des cibles aux criblages - Biogenouest

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RechercheFondamentaleTargetIdentificationLeadIdentificationCandidateIdentificationPre-Clinical Phase I/IIa Phase IIb Phase IIIRegulatoryReviewSales,Phase IVstudies0 2 4 6 8 10 12 14 16YearsCriblageUSR3151 -CNRS
Main steps of Pharmaceutical R&DResearch (2-10 years)Preclinical testing (3-4 years)Laboratory and animal testingPhase I (1 year)20-80 Healthy volunteers used todetermine safety and dosageDrug development cost : $802 MPhase II (2 years)100-800 Patient volunteers used to look forefficacy and side effectsPhase III (3 years)1000-8000 Patient volunteers used tomonitor adverse reactions to long-term useAgencies Review/Approval0 2 4 6 8 10 12 14 16YearsUSR3151 -CNRS
Page 4 and 5: Criblage phénotypique : sélection
Page 8 and 9: Criblage moléculaireUne cible thé
Page 11: Problématique scientifiqueFDA appr
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Page 18 and 19: Criblage moléculaireLake Cowal min
Page 20 and 21: ...3456
Page 22 and 23: RadioactivitéProtein Kinases (+518
Page 24 and 25: COMPTAGE et INTERPRETATION des rés
Page 26 and 27: Validation de l’essai pour laréa
Page 28 and 29: Une collection de molécules à ana
Page 31 and 32: An important tool in Medicinal Chem
Page 33 and 34: RésultatsUSR3151L. Meijer
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Page 37: USR3151 - CNRS - KISSf(1 CR CNRS, 2

des cibles aux criblages - Biogenouest

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