programa - XIV Congreso Nacional de la Sociedad Española de ...

Reunión Científica Red de Trastornos Adictivos-CIBERSAMSalamanca 27 y 28 de septiembre de 2011O30. Long-term survival of drug and alcohol-dependant patients in Barcelona, Spain, 1985-2006.Robert Muga 1 , Marta Torrens 2 , Ferran Bolao 3 , Inmaculada Rivas 4 , Elisenda Martínez 1 , Arantza Sanvisens 1 ,Santiago Perez-Hoyos 5 , Gabriel Vallecillo 2 , Francina Fonseca 2 , Daniel Fuster 1 , Jordi Tor 11Department of Internal Medicine. Hospital Universitari Germans Trias i Pujol, Badalona, Spain. UniversitatAutònoma Barcelona.2Institute of Neuropsychiatry & Addictions. Parc de Salut Mar, Barcelona, Spain. Universitat AutònomaBarcelona.3Department of Internal Medicine. Hospital Universitari de Bellvitge, L’Hospitalet de Llobregat, Spain. Universitatde Barcelona.4Municipal Centre for Substance Abuse Treatment (Centro Delta). Badalona, Spain;5Department of Preventive Medicine and Public Health. Institut de Recerca Hospital Vall d’Hebrón. UniversitatAutònoma Barcelona, SpainObjective: Mortality of drug and alcohol abusers has been historically high and it is still higher than generalpopulation. Our objective was to characterize long-term survival of drug and alcohol-dependant patients seekingtreatment in Barcelona, Spain.Methods: longitudinal study of patients admitted to treatment between 1985 and 2006 in 3 hospital-baseddetoxification units (Hospital Universitari de Bellvitge, Parc de Salut Mar, Hospital Universitari Germans Trias IPujol). Demographic data, drug use characteristics and biological markers were collected during admission. Theoutcome of interest was to analyze long-term survival after admission. Vital status was ascertained by clinicalcharts and cross-checking with the Catalonian mortality register by December 2008. Death rates, causes of deathand survival estimates (Kaplan-Meier) were analyzed.Results: 5.041 patients were admitted from 1/1985 to 12/2006, 78.3% men; age at admission was 29 years (IQR:25-35 years). Main drugs of abuse were opiates (67.5%), cocaine (18.8%) and alcohol (13.7%); overall, 75.1 % ofpatients had antecedent of injection drug use. Prevalence of HIV and HCV infection was 41.5% and 60%,respectively.Median follow-up was 9.3 years (IQR: 4.8-14.6 yrs). A total of 1.530 (30,3 %) patients died during and, overallmortality rate was 3.05 x 100 PY (95% CI: 2.9-3.2). According to Kaplan-Meier estimates, the risk of death after 8years and 24 years of admission to treatment was 25% and 50%, respectively. With respect to the main drug ofabuse, survival function was similar in all 3 groups (p=0.23).Conclusions: drug and alcohol-dependant patients are at increased risk of death irrespective of the substancethat motivates admission to treatment, thus highlighting the impact of addiction itself in the prognosis of disease.Página 39 de 41