Inhibidores de la Bomba de Protones: OMEPRAZOL Y ...
Inhibidores de la Bomba de Protones: OMEPRAZOL Y ...
Inhibidores de la Bomba de Protones: OMEPRAZOL Y ...
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<strong>Inhibidores</strong> <strong>de</strong> <strong>la</strong> <strong>Bomba</strong> <strong>de</strong> <strong>Protones</strong>: <strong>OMEPRAZOL</strong> Y ES<strong>OMEPRAZOL</strong><br />
SÍNTESIS NTESIS DEL DEL ES<strong>OMEPRAZOL</strong><br />
C<br />
H 3<br />
O<br />
N<br />
N<br />
O<br />
O<br />
S<br />
O<br />
OH<br />
Ph<br />
N<br />
CH 3<br />
CH 3<br />
O<br />
CH 3<br />
2) MgCl 2 , H 2 O<br />
86%<br />
1) NaOH, MeOH/H 2 O<br />
t.amb., 10min<br />
77%<br />
C<br />
H 3<br />
P. Er<strong>la</strong>ndsson, R. Isaksson, P. Lorentzon, P. Lindberg; J. Chromatography, 1990, 532, 305-319<br />
A mayor esca<strong>la</strong>:<br />
WO 9208716, 1992<br />
P.L. Lindberg, S. Von Unge, US 5714504, 1998<br />
O<br />
-<br />
N<br />
N<br />
S<br />
O N<br />
(S) – Omeprazol<br />
ES<strong>OMEPRAZOL</strong><br />
CH 3<br />
CH 3<br />
O<br />
CH 3<br />
2<br />
37<br />
Mg 2+
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