Inhibidores de la Bomba de Protones: OMEPRAZOL Y ...
Inhibidores de la Bomba de Protones: OMEPRAZOL Y ...
Inhibidores de la Bomba de Protones: OMEPRAZOL Y ...
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<strong>Inhibidores</strong> <strong>de</strong> <strong>la</strong> <strong>Bomba</strong> <strong>de</strong> <strong>Protones</strong>: <strong>OMEPRAZOL</strong> Y ES<strong>OMEPRAZOL</strong><br />
SÍNTESIS NTESIS DEL DEL ES<strong>OMEPRAZOL</strong><br />
C<br />
H 3<br />
C<br />
H 3<br />
O<br />
O<br />
N<br />
N<br />
N<br />
N<br />
O<br />
S<br />
O<br />
O<br />
(±)-<strong>OMEPRAZOL</strong><br />
<strong>OMEPRAZOL</strong><br />
S<br />
O<br />
N<br />
OH<br />
Ph<br />
N<br />
1 Diastereómeros<br />
Diastere meros<br />
CH 3<br />
CH 3<br />
CH 3<br />
O<br />
CH 3<br />
O<br />
CH 3<br />
CH 3<br />
1. CH 2 O<br />
2. SOCl 2<br />
C<br />
H 3<br />
C<br />
H 3<br />
O<br />
O<br />
HO<br />
Ác. . (R)-(–)-mand<br />
( mandélico lico<br />
HPLC<br />
en fase reversa<br />
O<br />
N<br />
N<br />
N<br />
N<br />
Cl<br />
S<br />
O<br />
N<br />
CH 3<br />
CH 3<br />
O<br />
CH 3<br />
Ph<br />
OH<br />
NaOH, Bu4NHSO4 CHCl3 / H2O, reflujo<br />
38%<br />
O<br />
O<br />
S<br />
O<br />
OH<br />
Ph<br />
N<br />
2 Diastereómeros<br />
Diastere meros<br />
CH 3<br />
CH 3<br />
O<br />
CH 3<br />
36
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