La dispnea nell'anziano - Associazione Geriatri Extraospedalieri

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AT 1-receptor binding affinity Longest dissociation half-life of clinically available ARBs Valsartan Losartan Candesartan Olmesartan Telmisartan † † Active metabolite EXP3174 0 50 100 150 200 250 Receptor dissociation half life (min) Kakuta et al. Int J Clin Pharmacol Res 2005;25:41–46
n = 7,800 Telmisartan 80 mg/day‡ + placebo Screening Randomisation (n=23,400) * n = 7,800 Ramipril 10 mg/day + placebo Follow-up at 6 weeks Follow-up at 6 months for 5.5 years *planned Actual = 25,620 ONTARGET ® study design n = 7,800 Telmisartan 80 mg/day + ramipril 10mg/day ‡ Maximum approved dose for the treatment of hypertension 5.5 Years Primary endpoints Composite CV endpoint – Cardiovascular mortality – Non-fatal myocardial infarction – Hospitalisation for congestive heart failure – Non-fatal stroke Teo K, et al. Am Heart J 2004;148:52–61; The ONTARGET Investigators. N Engl J Med 2008;358:1547–1559
Page 1 and 2:
S.O.C. di Medicina Interna Az. Osp.
Page 3 and 4:
Definizione di Dispnea e Segni corr
Page 5 and 6:
Ortopnea E’ legata ad un aumento
Page 7 and 8:
Iper-ventilazione Tipi di respiro S
Page 9 and 10:
Respiro periodico di Cheyne-Stokes
Page 11 and 12:
TOSSE Si distingue in: tosse: secca
Page 13 and 14:
Dispnea nello Scompenso Cardiaco Lo
Page 17:
Studio CONFINE P.Biagi Congresso Na
Page 21 and 22:
Criteri Diagnostici di Scompenso Ca
Page 23: Insufficienza Cardiaca Sinistra
Page 26 and 27: Insufficienza cardiaca Destra
Page 28 and 29: Ipertensione arteriosa,Cardiopatia
Page 30 and 31: P.Biagi Congresso Naz FADOI Firenze
Page 32: P.Biagi Congresso Naz FADOI Firenze
Page 37: Dispnea e Insufficienza Respiratori
Page 40 and 41: BRONCOPNEUMOPATIA CRONICA OSTRUTTIV
Page 42 and 43: Lo spettro delle Pneumopatie Cronic
Page 44 and 45: BRONCOPNEUMOPATIA CRONICA OSTRUTTIV
Page 46 and 47: Malattie Ostruttive Croniche delle
Page 48 and 49: Blue bloater (l’edematoso blu)
Page 50 and 51: PINK PUFFERS (soffiatori rosa) Nell
Page 52: ASMA BRONCHIALE
Page 55 and 56: Efficacia della terapia nello Scomp
Page 57: P.Biagi Congresso Naz FADOI Firenze
Page 60 and 61: Scompenso cardiaco e betabloccanti
Page 62 and 63: Scompenso cardiaco e betabloccanti.
Page 64 and 65: BRING-UP Study (peggioramento, ospe
Page 66 and 67: SENIORS vs.COPERNICUS.Endpoint: Mor
Page 68 and 69: SENIORS vs. CIBIS II.Endpoint: Mort
Page 70 and 71: CIBIS III DISEGNO DELLO STUDIO Lo s
Page 72 and 73: CONCLUSIONI: CIBIS III L’inizio d
Page 76 and 77: The antihypertensive Telmisartan 80
Page 79 and 80: β 2 stimolanti nella Insufficienza
Page 81 and 82: HO HO HO HO OH CH3 CH-CH2-NH-C-CH3
Page 83 and 84: TORCH Study Caverley PMA,et al. J.
Page 85 and 86: Qualità di Vita Endpoints Secondar
Page 87 and 88: FEV 1 Post-broncodilatore Variazion
Page 90: Grazie dell’attenzione!
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La dispnea nell'anziano - Associazione Geriatri Extraospedalieri

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