HematopoieticSC 25Oct2011 [modalità compatibilità].pdf - HUMAN ...

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EMATOPOIESI DEFINITIVA -Yolk Yolk Sac • Developmental cells that can give rise to the complete set of hematopoietic cells. Thought to be a distinct developmental event from primitive hematopoiesis • Initiates in yolk sac and continues in the embryo proper. • BFU BFU-E E and CFU-E CFU E originate in yolk sac ( (mouse mouse E8.5 and 9.5 respectively respectively) • Theses cells then migrate into the newly formed embryo where they fully differentiate. • Macrophage precursors are also found in early development in the yolk sac again suggesting definitive definitive hematopoiesis in the yolk sac. BFU BFU-E E = Burst-Forming Burst Forming cell Unit Unit-Erythrocytes Erythrocytes (unità di formazione esplosiva di colonie eritrocitarie) in vitro circa 5000 cell/colonia in presenza di IL3; insens. EPO CFU CFU-E E = Colony formation Unit- Unit Erythrocytes (unità di formazione di colonie eritrocitarie in vitro circa 60 cell/colonia in presenza di EPO
EMATOPOIESI DEFINITIVA - in Embryo Proper • Definitive hematopoiesis hematopoiesis-generation generation of more complex (lymphoidmyeloid myeloid-erythroid) erythroid) progenitors and adult repopulating hematopoietic stem cells. • Site Site-paraaortic paraaortic splanchnopleura (PAS) and aorta-gonad aorta gonad-mesonephros mesonephros (AGM) region • Primary site of fetal hematopoiesis is the liver • Key to understanding the development of the HSC is understanding the unique microenvironment of each of the sites(Growth factors, cell- cell contacts) • Hematopoietic Stem Cells (HSC) are pluripotent cells that can develop into all blood cell lineages and other (??) cell types.
Page 1 and 2: CELLULE STAMINALI APPLICAZIONI TERA
Page 3 and 4: • HUMAN ANATOMY II - LESSONS- PAV
Page 5 and 6: CELLULE STAMINALI EMATOPOIETICHE
Page 7 and 8: Ematopoiesi embrionale • Primitiv
Page 9 and 10: Hemangioblasts (emangioblasta) •
Page 11: Ruolo dei fattori di crescita nel
Page 16 and 17: Adult Hematopoiesis
Page 18 and 19: Maintenance of Stem Cell Population
Page 20 and 21: Steps in Erythropoiesis Self renewa
Page 23 and 24: CELLULE STAMINALI EMOPOIETICHE (HSC
Page 27 and 28: IRRADIAZIONE X LO STUDIO DI CELLULE
Page 29 and 30: CD34 positive nella aorta dorsale d
Page 31 and 32: FREQUENZA di HSC
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Page 35: ESISTE UN PROGRAMMA GENETICO PER DE
Page 38 and 39: PUO’ UNA CELLULA STAMINALE PLURIP
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