("63"/@,D/,Camellia Camellia sinensis KiGM,r+%&e/,/&,D/,(/(,
?.)$"&"(,6+0&$?"/(G,
i/,&3",?/)&,6'%&$/%&,
i/,&3",?/)&,6'%&$/%&,.+,:$%$:+:,Q@O,X,D/,6.#"$%/,
.+,:$%$:+:,Q@O,X,D/,6.#"$%/,6.06+0",5.),).55')&,
6.06+0",5.),).55')&,
=,0.,D)'H+/,D/(("63"/
THÉ NOIR KCamelliae Camelliae sinensis fermentata folia foliaM
V/+$00/,P/+%/@,#/):/%&"/@,('+:$(/,=,+%/,D/(($66.&$'%,).5$D/,=,
63.+D@,5+$(,("63"/@,D/,
63.+D@,5+$(,("63"/@,D/,Camellia Camellia sinensis KiGM,r+%&e/,/&,D/,(/(,
?.)$"&"(,6+0&$?"/(G,
i/,&3",%'$),6'%&$/%&,
i/,&3",%'$),6'%&$/%&,.+,:$%$:+:,Q@W,X,6/%&,D/,6.#"$%/,
.+,:$%$:+:,Q@W,X,6/%&,D/,6.#"$%/,6.06+0",5.),
6.06+0",5.),
).55')&,=,0.,D)'H+/,D/(("63"/G,
DOMAINE PHARMACEUTIQUE
Monographies analytiques du thé
;7.:/%,:$6)'(6'5$9+/,
;7.:/%,:$6)'(6'5$9+/,F
.G,,:.60/(,D_'7.0.&/,D/,8.,/&,5'$0(,&/6&/+)(,+%$6/00+0.$)/(,=,5.)'$(,"5.$((/,/&,/7&)":$&",6'%$9+/
*G,,(60")$&/(
6G,,"5$D/):/,(+5")$/+),%'%,(&':.&$#4)/
DG,,"5$D/):/,$%#")$/+),(&':.&$#4)/,.?/6,(&':.&/(,/%&'+)"(,5.),Z,'+,N,6/00+0/(,.%%/7/(

DOMAINE PHARMACEUTIQUE
Monographies analytiques du thé
;7.:/%,/%,63)':.&'H).53$/,(+),6'+63/,,
:$%6/,F
~$(+.0$(.&$'%,D/,0.,6.#"$%/,/&,D/,0.,&3"'*)':$%/,
~$(+.0$(.&$'%,D/,0.,6.#"$%/,/&,D/,0.,&3"'*)':$%/,/%,U~ /%,U~
K,QWN,%:,M,/&,5.),5+0?")$(.&$'%,D/,
K,QWN,%:,M,/&,5.),5+0?")$(.&$'%,D/,)".6&$#,$'D'
K M 5 5
)".6&$#,$'D'-$'D+)", $'D+)",
/%,5)"(/%6/,D_+%,&":'$%,D/,6.#"$%/
>/)&/,=,0.,D/(($6.&$'%,F,
>/)&/,=,0.,D/(($6.&$'%,F,h,X h,X
8/%D)/(,&'&.0/(,F,
8/%D)/(,&'&.0/(,F,b,X b,X
!'(.H/,D/,0.,6.#"$%/,5.),8ik>
LE MATÉ : Ilex paraguariensis
LE MATÉ : Ilex paraguariensis

FORMES COMMERCIALES DU MATÉ
CONSTITUANTS ACTIFS PRINCIPAUX DU MATE
DOMAINE PHARMACEUTIQUE
Monographie analytique du maté
MATÉ VERT KIlex Ilex paraguarensis
paraguarensisM,,>3G,V).%t.$(/,\O
M,,>3G,V).%t.$(/,\O 4:/ "D$&$'%
i.,5.)&$/,+&$0$(",D+,:.&",?/)&,/(&,6'%(&$&+"/,5.),0.,#/+$00/,D/,
i.,5.)&$/,+&$0$(",D+,:.&",?/)&,/(&,6'%(&$&+"/,5.),0.,#/+$00/,D/,Ilex Ilex
paraguarensis B&G,k$0G,('+:$(/,=,+%/,D/(($66.&$'%,).5$D/,=,
63.+D@,5+$(,$%6$("/,G,i/,:.&",?/)&,6'%&$/%&,
63.+D@,5+$(,$%6$("/,G,i/,:.&",?/)&,6'%&$/%&,.+,:$%$:+:,\@O,X,
.+,:$%$:+:,\@O,X,
D/,6.#"$%/ 6.06+0",5.),).55')&,=,0.,D)'H+/,D/(("63"/
i/ i/,:.&",(/,5)"(/%&/,/%,:')6/.+7,$))"H+0$/)(@,.%H+0/+7@,
:.&" (/ 5)"(/%&/ /% :')6/.+7 $))"H+0$/)( .%H+0/+7
H0.*)/(@,?/)&,P.+%s&)/@,/&,:/(+).%&,D.%(,0/+),50+(,H).%D/,
D$:/%($'%,D/,Q::,=,N::G
;7.:/%,/%,63)':.&'H).53$/,(+),6'+63/,:$%6/,F
- ?$(+.0$(.&$'% D/ 0. 6.#"$%/ /& D/ 0. &3"'*)':$%/ /% U~ KQWN QWN %: M
- 5+0?")$(.&$'% D/ )".6&$# $'D'-$'D+)"
$'D' $'D+)" /% 5)"(/%6/ D/ &":'$% 6.#"$%/
>/)&/,=,0.,D/(($6.&$'%,F,,h,X
8/%D)/(,&'&.0/(,F,,h,X
!'(.H/,D/,0.,6.#"$%/,5.),8ik>

DOMAINE PHARMACEUTIQUE
Analyse microscopique du maté
LE GUARANA : Paullinia cupana Kunth
var. sorbilis
E)*+(&/ D/,0.,#.:$00/,D/(,,
B.5$%D.6"/(,')$H$%.$)/,D/,
0.,)"H$'%,.:.e'%$/%%/
i/(,#)+$&(,F,*.$/(,)'+H/,-
').%H"/( ').%H"/(,6'%&/%.%&,,Z,H).$%/(,
6'%&/%.%& Z H).$%/(
i.,D)'H+/,F,.:.%D/,D/,0.,
H).$%/ '*&/%+/,.5)4(,5.((.H/,
(+),+%/,('+)6/,D/,63.0/+)
U(.H/,.%6$/%,5.),0/(,
6'::+%.+&"(,.:.e'%$/%%/(,
6'::/,.%&$:.0.)$9+/@,(&$:+0.%&
/&,` .%&$-#.$: a
COMPOSES ACTIFS DU GUARANA
1.(/(,7.%&3$9+/(,
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FORMES COMMERCIALES DU GUARANA
DOMAINE PHARMACEUTIQUE
Monographies analytiques du guarana
Pharmacopée française : 2 monographies (graine et pâte)
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DOMAINE PHARMACEUTIQUE
Monographies analytiques du guarana
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LE CACAO
Theobroma cacao L.
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LE CACAO
Culture et variété
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LE CACAO
Du traitement post-récolte au cacao marchand
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LE CACAO
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LE CACAO
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LE CACAO
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LE CACAO
Du cacao marchand au produit semi-fini
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LE CACAO
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CACAO ET CHOCOLAT
Aspects nutritionnels

CACAO ET CHOCOLAT
Le cacao contient-il de la caféine ?
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Fèves de cacao : 1,1 – 4,3 % Chocolat au lait : 0,1 – 0,2 %
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CACAO ET CHOCOLAT
Polyphénols du cacao
CACAO ET CHOCOLAT
Aspects règlementaires (décret n°76-692)
Chocolat F,5)'D+$&,'*&/%+,=,5.)&$),D/,6.6.',/%,H).$%(@,D/,6.6.',/%,5s&/@,D/,
6.6.',/%,5'+D)/,'+,D/,6.6.',:.$H)/,/%,5'+D)/,/&,D/,(.663.)'(/@,.?/6,'+,
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CACAO ET CHOCOLAT
Contrôle de la qualité finale
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COMPARAISON DANS LA TENEUR EN CAFEINE
DE DIVERSES BOISSONS
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INTRODUCTION
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PLANTES D’ORIGINE
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L’OPIUM
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EXTRACTION DE LA MORPHINE
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QUINQUINA ET QUININE
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INTRODUCTION ET DEFINITION
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LES ESPECES
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INTRODUCTION
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