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tratamiento-del-angioedema-atd-2008-pdf - PIEL-L Latinoamericana

tratamiento-del-angioedema-atd-2008-pdf - PIEL-L Latinoamericana

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FISIOPATOLOGIA DEL ANGIOEDEMA HEREDITARIO<br />

El principal mediador de AE es bradiquinina<br />

Sistema Fibrinolitico<br />

Generación de bradiquinina:<br />

(Davies A.E. <strong>2008</strong>)<br />

KalliKreina <strong>del</strong> plasma activada y Factor Hageman (XIIa) cliva el kininógeno de alto peso molecular<br />

liberando bradiquinina.<br />

Bradiquinina potente péptido inflamatorio que causa aumento de la permeabilidad vascular entre otros<br />

efectos.

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