influencia sobre la recidiva en el cáncer vesical superficial - Redalyc
influencia sobre la recidiva en el cáncer vesical superficial - Redalyc
influencia sobre la recidiva en el cáncer vesical superficial - Redalyc
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Urología Oncológica<br />
Arch. Esp. Urol., 60, 1 (36-43), 2007<br />
TERAPIA ENDOVESICAL: INFLUENCIA SOBRE LA RECIDIVA EN EL CÁNCER<br />
VESICAL SUPERFICIAL.<br />
Jorge García Rodríguez, Jesús María Fernández Gómez, Safwan Escaf Barmadah, Roberto<br />
Carlos González Álvarez, Antonio Jalón Monzón, Francisco Javier Martínez Gómez, Alberto<br />
Sánchez Tril<strong>la</strong> y Javier Regadera Sejas.<br />
Servicio de Urología I. Hospital C<strong>en</strong>tral de Asturias. Oviedo. Asturias. España.<br />
Resum<strong>en</strong>.- OBJETIVO: Revisar <strong>la</strong> <strong>influ<strong>en</strong>cia</strong> de distintos<br />
tratami<strong>en</strong>tos <strong>en</strong>do<strong>vesical</strong>es <strong>sobre</strong> <strong>la</strong> recurr<strong>en</strong>cia d<strong>el</strong><br />
<strong>cáncer</strong> <strong>vesical</strong> <strong>superficial</strong>.<br />
MÉTODOS: Se revisaron retrospectivam<strong>en</strong>te un total<br />
de 473 neop<strong>la</strong>sias <strong>vesical</strong>es <strong>superficial</strong>es. A partir d<strong>el</strong><br />
diagnóstico y <strong>la</strong> RTU <strong>vesical</strong>, y <strong>en</strong> función d<strong>el</strong> resultado<br />
anatomopatológico, se p<strong>la</strong>ntearon distintos esquemas<br />
de seguimi<strong>en</strong>to y tratami<strong>en</strong>to complem<strong>en</strong>tario.<br />
RESULTADO: Resultaron indep<strong>en</strong>di<strong>en</strong>tes para explicar<br />
mayor tiempo libre hasta <strong>la</strong> recurr<strong>en</strong>cia <strong>superficial</strong> los<br />
sigui<strong>en</strong>tes factores: empleo de <strong>la</strong>vados <strong>en</strong>do<strong>vesical</strong>es,<br />
tratami<strong>en</strong>to con dosis altas de BCG y terapia de mant<strong>en</strong>imi<strong>en</strong>to<br />
fr<strong>en</strong>te a inducción.<br />
Correspond<strong>en</strong>cia<br />
Jorge García Rodríguez<br />
Martínez Vigil, 2 - 2º dcha<br />
33010 Oviedo. (España)<br />
jgrmed@hotmail.com<br />
Trabajo recibido: 18 de junio 2006<br />
CONCLUSIONES: El empleo de insti<strong>la</strong>ciones <strong>vesical</strong>es<br />
increm<strong>en</strong>taron de forma indep<strong>en</strong>di<strong>en</strong>te <strong>el</strong> tiempo hasta<br />
<strong>la</strong> <strong>recidiva</strong>. Se demostró que <strong>la</strong> recurr<strong>en</strong>cia se produjo<br />
significativam<strong>en</strong>te más tarde cuando se habían empleado<br />
dosis altas de BCG y terapia de mant<strong>en</strong>imi<strong>en</strong>to.<br />
Pa<strong>la</strong>bras c<strong>la</strong>ve: Cáncer <strong>vesical</strong> <strong>superficial</strong>. Recidiva.<br />
Tratami<strong>en</strong>to <strong>en</strong>do<strong>vesical</strong>.<br />
Summary.- OBJECTIVES: To review the influ<strong>en</strong>ce of<br />
various intra<strong>vesical</strong> treatm<strong>en</strong>ts on <strong>superficial</strong> b<strong>la</strong>dder<br />
cancer recurr<strong>en</strong>ce.<br />
METHODS: We retrospectiv<strong>el</strong>y reviewed 473 <strong>superficial</strong><br />
b<strong>la</strong>dder neop<strong>la</strong>sias. Based on diagnosis and transurethral<br />
resection of b<strong>la</strong>dder tumor (TUR BT), and dep<strong>en</strong>ding on<br />
pathology, we proposed differ<strong>en</strong>t adjuvant treatm<strong>en</strong>t<br />
and follow-up schemes.<br />
RESULTS: The following factors were indep<strong>en</strong>d<strong>en</strong>t risk<br />
factors for a longer recurr<strong>en</strong>ce-free time: intra<strong>vesical</strong><br />
instil<strong>la</strong>tions, high dose BCG, and maint<strong>en</strong>ance therapy<br />
in comparison to induction.<br />
CONCLUSIONS: The use of intra<strong>vesical</strong> instil<strong>la</strong>tions<br />
indep<strong>en</strong>d<strong>en</strong>tly increases the time to recurr<strong>en</strong>ce. It was<br />
demonstrated that recurr<strong>en</strong>ce was significantly <strong>la</strong>ter<br />
wh<strong>en</strong> high dose BCG and maint<strong>en</strong>ance therapy were<br />
employed.<br />
Keywords: Superficial b<strong>la</strong>dder cancer. Progression.<br />
Intra<strong>vesical</strong> treatm<strong>en</strong>t.
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