CV Sebastian Amigorena - Institut Curie

CURRICULUM VITAE – SEBASTIAN AMIGORENAPERSONAL INFORMATIONCitizenship:FRANCEAddress:Institut CurieUnité INSERM 932, Immunity and Cancer26, rue D’Ulm75005 Paris, Francee-mail : sebastian.amigorena@curie.frEDUCATION and PROFESSIONAL POSITIONS, MEMBERSHIPS and HONORSEducation and positions1984 “Maîtrise de Biochimie”, University Paris VII, Biochemistry1985-1990 PhD, Biochemistry, Immunology, University Paris VII, Paris, FranceFcR expression in B lymphocytes, Laboratoire d'Immunologie Cellulaire etClinique, Institut Curie, ParisLab of W. H. Fridman1990 “Chargé de Recherche”, CNRS1992-1994 Post doctoral fellow, FcR structure and function in B lymphocytesLaboratoire d'Immunologie Cellulaire et Clinique, Institut Curie, ParisLab of W. H. Fridman1992-1994 Postdoctoral Fellow, “Cell biology of antigen presentation in B lymphocytes”Cell Biology Dept., Yale University School of Medicine, New Haven, CTLab of I. Mellman1995-2003 Group leader, “Cell biology of antigen presentation”Section Recherche, INSERM U520, Institut Curie, Paris1999 “Directeur de Recherche”, CNRS2003-2010 Director of INSERM Unit 932, Immunity and Cancer, Institut Curie, Paris2010 “Directeur de Recherche de Classe Exceptionnelle”, CNRS

Sebastian Amigorena Page 2 of 3Professional memberships1989-present Member, French Association of Immunology1991-present Member, American Association of Immunology2006 Member of the French “Académie des Sciences”2006 Member of the EMBOScientific advisory boards2008-2012 “Conseil Scientique de l’INSERM”2008-present “Conseil Scientique de la Fondation Bettencourt”2007 “Conseil Scientifique du programme blanc”, ANR,2004-2007 “Conseil Scientique de la Fondation pour la Recherche Médicale”2002-2005 “Conseil Scientique du programe, AVENIR” (young investigator’s award,INSERM2003-2004 “Conseil Scientique du COSSEC (clinical trials committee), INSERM2001-2004 “Conseil Scientique de Ligue Nationale Contre le Cancer”1998, 2000 “Conseil Scientique du Departement de Recherche Médicale”, CEA1999-2002 “Conseil Scientique de l’AP Immunology and Microbiology”, INSERMEditorial activities2000-2003 Editorial Board of European Journal of Immunlogy (2000-2003)2000-2005 Executive Editor of European Journal of Immunlogy (2003-2005)2002-present Editorial Board of the Journal of Immunlogy (2002- )1998-present Regular reviewer for Nature, Science, Cell, Nature Immuology, NatureMedicine, Nature Cell Biology, Immunity, Blood, JEM, EMBO J.2011 Board of Reviewing Editors ScienceHonors and awards1995 “Prix de la Fondation pour la Recherche Médicale”2001 “Prix Lucien Tartois”, Fondation pour la Recherche Médicale2005 “Médaille d’Argent du CNRS”2005 “Prix Liliane Bettencourt pour les Sciences du Vivant”2007 “Prix Léopold Griffuel”, ARC2008 Senior European Research Council (ERC) grant2010 Prix Gallet et Breton, Académie de MedecineMentoring1998-present4 PhD students, 16 post doctoral fellows (7 have become independentgroup leaders in Europe and the US)Publication and invited conferences records1986- present 149 published articles,12 original publications as first or last author injournal with impact factors higher than 20, 8600 citations in the literature, 9publications cited over 300 times, 25 over 100 times, 5 patent applications(one granted in the US)1990-presentover 30 invited conferences (including 5 “Keystone Meetings”, 3 “GordonConferences“, 3 “International Immunology Meetings“, 4 “EuropeanImmunology meetings”, 3 “FASEB summer conferences”).

Sebastian Amigorena Page 3 of 3BIBLIOGRAPHY (SELECTED PUBLICATIONS)Savina A, Jancic C, Hugues S.,Guermonprez P, Vargas P, Moura I C, Lennon-Dumenil A-M, SeabraM C, Raposo G, Amigorena S (2006), NOX controls phagosomal pH to regulate antigen processingduring crosspresentation by dendritic cells. Cell, 16, 126:205-18.Hugues, S, A Scholer, A Boissonnas, A Nussbaum, C Combadiere, S Amigorena, and L Fetler.(2007). Dynamic imaging of chemokine-dependent CD8+ T cell help for CD8+ T cell responses. NatImmunol 8:921-930.Boissonnas, A, L. Fetler, I S Zeelenberg, S Hugues, and S Amigorena (2007). In vivo imaging ofcytotoxic T cell infiltration and elimination of a solid tumor. J Exp Med 204:345-356.Jancic, C, A. Savina, C Wasmeier, T Tolmachova, J El-Benna, P M. Dang, S Pascolo, M A Gougerot-Pocidalo, G Raposo, M C Seabra and S Amigorena (2007). Rab27a regulates phagosomal pH andNADPH oxidase recruitment to dendritic cell phagosomes. Nat Cell Biol 9:367-378.Scholer A, Hugues S, Boissonnas A, Fetler L, Amigorena S (2008). Intercellular adhesion molecule-1-dependent stable interactions between T cells and dendritic cells determine CD8+ T cell memory.Immunity. 28(2):258-70.Savina A, Peres A, Cebrian I, Carmo N, Moita C, Hacohen N, Moita LF, Amigorena S (2009) Thesmall GTPase Rac2 controls phagosomal alkalinization and antigen crosspresentation selectively inCD8(+) dendritic cells. Immunity. 17;30(4):544-55.Boissonnas A, Scholer-Dahirel A, Simon-Blancal V, Pace L, Valet F, Kissenpfennig A, Sparwasser T,Malissen B, Fetler L, Amigorena S (2010) Foxp3(+) T Cells Induce Perforin-Dependent Dendritic CellDeath in Tumor-Draining Lymph Nodes. Immunity. 26;32(2):266-78.