OTTONELLO - Abuso dipendenza e deprivazione BDZ.pdf

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Xiang K, Tietz EI: Benzodiazepine-induced hippocampal CA1 neuron alpha-amino-3-hydroxy-5-methylisoxasole-4propionic acid (AMPA) receptor plasticity linked to severity of withdrawal anxiety: differential role of voltage-gated calcium channels and N-methyl-D-aspartic acid receptors. Behav Pharmacol. 2007;18:447-60.
Page 1 and 2: Benzodiazepine Abuso Dipendenza e D
Page 5 and 6: History Benzodiazepines are “new
Page 7 and 8: Epidemiology Life time use: 10-15%
Page 9 and 10: Dependence 10,861 patients of the
Page 11 and 12: Allosteric Interactions
Page 14: Receptor mechanisms of Abuse Decre
Page 18 and 19: Dipendenza da BDZ Nel caso delle BD
Page 20 and 21: Changing definitions of dependence
Page 22 and 23: Tolerance developement Tolerance o
Page 24 and 25: Withdrawal Symptoms include many t
Page 26 and 27: Human No RCT Treatment Few uncont
Page 28 and 29: Grazie per l’ attenzione
Page 31 and 32: Acute Withdrawal Exclude life-thre
Page 33 and 34: Altri usi: BDZ e Alcohol-Withdrawal
Page 36: GABA Effects of Withdrawal
Page 42 and 43: Song J, et al. Benzodiazepine withd
Page 49: Voltage Dependent Ca 2+ Channels
Page 54 and 55: Diazepam 10 mg q6h x years 10 days
Page 56: Continued Haloperidol 20 mg over 2
Page 64: Net Result on GABA A General resis

OTTONELLO - Abuso dipendenza e deprivazione BDZ.pdf

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