CURRICULUM VITAE Gabriella Lupo Data e luogo di ... - Medicina
CURRICULUM VITAE Gabriella Lupo Data e luogo di ... - Medicina
CURRICULUM VITAE Gabriella Lupo Data e luogo di ... - Medicina
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<strong>CURRICULUM</strong> <strong>VITAE</strong><br />
<strong>Gabriella</strong> <strong>Lupo</strong><br />
<strong>Data</strong> e <strong>luogo</strong> <strong>di</strong> nascita: 15 Luglio 1961<br />
Catania, Italia<br />
Citta<strong>di</strong>nanza: Italiana<br />
Linee <strong>di</strong> ricerca:.<br />
1) Metabolismo fosfolipi<strong>di</strong>co in cellule endoteliali <strong>di</strong> microcapillari cerebrali e periciti <strong>di</strong> retina.<br />
Fosfolipasi A2 citosolica, Proteina Kinasi C e vie <strong>di</strong> segnale MAPK/ERK in co-culture <strong>di</strong> cellule<br />
endoteliali e periciti.<br />
2) Adesione e crescita cellulare su superfici <strong>di</strong> poliidrossimetilsillossano plasma mo<strong>di</strong>ficate e<br />
irra<strong>di</strong>ate.<br />
Stu<strong>di</strong> e relativi titoli conseguiti<br />
1995 Dottorato <strong>di</strong> Ricerca in Scienze Biochimiche e Biomolecolari, Facoltà <strong>di</strong> Me<strong>di</strong>cina,<br />
Università <strong>di</strong> Catania.<br />
1991 Specializzazione in Microbiologia, Facoltà <strong>di</strong> Me<strong>di</strong>cina, Università <strong>di</strong> Catania.<br />
1986 Laurea in Scienze Biologiche, Università <strong>di</strong> Catania.<br />
Borse <strong>di</strong> stu<strong>di</strong>o<br />
1986-88: Ministero dell’Università e della Ricerca Scientifica e Tecnologica, Istituto <strong>di</strong><br />
Microbiologia, Università <strong>di</strong> Catania.<br />
1989-91: CNR, Istituto per lo stu<strong>di</strong>o delle sostanze naturali <strong>di</strong> interesse alimentare e chimicofarmaceutico,<br />
Università <strong>di</strong> Catania.<br />
1996-97: Postdottorato.in Neurobiologia, Dipartimento <strong>di</strong> Chimica biologica, Chimica me<strong>di</strong>ca e<br />
Biologia molecolare.<br />
1995-96: CNR, Istituto <strong>di</strong> Bioimmagini e Fisiopatologia del Sistema Nervoso Centrale, Università<br />
<strong>di</strong> Catania<br />
Posizione professionale<br />
Novembre 2003-ad oggi: Professore Associato <strong>di</strong> Biochimica, Dipartimento <strong>di</strong> Chimica biologica,<br />
Chimica me<strong>di</strong>ca e Biologia molecolare.<br />
Esperienza <strong>di</strong> ricerca<br />
1999-2002: Assegno per la collaborazione alla ricerca, settore scientifico-<strong>di</strong>sciplinare E05A<br />
Biochimica (BIO/10) presso il Dip. <strong>di</strong> Chimica biologica, Chimica me<strong>di</strong>ca e Biologia molecolare<br />
Marzo-Agosto 1993 presso il “Lipid and Lipoprotein Research Group”, Faculty of Me<strong>di</strong>cine,<br />
University of Alberta, Canada, (Prof. Dennis E. Vance).<br />
Attività Didattica<br />
2002-ad oggi: Biochimica, Corso <strong>di</strong> Laurea in Me<strong>di</strong>cina e Chirurgia, Università <strong>di</strong> Catania.<br />
2006- ad oggi: Biochimica, Corso <strong>di</strong> Laurea Specialistica in Scienze e Tecniche delle Attività<br />
Motorie Preventive e Adattative, Università <strong>di</strong> Catania.<br />
2006- ad oggi: Biochimica, Corso <strong>di</strong> Laurea in Ostetricia, Università <strong>di</strong> Catania<br />
Appartenenza a Società Scientifiche:<br />
Società Italiana <strong>di</strong> Biochimica (SIB)<br />
Società Europea <strong>di</strong> Neurochimica (ESN)
Pubblicazioni:<br />
1- G. <strong>Lupo</strong>, C.D. Anfuso, N. Ragusa, R. P. Strosznajder, M. Walski and M. Alberghina.<br />
t-Butyl hydroperoxide and and oxi<strong>di</strong>zed low density lipoprotein enhance phospholipid hydrolysis<br />
in lipopolysacchride – stimulated retinal pericytes. Biochim. Biophys. Acta (BBA), 1531:143-155,<br />
2001<br />
2-G. <strong>Lupo</strong>, C.D. Anfuso, G. Assero, R. P. Strosznajder, M. Walski, R. Pluta and M. Alberghina.<br />
Amyloid β(1-42) and its β(25-35) fragment induce in vitro phosphatidylcholine hydrolysis in<br />
bovine retina capillary pericytes. Neurosci. Lett., 303: 185-188, 2001<br />
3-G, Assero, G. <strong>Lupo</strong>, C.D. Anfuso, N. Ragusa, and M. Alberghina.<br />
High glucose and advanced glycation end product induce phospholipid hydrolysis and<br />
phospholipid enzyme inhibition in bovine retinal pericytes. Biochim. Biophys. Acta (BBA),<br />
1533/2:128-140, 2001<br />
4-G. <strong>Lupo</strong>, G. Assero, C. D. Anfuso, A. Nicotra, M. Palumbo, G. Cannavò, M. Renis, N. Ragusa<br />
and M. Alberghina<br />
Cytosolic phospholipase A2 me<strong>di</strong>ates arachidonoyl phospholipid hydrolisys in immortalized rat<br />
brain endothelial cells stimulated by oxi<strong>di</strong>zed LDL.<br />
Biochim. Biophys. Acta (BBA), 1585 (2002), 19-29.<br />
5-C.D. Anfuso, S. Sipione, G. <strong>Lupo</strong>., N. Ragusa and M. Alberghina. (2003). Characterization of<br />
glycerophosphocholine phospho<strong>di</strong>esterase activity and phosphatidylcholine biosynthesis in<br />
cultured retinal microcapillary percytes. Effect of adenosine and endothelin-1. LIPIDS. vol. 38, pp.<br />
45-52.<br />
6-M. Alberghina, <strong>Lupo</strong> G. (2003). Phospholipid metabolism in microvascular endothelial cells and<br />
pericytes. In: PANDALAI S.G. Recent research Development in Biochemistry. (pp. 475-502).<br />
7-M. Alberghina, <strong>Lupo</strong> G., C.D. A, A. Nicotra and G. Giurdanella. (2004). Phospholipase A2 in<br />
microvascular cells: role of MAP kinases signaling pathway and gene expression. In: M.<br />
Alberghina. Biochemistry of Lipids in Vascular Function. (pp. 1-28).<br />
8-G. Assero, C. Satriano, <strong>Lupo</strong> G., C.D. Anfuso, G. Marletta and M. Alberghina. (2004). Pericyte<br />
adhesion and growth onto polyhydroxymethylsiloxane surfaces nanostructured by plasma<br />
treatment and ion irra<strong>di</strong>ation. Microvascular Research. vol. 68, pp. 209-220.<br />
9-C.D. Anfuso, G, Assero, <strong>Lupo</strong> G., A. Nicotra, G. Cannavò, R.P. Strosznajder, P. Rapisarda, R.<br />
Pluta and M. Alberghina. (2004). Amyloid β(1-42) and its β(25-35) fragment induce activation and<br />
membrane translocation of cytosolic phospholipase A2 in bovine retina capillary pericytes.<br />
Biochim. Biophys. Acta (BBA), vol. 1686, pp. 125-138<br />
10-<strong>Lupo</strong> G., A. Nicotra, G. Giurdanella, C.D. Anfuso, N. Ragusa, C. Tirolo, B. Marchetti and M.<br />
Alberghina. (2005). Activation of phospholipase A2 and MAP kinases by oxi<strong>di</strong>zed low density
lipoprotein in immortalized GP8.39 endothelial cells. Biochim. Biophys. Acta (BBA), vol. 1735,<br />
pp. 135-150.<br />
11- A. Nicotra, <strong>Lupo</strong> G., G. Giurdanella, C.D. Anfuso, N. Ragusa, C. Tirolo, B. Marchetti and M.<br />
Alberghina. (2005). MAPKs me<strong>di</strong>ate activation of cytosolic phospholipase A2 by amyloid β(25-<br />
35) peptide in bovine retina pericytes. Biochim Biophys Acta. vol. 1733, pp. 172-186.<br />
12- <strong>Lupo</strong> G, Anfuso CD, Ragusa N, Tirolo C, Marchetti B, Gili E, La Rosa C, Vancheri C.<br />
Activation of cytosolic phospholipase A2 and 15-lipoxygenase by oxi<strong>di</strong>zed low-density<br />
lipoproteins in cultured human lung fibroblasts.Biochim Biophys Acta. 2007 Apr;1771(4):522-32.<br />
Epub 2007 Feb 4.<br />
13- Anfuso CD, <strong>Lupo</strong> G, Romeo L, Giurdanella G, Motta C, Pascale A, Tirolo C, Marchetti B,<br />
Alberghina M.<br />
Endothelial cell-pericyte cocultures induce PLA2 protein expression through activation of<br />
PKCalpha and the MAPK/ERK cascade.J Lipid Res. 2007 Apr;48(4):782-93. Epub 2007 Jan 31.<br />
14- Formosa F, Anfuso CD, Satriano C, <strong>Lupo</strong> G, Giurdanella G, Ragusa N, Marletta G, Alberghina<br />
M.<br />
UV-O3-treated and protein-coated polymer surfaces facilitate endothelial cell adhesion and<br />
proliferation me<strong>di</strong>ated by the PKCalpha/ERK/cPLA2 pathway.Microvasc Res. 2008 Apr;75(3):330-<br />
42. Epub 2007 Dec .<br />
15- Morale MC, L'Episcopo F, Tirolo C, Giaquinta G, Caniglia S, Testa N, Arcieri P, Serra PA,<br />
<strong>Lupo</strong> G, Alberghina M, Harada N, Honda S, Panzica GC, Marchetti B.<br />
Loss of aromatase cytochrome P450 function as a risk factor for Parkinson's <strong>di</strong>sease?Brain Res Rev.<br />
2008 Mar;57(2):431-43. Epub 2007 Nov 7. Review.<br />
16- Scuderi MR, Anfuso CD, <strong>Lupo</strong> G, Motta C, Romeo L, Guerra L, Cappellani A, Ragusa N,<br />
Cantarella G, Alberghina M.<br />
Expression of Ca(2+)-independent and Ca(2+)-dependent phospholipases A(2) and<br />
cyclooxygenases in human melanocytes and malignant melanoma cell lines.Biochim Biophys Acta.<br />
2008 Oct;1781(10):635-42. Epub 2008 Aug 3.<br />
17- Ama<strong>di</strong>o M, Scapagnini G, <strong>Lupo</strong> G, Drago F, Govoni S, Pascale A.<br />
PKCbetaII/HuR/VEGF: A new molecular cascade in retinal pericytes for the regulation of VEGF<br />
gene expression.Pharmacol Res. 2008 Jan;57(1):60-6. Epub 2007 Dec 5.<br />
18- Anfuso CD, Giurdanella G, Motta C, Muriana S, <strong>Lupo</strong> G, Ragusa N, Alberghina M.<br />
PKCalpha-MAPK/ERK-phospholipase A2 signaling is required for human melanoma-enhanced<br />
brain endothelial cell proliferation and motility.Microvasc Res. 2009 Dec;78(3):338-57. Epub 2009<br />
Sep 10.<br />
19- Giurdanella G, Motta C, Muriana S, Arena V, Anfuso CD, <strong>Lupo</strong> G, Alberghina M.<br />
Cytosolic and calcium-independent phospholipase A(2) me<strong>di</strong>ate glioma-enhanced proangiogenic<br />
activity of brain endothelial cells. Microvasc Res. 2011 Jan;81(1):1-17.
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