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AGPI - Lipides et signalisation cellulaire

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11 études<br />

<strong>AGPI</strong> n-3 : Immunosuppresseurs<br />

Owerview of double-blind, randomised studles of the effect of supplementation<br />

with ω-3 polyunsaturated fatty-acids (n-3 PUFA) in patients with rheumatoid arthritis.<br />

No. of No. of Duration n-3 PUFA Main findings<br />

patients patients compl<strong>et</strong>ed weeks supplement (g/day)<br />

52 37 12 3.0 no. tender joints<br />

morning stiffness<br />

40 3 14 4.5 no. tender joints, time to fatigue<br />

LTB 4 and LTB 5<br />

65 49 24 3.2 no. tender joints, no.swollen joints<br />

6.4 grip strength , morning stiffness<br />

LTB4 and interleukin-1<br />

12 12 4 2.7 Ritchie joint index, morning stiffness<br />

grip strength<br />

48 33 52 0.5 daily intake of NSAID<br />

60 46 12 5.2 tender joints, grip strength LTB 4<br />

16 14 12 3.4 tenders joints, morning stiffness<br />

LTB 4 and LTB 5<br />

48 43 26 3.0 dally intake of NSAID<br />

improvment of global assessment<br />

74 67 16 5.8 moming stiffness<br />

55 51 12 3.6 moming stiffness, no. Tender joints

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