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placenta p34

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Trophoblaste extravilleux<br />

• Modulation expression intégrines<br />

– E-cadhérine, intégrine α6β4<br />

– VE-cadhérine, αvβ3, α1β1<br />

– souris αv-/-, β3-/- : RCIU avec petit <strong>placenta</strong><br />

– éclampsie<br />

• modulation expression connexines<br />

– jonctions communicantes<br />

– trophoblaste villeux : cnx43<br />

– trophoblaste extravilleux : cnx 40<br />

cell, 1998, J Clin Inv 1999<br />

Evain-Brion D, 2000

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