Dermatologie du voyageur - Infectiologie

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Key drugs to treat LC leishmaniasis • Antimonials IM (NW) or IL (OW) • Pentamidine isethionate (NW; Lg complex) • Fluconazole oral (OW; L.major) • Ketoconazole oral (NW; L.mexicana) • Miltefosine oral (NW; not L.b complex) • Paromomycin Topical (OW) • Heat, 50°C 30 sec (OW; L.tropica) Wortmann G. Clin Infect Dis 2005; 40:1156-1158
Miltefosine vs AM IM, LCL (L. major) Iran Miltefosine AM Dose 2,5 mg/kg 20 mg/kg Durée 28 jrs 14 jrs Voie PO IM N = 32 31 45 jrs 43 jrs ITT(M3) 81 % 80 % PP(M3) 92 % 83 % Intolérance 9,8 % 41 % [Mokebeli M et al. Acta Tropica 2007;103:33-40]
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Dermatologie du voyageur - Infectiologie

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