OTTONELLO - Abuso dipendenza e deprivazione BDZ.pdf

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Net Result on GABA A General resistance to benzodiazepines caused by a change in receptor subunit conformation Shift toward BZ2 receptor – tolerance to sedation with some maintenance of anticonvulsant effects
Page 1 and 2:
Benzodiazepine Abuso Dipendenza e D
Page 5 and 6:
History Benzodiazepines are “new
Page 7 and 8:
Epidemiology Life time use: 10-15%
Page 9 and 10: Dependence 10,861 patients of the
Page 11 and 12: Allosteric Interactions
Page 14: Receptor mechanisms of Abuse Decre
Page 18 and 19: Dipendenza da BDZ Nel caso delle BD
Page 20 and 21: Changing definitions of dependence
Page 22 and 23: Tolerance developement Tolerance o
Page 24 and 25: Withdrawal Symptoms include many t
Page 26 and 27: Human No RCT Treatment Few uncont
Page 28 and 29: Grazie per l’ attenzione
Page 31 and 32: Acute Withdrawal Exclude life-thre
Page 33 and 34: Altri usi: BDZ e Alcohol-Withdrawal
Page 36: GABA Effects of Withdrawal
Page 42 and 43: Song J, et al. Benzodiazepine withd
Page 47: Xiang K, Tietz EI: Benzodiazepine-i
Page 53 and 54: Poorly described Syndrome Time cou
Page 55 and 56: Tex Med 1990;86:44 Alprazolam 1 mg
Page 58: BZ Receptor Requirements γ subuni
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OTTONELLO - Abuso dipendenza e deprivazione BDZ.pdf

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