CIC IT - GIPSO

Clinical Research Center
for Technological Innovations
CRC-IT
in Biomaterials
"CRC-TI : an interface for médical research
valorization"
The CRC-TI abilities take place between
fundamental and clinical research in Biomaterials,
Médical Devices and Tissue Engineeringfîelds :
It is your partner to make thé proof of
concept of your innovative technology, and then
gives you thé opportunity to conduct a pilot clinical
study.
"Technical and human facilities"
The CRC-TI associâtes manufacturers to
hospital and university environment into thé
Technological Platform for Biomédical
Innovation in Xavier Arnozan.
It brings together clinicians, recognized
research departments, and local industries, with
access to performing equipments.
"Services a la carte or Partnership"
The CRC-TI assumes first-quality R&D
skills, since thé préparation phase of thé project
until its realization and its follow up. It offers
methodological support and technical assistance
during thé whole process, in compliance with :
- ISO NF EN 10993-là-18
- Ethical and law international régulations.
Physical and chemical characterization
In vitro studies (cellular & molecular biology,
biochemistry)
In vivo studies on little and big animais
(implantation, imaging, histology)
Pilot clinical studies (protocol writing, access to
clinical departments (Clinical Research Centers))
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Chemical-physical
characterization
Characterization
& mechanical
properties tests
i.e. strips for
urinary
incontinence
Tissue Engineering
In vitro cytotoxicity/
cytocompatibility
Endothelial, urothelial cells,
smooth muscle, and bone cells cultures
Direct & indirect toxicity
Immunohistochemistry
i.e. radio-opaque products in silicone
for ureteral material, bone substitutes,
collagen sponges
In vivo/ex vivo biocompatibility
biofonctionnality
Surgery and imaging follow
up on mice, rats, pigs, sheeps,
goats Paraffm and resin inclusions,
Histology & histomorphometry, SEM, NMR, (J.CT,
i.e. bone substitutes / osteosynthesis (fémur, jaw, vertebra),
vascular prosthesis functionalization, artificial bladders,
collagen membranes