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Robert C. Moellering, Jr.,<br />
Editor in Chief (1990)<br />
New Engl<strong>and</strong> Deaconess Hospital<br />
Boston, Mass.<br />
Michael Barza, Editor (1990)<br />
New Engl<strong>and</strong> Medical Center<br />
Hospitals<br />
Boston, Mass.<br />
Lawrence E. Bryan, Editor (1992)<br />
University of Calgary<br />
Calgary, Alberta, Canada<br />
Vincent T. Andriole (1990)<br />
Bascom F. Anthony (1988)<br />
Gordon L. Archer (1989)<br />
George R. Aronoff (1989)<br />
Rashmi H. Barbhaiya (1989)<br />
Arthur L. Barry (1989)<br />
John G. Bartlett (1990)<br />
Arnold S. Bayer (1988)<br />
William M. Bennett (1990)<br />
Michel G. Bergeron (1989)<br />
Richard F. Bergstrom (1988)<br />
Karen K. Biron (1990)<br />
Gerald P. Bodey (1989)<br />
Ward Bullock (1990)<br />
Tsun Chang (1989)<br />
Anthony Chow (1988)<br />
C. Glenn Cobbs (1989)<br />
Paul S. Cohen (1989)<br />
William A. Craig (1990)<br />
Naomi Datta (1990)<br />
Lawrence E. Day (1989)<br />
William E. Dismukes (1990)<br />
Gary V. Doern (1990)<br />
Susan M. Dorrbecker (1989)<br />
R. Gordon Douglas, Jr. (1989)<br />
John C. Drach (1990)<br />
George L. Drusano (1990)<br />
Theodore Eickhoff (1988)<br />
Gertrude B. Elion (1990)<br />
George M. Eliopoulos (1988)<br />
Arthur English (1989)<br />
ANTIMICROBIAL AGENTS AND<br />
CHEMOTHERAPY<br />
VOLUME 32 DECEMBER 1988 NUMBER 12<br />
Jack M. Gwaltney, Jr., Editor (1990)<br />
University of Virginia School of<br />
Medicine<br />
Charlottesville<br />
George A. Jacoby, Jr., Editor (1990)<br />
Massachusetts General Hospital<br />
Boston<br />
EDITORIAL BOARD<br />
Robert J. Fass (1988)<br />
Stuart Feldman (1988)<br />
Sydney Finegold (1988)<br />
Martin Forbes (1989)<br />
John N. Galgiani (1990)<br />
Dale N. Gerding (1988)<br />
Allan Godfrey (1990)<br />
Irving H. Goldberg (1988)<br />
Thomas D. Gootz (1988)<br />
Stephen B. Greenberg (1989)<br />
Scott M. Hammer (1989)<br />
Margaret R. Hammerschlag (1989)<br />
Robert E. W. Hancock (1989)<br />
W. Lee H<strong>and</strong> (1989)<br />
H. Hunter H<strong>and</strong>sfield (1989)<br />
Frederick G. Hayden (1990)<br />
Leonid B. Heifets (1990)<br />
Michael L. Higgins (1989)<br />
David C. Hooper (1990)<br />
Richard Hornick (1989)<br />
George Gee Jackson (1989)<br />
Michael R. Jacobs (1990)<br />
James H. Jorgensen (1990)<br />
William J. Jusko (1989)<br />
A. W. Karchmer (1988)<br />
Donald Kaye (1988)<br />
Mark S. Klempner (1989)<br />
George S. Kobayashi (1988)<br />
Jeffrey R. Koup (1990)<br />
Donald J. Krogstad (1989)<br />
Philip Todd Lavin (1989)<br />
Stephen A. Lerner (1989)<br />
Stuart B. Levy (1989)<br />
David R. Luke (1990)<br />
Joan Lusk (1989)<br />
R. Luthy (1989)<br />
Gerald L. M<strong>and</strong>ell (1989)<br />
Gary R. Matzke (1989)<br />
George H. McCracken (1990)<br />
Antone A. Medeiros (1990)<br />
Michael Miller (1990)<br />
Barbara E. Murray (1990)<br />
Henry W. Murray (1990)<br />
John D. Nelson (1989)<br />
Harold C. Neu (1989)<br />
Lawrence A. Pachla (1990)<br />
Joseph S. Pagano (1990)<br />
James E. Pennington (1989)<br />
T. J. Perun (1989)<br />
Lance R. Peterson (1988)<br />
W. H. G. Richards (1989)<br />
Douglas D. Richman (1990)<br />
Glenn D. Roberts (1989)<br />
Richard Roberts (1988)<br />
Ian M. Rollo (1988)<br />
Allan Ronald (1990)<br />
John P. Rosazza (1989)<br />
Jon E. Rosenblatt (1988)<br />
Robert H. Rubin (1990)<br />
Merle S<strong>and</strong>e (1988)<br />
W. Eugene S<strong>and</strong>ers, Jr. (1990)<br />
W. Michael Scheld (1989)<br />
Christine C. S<strong>and</strong>ers, Editor (1989)<br />
Creighton University School of<br />
Medicine<br />
Omaha, Neb.<br />
John A. Washington II, Editor (1991)<br />
Clevel<strong>and</strong> Clinic Foundation<br />
Clevel<strong>and</strong>, Ohio<br />
Peter G. Welling, Editor (1988)<br />
Warner-Lambert Co.<br />
Ann Arbor, Mich.<br />
Jerome J. Schentag (1988)<br />
Raymond F. Schinazi (1989)<br />
Fritz D. Schoenknecht (1989)<br />
Robert T. Schooley (1990)<br />
F. C. Sciavolino (1988)<br />
William M. Shannon (1989)<br />
Charles Shipman, Jr. (1988)<br />
David M. Shlaes (1988)<br />
Robert W. Sidwell (1990)<br />
Herbert M. Sommers (1989)<br />
P. Frederick Sparling (1990)<br />
Harold St<strong>and</strong>iford (1988)<br />
David A. Stevens (1989)<br />
Stephen E. Straus (1990)<br />
R. Sutherl<strong>and</strong> (1988)<br />
Morton N. Swartz (1988)<br />
Richard B. Sykes (1988)<br />
Francis P. Tally (1990)<br />
Fred C. Tenover (1988)<br />
Alex<strong>and</strong>er Tomasz (1988)<br />
Roger D. Toothaker (1988)<br />
Francis L. S. Tse (1989)<br />
Michael Waring (1990)<br />
Bernard Weisblum (1988)<br />
Peter F. Weller (1989)<br />
Richard Wise (1989)<br />
John S. Wolfson (1990)<br />
David J. Wyler (1989)<br />
Lowell Young (1988)<br />
Pauline K. W. Yu (1988)<br />
Helen R. Whiteley, Chairman, Publications Board Kirk Jensen, Director of Publications<br />
Linda M. Illig, Managing Editor, Journals<br />
Carol J. Neff, Production Editor<br />
<strong>Antimicrobial</strong> <strong>Agents</strong> <strong>and</strong> <strong>Chemotherapy</strong> (ISSN 0066-4804), an interdisciplinary publication of the American Society for Microbiology,<br />
1913 I St., N.W., Washington, DC 20006, is devoted to the dissemination of knowledge relating to all aspects of antimicrobial, antiparasitic,<br />
<strong>and</strong> anticancer agents <strong>and</strong> chemotherapy. Instructions to authors are published in the January issue each year; reprints are available from the<br />
editors <strong>and</strong> the Publications Department. <strong>Antimicrobial</strong> <strong>Agents</strong> <strong>and</strong> <strong>Chemotherapy</strong> is published monthly, one volume per year. The<br />
nonmember subscription price is $220 per year; single copies are $30. The member subscription price is $35 (foreign, $56 [air drop shipping])<br />
per year; single copies are $8. Correspondence relating to subscriptions, reprints, defective copies, availability of back issues, lost or late<br />
proofs, disposition of submitted manuscripts, <strong>and</strong> general editorial matters should be directed to the ASM Publications Department, 1913 I<br />
St., N.W., Washington, DC 20006 (phone: 202 833-9680).<br />
Claims for missing issues from residents of the United States, Canada, <strong>and</strong> Mexico must be submitted within 3 months after publication<br />
of the issues; residents of all other countries must submit claims within 6 months of publication of the issues. Claims for issues missing<br />
because of failure to report an address change or for issues "missing from files" will not be allowed.<br />
Second-class postage paid at Washington, DC 20006, <strong>and</strong> at additional mailing offices.<br />
POSTMASTER: Send address changes to <strong>Antimicrobial</strong> <strong>Agents</strong> <strong>and</strong> <strong>Chemotherapy</strong>, ASM, 1913 I St., N.W., Washington, DC 20006.<br />
Made in the United States of America.<br />
Copyright C) 1988, American Society for Microbiology. 43*:I^ &'iAK,J L Um{f,1; ( I13'f<br />
All Rights Reserved.<br />
The code at the top of the first page of an article in this journal indicates the copyright owner's consent that copies of the article may be<br />
made for personal use or for personal use of specific clients. This consent is given on the condition, however, that the copier pay the stated<br />
per-copy fee through the Copyright Clearance Center, Inc., 21 Congress St., Salem, MA 01970, for copying beyond that permitted by Sections<br />
107 <strong>and</strong> 108 of the U.S. Copyright Law. This consent does not extend to other kinds of copying, such as copying for general distribution, for<br />
advertising or promotional purposes, for creating new collective works, or for resale.
Abele, Gunnar, 1807<br />
Akabane, Taro, 1864<br />
Arnold, Barbara H., 1784<br />
Barg, Neil L., 1834<br />
Beale, Angela S., 1830<br />
Benoni, G., 1875<br />
Bertr<strong>and</strong>, G., 1875<br />
Blumer, Jeffrey L., 1780<br />
Boehme, Richard E., 1887<br />
Brown, David C., 1899<br />
Bubrick, Melvin P., 1845<br />
Budtz-J0rgensen, Ejvind, 1859<br />
Call, N. Branson, 1820<br />
Cannon, Deborah L., 1784<br />
Casas, Ivan A., 1854<br />
Chang, Stephen C., 1763<br />
Chen, Ming S., 1887<br />
Chernow, Marlene, 1887<br />
Chuang, Ronald Y., 1887<br />
Chung, Tung C., 1854<br />
Cocchetto, David M., 1845<br />
Consolo, U., 1875<br />
Cornford, Richard J., 1879<br />
Courvalin, Patrice, 1793<br />
Crenshaw, Deborah, 1780<br />
Cunningham, Eloise, 1788<br />
Curtis, Nigel A. C., 1879<br />
Cuzzolin, L., 1875<br />
Datema, Roelf, 1807<br />
Davis, Joanne, 1801<br />
de Clercq, Erik, 1839<br />
Dirks, Monte S., 1820<br />
Dobrogosz, Walter J., 1854<br />
Doern, Gary V., 1747<br />
East, Simon J., 1879<br />
Edlund, Charlotta, 1869<br />
Eisenstadt, Rosemary L.,<br />
1879<br />
Feldberg, Ross S., 1763<br />
Ferro, Adolph J., 1904<br />
Ferronato, G., 1875<br />
Fitchen, John H., 1904<br />
Flaherty, John F., 1825<br />
Fleishaker, Joseph C., 1825<br />
Fletcher, Courtney V., 1899<br />
Fracasso, M. E., 1875<br />
Franzblau, Scott G., 1758<br />
Gambertoglio, John G., 1825<br />
Gates, Mark L., 1893<br />
Gisby, John, 1830<br />
Goldfarb, Johanna, 1780<br />
Guglielmo, B. Joseph, 1825<br />
Gustavson, Linda E., 1813<br />
Hastings, Robert C., 1758<br />
Hayden, Frederick G., 1813<br />
Heim-Duthoy, Karen L., 1845<br />
Holmstrup, Palle, 1859<br />
Holy, Antonin, 1839<br />
Hori, Ritsuko, 1848<br />
Inoue, Matsuhisa, 1848<br />
Isayama, Yasuro, 1891<br />
Ishikawa, Hitoshi, 1891<br />
Jacobson, Jay A., 1820<br />
Jechorek, Robert P., 1769<br />
Jones, Ronald N., 1747<br />
Joyce, Lyle D., 1899<br />
Karaffa, Camile, 1754<br />
Kasworm, Evelyn M., 1820<br />
Knapp, Cynthia, 1754, 1896<br />
Komiyama, Atsushi, 1864<br />
Kotik, Alan N., 1763<br />
Krogh, Palle, 1859<br />
Lake, Kathleen D., 1899<br />
Lake-Bakaar, Desmond M.,<br />
1807<br />
Author Index<br />
Lemon, Eloise, 1780<br />
Leone, R., 1875<br />
Levy, Stuart B., 1797, 1801<br />
Lindborg, Bjorn, 1807<br />
Lindqvist, Lennart, 1869<br />
Love, Kathryn R., 1899<br />
Maddaus, Michael A., 1769<br />
Marshall, Bonnie, 1801<br />
Martino-Saltzman, David,<br />
1784<br />
Marx, Preston A., 1887<br />
Masuda, Midori, 1864<br />
Matsuoka, Takafumi, 1864<br />
Matthews, Thomas R., 1887<br />
Matzke, Gary R., 1845<br />
McGinnis, E., 1788<br />
McRoberts, Mary Jane, 1887<br />
Mitsuhashi, Susumu, 1848<br />
Mitsuyama, Junichi, 1848<br />
Murata, Kenjiro, 1864<br />
Nadler, Marcus, 1763<br />
Neuwirth, Zeev, 1763<br />
Nord, Carl Erik, 1869<br />
Ohmae, Kenichi, 1891<br />
O'Horo, Jennifer, 1780<br />
Papadopoulou, Barbara, 1793<br />
Parham, Christine, 1788<br />
Park, Britt H., 1797<br />
Prisbe, Ernest J., 1887<br />
Pritzker, Marc R., 1899<br />
Puchetti, V., 1875<br />
Riscoe, Michael K., 1904<br />
Rodondi, Lisa C., 1825<br />
Rosenberg, Ivan, 1839<br />
Rowse, Deborah, 1801<br />
Saikawa, Isamu, 1848<br />
Sakuma, Takashi, 1839<br />
S<strong>and</strong>ers, Christine C., 1893<br />
S<strong>and</strong>ers, W. Eugene, Jr., 1893<br />
Schinazi, Raymond F., 1784<br />
Schluederberg, Susan, 1801<br />
Selitrennikoff, Claude P., 1901<br />
Sierra-Madero, Juan, 1754,<br />
1896<br />
Simmons, Richard L., 1769<br />
Smith, John M., 1776<br />
Snoeck, Robert, 1839<br />
Soike, Kenneth F., 1807<br />
Stark, Tracey, 1901<br />
Steele, Lorraine C., 1776<br />
Sumter, Gwendolyn, 1776<br />
Sundstrom, David C., 1763<br />
Suttmann, Rebecca T., 1887<br />
Taft, Cathy S., 1901<br />
Talarico, Todd L., 1854<br />
Thompson, Nathan H., 1763<br />
Tominack, Rebecca L., 1813<br />
Townsend, Raymond J., 1825<br />
Turner, Ronald B., 1820<br />
Walker, Linda A., 1879<br />
Wallace, Richard J., Jr., 1776<br />
Washington, John A., 1754,<br />
1896<br />
Wells, Carol L., 1769<br />
White, Anthony J., 1879<br />
Wills, Robert J., 1813<br />
Wu, John C., 1887<br />
Yamazaki, Munehiro, 1864<br />
Yasuda, Takashi, 1848<br />
Yasui, Kozo, 1864<br />
Yotsuji, Akira, 1848<br />
Zilhao, Rita, 1793
ACKNOWLEDGMENT<br />
The following persons served as invited special reviewers for the journal during 1988, <strong>and</strong> their help is greatly appreciated.<br />
Charles A. Alford, Jr.<br />
J. Davis Allen<br />
R. Anderson<br />
F. S. Archibald<br />
Devron Averett<br />
Johan S. Bakken<br />
Robert M. Bannatyne<br />
Jules Baum<br />
Robert Beahner<br />
Michael Bennish<br />
J. D. Berman<br />
Robert F. Betts<br />
A. Bock<br />
John M. Boyce<br />
Volkman Braun<br />
Sam Broder<br />
Kenneth Brown<br />
Karen Bush<br />
Peter Canonico<br />
Stephen J. Cavalier<br />
Henry Chambers<br />
John Chapman<br />
Stephen A. Chartr<strong>and</strong><br />
Ming S. Chen<br />
Yung-Chi Cheng<br />
Ian Chopra<br />
Gordon Christensen<br />
Richard B. Clark<br />
Donald Coen<br />
Patrice Courvalin<br />
W. A. Cramer<br />
Lawrence R. Crane<br />
Jorge Crosa<br />
Clyde Crumpacker<br />
George Cuchural, Jr.<br />
Thomas Curran<br />
Richard Davey<br />
Bernard Davis<br />
Eric De Clercq<br />
David Diuguid<br />
Thomas Dougherty<br />
Kathleen M. Downey<br />
Richard Duma<br />
Paul H. Edelstein<br />
Roslyn Eisenberg<br />
Suzanne U. Emerson<br />
Richard H. K. Eng<br />
Lawrence Eron<br />
J. 0. Falkinham<br />
Barry M. Farr<br />
David Feingold<br />
Robert Fekety<br />
A. Ferrante<br />
A. Kirk Field<br />
Cay Fitch<br />
Robert J. Fitzgerald<br />
Cecil W. Forsberg<br />
A. Forsgren<br />
Eben Fox<br />
I. Fridovich<br />
K. P. Fu<br />
Philip Furman<br />
James Fyfe<br />
Denise Galloway<br />
Peter Gemski<br />
Nafsika Georgopapadakou<br />
Donald K. Giger<br />
David Gilbert<br />
Michael Glauser<br />
Joseph Glorioso<br />
Richard V. Goering<br />
Myles Gombert<br />
Robert C. Good<br />
John E. Greenlee<br />
Jerome E. Groopman<br />
Gerri S. Hall<br />
J. Owen Hendley<br />
Martin Hirsch<br />
Jan V. Hirschmann<br />
Glen R. Hodger<br />
B. Houwen<br />
Walter Hughes<br />
Pentti Huovinen<br />
J. Michael J<strong>and</strong>a<br />
Susan Jensen<br />
Dave Johns<br />
Allen Kaiser<br />
Earl R. Kern<br />
A. Kerr<br />
W. M. M. Kirby<br />
Saul Kit<br />
T. R. Klaenhammer<br />
Vernon Knight<br />
M. Kozak<br />
Donald Leblanc<br />
William Ledger<br />
Tim Lee<br />
Rol<strong>and</strong> A. Lev<strong>and</strong>owski<br />
J. J. Lipsky<br />
L. F. Liu<br />
David Livermore<br />
G. Lopez-Berestein<br />
Lionel A. M<strong>and</strong>ell<br />
Joseph Marr<br />
J. R. Martin<br />
Kenneth Mayer<br />
J. K. McClatchy<br />
Mark A. McKinlay<br />
Colin McLaren<br />
Cody Meissner<br />
Miklos H. Muller<br />
William N. Murphy<br />
Kenrad E. Nelson<br />
R. H. Neubauer<br />
Franklin Neva<br />
Ernest Newbrun<br />
Thalia Nicas<br />
H. Nikaido<br />
Carl-Erik Nord<br />
Richard Novick<br />
Paul O'Keefe<br />
Andrew Onderdonk<br />
Michael Otto<br />
W. Paranchych<br />
Roberta Parente<br />
J. T. Parisi<br />
T. Parr<br />
Robert Pass<br />
Gerald Peir<br />
L. Piddock<br />
Philip Pizzo<br />
Laurel C. Preheim<br />
Alice Prince<br />
Peter J. Quesenberry<br />
Jonathan I. Ravdin<br />
D. J. Reed<br />
Jack Remington<br />
K. L. Rinhart, Jr.<br />
Marilyn Roberts<br />
William Robinson<br />
Hans G. Sahl<br />
Irving Salit<br />
K. S<strong>and</strong>erson<br />
Prem Sarin<br />
Priscilla Schaeffer<br />
Charles J. Schleupner<br />
A. Schryvers<br />
Warren Shaw<br />
G. Shockman<br />
Robert Shoemaker<br />
Robert E. Shope<br />
Simon Silver<br />
John Sixbey<br />
Craig A. Smith<br />
Thomas Smith<br />
Jack Sobel<br />
Kenneth F. Soike<br />
Pam Sokol<br />
Tom Specter<br />
David Speert<br />
Magel Spitz<br />
Brian Spratt<br />
Walter Stamm<br />
Victor Stollar<br />
Barbara Styrt<br />
J. W. Suttie<br />
Richard L. Sweet<br />
Francis P. Szoka<br />
H. Taber<br />
Janson M. Tanzer<br />
Martin Tauber<br />
Raymond Testa<br />
Charles Thoen<br />
Clyde Thornsberry<br />
Richard Tidwell<br />
Carmelita Tuazon<br />
E. Tuomanen<br />
Ronald B. Turner<br />
M. Vaara<br />
Leo Vining<br />
Edward E. Walsh<br />
Richard J. Whitley<br />
Kirk Wilhelmis<br />
Murray Wittner<br />
Emanuel Wolinsky<br />
Brian Wong<br />
D. E. Woods<br />
Philip Wyde<br />
Robert Yarchoan<br />
Stephen Zinner<br />
M. Zweerink
Abele, G., 1137, 1807<br />
Abraham, Soman N., 1274<br />
Acar, J. F., 9, 195<br />
Adinolfi, Luigi E., 1012<br />
Adloff, M., 1360<br />
Aguirre, Tania, 1237<br />
Aikawa, M., 1655<br />
Aizawa, Noboru, 1648<br />
Akabane, Taro, 1864<br />
Akerfeldt, Stig, 1720<br />
Akimoto, Yoshiaki, 566<br />
Alarc6n, Balbino, 1257, 1412<br />
Albrecht, Janice K., 47, 224<br />
Alcina, Antonio, 1412<br />
Aidridge, Kenneth, 717<br />
Allais, Jean M., 1327, 1740<br />
Allegra, Carmen J., 324, 430<br />
Allison, Patricia E., 137<br />
Alonso, Marie-Jose, 1204<br />
Alvarez, Emilio, 1061<br />
An, Florence Y., 547<br />
An<strong>and</strong>, Rita, 684<br />
Andrade, J., 780<br />
Andremont, Antoine, 1204<br />
Andrews, J. M., 617, 1251, 1508<br />
Andrews, Kenneth J. M., 814<br />
Andry, G., 1557<br />
Ansehn, Steffan, 1208<br />
Antikainen, Riitta, 1019<br />
Anwar, Hosmin, 364<br />
Aoyagi, Teruo, 110<br />
Aoyama, Hiroshi, 104, 922<br />
Apicella, Michael A., 777<br />
Appelbaum, Frederick R., 271<br />
Arai, Mamoru, 110<br />
Arai, Susumu, 1040, 1396<br />
Arai, Toshihiko, 110<br />
Arakawa, Soichi, 1080<br />
Arathoon, Eduardo G., 369<br />
Araujo, Fausto G., 755<br />
Arca, Pilar, 1552<br />
Armstrong, D., 780, 1676<br />
Arnold, Barbara H., 1784<br />
Arnold, John, 42<br />
Aronoff, Stephen C., 395, 1636<br />
Ashby, J. P., 617, 1251, 1508<br />
Ashdown, Leslie R., 1435<br />
Asmar, Basim I., 1375<br />
Auclair, Pierre, 736<br />
Azuma, Masanobu, 1547<br />
Baba, Masanori, 1025, 1742<br />
Babin-Chevaye, C., 1124<br />
Bachmann, Kenneth, 75, 730<br />
Bacon, Teresa H., 358<br />
Baker, Cynthia B., 374<br />
Baker, Pamela J., 1521<br />
Baker, Richard H., 462<br />
Bakken, Johan S., 1314<br />
Bakker, Leendert J., 473<br />
Bakker-Woudenberg, Irma A.J.M., 1560<br />
Balis, Frank M., 324<br />
Baltch, Aldona L., 1450, 1565<br />
Balzarini, Jan, 1025<br />
Baqar, Shahida, 462<br />
Barber, William E., 814<br />
Barg, Neil L., 202, 1834<br />
Barnett, Bill B., 331<br />
Baron, Patricia A., 1269<br />
Barredo, Jose L., 1061<br />
AUTHOR INDEX<br />
VOLUME 32<br />
Barriere, Steven L., 298<br />
Barry, Arthur L., 150, 346, 443, 752, 1576<br />
Bartlett, J. C., 598<br />
Bartlett, Karen H., 782<br />
Bartlett, Marilyn S., 897<br />
Bartosek, IVan, 1541<br />
Bartucci, F., 1461<br />
Bassford, Philip J., Jr., 164<br />
Baumann, Russell J., 1119<br />
Bayer, Arnold S., 141, 231<br />
Beachey, Edwin H., 1274, 1370, 1603,<br />
1609<br />
Beale, Angela S., 1830<br />
Beauchamp, Denis, 992<br />
Beckman, Howard B., 510<br />
Beggs, William H., 209<br />
Bellin, Eran Y., 1113<br />
Bemis, A. Todd, 63<br />
Bennett, D. B., 758<br />
Bennett, John E., 1619<br />
Bennett, Renee L., 209<br />
Bennett, William M., 844<br />
Benoni, G., 1875<br />
Berger-Bachi, Brigitte, 1494<br />
Bergeron, Michel G., 354, 561, 736, 1227,<br />
1231, 1433, 1515<br />
Bergman, Jan, 1720<br />
Berk, Shirley, 78<br />
Berk, Steven, 78<br />
Berkey, Peter, 1078<br />
Bermudez, Luiz Eduardo M., 1149<br />
Bernard, E. M., 780, 1676<br />
Bernareggi, Alberto, 246, 1223<br />
Bernstein, David I., 761<br />
Berthe, Jackie, 250<br />
Bertino, Joseph S., Jr., 236, 1446<br />
Bertr<strong>and</strong>, G., 1875<br />
Berube, Denise, 354, 1227<br />
Beyer, Jill M., 1710<br />
Bia, Frank J., 1182<br />
Bianchi, A., 1350<br />
Billot-Klein, D., 9, 195<br />
Biron, Karen, 265<br />
Biron, Simon, 1231<br />
Bishop, Monica, 1565<br />
Bittner, Marvin J., 1327<br />
Black, William A., 1441<br />
Blasecki, John W., 1699<br />
Blickens, Donald, 42<br />
Blickle, J. F., 1360<br />
Blum, Robert A., 848<br />
Blumer, Jeffrey L., 1780<br />
Bocquet, V., 1590<br />
Bodey, Gerald P., 1365<br />
Bodhidatta, Ladaporn, 723<br />
Boeckh, Michael, 92<br />
Boehm, Diane M., 137<br />
Boehme, Richard, 1154, 1887<br />
Boelaert, J., 1595<br />
Bohme, Ekkehard H., 1119<br />
Bongaerts, Ger P. A., 740<br />
B3onventre, Peter F., 1012<br />
Boot, J. M., 426<br />
Bornemann, L. D., 592<br />
Borner, Klaus, 92<br />
Borsa, Francoise, 938<br />
Boscia, Jerome A., 262, 877<br />
Boslego, John W., 775<br />
Bottner, Wayne A., 1446<br />
Bower, Robert R., 27<br />
Bowles, Susan K., 510<br />
Boyd, James C., 1644<br />
Boyd, Malcolm R., 358<br />
Bradley, S. G., 962<br />
Brajtburg, Janina, 327, 702<br />
Brafia, Alfredo F., 1552<br />
Br<strong>and</strong>icourt, Olivier, 250<br />
Br<strong>and</strong>t, Roger, 573<br />
Broadhurst, Anne V., 814<br />
Brogard, J. M., 1360<br />
Brown, David C., 1899<br />
Brown, Michael R. W., 364<br />
Brown, Robert, 1269<br />
Brown, S. Anthony, 595<br />
Brown, William J., 385<br />
Brunner, H., 57<br />
Brust, Paula, 1640<br />
Bryan, L. E., 498<br />
Bubrick, Melvin P., 1845<br />
Budtz-J0rgensen, Ejvind, 1859<br />
Bull, Herbert G., 319<br />
Bundy, J. McCall, 882<br />
Bush, Larry M., 877<br />
Byrne, Sean K., 1441<br />
Cabeza Meckert, Patricia, 241<br />
Cacalano, Grace Soong, 838<br />
Cafarell, Robert F., 777<br />
Calame, Wim, 1456<br />
Call, N. Branson, 182Q<br />
Campos, Jos4, 477, 706<br />
Canawati, Hanna N., 81<br />
Cannon, Deborah L., 1784<br />
Cantoral, Jesus M., 1061<br />
Canupp, Kay C., 1500<br />
Carbon, C., 1590<br />
Carlet, J., 9<br />
Carlisle, Ricarda, 997<br />
Carr, Mary E., 844<br />
Carrasco, Luis, 1257<br />
Carret, G., 454<br />
Casadaban, Malcolm, 1379<br />
Casalino, Mariassunta, 1262<br />
Casas, Ivan A., 1854<br />
Casey, Sharon W., 337<br />
Casin, I., 1350<br />
Cassano, Karen, 1031<br />
,Cassell, Gail H., 1500<br />
Castellano, S., 592<br />
Catherall, Elaine J., 1705<br />
Catlin, B. Wesley, 971<br />
Cattier, Bl<strong>and</strong>ine, 147<br />
Cavenaghi, Luigi, 246, 1223<br />
Chabner, Bruce A., 324, 430<br />
Chaffin, Donald O., 706<br />
Chalkley, Lynda J., 24<br />
Chamb6, Jorge G., 241<br />
Chamorro, Roxana M., 1416<br />
Champlin, Franklin R., 1354<br />
Chan, gobert, 1231<br />
Chanal, Catherine M., 626, 1660<br />
Chang, Hernan R., 524<br />
Chang, Stephen C., 1763<br />
Chanock, Robert M., 1269<br />
Chantrain, G., 1557<br />
Chapman, John S., 438<br />
Chastang, Claude, 303<br />
Chen, Man, 678<br />
Chen, Ming S., 1887<br />
Cheng, Nick, 788<br />
Chernow, Marlene, 1887
ii AUTHORINDEX<br />
Chin, Nai Xing, 838<br />
Chin, Nai-Xun, 84, 580, 656, 663, 671,<br />
1666<br />
Chitwarakorn, Anupong, 723<br />
Chongsuphajaisiddhi, T., 250<br />
Chow, AnthonyNW., 782, 788<br />
Chow, Raymond T., 1113<br />
Christenson, James G., 1005<br />
Chu, Chun-Jung, 858<br />
Chu, D. T. W., 27<br />
Chuang, Ronald Y., 1887<br />
Chung, Menger, 42<br />
Chung, Tung C., 1854<br />
Citron, Diane M., 213, 1143<br />
Clark, Richard B., 689, 1314<br />
Clarkson, Allen B., Jr., 1158<br />
Clavier, Francoise, 568<br />
Clayton, Christopher, 1213<br />
Cleary, Timothy, 717<br />
Cleel<strong>and</strong>, Roy, 770<br />
Clewell, Don B., 547<br />
Cluzel, Roger A., 626, 1660<br />
Cocchetto, David M., 1845<br />
Cohen, L. A., 1655<br />
Cohen, Paul S., 770<br />
Cohen, Seth P., 1187<br />
Cohn, Robert C., 395<br />
Cole, Gerald A., 462<br />
Coll, Ram6n, 636<br />
Collaborative <strong>Antimicrobial</strong> Susceptibility<br />
Testing Group, 346<br />
Collatz, E., 195, 1289<br />
Comereski, C. R., 758<br />
Conroy, Joseph V., 1450, 1565<br />
Consolo, U., 1875<br />
Conte, John E., Jr., 1490<br />
Cook, S<strong>and</strong>ra, 1439<br />
Corada, Monica, 1541<br />
Cornaglia, Giuseppe, 552<br />
Corner, Anne-Marie, 350<br />
Cormford, Richard J., 1879<br />
Courtney, Harry S., 1370<br />
Courvalin, Patrice, 15, 945, 1107, 1174,<br />
1793<br />
Couvreur, Patrick, 1204<br />
Craig, William A., 51<br />
Crawford, Carol E., 1441<br />
Crenshaw, Deborah, 1780<br />
Crokaert, F., 1632<br />
Crook, Derrick, 717<br />
Crosa, Jorge H., 1416<br />
Crossley, Kent B., 848<br />
Croteau, Daniel, 561, 1227<br />
Cuchural, George J., Jr., 717<br />
Cuevas, Thomas A., 1327<br />
Cullmann, Wolfgang, 1090<br />
Cunningham, Eloise, 1788<br />
Curran, James W., 684<br />
Curtis, Nigel A. C., 1879<br />
Cushion, Melanie T., 96, 896<br />
Cuzzolin, L., 1875<br />
Daghlian, Charles P., 1627<br />
Daikos, George L., 785<br />
Dajani, Adnan S., 1375<br />
Daly, Jennifer S., 1341<br />
Daneau, D., 1557<br />
Daneels, R., 1595<br />
Danese, Antonio, 246, 1223<br />
Dangor, Y., 1458<br />
Darfeuille-Richaud, Arlette, 1282<br />
Daschner, F. D., 930<br />
Datema, Roelf, 1807<br />
Daum, Robert S., 1034<br />
Davis, Joanne, 1801<br />
Davis, Robin L., 274<br />
Debbia, Eugenio, 279<br />
De Beule, K., 1595<br />
Debs, Robert J., 1404<br />
de Clercq, Erik, 906, 1025, 1742, 1839<br />
Deeg, H. Joachim, 271<br />
Deffrennes, Dominique, 467<br />
de Groot, Ronald, 477<br />
de las Heras, Federico G., 1257<br />
Delgado, Rafael, 1598<br />
Deloron, Philippe, 391<br />
Derouin, Francis, 303<br />
Desmyter, Jan, 1025<br />
Diez, Bruno, 1061<br />
DiGiovanni, Maria A., 982<br />
DiMattia, Arthur, 882<br />
Dirks, Monte S., 1820<br />
Dismukes, William E., I<br />
Divo, Alan A., 1182<br />
Dix, Barbara A., 770<br />
Dobrogosz, Walter J., 1854<br />
Doern, Gary V., 180, 259, 1747<br />
Dohtsu, Yasumasa, 1427<br />
Dolan, Margaret M., 350<br />
Dolan, Stephen A., 928<br />
Dor, P., 1557<br />
Dornbusch, Katherine, 1484<br />
Dorrington, Susan M., 518<br />
Dougherty, Steven H., 337<br />
Dougherty, Thomas J., 1113<br />
Douwes-Idema, Nora, 1456<br />
Draft, Kenneth, 773<br />
Drake, James C., 324, 430<br />
Drucker, William R., 882<br />
Druilhe, Pierre, 250<br />
Drusano, George L., 289, 1537<br />
Dubach, Ulrich C., 573<br />
Dudley, Michael N., 128<br />
Dufresne, Julien, 819<br />
Durica, David, 391<br />
Durkin, Michelle M., 807<br />
Durnell, Monty, 882<br />
Duroux, Michel H., 298<br />
Duzgunes, Nejat, 1404<br />
Dworzack, David L., 1740<br />
East, Simon J., 1879<br />
Ebert, S., 37<br />
Echeverria, Peter, 723<br />
Edelstein, Howard, 1031<br />
Edlund, Charlotta, 1869<br />
Edmondson, Diane G., 68<br />
Edwards, David J., 510<br />
Edwards, F., 780<br />
Ehret, Josephine M., 773, 1295<br />
Eisenstadt, Rosemary L., 1879<br />
Elberg, Svetlana, 327, 702<br />
Eliopoulos, G. M., 434, 1341, 1528<br />
Elvrum, Patricia M., 1170<br />
Elwell, Lynn P., 1086<br />
Elzinga, Lawrence W., 844<br />
Enthoven, D., 592<br />
Eriksson, B., 1137<br />
Escajadillo, A., 1655<br />
Espinoza, Ana Maria, 663<br />
Esteve, Montserrat, 636<br />
Eustice, D. C., 1218<br />
Everett, E. Dale, 928<br />
Evron, Ruth, 1586<br />
ANTIMICROB. AGENTS CHEMOTHER.<br />
Exposto, F. da L., 1458<br />
Fardel, G., 454<br />
Farinotti, R., 1590<br />
Fasco, Michael J., 1446<br />
Fass, Robert J., 1082<br />
Fattal, Elias, 1204<br />
Faurisson, Francois, 568<br />
Feld, Ron, 1231<br />
Feldberg, Ross S., 1763<br />
Feldman, P. A., 1218<br />
Fern<strong>and</strong>es, Prabhavathi B., 27, 1500, 1710<br />
Fern<strong>and</strong>ez-Guerrero, Manuel, 747<br />
Ferraro, Frank M., 1740<br />
Ferrea, Giuseppe, 1223<br />
Ferro, Adolph J., 1904<br />
Ferronato, G., 1875<br />
Fesik, Stephen W., 308<br />
Fetchick, Richard, 1310<br />
Fidalgo, S., 420<br />
Fillastre, Jean-Paul, 919, 938, 942<br />
Finegold, Sydney M., 403, 601, 611, 717<br />
Finnerty, Edmund F., 882<br />
Fischer, James H., 848<br />
Fitchen, John H., 1904<br />
Flaherty, John F., 1825<br />
Fl<strong>and</strong>rois, J. P., 454<br />
Fleishaker, Joseph C., 1825<br />
Fletcher, Courtney V., 1899<br />
Fleurette, J., 873<br />
Foddis, Giovanni, 552<br />
Folan, David W., Jr., 882<br />
Fong, Ignatius W., 834, 1231<br />
Forrest, Alan, 1537<br />
Foster, Timothy J., 1174<br />
Foucault, Paule, 1433<br />
Fourgeaud, M., 1094<br />
Foxall, Carrol, 710<br />
Foy, Jilanna, %, 896<br />
Fracasso, M. E., 1875<br />
Fraimow, Henry S., 1113<br />
Frances, Cathy A., 773<br />
Frank, U., 930<br />
Franzblau, Scott G., 1583, 1758<br />
Franzus, Bettylene, 78<br />
Freimer, E. H., 530<br />
Frelon, Jean-Hughes, 942<br />
French, G. L., 20<br />
Freney, J., 276, 873<br />
Fresno, Manuel, 1412<br />
Fuchs, Peter C., 346<br />
Fujii, Akira, 566, 1080<br />
Fujii, Tadashi, 104, 922<br />
Fujimaki, Kazuo, 104, 827, 922<br />
Fujimoto, Teruo, 1336<br />
Fung-Tomc, Joan, 1443<br />
Fuse, Aisaku, 587<br />
Gadebusch, Hans, 319<br />
Gaffey, Michael J., 1644<br />
Galioto, G. B., 1461<br />
Gambertoglio, John G., 298, 1825<br />
Gangadharam, Pattisapu R. J., 886, 1400,<br />
1404<br />
Garcia-Lopez, M. Teresa, 1257<br />
Gargallo, Domingo, 636<br />
Garry, Franklyn B., 595<br />
Gates, Mark L., 1893<br />
Gaudebout, Claude, 568<br />
Gavignet, Martine, 147
VOL . 32, 1988<br />
Gavini, F., 873<br />
Gaylord, Janet C., 1699<br />
Gaynes, Robert, 1379<br />
Geddes, Glenna L., 1441<br />
Georgopapadakou, Nafsika H., 438<br />
Gerard, M., 1557<br />
Gerbaud, Guy, 15, 626<br />
Gibbs, Ronald S., 853<br />
Gibson, Gene A., 1320<br />
Gilbert, Brian E., 117, 890<br />
Gilbert, Peter, 1693<br />
Ginunas, Virginia J., 81<br />
Girard, Arthur E., 1347<br />
Gisby, John, 1830<br />
Glupczynski, Y., 276, 1632<br />
Godin, Michel, 938, 942<br />
Goering, Richard V., 1164<br />
Golden, Jeffrey A., 1490<br />
Goldfarb, Johanna, 1780<br />
Goldmann, D., 1528<br />
Goldspiel, Barry R., 853<br />
Goldstein, Ellie J. C., 213, 1143<br />
Goldstein, F. W., 9, 195<br />
Goldstein, Jayne A., 1404<br />
Golenbock, D. T., 37<br />
Golper, Thomas A., 844<br />
Gonzalez, M. Eugenia, 1257<br />
Gootz, Thomas D., 159<br />
Goransson, Evelyn, 1484<br />
Gorbach, Sherwood L., 1439<br />
Gordin, Ariel, 1019<br />
Goudeau, Alain, 147<br />
Graham, Theodore, 271<br />
Graybill, John R., 1310<br />
Grayston, J. Thomas, 257<br />
Graziani, Amy L., 1320<br />
Greenberg, Richard, 710<br />
Gresser-Burns, Mary E., 513<br />
Griffith, Brigitte P., 678<br />
Griggs, D., 1508<br />
Groisman, Eduardo, 1379<br />
Gross, M. L., 530<br />
Guay, D. R. P., 485<br />
Guglielmo, B. Joseph, 298, 1511, 1825<br />
Guinea, Jesus, 636<br />
Guizie, Miriam, 1586<br />
Guptill, Douglas R., 755<br />
Gurwith, Dorothy, 802<br />
Gurwith, Marc, 802<br />
Gustavson, Linda E., 1813<br />
Gutmann, L., 9, 195<br />
Gwaltney, Jack M., Jr., 1644<br />
Haase, David A., 1292<br />
Hadley, W. K., 1392<br />
Hall, Gerti S., 1331<br />
Hall, Michael J., 814<br />
Hamati, Fawwaz, 78<br />
Hammer, Mark C., 1450, 1565<br />
Hancock, Robert E. W., 649<br />
H<strong>and</strong>sfield, H. Hunter, 773<br />
Haneishi, Tatsuo, 110<br />
Hanger, D. P., 646<br />
Hanna, Charles B., 882<br />
Hansen, W., 276<br />
Hanson, Charles W., 27<br />
Hanson, Linda H., 369<br />
Hara, Kohei, 1427<br />
Hardin, Thomas C., 1310<br />
Harding, Godfrey K., 1231, 1292<br />
Hardisson, C., 420, 1552<br />
Hardy, Dwight J., 27, 1710<br />
Harkonen, Scott, 710<br />
Harmenberg, J., 1100, 1137, 1533, 1720<br />
Harris, Jeffrey P., 865<br />
Hart, Mark E., 1354<br />
Hartstein, Alan I., 369<br />
Hastings, Robert C., 1758<br />
Haug, Alfred, 308, 649<br />
Hauser, M., 1676<br />
Hayakawa, Tomihiro, 726<br />
Hayasaka, Hiroshi, 1588<br />
Hayashi, Shoryo, 1040, 1396<br />
Hayashi, Toshiaki, 1427<br />
Hayashi, Toshikatsu, 458<br />
Hayashi, Toshio, 912<br />
Hayden, Frederick G., 224, 409, 1644,<br />
1813<br />
Hecht, David, 717<br />
Heeres-Weststrate, P. L., 426<br />
Heifets, Leonid, 1002, 1131<br />
Heim-Duthoy, K. L., 485, 1845<br />
Helsel, Valerie L., 1082<br />
Hemming, Val G., 1269<br />
Hengstler, Bruno, 364<br />
Henry, Nancy, 747<br />
Hensey, Dena M., 1710<br />
Hentges, David J., 337<br />
Herwaldt, Barbara L., 793, 799, 953, 957<br />
Heykants, J., 1595<br />
Hicks, R., 589<br />
Higashi, Katsuyoshi, 726<br />
Higgins, J. T., Jr., 530<br />
Hill, Carter D., 882<br />
Hill, Gale, 717<br />
Hill, James M., 978<br />
Hill, Lori, 1565<br />
Hirai, Keiji, 922<br />
Hirano, Lance, 141, 231<br />
Hirata, Koichi, 1588<br />
Hirota, Masaki, 1427<br />
Hitchcock, Michael J. M., 186<br />
Hoban, Daryl J., 1292<br />
Hobden, Jeffery A., 978<br />
Hoepelman, Andy I. M., 473<br />
Hoffken, Gert, 92<br />
Hoffman, Howard E., 1699<br />
Hoffner, Sven E., 1208<br />
Hohl, P., 1593<br />
Holden, Patricia, 450<br />
Holmstrup, Palle, 1859<br />
Holy, Antonin, 1025, 1839<br />
Hook, Edward W., III, 773<br />
Hooper, David C., 1187<br />
Hooton, Thomas M., 1640<br />
Hopewell, Philip C., 1057<br />
Hori, Michael, 1314<br />
Hori, Ritsuko, 1097, 1848<br />
Horowitz, Edward A., 1740<br />
Hoshino, Makoto, 726<br />
Hosotsubo, Hideo, 1103<br />
Hosotsubo, Kikumi, 1103<br />
Hostetter, Marcia K., 689<br />
Hottendorf, G. H., 314<br />
Howard, R. J., 1655<br />
HPA-23 Cooperative Study Group, 1300<br />
Hsiung, G. D., 678<br />
Huczko, Elizabeth, 1443<br />
Huffman, John H., 331<br />
Huggins, John W., 1304<br />
Hughes, Carolyn E., 209<br />
Hughes, Walter T., 623, 1057<br />
Hull, Richard, 768<br />
Humbert, Guy, 919<br />
Huovinen, Pentti, 134, 175<br />
AUTHOR INDEX iii<br />
Huovinen, Saara, 134, 175, 1730<br />
Hussoh, M. O., 873<br />
Iaconis, Joseph P., 1365<br />
Iannini, Paul, 717<br />
Ihler, Garret M., 391<br />
Ikeda, Fumiaki, 1243<br />
Ikeda, Haruo, 282<br />
Ikeda, Yasushi, 1073<br />
Inoue, Matsuhisa, 104, 587, 827, 922, 1097,<br />
1421, 1848<br />
Isayama, Yasuro, 1891<br />
Iseman, Michael D., 886, 1400<br />
Ishiguro, Edward E., 1247<br />
Ishiguro, Junzo, 1648<br />
Ishii, Junko, 378<br />
Ishikawa, Hitoshi, 1891<br />
Ito, Kazuyuki, 726<br />
Ito, Yasuo, 156<br />
Izard, D., 873<br />
Jackson, George Gee, 785<br />
Jacobs, Michael, 395<br />
Jacobs, Nicholas J., 1627<br />
Jacobs, Richard F., 1481<br />
Jacobson, Jay A., 1820<br />
Jacobson, Kirk D., 882<br />
Jacobus, Nilda V., 584, 717<br />
Jacoby, George A., 134, 175<br />
Janicke, David M., 777<br />
Jauregui, Luis, 75, 730<br />
Jay, Margaret A., 807<br />
Jechorek, Robert P., 1769<br />
Jehl, F., 1360<br />
Jevons, S., 646<br />
Jiang, Baoming M., 986<br />
Johnson, Carolyn R., 1640<br />
Johnson, Curtis A., 51<br />
Johnson, Steven R., 765<br />
Johnston, Michael, 1196<br />
Joly, Bernard H., 1282<br />
Jones, Ronald N., 346, 443, 752, 1576,<br />
1747<br />
Jonsson, Monica, 1278<br />
Jorgensen, James H., 180, 1477<br />
Joshi, Bharati, 285<br />
Joyce, Lyle D., 1899<br />
Judson, Franklyn N., 773, 1295<br />
Junakovic, Nikolaj, 1262<br />
Jusko, William J., 777<br />
Kadurugamuwa, Jagath L., 364<br />
Kaiser, Allen B., 202<br />
Kaiser, Donald L., 224<br />
Kam, K. M., 20<br />
Kamidono, Sadao, 1080<br />
Kamimura, Toshiaki, 1243<br />
Kan, Virginia L., 1619<br />
Kane, James G., 882<br />
Kaneda, Yoshimasa, 966<br />
Kaneko, Kenji, 566<br />
Karaffa, Camile, 1754<br />
Karasawa, Gakuyo, 1588<br />
Karchmer, Adolf W., 434<br />
Karle, Isabella L., 540<br />
Karle, Jean M., 540<br />
Karlsson, A., 1100<br />
Karlsson, Inga, 1484<br />
Kasworm, Evelyn M., 1820<br />
Katagiri, Kenji, 726<br />
Katahira, Junichi, 912<br />
Katayama, Toshiaki, 110
iv AUTHOR INDEX<br />
Kato, Hideo, 190<br />
Kato, Naoki, 1437<br />
Katsu, Kanemasa, 693<br />
Kawahapa, Yukinori, 110<br />
Kaye, Donald, 262, 877<br />
Kayser, Fritz H., 1494<br />
Kearns, Gregory L., 148i<br />
Keeler, Girard H., 1347<br />
Keith, Dennis D., 1005<br />
Kennedy, Donald, 710<br />
Kennedy, James K., 1292<br />
Kernodle, Douglas S., 202<br />
Kernutt, Ian, 1705<br />
Kesavalu, L., 886, 1400, 1404<br />
Kessler, Robert E., 1443<br />
Khan, Waheed N., 775<br />
Kim, C. Kurtis, 96, 8%<br />
Kimura, Hiromichi, 1588<br />
Kirihara, Jean, 1392<br />
Kirk, K. L., 1655<br />
Kirouac, Daniel, 1227<br />
Kitayama, Rieko, 912<br />
Kitoh, Kyosuke, 693<br />
Kitzis, M. D., 9<br />
Klamerus, Karen J., 631<br />
Klastersky, J., 1557<br />
Knapp, Cynthia, 131, 170, 1754, 1896<br />
Knapp, J. S., 426, 488, 765, 1430<br />
K'night, Vernon, 890<br />
Knodel, Leroy C., 853<br />
Kobasa, William D., 262<br />
Kobayashi, George S., 327, 702<br />
Kobayashi, Shinzo, 1046, 13%<br />
Kdeppe, Peter, 92<br />
Koga, Hironobu, 1427<br />
Kohno,'Shigeru, 1427<br />
Kokkonen, Paula, 1019<br />
Kolnig, Anne-Marie, 936<br />
Komiya, Masamichi, 566<br />
Komiyama, Atsushi, 1864<br />
Kondo, Eiko, 110<br />
Kondo, Sinichi, 1421<br />
Konno, Kenji, 906<br />
Koornhof, H. J., 24, 1458<br />
Koseki, Yuichi, 110<br />
Kosuzume, Hiroshi, 1648<br />
Kotaki, Hiromichi, 282<br />
Kotik, Alan N., 1763<br />
Koubaa, Nedra, 147<br />
Koup, Jeffrey R., 274, 573<br />
Kovacs, Joseph A., 430<br />
Kreindler, Thdmas G., 882<br />
Kresken, M.; 1285<br />
Krogh, Palle, 1859<br />
Krogstad, Donald J., 793, 799, 953, 957<br />
Kromann-Andersen, Bjarne, 936<br />
Kronvall, G6ran, 1484<br />
Kuhn, Jbhn G., 1310<br />
Kumada, Teppei, 912<br />
Kumano, Katsuhiko, 912<br />
Kumar, Ashir, 882<br />
Kume, Yothihiro, 190<br />
Kunka, R. L., 1503<br />
Kunz, Samuel, 364<br />
Kuo, Cho-chou, 257<br />
Kurihara, Kozo, 110<br />
Kurth, Reinhard, 1733<br />
Kurzynski, Terrence A., 137<br />
kusmiesz, Helen, 1738<br />
Kusser, Wolfgang C., 1247<br />
Kuvanont, Krit, 723<br />
Labedan, Bernard, 153<br />
Labia, Roger, 626, 1660<br />
Labro, M. T., 1124<br />
Labroo, V. M., 1655<br />
Laforest, H., 1094<br />
Lagrange, P. H., 1094<br />
Laguens, Ruben P., 241<br />
Lake, Kathleen D., 1899<br />
Lake-Bakaar, Desmond M., 1807<br />
Lally, Richard T., 513<br />
Lam, A. W., 20<br />
Lam, Y. W. Francis, 298<br />
Lambert, Thierry, 15<br />
Lane, H. Clifford, 324<br />
Laska, D. A., 314<br />
Laughon, B. E., 598<br />
Laux, David C., 770<br />
Lawson, Lisa A., 1320<br />
Lazardi, Keyla, 1237<br />
LeBel, Marc, 354, 561, 1227, 1515<br />
Leclerc, H., 873<br />
Lee, A. T., 1655<br />
Leggett, James E., 51<br />
Lemel<strong>and</strong>, Jean-Francois, 919<br />
Lemon, Eloise, 1780<br />
Leone, R., 1875<br />
Leoung, Gifford, 1057<br />
Lerner, Stephen A., 1196, 1379<br />
Leroy, Annie, 938<br />
Leslie, James, 1537<br />
Lessard, Celine, 736, 1433<br />
Lettieri, John, 75<br />
Levesque, Roger C., 819<br />
Levine, Bernard E., 369<br />
Levitsky, Sidney, 63i<br />
Levy, Mordekhai, 1586<br />
Levy, Stuart B., 1187, 1797, 1801<br />
Liebowitz, Lynne D., 24<br />
Lin, A. H., 592<br />
Lin, Jung-Chung, 265, 1068<br />
Lindborg, Bjorn, 1807<br />
Lindner, David L., 159<br />
Lindqvist, Lennart, 1869<br />
Ling, Julia, 20<br />
Linke, Michael J., 96, 98%<br />
Lismont, M. J., 1632<br />
Livermore, David M., 1385<br />
Livrelli, Valerie 0., 1282<br />
Lloyd, William J., 814<br />
Lode, Hartmut, 92<br />
Lokerse, A. F., 1560<br />
Lolans, Valentina T., 785<br />
London, William T., 1269<br />
Love, Kathryn R., 1899<br />
Lower, Johannes, 1733<br />
Loy, Anna, 1223<br />
Lucia, Helen L., 678<br />
Lundblad, Leif, 1720<br />
MacGregor, Rob Roy, 1320<br />
Machida, H., 1046, 1068, 1547<br />
Maddaus, Michael A., 1769<br />
Madier, S., 873<br />
Maeda, Hiroshi, 1080<br />
Maher, Louise A., 180, 1477<br />
Mahl<strong>and</strong>t, Bill G., 1304<br />
Maimorie, Francesco, 1262<br />
MalamUld, Daniel, 350<br />
Malouin, F., 498<br />
M<strong>and</strong>ell, Lionel, 1231<br />
Mannisto, Pekka T., 1019<br />
Mant, T. G. K., 1503<br />
ANTIMICROB. AGENTS CHEMOTHER.<br />
Marble, Dwight A., 503<br />
Marciano-Cabral, F., 962<br />
Marini, Patricia M., 1416<br />
Marshall, Bonnie, 1801<br />
Martel, Jean-Louis, 1282<br />
Martin, Juan F., 1061<br />
Martin, Mary E., 730<br />
Martino-Saltzman, David, 1784<br />
Martra, A., 873<br />
Marx, Preston A., 1887<br />
Masecar, Barbara L., 122<br />
Masuda, Midori, 1864<br />
Masur, Henry, 324, 430<br />
Mateos-Mora, Miguel, 170<br />
Matsui, Hidefumi, 33<br />
Matsumoto, Y., 1243, 1655<br />
Matsuoka, Takafumi, 1864<br />
Matthews, R. S., 617<br />
Matthews, Thomas R., 1154, 1887<br />
Matthys, E., 1595<br />
Mattie, Herman, 1456<br />
Matzke, G. R., 485, 1845<br />
McCabe, Robert, 1031<br />
McChesney, Daniel G., 775<br />
McClain, J. Bruce, 285<br />
McCormack, William M., 773<br />
McDonald, Edith'J., 1710<br />
McGinnis, E., 1788<br />
McGroarty, Estelle J., 308, 649<br />
McIntyre, 0. Ross, 1627<br />
McKee, Kelly T., Jr., 1304<br />
McMurry, Laura M., 1187<br />
McRoberts, Mary Jane, 1887<br />
Medina, Ileana, 1057<br />
Medoff, Gerald, 327, 702<br />
Mellencamp, Martha A., 1327<br />
Mendelman, Paul M., 706<br />
Mendelson, Jack, 1231<br />
Mendez, F. J., 420<br />
Mendez-Castrill6n, Paloma P., 1257<br />
Meunier, F., 1557<br />
Mevio, E., 1461<br />
Meyers, Joel D., 271<br />
Michel, M. F., 426<br />
Michelsen, Phyllis, 1565<br />
Mikami, Hidetada, 587<br />
Miller, Michael H., 1113<br />
Miller, S. D., 1458<br />
Mills, John, 1057<br />
Mine, Yasuhiro, 1243<br />
Mintzer, C. L., 391<br />
Mischak, Ronald P., 710<br />
Mitelman, Felix, 936<br />
Mitsuhashi, Susumu, 104, 587, 827, 922,<br />
1097, 1421, 1848<br />
Mitsuyama, Junichi, 1097, 1848<br />
Miyaji, Makoto, 726<br />
Miyauchi, Masayuki, i437<br />
Mizen, Linda, 1705<br />
Mobashery, Shahriar, 1196<br />
Mochida, Ei, 1648<br />
Mochizuki, Hidenori, 1648<br />
Moellering, R. C., Jr., 434, 1341, 1528<br />
Moncla, Bernard J., 1271<br />
Monteil; H., 1360<br />
Montgomerie, John Z., 81<br />
Monto, Arnold S., 47<br />
Moore, pavid, 1078<br />
Moore, Jennifer L., 684<br />
Moosdeen, F., 925<br />
Mor<strong>and</strong>, Annick, 1660<br />
Moriyama, Megumi, 693<br />
Moros, Mariano, 636
VOL. 32, 1988<br />
Morrison, P. J., 1503<br />
Morse, Stephen A., 765<br />
Mosadomi, H. A., 598<br />
Moseley, Steve L., 477<br />
Moskovitz, Bruce L., 1300<br />
Moulin, Bruno, 938, 942<br />
Mounier, J., 195<br />
Mullany, Peter, 1213<br />
Mummaw, Nancy, 1323<br />
Murakami, Kimihiro, 1648<br />
Murata, Kenjiro, 1864<br />
Murphy, James R., 462<br />
Murphy, Robert F., 324<br />
Murray, Barbara E., 547, 768<br />
Murray, Dennis L., 882<br />
Muto, Yoshinori, 1437<br />
Myles, Camille, 1331<br />
Nadler, Marcus, 1763<br />
Nagata, Osamu, 156, 190<br />
Nagayama, Ariaki, 1735<br />
Nakae, Taiji, 378, 966<br />
Nakajima, Mutsuo, 110<br />
Nakamura, Kiyoto, 906<br />
Nakao, Tomokazu, 1735<br />
Nakata, Katsuhisa, 1080<br />
Narukawa, Noriaki, 458<br />
Nassos, Patricia, 1392<br />
Nelson, Eric, 1379<br />
Nelson, John D., 268, 1738<br />
Neu, Harold C., 84, 580, 656, 663, 671,<br />
1666<br />
Neuwirth, Zeev, 1763<br />
Nichols, James S., 1119<br />
Nichols, Wright W., 518<br />
Nickell, Steven P., 462<br />
Nicolau, Claude, 391<br />
Nicoletti, Mauro, 1262<br />
Nightingale, Charles H., 128<br />
Nilsson, Lennart E., 1208<br />
Nishimura, Hitoshi, 566<br />
Nishino, Takeshi, 1073, 1192<br />
Nishiyama, Yukihiro, 1053<br />
Nix, David E., 450<br />
Nord, Carl Erik, 1869<br />
Norman, G. T. 1503<br />
Norrby, Ragnar, 936<br />
Norrby, S. Ragnar, 1278<br />
Norris, Steven J., 68<br />
Norton, James A., 63<br />
Noumi, Toshihiko, 827<br />
Novelli, Andrea, 580, 656, 663, 1666<br />
Oberg, Bo, 1733<br />
O'Callaghan, Richard J., 978<br />
Ochi, James W., 865<br />
O'Connell, Kevin, 492<br />
Ogborne, Kevin T., 186<br />
O'Hara, Denise, 1494<br />
O'Hare, J., 144<br />
Ohmae, Kenichi, 1891<br />
O'Horo, Jennifer, 1780<br />
Oikawa, Yoshihiro, 1648<br />
Okamoto, Ryoichi, 1421<br />
O'Keefe, J. Paul, 717<br />
Okezaki, Eiichi, 156, 190<br />
Okuda, Takao, 33<br />
Olson, L., 589<br />
Omnes, Anne, 1204<br />
Omura, Satoshi, 282<br />
O'Neill, Melanie J., 1725<br />
Opheim, Kent, 274, 1640<br />
Ortisi, G., 1461<br />
Osada, Yasuaki, 1336<br />
Oster, Sharon, 1031<br />
O'Sullivan, John F., 1583<br />
Otero, Joaquin R., 1598<br />
Ouellette, Marc, 397<br />
Pacheco, F., 589<br />
Pagano, Joseph S., 265<br />
Pakiz, Cathy B., 689<br />
Panneton, Anne-Claire, 354, 1515<br />
Panton, L. J., 1655<br />
Papadopoulou, Barbara, 945, 1793<br />
Pares, Juan, 636<br />
Parham, Christine, 1788<br />
Park, Britt H., 1797<br />
Parker, Steven W., 777<br />
Parrillo, Joseph E., 324, 430<br />
Parry, Michael F., 982<br />
Patchett, Arthur A., 319<br />
Patel, I. H., 592<br />
Patterson, Jan Evans, 122<br />
Patterson, Jean L., 492<br />
Patton, Curtis L., 1182<br />
Paul, Gerard C., 397<br />
Pauwels, Rudi, 1025, 1742<br />
Pearce, Maria, 1443<br />
Pechere, Jean-Claude F., 524<br />
Pelletier, Lawrence L., Jr., 374<br />
Peltier, G. L., 485<br />
Perol, Y., 1350<br />
Perumal, Veluchamy K., 886, 1400, 1404<br />
Pesce, Adelaide, 279<br />
Petit, Agnes, 626, 1660<br />
Pettigrew, Martine, 992<br />
Philippon, Alain M., 397<br />
Phillipson, J. David, 1725<br />
Pierson, Carl, 717<br />
Pifat, Dominique Y., 331<br />
Piras, Marta M., 1237<br />
Piras, Romano, 1237<br />
Plaisance, Karen I., 1537<br />
Podapati, N. Rao, 1400<br />
Polacheck, Itzhack, 1586<br />
Pompei, Raffaello, 552<br />
Poplack, David G., 324<br />
Popovski, Zagorka, 510<br />
Portnoy, J., 589<br />
Prainito, Marie, 1375<br />
Pratt, Kathleen J., 1331<br />
Preheim, Laurel C., 1327<br />
Preston, David A., 180<br />
Prince, Alice, 838<br />
Prince, Gregory A., 1269<br />
Prisbe, Ernest J., 1887<br />
Pritzker, Marc R., 1899<br />
Privitera, G., 1461<br />
Proctor, R. A., 37<br />
Pruess, David L., 1005<br />
Puchetti, V., 1875<br />
Pussard, Eric, 568<br />
Queener, Sherry F., 807<br />
Quentin, Rol<strong>and</strong>, 147<br />
Quinn, John P., 1267<br />
Quintiliani, Richard, 128<br />
Quiros, L. M., 420<br />
Rachlis, Anita, 1231<br />
Radstrom, Peter, 1684<br />
Ramer, Nancy R., 27<br />
Rao, Podapati N. R., 886<br />
AUTHOR INDEX v<br />
Raoult, D., 255<br />
Rash, Jay J., 1347<br />
Rashad, Abdel L., 844<br />
Rauramaa, Veikko, 1019<br />
Redding, Judith S., 180, 1477<br />
Rehavi, M., 1624<br />
Reiszner, E., 1528<br />
Reitberg, Donald P., 42, 51, 503, 730<br />
Remington, Jack S., 755<br />
Rescott, Denise L., 450<br />
Reuman, Peter D., 761<br />
Reynolds, Janet, 63<br />
Reynolds, Peter, 1494<br />
Rice, Robert, 285<br />
Rice-Ficht, Allison, 391<br />
Rich, Chantal D., 1282<br />
Richardson, James D., 807<br />
Richet, H., 1094<br />
Richman, Douglas D., 865<br />
Richwald, Gary A., 213<br />
Rico, Manuel, 1552<br />
Riff, Louise J., 848<br />
Rikihisa, Yasuko, 986<br />
Rinaldi, Michael G., 1310<br />
Ringertz, Signe, 1484<br />
Riscoe, Michael K., 1904<br />
Rittenhouse, Brian R., 834<br />
Rivera, Mildred, 649<br />
Roberts, Elizbeth, 462<br />
Roberts, Marilyn C., 488, 765, 1271, 1430<br />
Robillard, Norman J., 535<br />
Robinson, J., 1503<br />
Roblot-Treupel, Liliane, 1204<br />
Roccaforte, Jane S., 1327<br />
Rocque, Warren J., 308<br />
Rodondi, Lisa C., 1511, 1825<br />
Rodvold, Keith A., 631, 848<br />
Roerdink, F. H., 1560<br />
Roessner, Charles A., 391<br />
Rogers, Paul, 324<br />
Rolston, Kenneth, 1078<br />
Ronald Allan R., 1292<br />
Roon, Richard A., 274<br />
Root, Carol J., 773<br />
Root, Jennifer L., 1627<br />
Rootman, David S., 978<br />
Rosenberg, Carl, 1158<br />
Rosenberg, Ivan, 1025, 1839<br />
Rosina, Rita, 1223<br />
Rossan, R. N., 1655<br />
Rotimi, V. O., 598<br />
Rotschafer, John C., 848<br />
Rott-Petri, Jean A., 137<br />
Rouse, Mark, 747<br />
Roussellier, P., 255<br />
Rowse, Deborah, 1801<br />
Roy, Paul H., 397<br />
Roy, Rejean, 1433<br />
Rubinstein, E., 1624<br />
Russo, T., 717, 1439<br />
Rutala, William A., 642<br />
Rybak, Michael J., 510<br />
Saag, Michael S., I<br />
Saez-Nieto, Juan A., 706<br />
Saha, Gita, 580<br />
Saikawa, Isamu, 827, 912, 1097, 1848<br />
Saino, Yushi, 587<br />
Saito, Akira, 156<br />
Saito, Atsushi, 1427<br />
Saito, Hajime, 400<br />
Sakaguchi, Takashi, 1040, 1396
Vi AUTHOR INDEX<br />
Sakuma, Takashi, 1046, 1547, 1839<br />
Salas, J. A., 420<br />
Salfinger, Max, 1002<br />
Salmeron, C. M., 1350<br />
Samonis, George, 1365<br />
S<strong>and</strong>ers, Christine C., 689, 1314, 1365,<br />
1740, 1893<br />
S<strong>and</strong>ers, Cynthia, 1392<br />
S<strong>and</strong>ers, W. Eugene, Jr., 1740, 1893<br />
Sapico, Francisco L., 81<br />
Sartorelli, Alan C., 1182<br />
Sassella, D., 1461, 1541<br />
Sato, Hitoshi, 190<br />
Sato, Kenichi, 104, 922, 1336<br />
Satta, Giuseppe, 552<br />
Saunders, Jean, 24<br />
Sauzieres, Jacques, 1204<br />
Saviteer, Susan M., 642<br />
Savolainen, Seppo, 1019<br />
Sawyer, Janet G., 649<br />
Scannon, Patrick, 710<br />
Scarpa, Alphonse L., 535<br />
Schalla, W. O., 426<br />
Scheifele, David W., 1034<br />
Schell, Ronald F., 137<br />
Schentag, Jerome J., 450, 503<br />
Schiff, Gilbert M., 761<br />
Schifferli, Dieter M., 1603, 1609<br />
Schinazi, Raymond F., 997, 1784<br />
Schindler, M., 930<br />
Schito, Gian Carlo, 279<br />
Schlesinger, Paul H., 793, 799, 953, 957<br />
Schlosser, V., 930<br />
Schluederberg, Susan, 1801<br />
Schmidt-Eisenlohr, E., 930<br />
Schmitt, B., 780<br />
Schmitt, H. J., 780, 1676<br />
Schols, Dominique, 1025<br />
Schuening, Friedrich, 271<br />
Schultz, Robert W., 503<br />
Schurgers, M., 1595<br />
Schwartz, Jules, 75, 730<br />
Schwartz, Stanley A., 47<br />
Schwartzman, Michael S., 236<br />
Scieux, C., 1350<br />
Scott, Virginia R., 1154<br />
Sears, S. D., 144<br />
Segal, Neil B., 1231<br />
Segev, S., 1624<br />
Selitrennikoff, Claude P., 1901<br />
Serfass, Debra A., 706<br />
Shalaby, Lamaat M., 1699<br />
Sh<strong>and</strong>s, Joseph W., 773<br />
Sharp, Patricia A., 865<br />
Shaw, J. T. B., 646<br />
Shearer, Glenmore, Jr., 341<br />
Sheehan, Gerard J., 1292<br />
Shelton, Sharon, 268, 1738<br />
Shepherd, Julia A., 1693<br />
Sherwood, James R., 761<br />
Shigeta, Shiro, 906<br />
Shimada, Nobuyoshi, 1053<br />
Shimizu, Kihachiro, 912<br />
Shinners, Elizabeth N., 971<br />
Shiraishi, Akio, 110<br />
Shiramatsu, Koji, 1588<br />
Shyu, Wen Chyi, 128<br />
Siber, George R., 1034<br />
Sidwell, Robert W., 331<br />
Sieradzan, Raymond R., 1446<br />
Sierra-Madero, Juan, 1754, 1896<br />
Silva, Eric J., 865<br />
Silverman, Norman A., 631<br />
Simbul, Moises, 834<br />
Simmons, Richard L., 1769<br />
Simon, Francois, 568<br />
Sirot, Danielle L., 626, 1660<br />
Sirot, Jacques L., 626, 1660<br />
Six, Howard R., 890<br />
Slack, Mary P. E., 518<br />
Slee, A. M., 1218<br />
Sligh, James E., Jr., 702<br />
Smego, Douglas A., 982<br />
Smeltzer, Brian D., 236<br />
Smith, Arnold L., 477, 706, 1034<br />
Smith, Arnold N., 274<br />
Smith, Gary G., 595<br />
Smith, J. Kelly, 78<br />
Smith, James W., 63, 807<br />
Smith, John M., 1776<br />
Smith, M. Carolyn, 265<br />
Smith, Raymond P., 1450, 1565<br />
Smithwick, Ronald W., 125<br />
Snoeck, Robert, 1742, 1839<br />
Soike, Kenneth F., 1807<br />
Sokol-Anderson, Marcia, 702<br />
Somani, P., 530<br />
Someya, Tetsufumi, 1588<br />
Sommadossi, Jean-Pierre, 997<br />
Sommer, Peter, 936<br />
Sookpranee, Mondej, 1740<br />
Souza, Kathleen S., 1187<br />
Sperber, Steven J., 409<br />
Spillner, G., 930<br />
Spitler, Lynn E., 710<br />
Spitzer, Peter G., 434<br />
Srinivasan, A., 684<br />
Stamm, John M., 27<br />
Stamm, Lola V., 164<br />
Stamm, Walter E., 1640<br />
St<strong>and</strong>iford, Harold C., 1537<br />
Stankewich, Joseph P., 1347<br />
Stapleton, Jack T., 164<br />
Stark, Tracey, 1901<br />
Steele, Lorraine C., 1776<br />
Stein, Gary E., 802<br />
Steinberg, Marvin A., 1320<br />
Stenberg, Kjell, 1533<br />
Stevens, David A., 369<br />
Stieglitz, Michaela, 1090<br />
Stoeckel, Klaus, 573<br />
Stolz, E., 426<br />
Stone, J. W., 1508<br />
Storb, Rainer, 271<br />
Storrs, Michele J., 1174<br />
Strassle, Anni, 1494<br />
Strombeck, Bodil, 936<br />
Struck, Douglas K., 391<br />
Studemeister, Alex E., 1267<br />
Suarez, Juan E., 1552<br />
Subashi, Timothy A., 159<br />
Suenaga, Itaru, 458<br />
Sugarman, Barrett, 1323<br />
Sugimoto, Kyoko, 595<br />
Suh, Byungse, 1571<br />
Sumter, Gwendolyn, 1776<br />
Sun, Daxi, 1274, 1370<br />
Sundstrom, David C., 1763<br />
Suttmann, Rebecca T., 1887<br />
Sutton, David, 358<br />
Suzutani, Tatsuo, 1046, 1547<br />
Swan, Judith C., 430<br />
Swanson, Robert N., 27<br />
Swarz, Herbert, 42<br />
Swedberg, Gote, 1684<br />
Sypherd, Paul S., 341<br />
ANTIMICROB. AGENTS CHEMOTHER.<br />
Syriopoulou, Vassiliki P., 1034<br />
Szoka, Francis C., Jr., 858<br />
Tabaqchali, Soad, 1213<br />
Tachibana, Hiroshi, 966<br />
Taen, Haruko, 1735<br />
Taenaka, Nobuyuki, 1103<br />
Taft, Cathy S., 1901<br />
Takahara, Yoshio, 156<br />
Takahash, Katsutoshi, 1053<br />
Takahata, Masahiro, 1192<br />
Takano, Mitsuo, 1680<br />
Takeuchi, Toshihiko, 726<br />
Takezawa, Jun, 1103<br />
Talarico, Todd L., 1854<br />
Talbot, M. Kelly, 1005<br />
Tally, Francis P., 584, 717<br />
Tamai, Ikumi, 190<br />
Tamalet, J., 255<br />
Tamura, Atsushi, 1421<br />
Tamura, Toyoyuki, 566<br />
Tamura, Yuka, 932<br />
Tanaka, Haruo, 282<br />
Tancrede, Cyrille, 1204<br />
Tartaglione, Teresa A., 1640<br />
Taub, David, 319<br />
Tay, L. K., 314<br />
Taylor, David N., 723<br />
Taylor, Diane E., 1107<br />
Tenover, Fred C., 1170<br />
Terragna, Alberto, 1223<br />
Tesch, Wolfgang, 1494<br />
Thal, Wendy R., 337<br />
Thauvin, Claudie, 919<br />
Thomann, Charlotte A., 642<br />
Thompson, Nathan H., 1763<br />
Thomson, Margaret J., 1292<br />
Thomberry, Nancy A., 319<br />
Thornsberry, Clyde, 180, 752<br />
Tokunaga, Tohru, 110<br />
Tolmasky, Marcelo E., 1416<br />
Toltzis, Philip, 492<br />
Tomich, Paul K., 1465, 1472<br />
Tominack, Rebecca L., 1813<br />
Tomioka, Haruaki, 400<br />
Torikata, Akio, 110<br />
Townsend, Raymond J., 1825<br />
Trahan, Creighton J., 1304<br />
Tran Ba Huy, Patrice, 467<br />
Tran Van Nhieu, G., 9, 1289<br />
Treger, Thomas, 63<br />
Trouvin, J. H., 1590<br />
Tsuchido, Tetsuaki, 1680<br />
Tsuji, Akira, 190<br />
Tsukada, Katsuhiko, 726<br />
Tubert, Tracey, 180, 259<br />
Tucker, Richard M., 369<br />
Tuna, Ishik C., 209<br />
Turley, C. Patrick, 1481<br />
Turner, Ronald B., 1820<br />
Ueno, Kazue, 1437<br />
Une, Tsutomu, 1336<br />
Urbina, Julio A., 1237<br />
Urias, Barbara, 1292<br />
Usuki, Toshihiro, 1588<br />
Vaal, Mark, 1119<br />
Valiant, Mary E., 319<br />
Vall6e, Francois, 354<br />
V<strong>and</strong>enbroucke, Arthur C., 834<br />
Van der Auwera, P., 1557
VOL. 32, 1988<br />
van der Linden, M. P., 1632<br />
van der Waals, Ron, 1456<br />
van der Willigen, A. H., 426<br />
van Furth, Ralph, 1456<br />
van Klingeren, B., 426<br />
Van Peer, A., 1595<br />
Vavra, James J., 216<br />
Verdier, Francoise, 568<br />
Verdon, Michael S., 773<br />
Verghese, Abraham, 78<br />
Verhoef, Jan, 473<br />
Vermerie, N., 1590<br />
Vezina, Guy, 819<br />
Villa, Pia, 1541<br />
Villar, Claudio J., 1552<br />
Vliegenthart, John S., 740<br />
Vojtko, Charlene, 1710<br />
von Graevenitz, A., 1593<br />
Vrang, Lotta, 1733<br />
Wadstein, Jan, 936<br />
Wadsworth, S<strong>and</strong>ra J., 1571<br />
Wagenvoort, J. H. T., 426<br />
Wagner, Jutta, 92<br />
Wahren, B., 1137, 1720<br />
Waigh, Roger D., 1693<br />
Waites, Ken B., 1500<br />
Walker, Linda A., 1879<br />
Wallace, Richard J., Jr., 1776<br />
Walmsley, Harold L., 518<br />
Walton, Leslie, 1086<br />
Walzer, Peter D., 96, 8%<br />
Warhurst, David C., 1725<br />
Washington, John A., 131, 170, 1331, 1754,<br />
1896<br />
Watanabe, Kunitomo, 1437<br />
Watanabe, Nao-Aki, 693<br />
Watanabe, Yasuo, 912<br />
Waxman, Kenneth, 882<br />
Weber, David A., 1164<br />
Weber, David J., 642<br />
Weir, Matthew, 1537<br />
Weissberger, Barbara, 319<br />
Wells, Carol L., 1769<br />
Wennersten, C., 1528<br />
Wentworth, Berttina B., 216<br />
Wexler, Hannah M., 403, 601, 611<br />
Whall, Thomas J., 42, 51, 503<br />
Wheat, Lawrence J., 63<br />
White, Anthony J., 1879<br />
Whitney, Charles C., Jr., 1699<br />
Wiedemann, B., 1285<br />
Will, J. A., 37<br />
Willey, S<strong>and</strong>ra, 1341<br />
Williams, Deborah E., 1158<br />
Williams, J. D., 925<br />
Williams, P. D., 314, 758<br />
Williams, Paul L., 369<br />
Williamson, R., 9, 195<br />
Wills, Robert J., 1813<br />
Wilson, Mark E., 1521<br />
Wilson, Samuel Z., 890<br />
Wilson, Walter, 747<br />
Winton, Mark D., 928<br />
Wise, R., 617, 1251, 1508<br />
Wiseman, Jeffrey S., 1119<br />
Woestenborghs, R., 1310, 1595<br />
Wofsy, Constance, 1057<br />
Wolfson, John S., 1187<br />
Wong, Justina, 782<br />
Wong-Kai-In, Philippe, 814<br />
Wood, Mark S., 838<br />
Woodley, Charles L., 125<br />
Woodnutt, Gary, 1705<br />
Woods, Gail L., 1614<br />
Woolf, Nigel K., 865<br />
Woolfrey, Bert F., 513<br />
Wren, Brendan W., 1213<br />
Wright, Colin W., 1725<br />
Wu, John C., 1887<br />
Wyde, Philip R., 117, 890<br />
Wyss, Ronald, 573<br />
Xicota, M. Angels, 636<br />
Yagi, Betty Hannon, 216<br />
Yajko, David M., 1392<br />
Yam, Paul, 1614<br />
Yamabe, S., 925<br />
AUTHOR INDEX vii<br />
Yamada, Hidehiko, 1648<br />
Yamada, Takehisa, 156<br />
Yamada, Takeshi, 1588<br />
Yamaguchi, Keizo, 1427<br />
Yamamoto, Haruo, 1421<br />
Yamamoto, Naohiko, 1053<br />
Yamamoto, Tatsuo, 932<br />
Yamamoto, Toshiyuki, 726<br />
Yamazaki, Munehiro, 1864<br />
Yamazaki, Toshiyuki, 458<br />
Yang, Youjun, 1385<br />
Yankell, Samuel L., 350<br />
Yasuda, Takashi, 912, 1097, 1848<br />
Yasui, Kozo, 1864<br />
Yih, Jennifer, 141, 231<br />
Ylikoski, Jukka, 1019<br />
Yokota, Takeshi, 932<br />
Yokota, Tomoyuki, 906<br />
Yokota, Yoshiko, 1243<br />
Yoshida, Takashi, 1421<br />
Yoshihara, Eisaku, 966<br />
Yoshiya, Ikuto, 1103<br />
Yotsuji, Akira, 1097, 1848<br />
Young, Elizabeth C., 761<br />
Young, Lowell S., 1149<br />
Yourassowsky, E., 276, 1632<br />
Youssef, Mohammad, 1204<br />
Zajac, I., 1218<br />
Zak, Oto, 364<br />
Zehavi, Uri, 1586<br />
Zeiler, H.-J., 57<br />
Zenilman, Jonathan M., 765<br />
Zervos, Marcus J., 122<br />
Zhang, Lei, 962<br />
Zhang, Zhen-Xi, 265<br />
Zhou, Zhu, 997<br />
Zighelboim-Daum, S., 1528<br />
Zilhao, Rita, 1793<br />
Zimmerman, Stephen W., 51<br />
Zokufa, Humphrey Z., 848<br />
Zollinger-Iten, J., 1593<br />
Zscheck, Karen K., 768<br />
Zurenko, Gary E., 216
A723U<br />
herpes simplex virus type 1, 1100<br />
A40926<br />
pharmacokinetics, 246<br />
A-56268<br />
H. ducreyi, 1458<br />
T. gondii, 524<br />
A-56620<br />
M. tuberculosis, 1441<br />
Nocardia spp., 1078<br />
P. maltophilia, 782<br />
A-61827<br />
B. fragilis, 27<br />
C. jejuni, 27<br />
E. coli, 27<br />
Enterobacteriaceae, 27<br />
H. influenzae, 27<br />
L. pneumophila, 27<br />
N. gonorrhoeae, 27<br />
P. aeruginosa, 27<br />
S. aureus, 27<br />
S. pyogenes, 27<br />
S. typhimurium, 27<br />
Staphylococcus spp., 27<br />
Streptococcus spp., 27<br />
A-62254<br />
Nocardia spp., 1078<br />
A-62671<br />
comparative activity, 1710<br />
A-63075<br />
comparative activity<br />
erythromycin, 1500<br />
M. hominis, 1500<br />
M. pneumoniae, 1500<br />
U. urealyticum, 1500<br />
Acetyltransferase<br />
chloramphenicol<br />
C. difficile, 1213<br />
3-V-acetyltransferase<br />
gene probe, 1834<br />
6'-N-Acetyltransferase type 4<br />
Enterobacteriaceae, 1289<br />
S. marcescens, 1289<br />
Acinetobacter spp.<br />
3'-aminoglycoside phosphotransferase,<br />
15<br />
E1040, 693<br />
PD 117,596, 1450<br />
R plasmid, 15<br />
tigemonam, 84<br />
U-76,253A, 443<br />
Acquired immunodeficiency syndrome<br />
HPA-23, 1300<br />
M. avium complex, 1392<br />
P. carinii, 1057<br />
Acriflavin<br />
S. aureus resistance, 932<br />
Acrinol<br />
S. aureus resistance, 932<br />
Acrolein<br />
amoebic meningoencephalitis, 962<br />
N. fowleri, 962<br />
Actinobacillus actinomycetemcomitans<br />
clindamycin, 1521<br />
neutrophil killing, 1521<br />
Actinobacillus lignieresii<br />
actinomycin D, 1354<br />
daptomycin, 1354<br />
novobiocin, 1354<br />
phospholipid composition, 1354<br />
polymyxin, 1354<br />
SUBJECT INDEX<br />
VOLUME 32<br />
rifamycin, 1354<br />
Actinomyces spp.<br />
daptomycin, 788<br />
paldimycin, 788<br />
Actinomycin D<br />
A. lignieresii, 1354<br />
P. multocida, 1354<br />
Acyclovir<br />
combinations<br />
3'-azido-3'-deoxythymidine, 265<br />
AZT, 265<br />
Epstein-Barr virus, 265<br />
comparative activity<br />
I-3-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil<br />
<strong>and</strong><br />
E-5(2-bromovinyl)-2'-deoxyuridine,<br />
1068<br />
Epstein-Barr virus, 1068<br />
guinea pig embryonic fibroblasts, 1533<br />
herpes simplex virus type 1, 1100, 1533<br />
monophosphate<br />
guinea pig embryonic fibroblasts, 1533<br />
herpes simplex virus type 1, 1533<br />
triphosphate<br />
DNA polymerases, 1137<br />
varicella-zoster virus, 1137<br />
(RS)-3-Adenin-9-yl-2-hydroxypropanoic<br />
acid<br />
influenza viruses, 906<br />
Adenovirus<br />
sulfated polysaccharides, 1742<br />
type 5<br />
P-536, 1257<br />
Adhesion, bacterial<br />
antibiotic modulation, 1603, 1609<br />
folate pathway, 1609<br />
membrane structures, 1609<br />
nucleic acid synthesis, 1609<br />
peptidoglycan synthesis, 1609<br />
protein synthesis, 1603<br />
minireviews, 1603, 1609<br />
Aerobic bacteria<br />
pristinamycin, 1094<br />
Aerobic-anaerobic infections<br />
minireview, 611<br />
Aeromonas hydrophila<br />
CS-807, 1082<br />
tigemonam, 84<br />
U-76,252, 1082<br />
Aeromonas spp.<br />
,B-lactam resistance, 1314<br />
13-lactamases, 1314<br />
Agar dilution plate count method<br />
effect of temperature on inoculum, 513<br />
errors, 513<br />
(RS)-AHPA<br />
influenza viruses, 906<br />
Alanine racemase<br />
halovinylglycine compounds, 319<br />
L-norvalyl peptide derivatives, 319<br />
Alcaligenes denitrificans subsp. xylosoxidans<br />
amdinocillin, 276<br />
amikacin, 276<br />
amoxicillin-clavulanic acid, 276<br />
ampicillin, 276<br />
cefam<strong>and</strong>ole, 276<br />
cefazolin, 276<br />
ceforanide, 276<br />
cefotaxime, 276<br />
cefotetan, 276<br />
viii<br />
ceftazidime, 276<br />
ceftriaxone, 276<br />
cefuroxime, 276<br />
ciprofloxacin, 276<br />
gentamicin, 276<br />
imipenem, 276<br />
netilmicin, 276<br />
norfloxacin, 276<br />
ofloxacin, 276<br />
pefloxacin, 276<br />
piperacillin, 276<br />
temocillin, 276<br />
ticarcillin-clavulanic acid, 276<br />
tobramycin, 276<br />
trimethoprim-sulfamethoxazole, 276<br />
Alcaligenes faecalis<br />
diffusion pore, 378<br />
Alginate<br />
P. aeruginosa<br />
tobramycin binding, 518<br />
Allicin<br />
mechanism of action, 1763<br />
S. typhimurium, 1763<br />
Alpha-2b interferon<br />
influenza A virus, 47<br />
influenza B virus, 47<br />
rhinovirus, 47<br />
AM-833<br />
C. trachomatis, 1080, 1735<br />
comparative activity<br />
doxycycline <strong>and</strong> minocycline, 1735<br />
Amdinocillin<br />
A. denitrificans subsp. xylosoxidans, 276<br />
combinations<br />
ceftazidime, 1632<br />
E. cloacae, 1632<br />
E. cloacae, 1632<br />
Amdinocillin pivoxil<br />
pharmacokinetics<br />
influence of food, 592<br />
Amicarbalide<br />
P. carinii, 896<br />
Amifloxacin<br />
comparative activity<br />
ciprofloxacin, enoxacin, norfloxacin,<br />
<strong>and</strong> ofloxacin, 928<br />
Nocardia spp., 1078<br />
P. falciparum, 1182<br />
P. pseudomallei, 928<br />
Amikacin<br />
A. denitrificans subsp. xylosoxidans, 276<br />
B. catarrhalis, 259<br />
combinations<br />
ceftazidime, 231<br />
ciprofloxacin, 782<br />
clindamycin, 1557<br />
clofazimine, 1400<br />
endocarditis, 231<br />
head <strong>and</strong> neck surgery in cancer patients,<br />
1557<br />
M. avium complex, 1149, 1400<br />
P. aeruginosa, 231<br />
P. maltophilia, 782<br />
resistance, development of, 231<br />
rifabutin, 1400<br />
tumor necrosis factor, 1149<br />
wound infections, 1557<br />
dysgonic fermenter 2, 78<br />
E. coli<br />
lipopolysaccharide, 1247<br />
Enterobacteriaceae, 873
VOL. 32, 1988<br />
resistance, 1289<br />
K. pneumoniae resistance, 1379, 1416<br />
liposome encapsulated<br />
M. avium-M. intracellulare, 1404<br />
M. avium, 1131<br />
M. avium complex, 886, 1149, 1400<br />
M. avium-M. intracellulare, 1404<br />
N. asteroides, 1776<br />
P. maltophilia, 782<br />
pharmacokinetics, 236<br />
S. aureus resistance, 932<br />
S. marcescens resistance, 1289, 1379<br />
Shigella spp., 20<br />
Amikacin-ceftazidime<br />
comparative activity<br />
pefloxacin, 23i<br />
endocarditis, 231<br />
P. aeruginosa, 231<br />
resistance, development of, 231<br />
Amiloride<br />
combinations<br />
Pseudomonas spp., 395<br />
tobramycin, 395<br />
Pseudomonas spp., 395<br />
y-Aminobutyric acid binding<br />
BMY-262252 758<br />
cefazolin, 758<br />
imipenem-cilastatin, 758<br />
inhibition of<br />
quiholones, 190<br />
rat model, 758,<br />
Aminoglycoside 3-V-acetyltransferase<br />
gene probe, 1834<br />
3'-Aminoglycoside phosphotransferase<br />
Acinetobacter spp., 15<br />
Aminoglycoside-modifying enzymes<br />
reaction rates, 740<br />
Aminoglycosides<br />
cochlear binding sites, 467<br />
P. aeruginosa resistance, 689<br />
S. faecalis resistance, 1528<br />
T. vaginalis, 144<br />
Amodiaquine<br />
polymorphonuclear neutrophils, 1124<br />
Ainoebic meningoencephalitis<br />
acrolein, 962<br />
cyclophosphamide, 962<br />
Amopyroquin<br />
comparative activity<br />
chloroquine <strong>and</strong> monodesethylamodiaquine,<br />
568<br />
P. falciparum, 568<br />
pharmacokinetics, 568<br />
Amooxicillin<br />
Bordetella spp., 137<br />
H. ducreyi, 1458<br />
P. pseudomallei, 1435<br />
Amoxicillin-clavulanic acid<br />
A. denitrificans subsp. xylosoxidans, 276<br />
B. catarrhalis, 259<br />
B. fragilis-E. coli, 1830<br />
bite wound bacteria, 1143<br />
comparative activity<br />
ampicillin-sulbactam, 1830<br />
Enterobacteriaceae, 873<br />
H. ducreyi, 1458<br />
P. multocida, 213<br />
P. pseudomallei, 1435<br />
Amphotericin B<br />
Aspergillus spp'., 1676<br />
C. albicans<br />
2-chloroethyl-1-nitrosoureas, 327<br />
resistance, 702<br />
comparative activity<br />
miconazole, 1864<br />
high-performance liquid chromatography,<br />
1103<br />
polymorphonuclear leukocytes, 1864<br />
pulmonary aspergillosis, 1676<br />
S. schenckii, 1619<br />
sporotrichosis, 1619<br />
T. vaginalis, 1323<br />
Ampicillin<br />
A. denitrificans subsp. xylosoxidans, 276<br />
B. bronchiseptica, 1891<br />
B. catarrhalis, 259<br />
bite wound bacteria, 1143<br />
Chlamydia sp. strain TWAR, 257<br />
combinations<br />
B. fragilis-E. coli, 1830<br />
biliary tract infections, 1231<br />
sulbactam, 1830<br />
tobramycin, 1231<br />
dental granuloma, 566<br />
E. coli, 450, 552<br />
Enterobacteriaceae, 873<br />
fecal flora resistance, 1801<br />
H. influenzae, 180<br />
in vitro simulation of serious infections,<br />
552<br />
L. monocytogenes, 1204, 1560<br />
liposome entrapped<br />
L. monocytogenes, 1560<br />
lipid composition, 1560<br />
M. morganii, 1385<br />
N. asteroides, 1776<br />
nanoparticle polyisohexylcyanoacrylate<br />
bound<br />
L. monocytogenes, 1204<br />
P. aeruginosa, 552<br />
P. carinii, 896<br />
P. multocida, 213<br />
P. vulgaris, 1385<br />
postantibiotic effect, 450<br />
S. paratyphi A, resistant, 195<br />
S. pneumoniae, 552<br />
Shigella spp., 20<br />
Ampicillin-gulbactam<br />
B. catarrhalis, 259<br />
B. fragilis-E. coli, 1830<br />
comparative activity<br />
amoxicillin-clavulanic acid, 1830<br />
Shigella spp., 20<br />
Ampicillin-tobramycin<br />
biliary tract infections, 1231<br />
comparative activity<br />
cefoperazone, 1231<br />
Anesthetics<br />
E. coli permeability, 153<br />
Anisomycin<br />
T. vaginalis, 144<br />
Anogeissus leiocurpus<br />
B. gingivalis, 598<br />
B. melaninogenicus, 598<br />
Antacids<br />
ciprofloxacin, 949<br />
letter to the editor, 949<br />
Antibiotic biosynthetic genes<br />
minireview, 1472<br />
Streptomyces spp., 1472<br />
Antibodies<br />
monoclonal<br />
C. trachomatis, 1295<br />
minireview, 1295<br />
P. aeruginosa, 649<br />
monoclonal anti-lipid A<br />
SUBJECT INDEX<br />
bacteremia, 710<br />
immunogenicity, 710<br />
pharmacokinetics, 710<br />
toxicity, 710<br />
Antifungal agents<br />
jasplakinolide, 1154<br />
minireview, I<br />
T. vaginalis, 144<br />
Antimalarial drugs<br />
polymorphonuclear neutrophils, 1124<br />
Apalcillin<br />
nephrotoxicity, 942<br />
pharmacokinetics, 942<br />
9-p-D-Arabinofuranosyladenine<br />
herpes simplex virus type 1, 1046<br />
1- ,-D-Arabinofuranosyl-E-5-(2-bromovinyl)<br />
uracil<br />
comparative activity<br />
acyclovir <strong>and</strong> E-5-(2-bromovinyl)-2'deoxyuridine,<br />
1068<br />
Epstein-Barr virus, 1068<br />
herpes simplex virus type 1, 1547<br />
herpes simplex virus type 2, 1547<br />
nucleosides, effect of, 1547<br />
1-4-D-Arabinofuranosyl-E-(2-bromovinyl)<br />
uracil<br />
herpes simplex virus type 1, 1046<br />
1-P-D-Arabinofuranosylthymine<br />
herpes simplex virus type 1, 1046<br />
Argentine hemorrhagic fever<br />
ribavirin, 1304<br />
Arthrobacter spp,<br />
carbomycin, 420<br />
celesticetin, 420<br />
clindamycin, 420<br />
erythromycin, 420<br />
josamycin, 420<br />
lincomycin, 420<br />
lincosamide resistance, 420<br />
ole<strong>and</strong>omycin, 420<br />
rosaramicin, 420<br />
spiramycin, 420<br />
tylosin, 420<br />
vernamycin B, 420<br />
Aspergillus spp.<br />
amphotericin B, 1676<br />
terbinafine, 780<br />
Astiban<br />
P. carinii, 896<br />
ATP<br />
M. tuberculosis bioluminescence assay,<br />
1208<br />
Avermectins<br />
glucose metabolism, 282<br />
3'-Azido-3'-deoxythymidine<br />
combinations<br />
acyclovir, 265<br />
Epstein-Barr virus, 265<br />
human immunodeficiency virus type 1,<br />
1784<br />
isoprinosine, 1784<br />
cytomegalovirus, 265<br />
Epstein-Barr virus, 265<br />
herpes simplex virus type 1, 265<br />
herpes simplex virus type 2, 265<br />
human immunodeficiency virus type 1,<br />
1784<br />
toxicity<br />
uridine, 997<br />
varicella-zoster virus, 265<br />
3'-Azido-3'-deoxythymidine triphosphate<br />
human immunodeficiency virus type 1,<br />
1733<br />
ix
x SUBJECT INDEX<br />
human immunodeficiency virus type 2,<br />
1733<br />
simian immunodeficiency virus, 1733<br />
Azithromycin<br />
B. catarrhalis, 752<br />
combinations<br />
M. avium complex, 1149<br />
tumor necrosis factor, 1149<br />
comparative activity, 1710<br />
clarithromycin, clindamycin, erythromycin,<br />
<strong>and</strong> roxithromycin, 752<br />
H. influenzae, 752<br />
L. monocytogenes, 752<br />
L. pneumophila, 752<br />
M. avium complex, 1149<br />
N. gonorrhoeae, 752<br />
N. meningitidis, 752<br />
T. gondii, 524, 755<br />
Azlocillin<br />
B. catarrhalis, 259<br />
Azoles<br />
minireview, 1<br />
AZT<br />
combinations<br />
acyclovir, 265<br />
Epstein-Barr virus, 265<br />
human immunodeficiency virus type 1,<br />
1784<br />
isoprinosine, 1784<br />
cytomegalovirus, 265<br />
Epstein-Barr virus, 265<br />
herpes simplex virus type 1, 265<br />
herpes simplex virus type 2, 265<br />
human immunodeficiency virus type 1,<br />
1784<br />
toxicity<br />
uridine, 997<br />
triphosphate<br />
human immunodeficiency virus type 1,<br />
1733<br />
human immunodeficiency virus type 2,<br />
1733<br />
simian immunodeficiency virus, 1733<br />
varicella-zoster virus, 265<br />
Aztreonam<br />
B. catarrhalis, 259<br />
combinations<br />
ciprofloxacin, 782<br />
P. maltophilia, 782<br />
dysgonic fermenter 2, 78<br />
E. coli, 552<br />
hyperbilirubinemia<br />
centrifugal ultrafiltration, 1571<br />
in vitro simulation of serious infections,.<br />
552<br />
P. aeruginosa, 552<br />
P. maltophilia, 782<br />
S. pneumoniae, 552<br />
B-220<br />
cytomegalovirus, 1720<br />
herpes simplex virus type 1, 1720<br />
mechanism of action, 1720<br />
varicella-zoster virus, 1720<br />
Babesia microti<br />
inositol hexaphosphate, 391<br />
Bacillus spp.<br />
cefazolin, 642<br />
cefotaxime, 642<br />
cefoxitin, 642<br />
cefuroxime, 642<br />
chloramphenicol, 642<br />
ciprofloxacin, 642<br />
clindamycin, 642<br />
daptomycin, 642<br />
erythromycin, 642<br />
gentamicin, 642<br />
imipenem, 642<br />
mezlocillin, 642<br />
oxacillin, 642<br />
penicillin, 642<br />
tetracycline, 642<br />
ticarcillin-clavulanate, 642<br />
trimethoprim-sulfamethoxazole, 642<br />
vancomycin, 642<br />
Bacillus stearothermophilus<br />
etoposide, 1456<br />
Bacillus subtilis<br />
etoposide, 1456<br />
letter to the editor, 949<br />
streptomycin adenylyltransferase, 949<br />
Bacteremia<br />
monoclonal anti-lipid A antibody, 710<br />
Bacterial adhesion<br />
antibiotic modulation, 1603, 1609<br />
folate pathway, 1609<br />
membrane structures, 1609<br />
nucleic acid synthesis, 1609<br />
peptidoglycan synthesis, 1609<br />
protein synthesis, 1603<br />
minireviews, 1603, 1609<br />
Bactericidal testing<br />
oxacillin, 1614<br />
S. aureus, 1614<br />
Bacteroides fragilis<br />
A-61827, 27<br />
P-lactam resistance, 1437<br />
P-lactamase, 1848<br />
cefam<strong>and</strong>ole, 1097, 1848<br />
cefazolin, 1097, 1848<br />
cefoperazone, 1097, 1848<br />
cefoperazone-sulbactam, 403<br />
cefotetan, 601<br />
cefoxitin, 1511<br />
ceftezole, 1097, 1848<br />
ceftizoxime, 1511<br />
cephalosporins<br />
outer membrane permeation, 1097<br />
resistance, 1848<br />
cephalothin, 1097, 1848<br />
ciprofloxacin, 1437<br />
clindamycin, 1825<br />
DR-3355, 1336<br />
DuP 105, 580<br />
DuP 721, 580<br />
enoxacin, 1437<br />
fluoroquinolone resistance, 1437<br />
lomefloxacin, 617<br />
mixed infection with E. coli<br />
amoxicillin-clavulanic acid, 1830<br />
ampicillin-sulbactam, 1830<br />
norfloxacin, 1437, 1869<br />
NY-198, 1437<br />
ofloxacin, 1437<br />
PD 127,391, 1251<br />
penicillin-binding proteins, 1848<br />
susceptibility patterns<br />
analysis by site of isolation, 717<br />
T-3262, 663, 1437<br />
tetracycline<br />
resistance, 1271<br />
trospectomycin, 584<br />
Bacteroides gingivalis<br />
A. leiocarpus, 598<br />
B. paradoxum, 598<br />
ANTIMICROB. AGENTS CHEMOTHER.<br />
chewing sticks, 598<br />
D. benthamianus, 598<br />
F. zanthoxyloides, 598<br />
M. accuminata, 598<br />
N. latifolia, 598<br />
Nigerian chewing sticks, 598<br />
S. werneckei, 598<br />
T. glaucescens, 598<br />
V. amygdalina, 598<br />
Bacteroides melaninogenicus<br />
A. leiocarpus, 598<br />
B. paradoxum, 598<br />
chewing sticks, 598<br />
D. benthamianus, 598<br />
F. zanthoxyloides, 598<br />
M. accuminata, 598<br />
N. latifolia, 598<br />
Nigerian chewing sticks, 598<br />
S. werneckei, 598<br />
T. glaucescens, 598<br />
V. amygdalina, 598<br />
Bacteroides spp.<br />
E-1040, 1666<br />
R-3746, 671<br />
tigemonam, 84<br />
trospectomycin, 216, 584<br />
Benzalkonium chloride<br />
S. aureus resistance, 932<br />
Berberine sulfate<br />
E. coli Pap fimbrial adhesion, 1274<br />
S. pyogenes<br />
fibronectin, 1370<br />
hexadecane, 1370<br />
host cell adherence, 1370<br />
P-Lactamases<br />
Aeromonas spp., 1314<br />
B. fragilis, 1848<br />
13C nuclear magnetic resonance spectroscopy,<br />
1196<br />
CTX-1, 9<br />
DNA probes, 175<br />
E-1040, 1666<br />
E. coli, 1243<br />
Enterobacteriaceae, 1365<br />
H. influenzae, 180<br />
isoelectric focusing, 397, 1730<br />
K. pneumoniae, 626, 1660<br />
letter to the editor, 158<br />
M. morganii, 1385<br />
ME1207, 1421<br />
N. asteroides, 1776<br />
N. gonorrhoeae, 158, 1430<br />
oligonucleotide probes, 397<br />
oxacillin susceptibility, 1754<br />
oxyimino-cephalosporins, 1243<br />
P. aeruginosa, 1443<br />
heterogeneity, 1893<br />
P. cepacia, 838<br />
P. maltophilia<br />
cloning of operon in E. coli, 819<br />
P. vulgaris, 1073, 1385<br />
PADAC assay, 1040<br />
Pasteurella spp., 1282<br />
PhastSystem, 1730<br />
plasmid mediated, 175<br />
PSE-2 sequence, 134<br />
pyridinium-2-azo-p-dimethylaniline chromophore<br />
assay, 1040<br />
S. aureus, 1614, 1754<br />
transposon, 1164<br />
S.faecalis, 122, 547<br />
hybridization studies, 768<br />
restriction mapping, 768
VOL. 32, 1988<br />
staphylococci, coagulase negative, 1754<br />
YTR 830, 925<br />
P-Lactams<br />
Aeromonas resistance, 1314<br />
-y-aminobutyric acid binding, 758<br />
B. fragilis, 1437<br />
K. pneumoniae resistance, 1660<br />
M. morganii, 1385<br />
P. cepacia resistance, 1636<br />
P. vulgaris, 1385<br />
paradoxical effect, 1073<br />
pentylenetetrazole convulsive threshold,<br />
758<br />
T. vaginalis, 144<br />
Bifidobacterium spp.<br />
daptomycin, 788<br />
paldimycin, 788<br />
Biliary drainage<br />
cefotiam, 726<br />
sulbenicillin, 726<br />
ursodeoxycholate, 726<br />
Biliary tract infections<br />
ampicillin-tobramycin, 1231<br />
cefoperazone, 1231<br />
ceftazidime, 1588<br />
tobramycin-ampicillin, 1231<br />
Bioassay<br />
sulbactam, 1347<br />
Biofilms<br />
E. coli, 770<br />
radiochemical method, 770<br />
Bioluminescence assay<br />
M. tuberculosis ATP, 1208<br />
Biosynthetic genes<br />
minireview, 1472<br />
Streptomyces spp., 1472<br />
Bite wound bacteria<br />
amoxicillin-clavulanic acid, 1143<br />
ampicillin, 1143<br />
cefadroxil, 1143<br />
cefuroxime, 1143<br />
cephalexin, 1143<br />
ciprofloxacin, 1143<br />
enoxacin, 1143<br />
ofloxacin, 1143<br />
penicillin G, 1143<br />
tetracycline, 1143<br />
BMY-26225<br />
y-aminobutyric acid binding, 758<br />
pentylenetetrazole convulsive threshold,<br />
758<br />
Bordetella bronchiseptica<br />
ampicillin, 1891<br />
antigenic modulation, 1891<br />
carbenicillin, 1891<br />
cephalothin, 1891<br />
chloramphenicol, 1891<br />
chlortetracycline, 1891<br />
colistin, 1891<br />
doxycycline, 1891<br />
erythromycin, 1891<br />
gentamicin, 1891<br />
kanamycin, 1891<br />
nalidixic acid, 1891<br />
neomycin, 1891<br />
novobiocin, 1891<br />
oxolinic acid, 1891<br />
oxytetracycline, 1891<br />
phase variation, 1891<br />
polymyxin B, 1891<br />
rifampin, 1891<br />
sulfadimethoxine, 1891<br />
sulfamonomethoxine, 1891<br />
tetracycline, 1891<br />
Bordetella spp.<br />
amoxicillin, 137<br />
ciprofloxacin, 137<br />
enoxacin, 137<br />
erythromycin, 137<br />
norfloxacin, 137<br />
ofloxacin, 137<br />
rifampin, 137<br />
roxithromycin, 137<br />
sulfamethoxazole-trimethoprim, 137<br />
tetracycline, 137<br />
Branhamella catarrhalis<br />
amikacin, 259<br />
amoxicillin-clavulanic acid, 259<br />
ampicillin, 259<br />
ampicillin-sulbactam, 259<br />
azithromycin, 752<br />
azlocillin, 259<br />
aztreonam, 259<br />
carbenicillin, 259<br />
cefaclor, 259<br />
cefam<strong>and</strong>ole, 259<br />
cefixime, 259, 1896<br />
cefonicid, 259<br />
cefoperazone, 259<br />
cefotaxime, 259<br />
cefoxitin, 259<br />
cefpodoxime, 1896<br />
ceftazidime, 259<br />
ceftibuten, 1576<br />
ceftizoxime, 259<br />
ceftriaxone, 259, 1896<br />
cefuroxime, 259<br />
cephalexin, 259<br />
cephalothin, 259<br />
chloramphenicol, 259<br />
ciprofloxacin, 259<br />
CS-807, 1082<br />
erythromycin, 259<br />
erythromycin estolate, 1227<br />
erythromycin ethylsuccinate, 1227<br />
erythromycin-sulfisoxazole, 259<br />
gentamicin, 259<br />
imipenem, 259<br />
LY163892, 268<br />
mezlocillin, 259<br />
minireview, 1747<br />
moxalactam, 259<br />
netilmicin, 259<br />
PD 117,596, 1450<br />
pefloxacin, 259<br />
penicillin, 259<br />
piperacillin, 259<br />
rifampin, 259<br />
sulfisoxazole, 259<br />
susceptibility testing, 1747<br />
T-3262, 663<br />
tetracycline, 259<br />
ticarcillin, 259<br />
ticarcillin-clavulanic acid, 259<br />
tigemonam, 84<br />
tobramycin, 259<br />
trimethoprim-sulfamethoxazole, 259<br />
trospectomycin, 216<br />
U-76,252, 1082<br />
U-76,253A, 443<br />
Branhamella spp.<br />
lomefloxacin, 656<br />
R-3746, 671<br />
BRL 39123<br />
comparative activity<br />
acyclovir, 358<br />
SUBJECT INDEX xi<br />
herpes simplex virus type 1, 358<br />
herpes simplex virus type 2, 358<br />
2-Bromo-2-nitropropane-1,3-diol<br />
E. coli, 1693<br />
mechanism of action, 1693<br />
2-Bromo-L-histidine<br />
P. falciparum, 1655<br />
E-5-(2-Bromovinyl)-2'-deoxyuridine<br />
comparative activity<br />
acyclovir <strong>and</strong> l-P-D-arabinofuranosyl-<br />
E-5-(2-bromovinyl)uracil, 1068<br />
Epstein-Barr virus, 1068<br />
Bromovinyl nucleoside analogs<br />
comparative activity<br />
acyclovir, 1068<br />
Epstein-Barr virus, 1068<br />
Bromovinyldeoxyuridine<br />
guinea pig embryonic fibroblasts, 1533<br />
herpes simplex virus type 1, 1533<br />
Bronopol<br />
E. coli, 1693<br />
mechanism of action, 1693<br />
Brucea javanica<br />
B. javanica, 1725<br />
E. histolytica, 1725<br />
quassinoids, 1725<br />
Buciclovir<br />
DNA polymerases, 1137<br />
guinea pig embryonic fibroblasts, 1533<br />
herpes simplex virus type 1, 1533<br />
monophosphate<br />
guinea pig embryonic fibroblasts, 1533<br />
herpes simplex virus type 1, 1533<br />
varicella-zoster virus, 1137<br />
4-(tert-Butyl)2-(tert-butylaminomethyl)-6-<br />
(4-chlorophenyl)phenol dihydrogen<br />
phosphate<br />
crystal <strong>and</strong> molecular structure, 540<br />
BW A855U<br />
cleavable-complex assay, 1086<br />
Bytyrospermum paradoxum<br />
B. gingivalis, 598<br />
B. melaninogenicus, 598<br />
C31G<br />
C. albicans, 350<br />
comparative activities<br />
chlorhexidine, Fluorigard, Listerine,<br />
<strong>and</strong> Viadent, 350<br />
S. sobrinus, 350<br />
Streptococcus spp., 350<br />
13C nuclear magnetic resonance spectroscopy<br />
P-lactamases, 1196<br />
Calcium fosfomycin<br />
pharmacokinetics, 938<br />
young <strong>and</strong> elderly adults, 938<br />
Campylobacter coli<br />
kanamycin resistance, 1170<br />
R plasmid, 1170<br />
Campylobacter jejuni<br />
A-61827, 27<br />
kanamycin resistance, 1170<br />
PD 117,596, 1450<br />
R plasmid, 1170<br />
Campylobacter spp.<br />
DNA annealing, 945<br />
kanamycin resistance, 945<br />
minireview, 1107<br />
resistance mechanisms, 1107<br />
tetracycline resistance gene, 1793
xii SUBJECT INDEX<br />
Cancer patients<br />
clindamycin-amikacin, 1557<br />
head <strong>and</strong> neck surgery, 1557<br />
ticarcillin-clavulanic acid, 1557<br />
wound infections, 1557<br />
C<strong>and</strong>ida albicans<br />
amphotericin B, 327<br />
resistance, 702<br />
C31G, 350<br />
2-chloroethyl-1-nitrosoureas, 327<br />
cilofungin, 1331, 1901<br />
denture stomatitis, 1859<br />
ergosterol, 702<br />
fluconazole, 209, 1859<br />
(1-3)-3-D-glucan synthase<br />
cilofungin, 1901<br />
jasplakinolide, 1154<br />
ketoconazole, 209<br />
stomatitis, denture, 1859<br />
C<strong>and</strong>ida parapsilosis<br />
cilofungin, 1331<br />
C<strong>and</strong>ida spp.<br />
jasplakinolide, 1154<br />
C<strong>and</strong>ida tropicalis<br />
cilofungin, 1331<br />
Capnocytophaga ochracea<br />
clindamycin, 1521<br />
neutrophil killing, 1521<br />
Capreomycin<br />
M. avium, 1131<br />
Carbapenems<br />
[14C]dimethyl sulfate labeling, 186<br />
high-performance liquid chromatography,<br />
186<br />
Carbenicillin<br />
B. bronchiseptica, 1891<br />
B. catarrhalis, 259<br />
hyperbilirubinemia<br />
centrifugal ultrafiltration, 1571<br />
M. morganii, 1385<br />
N. asteroides, 1776<br />
P. maltophilia, 782<br />
P. vulgaris, 1385<br />
Carbocyclin 3-deazaadenosine<br />
influenza viruses, 906<br />
Carbodine<br />
influenza viruses, 906<br />
Carbomycin<br />
Arthrobacter spp., 420<br />
Staphylococcus spp., 420<br />
Cardiac surgery<br />
Staphylococcus infection, 202<br />
Cardiopulmonary bypass<br />
netilmicin, 631<br />
vancomycin, 631<br />
Caromonam<br />
comparative activity<br />
ceftazidime, 1031<br />
urinary tract infections, 1031<br />
Carrageenans<br />
cytomegalovirus, 1742<br />
herpes simplex virus, 1742<br />
human immunodeficiency virus, 1742<br />
vesicular stomatitis virus, 1742<br />
Carumonam<br />
comparative activity<br />
gentamicin, 473<br />
Enterobacteriaceae, 1593<br />
high-pressure liquid chromatography,<br />
354<br />
L. pneumophila, 1593<br />
P. aeruginosa, 1593<br />
P. pseudomallei, 1435<br />
pharmacokinetics, 354<br />
urinary tract infections, 473<br />
Catechol-cephalosporins<br />
mechanisms of action, 1879<br />
Catheters<br />
disodium EDTA, 1627<br />
S. epidermidis, 1627<br />
vancomycin, 1627<br />
Cefaclor<br />
B. catarrhalis, 259<br />
H. influenzae, 180<br />
P. multocida, 213<br />
Cefadroxil<br />
bite wound bacteria, 1143<br />
P. maltocida, 213<br />
Cefam<strong>and</strong>ole<br />
A. denitrificans subsp. xylosoxidans, 276<br />
B. catarrhalis, 259<br />
B. fragilis, 1848<br />
outer membrane permeation, 1097<br />
comparative activity<br />
cefazolin, daptomycin, <strong>and</strong> vancomycin,<br />
63<br />
dysgonic fermenter 2, 78<br />
endocarditis, 63<br />
H. influenzae, 180<br />
S. epidermidis, 63<br />
Shigella spp., 20<br />
Cefazolin<br />
A. denitrificans subsp. xylosoxidans, 276<br />
y-aminobutyric acid binding, 758<br />
B. fragilis, 1848<br />
outer membrane permeation, 1097<br />
Bacillus spp., 642<br />
comparative activity<br />
cefam<strong>and</strong>ole, daptomycin, <strong>and</strong> vancomycin,<br />
63<br />
difloxacin <strong>and</strong> enoxacin, 262<br />
dysgonic fermenter 2, 78<br />
endocarditis, 63, 262<br />
nephrotoxicity, 314<br />
pentylenetetrazole convulsive threshold,<br />
758<br />
pharmacokinetics, 33<br />
S. aureus, 262<br />
S. epidermidis, 63<br />
Cefbuperazone<br />
P. vulgaris, 1073<br />
Cefepime<br />
Nocardia spp., 1078<br />
P. aeruginosa resistance, 1443<br />
Cefetamet<br />
pharmacokinetics, 573<br />
Cefetamet pivoxil<br />
pharmacokinetics, 573<br />
Cefixime<br />
B. catarrhalis, 259, 18%<br />
comparative activity<br />
cefpodoxime <strong>and</strong> ceftriaxone, 18%<br />
Enterobacteriaceae, 18%<br />
Enterococcus spp., 18%<br />
H. influenzae, 18%<br />
N. meningitidis, 18%<br />
P. aeruginosa, 18%<br />
Staphylococcus spp., 18%<br />
Cefmenoxime<br />
P. vulgaris, 1073<br />
Cefmetazole<br />
P. vulgaris, 1073<br />
Cefodizime<br />
comparative activity<br />
cefotaxime, 426<br />
gonorrhea, 426<br />
ANTIMICROB. AGENTS CHEMOTHER.<br />
N. gonorrhoeae, 426<br />
Cefonicid<br />
B. catarrhalis, 259<br />
high-performance liquid chromatography,<br />
485<br />
M. tuberculosis, 1441<br />
pharmacokinetics, 485<br />
protein binding, 128<br />
skin infections, 485<br />
skin structure infections, 485<br />
Cefoperazone<br />
B. catarrhalis, 259<br />
B. fragilis, 403, 1848<br />
outer membrane permeation, 1097<br />
biliary tract infections, 1231<br />
combinations<br />
B. fragilis, 403<br />
ceftazidime, 298<br />
ciprofloxacin, 782<br />
intra-abdominal infections, 730<br />
P. aeruginosa, 298<br />
P. maltophilia, 782<br />
pharmacokinetics, 730<br />
sulbactam, 403, 730<br />
comparative activity<br />
ampicillin-tobramycin, 1231<br />
dysgonic fermenter 2, 78<br />
high-pressure liquid chromatography,<br />
298<br />
hyperbilirubinemia<br />
centrifugal ultrafiltration, 1571<br />
nephrotoxicity, 314<br />
P. maltophilia, 782<br />
P. vulgaris, 1073<br />
pharmacokinetics, 42<br />
protein binding, 298<br />
Shigella spp., 20<br />
Cefoperazone-sulbactam<br />
B. fragilis, 403<br />
comparative activity<br />
cefoperazone, cefoxitin, chloramphenicol,<br />
clindamycin, imipenem, metronidazole,<br />
<strong>and</strong> penicillin G, 403<br />
pharmacokinetics, 42, 503<br />
continuous ambulatory peritoneal dialysis,<br />
51<br />
renal failure, 503<br />
Ceforanide<br />
A. denitrificans subsp. xylosoxidans, 276<br />
M. tuberculosis, 1441<br />
Cefotaxime<br />
A. denitrificans subsp. xylosoxidans, 276<br />
B. catarrhalis, 259<br />
Bacillus spp., 642<br />
combinations<br />
chloramphenicol, 1375<br />
E. coli, 1375<br />
gram-negative bacteria, 1375<br />
S. aureus, 1375<br />
streptococci, group B, 1375<br />
comparative activity<br />
cefodizime, 426<br />
dysgonic fermenter 2, 78<br />
Enterobacteriaceae, 873<br />
gonorrhea, 426<br />
H. ducreyi, 1458<br />
M. morganii, 1385<br />
M. tubetculosis, 1441<br />
N. asteroides, 1776<br />
N. gonorrhoeae, 426<br />
P. aerugindsa resistance, 1443<br />
P. pseudomallei, 1435<br />
P. vulgaris, 1073, 1385
VOL. 32, 1988<br />
pharmacokinetics<br />
protein binding, 128<br />
Shigella spp., 20<br />
Cefotetan<br />
A. denitrificans subsp. xylosoxidans, 276<br />
B. fragilis, 601<br />
C. difficile, 601<br />
comparative activity<br />
cefoxitin, ceftizoxime, chloramphenicol,<br />
clindamycin, <strong>and</strong> metronidazole,<br />
601<br />
prothrombin, 1446<br />
vitamin K metabolism, 1446<br />
Cefotiam<br />
biliary excretion<br />
ursodeoxycholate, 726<br />
P. vulgaris, 1073<br />
percutaneous transhepatic biliary drainage,<br />
726<br />
Cefoxitin<br />
B. catarrhalis, 259<br />
B. fragilis, 1511<br />
Bacillus spp., 642<br />
comparative activity<br />
ceftizoxime, 1511<br />
E. coli, 1511<br />
Enterobacteriaceae, 873<br />
H. ducreyi, 1458<br />
M. morganii, 1385<br />
P. vulgaris, 1385<br />
prothrombin, 1446<br />
serum bactericidal activity, 1511<br />
vitamin K metabolism, 1446<br />
Cefpiramide<br />
hepatic excretion, 1360<br />
high-performance liquid chromatography,<br />
1360<br />
pharmacokinetics, 33, 1360<br />
Cefpirome<br />
comparative activity<br />
cefoperazone, cefotaxime,<br />
ceftazidime, <strong>and</strong> moxalactam,<br />
1396<br />
croton oil-induced rat granuloma pouch,<br />
1396<br />
E. coli, 1396<br />
high-performance liquid chromatography,<br />
1481<br />
M. tuberculosis, 1441<br />
Nocardia spp., 1078<br />
P. aeruginosa, 1396<br />
pharmacokinetics, 1396<br />
S. aureus, 1396<br />
Cefpodoxime<br />
B. catarrhalis, 1896<br />
comparative activity<br />
cefixime <strong>and</strong> ceftriaxone, 1896<br />
Enterobacteriaceae, 1896<br />
Enterococcus spp., 1896<br />
H. influenzae, 1896<br />
N. meningitidis, 1896<br />
P. aeruginosa, 1891<br />
Staphylococcus spp., 1896<br />
Cefsulodin<br />
combinations<br />
ciprofloxacin, 782<br />
P. maltophilia, 782<br />
P. maltophilia, 782<br />
Ceftazidime<br />
A. denitrificans subsp. xylosoxidans, 276<br />
B. catarrhalis, 259<br />
biliary tract infections, 1588<br />
cholelithiasis, 1588<br />
combinations<br />
amdinocillin, 1632<br />
amikacin, 231<br />
cefoperazone, 298<br />
ciprofloxacin, 782<br />
E. cloacae, 1632<br />
endocarditis, 231<br />
P. aeruginosa, 231, 298<br />
P. maltophilia, 782<br />
resistance, development of, 231<br />
comparative activity<br />
carumonam, 1031<br />
concentrations in bile <strong>and</strong> gallbladder<br />
wall, 1588<br />
dysgonic fermenter 2, 78<br />
E. cloacae, 1632<br />
resistance, 1632<br />
high-performance liquid chromatography,<br />
1845<br />
high-pressure liquid chromatography,<br />
298<br />
nephrotoxicity, 314<br />
P. aeruginosa resistance, 1443<br />
P. maltophilia, 782<br />
P. pseudomallei, 1435<br />
P. vulgaris, 1073<br />
pharmacokinetics, 1845<br />
protein binding, 298<br />
Shigella spp., 20<br />
urinary tract infections, 1031<br />
Ceftazidime-amikacin<br />
comparative activity<br />
pefloxacin, 231<br />
endocarditis, 231<br />
P. aeruginosa, 231<br />
resistance, development of, 231<br />
Ceftazidime-vancomycin<br />
pharmacokinetics, 92<br />
Ceftetrame<br />
H. ducreyi, 1458<br />
Ceftezole<br />
B. fragilis, 1848<br />
outer membrane permeation, 1097<br />
Ceftibuten<br />
B. catarrhalis, 1576<br />
comparative activity<br />
amoxicillin, amoxicillin-clavulanic<br />
acid, cefaclor, cefixime, <strong>and</strong> cefuroxime,<br />
1576<br />
Enterobacteriaceae, 1576<br />
H. influenzae, 1576<br />
Neisseria spp., 1576<br />
Streptococcus spp., 1576<br />
susceptibility testing, 1576<br />
Ceftizoxime<br />
B. catarrhalis, 259<br />
B. fragilis, 1511<br />
comparative activity<br />
cefoxitin, 1511<br />
E. coli, 1511<br />
M. tuberculosis, 1441<br />
P. vulgaris, 1073<br />
pharmacokinetics<br />
protein binding, 128<br />
serum bactericidal activity, 1511<br />
Ceftriaxone<br />
A. denitrificans subsp. xylosoxidans, 276<br />
B. catarrhalis, 259, 1896<br />
combinations<br />
chloramphenicol, 1375<br />
E. coli, 1375<br />
gram-negative bacteria, 1375<br />
S. aureus, 1375<br />
SUBJECT INDEX xiii<br />
streptococci, group B, 1375<br />
comparative activity<br />
cefixime <strong>and</strong> cefpodoxime, 1896<br />
E. coli, 552<br />
Enterobacteriaceae, 1896<br />
Enterococcus spp., 1896<br />
H. ducreyi, 1458<br />
H. influenzae, 1896<br />
home parenteral therapy, 1439<br />
hyperbilirubinemia<br />
centrifugal ultrafiltration, 1571<br />
in vitro simulation of serious infections,<br />
552<br />
lidocaine reconstitution, 1439<br />
M. morganii, 1385<br />
N. asteroides, 1776<br />
N. meningitidis, 1896<br />
P. aeruginosa, 552, 1896<br />
P. pseudomallei, 1435<br />
P. vulgaris, 1073, 1385<br />
S. pneumoniae, 552<br />
Shigella spp., 20<br />
Staphylococcus spp., 1896<br />
Cefuroxime<br />
A. denitrificans subsp. xylosoxidans, 276<br />
B. catarrhalis, 259<br />
Bacillus spp., 642<br />
bite wound bacteria, 1143<br />
hyperbilirubinemia<br />
centrifugal ultrafiltration, 1571<br />
P. multocida, 213<br />
P. vulgaris, 1073<br />
Shigella spp., 20<br />
Cefuzonam<br />
P. vulgaris, 1073<br />
Celesticetin<br />
Arthrobacter spp., 420<br />
Staphylococcus spp., 420<br />
Cell cultures<br />
human immunodeficiency virus type 1,<br />
684<br />
Cephalexin<br />
B. catarrhalis, 259<br />
bite wound bacteria, 1143<br />
H. influenzae, 180<br />
P. multocida, 213<br />
Cephalexin hydrochloride<br />
comparative activity<br />
cephalexin monohydrate, 882<br />
gram-negative bacteria, 882<br />
S. aureus, 882<br />
S. pyogenes, 882<br />
skin infections, 882<br />
soft tissue infections, 882<br />
Staphylococcus spp., 882<br />
Cephalexin monohydrate<br />
comparative activity<br />
cephalexin hydrochloride, 882<br />
gram-negative bacteria, 882<br />
S. aureus, 882<br />
S. pyogenes, 882<br />
skin infections, 882<br />
soft tissue infections, 882<br />
Siaphylococcus spp., 882<br />
Cephaloglycin<br />
nephrotoxicity, 314<br />
Cephaloridine<br />
K. pneumoniae, 364<br />
M. morganii, 1385<br />
nephrotoxicity, 314<br />
piperacillin protective effect, 912<br />
P. vulgaris, 1073, 1385
xiv SUBJECT INDEX<br />
Cephalosporins<br />
B. fragilis, 1848<br />
outer membrane permeation, 1097<br />
catechol substituted<br />
mechanism of action, 1879<br />
K. pneumoniae resistance, 1660<br />
oxyimino<br />
3-lactamase, 1243<br />
E. coli, 1243<br />
S. aureus, 170<br />
Cephalothin<br />
B. bronchiseptica, 1891<br />
B. catarrhalis, 259<br />
B. fragilis, 1848<br />
outer membrane permeation, 1097<br />
Enterobacteriaceae, 873<br />
H. influenzae, 180<br />
nephrotoxicity, 314<br />
P. vulgaris, 1073<br />
S. aureus MBCs, 374<br />
Shigella spp., 20<br />
Cephapirin<br />
M. tuberculosis, 1441<br />
CGP 17520<br />
K. pneumoniae, 364<br />
Chagas' disease<br />
ketoconazole, 1237<br />
SF 86-327, 1237<br />
Charcoal<br />
tobramycin clearance, effect on, 274<br />
Chemotaxis<br />
T. vaginalis, 1323<br />
Chewing sticks<br />
B. gingivalis, 598<br />
B. melaninogenicus, 598<br />
Chlamydia trachomatis<br />
AM-833, 1080, 1735<br />
antibodies<br />
monoclonal, 1295<br />
Chlamydiazyme, 1350<br />
chloramphenicol, 1350<br />
ciprofloxacin, 1080, 1350, 1735<br />
doxycycline, 1350, 1735<br />
enoxacin, 1080<br />
erythromycin, 1350<br />
fleroxacin, 1080<br />
imipenem-cilastatin, 773<br />
josamycin, 1350<br />
minireview, 1295<br />
minocycline, 1080, 1350, 1735<br />
norfloxacin, 1080, 1350, 1735<br />
NY-198, 1080, 1735<br />
ofloxacin, 1080, 1350, 1735<br />
PD 127,391, 1251<br />
pefloxacin, 1350<br />
pipemidic acid, 1080<br />
rifampin, 1350<br />
rikamycin, 1350<br />
RO 23-6240, 1080<br />
rosoxacin, 1350<br />
roxithromycin, 1350<br />
sulfamethoxazole, 1350<br />
susceptibility testing, 1295, 1350<br />
T-3262, 1080<br />
tetracycline, 1350<br />
trospectomycin, 216<br />
Chlamydia sp. strain TWAR<br />
ampicillin, 257<br />
erythromycin, 257<br />
penicillin, 257<br />
sulfisoxazole, 257<br />
tetracycline, 257<br />
trospectomycin, 257<br />
Chlamydiazyme<br />
evaluation, 1350<br />
Chloramphenicol<br />
acetyltransferase<br />
C. difficile, 1213<br />
H. influenzae, 180<br />
B. bronchiseptica, 1891<br />
B. catarrhalis, 259<br />
Bacillus spp., 642<br />
C. trachomatis, 1350<br />
combinations<br />
cefotaxime, 1375<br />
ceftriaxone, 1375<br />
E. coli, 1375<br />
gram-negative bacteria, 1375<br />
S. aureus, 1375<br />
streptococci, group B, 1375<br />
comparative activity<br />
ciprofloxacin <strong>and</strong> gentamicin, 285<br />
dysgonic fermenter 2, 78<br />
E. coli<br />
heat treatment, 1680<br />
Enterobacteriaceae, 873<br />
fecal flora resistance, 1801<br />
H. ducreyi, 1458<br />
H. influenzae, 180<br />
susceptibility testing, 1484<br />
P. carinii, 8%<br />
P. multocida, 213<br />
scrub typhus, 285<br />
Shigella spp., 20<br />
Chlorhexidine<br />
S. aureus resistance, 932<br />
Chlorhexidine digluconate<br />
Enterobacteriaceae, 873<br />
3-Chlorodiaminopimelic acid<br />
diaminopimelic acid epimerase, 1119<br />
E. coli, 1119<br />
2-Chloroethyl- I -nitrosoureas<br />
amphotericin B<br />
C. albicans, 327<br />
2-Chloro-L-histidine<br />
P. falciparum, 1655<br />
Chloroquine<br />
malaria, 799<br />
minireview, 799<br />
P. falciparum, 799<br />
polymorphonuclear neutrophils, 1124<br />
resistance, 799<br />
5-Chlorotubercidin<br />
influenza viruses, 906<br />
Chlorovinylglycine<br />
comparative activity, 319<br />
gram-positive bacteria, 319<br />
Staphylococcus spp., 319<br />
Chlorpromazine<br />
E. coli permeability, 153<br />
P. carinii, 8%<br />
Chlortetracycline<br />
B. bronchiseptica, 1891<br />
Cholelithiasis<br />
ceftazidime, 1588<br />
CI-934<br />
cleavable-complex assay, 1086<br />
Cilofungin<br />
C. albicans, 1331<br />
(1-3)-p-D-glucan synthase, 1901<br />
C. parapsilosis, 1331<br />
C. tropicalis, 1331<br />
comparative activity<br />
amphotericin B, flucytosine, <strong>and</strong> ketoconazole,<br />
1331<br />
Cryptococcus spp., 1331<br />
ANTIMICROB. AGENTS CHEMOTHER.<br />
S. cerevisiae, 1331<br />
T. glabrata, 1331<br />
Cinchonidine<br />
P. falciparum, 250<br />
Cinchonine<br />
P. falciparum, 250<br />
Cinoxacin<br />
S. aureus, 1192<br />
Ciprofloxacin<br />
A. denitrificans subsp. xylosoxidans, 276<br />
antacids, 949<br />
B. catarrhalis, 259<br />
B. fragilis, 1437<br />
Bacillus spp., 642<br />
biliary excretion <strong>and</strong> metabolism, 982<br />
bite wound bacteria, 1143<br />
Bordetella spp., 137<br />
C. trachomatis, 1080, 1350, 1735<br />
chancroid, 723, 723<br />
cleavable-complex assay, 1086<br />
combinations<br />
amikacin, aztreonam, cefoperazone,<br />
cefsulodin, ceftazidime, gentamicin,<br />
imipenem, mezlocillin, piperacillin,<br />
<strong>and</strong> tobramycin, 782<br />
clofazimine, 1392<br />
erythromycin, 1392<br />
ethambutol, 1392<br />
M. avium complex, 1392<br />
P. maltophilia, 782<br />
rifabutin, 1392<br />
rifampin, 1392<br />
comparative activity<br />
A-56620, amikacin, aztreonam, carbenicillin,<br />
cefoperazone, cefsulodin,<br />
ceftazidime, difloxacin, gentamicin,<br />
imipenem, mezlocillin,<br />
norfloxacin, piperacillin, Sch<br />
34343, ticarcillin, <strong>and</strong> tobramycin,<br />
782<br />
amifloxacin, enoxacin, norfloxacin,<br />
<strong>and</strong> ofloxacin, 928<br />
ampicillin <strong>and</strong> chloramphenicol, 57<br />
chloramphenicol <strong>and</strong> gentamicin, 285<br />
doxycycline <strong>and</strong> minocycline, 1735<br />
gentamicin, imipenem, nafcillin, <strong>and</strong><br />
vancomycin, 747<br />
trimethoprim-sulfamethoxazole, 1327<br />
cytogenetic effects, 936<br />
dysgonic fermenter 2, 78<br />
E. coli, 450<br />
endocarditis, 747<br />
Enterobacteriaceae, 1327<br />
GABA receptor, 1624<br />
H. ducreyi, 723, 723, 1458<br />
Haemophilus spp., 147<br />
high-pressure liquid chromatography,<br />
1537<br />
letter to the editor, 949<br />
N. asteroides, 1776<br />
N. meningitidis, 1740<br />
Nocardia spp., 1078<br />
P. aeruginosa resistance, 535<br />
P. falciparum, 1182<br />
P. maltophilia, 782<br />
P. pseudomallei, 928, 1435<br />
pharmacokinetics, 949, 982, 1537<br />
polycystic kidney disease, 844<br />
postantibiotic effect, 450<br />
renal cyst infection, 844<br />
S. aureus, 747, 1192<br />
S. typhimurium, 57<br />
scrub typhus, 285
VOL. 32, 1988<br />
Shigella spp., 20<br />
theophylline pharmacokinetics, effect<br />
on, 75<br />
urinary tract infections, 1327<br />
Citrobacter diversus<br />
CS-807, 1082<br />
R-3746, 671<br />
tigemonam, 84<br />
U-76,252, 1082<br />
Citrobacter freundii<br />
DNA gyrase, 922<br />
E1040, 693<br />
norfloxacin resistance, 922<br />
ofloxacin resistance, 922<br />
quinolone resistance, 922<br />
R-3746, 671<br />
R plasmid, 9<br />
YTR 830, 925<br />
Citrobacter spp.<br />
E-1040, 1666<br />
Clarithromycin<br />
comparative activity, 1710<br />
erythromycin, 1500<br />
erythromycin <strong>and</strong> roxithromycin,<br />
1758<br />
M. hominis, 1500<br />
M. leprae, 1758<br />
M. pneumoniae, 1500<br />
U. urealyticum, 1500<br />
Cleavable-complex assay<br />
BW A855U, 1086<br />
CI-934, 1086<br />
ciprofloxacin, 1086<br />
nalidixic acid, 1086<br />
norfloxacin, 1086<br />
ofloxacin, 1086<br />
oxolinic acid, 1086<br />
quinolones, 1086<br />
Clindamycin<br />
A. actinomycetemcomitans, 1521<br />
Arthrobacter spp., 420<br />
B. fragilis, 1825<br />
Bacillus spp., 642<br />
C. ochracea, 1521<br />
combinations<br />
amikacin, 1557<br />
cost analysis, 853<br />
endomyometritis, 853<br />
enterococci, 1769<br />
gentamicin, 853<br />
head <strong>and</strong> neck surgery in cancer patients,<br />
1557<br />
P. carinii, 807<br />
primaquine, 807<br />
streptomycin, 1769<br />
wound infections, 1557<br />
dysgonic fermenter 2, 78<br />
E. corrodens, 1521<br />
enterococci, 1769<br />
high-performance liquid chromatography,<br />
1825<br />
neutrophil killing, 1521<br />
P. carinii, 807<br />
P. multocida, 213<br />
periodontal bacteria, 1521<br />
pharmacokinetics, 1825<br />
serum inhibitory activity, 1825<br />
Staphylococcus spp., 420<br />
Clindamycin-amikacin<br />
comparative activity<br />
ticarcillin-clavulanic acid, 1557<br />
head <strong>and</strong> neck surgery in cancer<br />
patients, 1557<br />
wound infections, 1557<br />
Clindamycin-gentamicin<br />
comparative activity<br />
cost analysis, 853<br />
moxalactam, 853<br />
endomyometritis, 853<br />
Clofazimine<br />
combinations<br />
amikacin, 1400<br />
ciprofloxacin, 1392<br />
ethambutol, 1392<br />
M. avium complex, 1392, 1400<br />
rifabutin, 1392<br />
M. leprae, 1583<br />
structure-activity relationship, 1583<br />
Cloning<br />
antibiotic biosynthetic genes, 1472<br />
biosynthetic genes, 1472<br />
minireviews, 1465, 1472<br />
Streptomyces spp., 1465, 1472<br />
Clostridium difficile<br />
cefotetan, 601<br />
chloramphenicol acetyltransferase determinant<br />
genetic analysis, 1213<br />
molecular cloning, 1213<br />
R plasmid, 1213<br />
trospectomycin, 216<br />
Clostridium spp.<br />
daptomycin, 788<br />
DuP 105, 580<br />
DuP 721, 580<br />
paldimycin, 788<br />
R-3746, 671<br />
trospectomycin, 216<br />
13C nuclear magnetic resonance spectroscopy<br />
P-lactamases, 1196<br />
Coccidioidal meningitis<br />
fluconazole, 369<br />
Colistin<br />
B. bronchiseptica, 1891<br />
Enterobacteriaceae, 873<br />
Common colds<br />
letters to the editor, 605, 606, 608<br />
zinc, 605, 606, 608<br />
Conjunctivitis<br />
H. influenzae, 1820<br />
norfloxacin, 1820<br />
S. aureus, 1820<br />
S. pneumoniae, 1820<br />
Staphylococcus spp., 1820<br />
streptococci, alpha-hemolytic, 1820<br />
tobramycin, 1820<br />
Coronary angioplasty<br />
Staphylococcus infection, 202<br />
Corynebacterium group JK<br />
DuP 105, 580<br />
DuP 721, 580<br />
gentamicin-teicoplanin, 434<br />
gentamicin-vancomycin, 434<br />
teicoplanin, 434<br />
teicoplanin-gentamicin, 434<br />
teicoplanin-tobramycin, 434<br />
tobramycin-teicoplanin, 434<br />
tobramycin-vancomycin, 434<br />
vancomycin, 434<br />
vancomycin-gentamicin, 434<br />
vancomycin-tobramycin, 434<br />
Corynebacterium spp.<br />
PD 117,596, 1450<br />
Co-trimoxazole<br />
H. ducreyi, 1458<br />
SUBJECT INDEX xv<br />
Coumermycin A<br />
P. falciparum, 1182<br />
Coxsackievirus<br />
sulfated polysaccharides, 1742<br />
Cryptococcus spp.<br />
cilofungin, 1331<br />
Cryptosporidium sp.<br />
letter to the editor, 1907<br />
sulfadimethoxine, 1907<br />
Crystal violet<br />
E. coli<br />
heat treatment, 1680<br />
CS-807<br />
A. hydrophila, 1082<br />
B. catarrhalis, 1082<br />
C. diversus, 1082<br />
comparative activity<br />
amoxicillin, amoxicillin-clavulanic<br />
acid, cefaclor, cefuroxime, cephalexin,<br />
<strong>and</strong> erythromycin, 1082<br />
E. coli, 1082<br />
E. faecalis, 1082<br />
Enterobacteriaceae, 1082<br />
H. influenzae, 1082<br />
Klebsiella spp., 1082<br />
P. aeruginosa, 1082<br />
P. mirabilis, 1082<br />
Staphylococcus spp., 1082<br />
Streptococcus spp., 1082<br />
5-Cyano- I -P-D-ribofuranosyl-imidazole-4carboxamide<br />
influenza viruses, 906<br />
5-Cyanoimidazole-4-carboxamide<br />
influenza viruses, 906<br />
Cyclohexane triones<br />
comparative activity<br />
cetrimide, chlorohexidine, FCCP, hexachlorophene,<br />
<strong>and</strong> tribromosalan,<br />
814<br />
gram-positive bacteria, 814<br />
H. influenzae, 814<br />
M. smegmatis, 814<br />
mechanisms of action, 814<br />
Cycloheximide<br />
M. racemosus, 341<br />
Cyclopentenyl cytosine<br />
influenza viruses, 906<br />
Cyclophosphamide<br />
amoebic meningoencephalitis, 962<br />
N. fowleri, 962<br />
Cyclosporine<br />
P. berghei, 462<br />
Cystic fibrosis<br />
P. cepacia, 1636<br />
Cystitis<br />
E-3846, 636<br />
E. coli, 1640<br />
ofloxacin, 1640<br />
trimethoprim-sulfamethoxazole, 1640<br />
Cytogenetic effects<br />
ciprofloxacin, 936<br />
ofloxacin, 936<br />
Cytomegalovirus<br />
3'-azido-3'-deoxythymidine, 265<br />
AZT, 265<br />
B-220, 1720<br />
carrageenans, 1742<br />
cochlear pathophysiology, 865<br />
dextran sulfate, 1742<br />
fucoidan, 1742<br />
ganciclovir, 865<br />
(S)-HPMPC, 1839<br />
(S)- 1-(3-hydroxy-2-phosphonylmethoxy-
xvi SUBJECT INDEX<br />
propyl)cytosine, 1839<br />
interferon, 678<br />
labyrinthitis, 865<br />
oxetanocin G, 1053<br />
pentosan polysulfate, 1742<br />
S26308, 678<br />
sulfated polysaccharides, 1742<br />
Dapsone<br />
combinations<br />
P. carinii, 623<br />
pneumonia, 623<br />
trimethoprim, 623<br />
comparative activity<br />
pentamidine, trimethoprim-dapsone,<br />
<strong>and</strong> trimethoprim-sulfamethoxazole,<br />
623<br />
P. carinii, 96, 623, 1057, 1158<br />
pneumonia, 623, 1057<br />
Daptomycin<br />
A. lignieresii, 1354<br />
Actinomyces spp., 788<br />
Bacillus spp., 642<br />
Bifidobacterium spp., 788<br />
Clostridium spp., 788<br />
combinations<br />
amikacin, fosfomycin, imipenem, netilmicin,<br />
rifampin, teicoplanin, <strong>and</strong><br />
vancomycin, 279<br />
endocarditis, 877<br />
Enterococcus spp., 279<br />
gentamicin, 81, 877<br />
pyelonephritis, 81<br />
S. aureus, 279<br />
S. epidermidis, 279<br />
S. faecalis, 81, 877<br />
Staphylococcus spp., 279<br />
comparative activity<br />
cefam<strong>and</strong>ole, cefazolin, <strong>and</strong> vancomycin,<br />
63<br />
daptomycin-gentamicin, penicillin G<br />
procaine, penicillin G procainegentamicin,<br />
vancomycin, vancomycin-gentamicin,<br />
877<br />
paldimycin, penicillin, <strong>and</strong> vancomycin,<br />
788<br />
penicillin G, 141<br />
vancomycin, 454<br />
E. faecalis, 24<br />
E. faecium, 24<br />
endocarditis, 63, 141, 877<br />
Enterococcus spp., 279<br />
Eubacterium spp., 788<br />
Lactobacillus spp., 788<br />
P. multocida, 1354<br />
Peptostreptococcus spp., 788<br />
Propionibacterium spp., 788<br />
pyelonephritis, 81<br />
S. aureus, 279, 454<br />
S. epidermidis, 63, 279<br />
S. faecalis, 81, 877<br />
translocation, 337<br />
S. pneumoniae, 24<br />
Staphylococcus spp., 24, 279<br />
Streptococcus spp., 141<br />
3-Deazaguanine<br />
influenza viruses, 906<br />
3-Deazauridine<br />
influenza viruses, 906<br />
Dehydroemetine<br />
P. carinii, 896<br />
Dehydropeptidase I<br />
purification <strong>and</strong> characterization, 587<br />
Demeclocycline<br />
comparative activity<br />
doxycycline, erythromycin, minocycline,<br />
nalidixic acid, oxytetracycline,<br />
rifampin, <strong>and</strong> tetracycline,<br />
986<br />
E. risticii, 986<br />
Dental granuloma<br />
ampicillin, 566<br />
talampicillin, 566<br />
Denture stomatitis<br />
C. albicans, 1859<br />
fluconazole, 1859<br />
5'-Deoxy-5-fluorouridine<br />
influenza viruses, 906<br />
Dermatophytes<br />
G2, 1586<br />
Dextran sulfate<br />
cytomegalovirus, 1742<br />
herpes simplex virus, 1742<br />
human immunodeficiency virus,<br />
1742<br />
vesicular stomatitis virus, 1742<br />
(S)-DHPA<br />
influenza viruses, 906<br />
Diallyl thiosulfinate<br />
mechanism of action, 1763<br />
S. typhimurium, 1763<br />
Diaminopimelic acid epimerase<br />
3-chlorodiaminopimelic acid, 1119<br />
E. coli, 1119<br />
Diaveridine<br />
P. carinii, 96<br />
Dibucaine<br />
E. coli permeability, 153<br />
Diclofenac<br />
GABA receptor, 1624<br />
y-aminobutyric acid receptor, 1624<br />
Dicloxacillin<br />
hyperbilirubinemia<br />
centrifugal ultrafiltration, 1571<br />
Difloxacin<br />
comparative activity<br />
cefazolin <strong>and</strong> enoxacin, 262<br />
erythromycin, 1500<br />
endocarditis, 262<br />
H. ducreyi, 1458<br />
M. hominis, 1500<br />
M. pneumoniae, 1500<br />
M. tuberculosis, 1441<br />
Nocardia spp., 1078<br />
P. maltophilia, 782<br />
S. aureus, 262<br />
U. urealyticum, 1500<br />
Difluoromethylornithine<br />
P. carinii, 896<br />
DL-a-Difluoromethylornithine<br />
combinations<br />
P. carinii, 1158<br />
suramin, 1158<br />
comparative activity<br />
dapsone, diminazene aceturate, suramin,<br />
<strong>and</strong> trimethoprim-sulfamethoxazole,<br />
1158<br />
P. carinii, 1158<br />
Dihydromycoplanecin A<br />
comparative activity<br />
isoniazid, ofloxacin, rifampin, <strong>and</strong><br />
streptomycin, 110<br />
Mycobacterium spp., 110<br />
pharmacokinetics, 110<br />
ANTIMICROB. AGENTS CHEMOTHER.<br />
Dihydropteroate synthase gene<br />
nucleotide sequence, 1684<br />
9-(3,4-Dihydroxybutyl)guanine<br />
triphosphate<br />
DNA polymerases, 1137<br />
varicella-zoster virus, 1137<br />
(S)-9-(2,3-Dihydroxypropyl)adenine<br />
influenza viruses, 906<br />
2,3,Dimethyl(dimethylaminoethyl)5H-indolo-(2,3-b)quinoxaline<br />
cytomegalovirus, 1720<br />
herpes simplex virus type 1, 1720<br />
mechanism of action, 1720<br />
varicella-zoster virus, 1720<br />
['4C]dimethyl sulfate<br />
carbapenem labeling, 186<br />
Diminazene<br />
P. carindi, 8%<br />
Diminazene aceturate<br />
P. carinii, 1158<br />
Dirithromycin<br />
comparative activity, 1710<br />
Disodium EDTA<br />
catheters, 1627<br />
S. epidermidis, 1627<br />
Distemonanthus benthamianus<br />
B. gingivalis, 598<br />
B. melaninogenicus, 598<br />
DNA gyrase<br />
C. freundii, 922<br />
cleavable-complex assay, 1086<br />
inhibitors<br />
N. gonorrhoeae, 1788<br />
quinolones, 1086<br />
resistance, 104<br />
S. aureus, 1192<br />
DNA polymerases<br />
varicella-zoster virus, 1137<br />
DNA probes<br />
,B-lactamases, 175<br />
DNA synthesis<br />
E. coli, 1113<br />
quinolones, 1113<br />
Doxycycline<br />
B. bronchiseptica, 1891<br />
C. trachomatis, 1350<br />
comparative activity<br />
demeclocycline, erythromycin, minocycine,<br />
nalidixic acid,<br />
oxytetracycline, rifampin, <strong>and</strong><br />
tetracycline, 986<br />
E. risticii, 986<br />
Enterobacteriaceae, 873<br />
H. ducreyi, 1458<br />
DR-3355<br />
B. fragilis, 1336<br />
comparative activity<br />
ciprofloxacin, fleroxacin, methicillin,<br />
NY-198, <strong>and</strong> ofloxacin, 1336<br />
Peptococcus spp., 1336<br />
Staphylococcus spp., 1336<br />
DuP 105<br />
B. fragilis, 580<br />
Clostridium spp., 580<br />
comparative activity<br />
amoxicillin-clavulanic acid,<br />
cephalexin, teicoplanin, <strong>and</strong> vancomycin,<br />
580<br />
ampicillin, cefaclor, ciprofloxacin,<br />
erythromycin, <strong>and</strong> vancomycin,<br />
150<br />
Corynebacterium group JK, 580<br />
E. faecalis, 580
VOL. 32, 1988<br />
Enterobacteriaceae, 580<br />
Enterococcus spp., 150<br />
L. monocytogenes, 150, 580<br />
P. aeruginosa, 580<br />
S. aureus, 580<br />
S. epidermidis, 580<br />
Staphylococcus sop., 150<br />
Streptococcus spp., 150, 580<br />
DuP 721<br />
B. fragilis, 580<br />
Clostridium spp., 580<br />
comparative activity<br />
amoxicillin-clavulanic acid,<br />
cephalexin, teicoplanin, <strong>and</strong> vancomycin,<br />
580<br />
ampicillin, cefaclor, ciprofloxacin,<br />
erythromycin, <strong>and</strong> vancomycin,<br />
150<br />
Corynebacterium group JK, 580<br />
E. faecalis, 580<br />
Enterobacteriaceae, 580<br />
Enterococcus spp., 150<br />
gram-positive bacteria, 1218<br />
L. monocytogenes, 150, 580<br />
mechanism of action, 1218<br />
P. aeruginosa, 580<br />
protein synthesis, 1218<br />
S. aureus, 580<br />
S. epidermidis, 580<br />
Staphylococcus spp., 150<br />
Streptococcus spp., 150, 580<br />
Dysgonic fermenter 2<br />
amikacin, 78<br />
aztreonam, 78<br />
cefam<strong>and</strong>ole, 78<br />
cefazolin, 78<br />
cefoperazone, 78<br />
cefotaxime, 78<br />
ceftazidime, 78<br />
chloramphenicol, 78<br />
ciprofloxacin, 78<br />
clindamycin, 78<br />
erythromycin, 78<br />
gentamicin, 78<br />
imipenem, 78<br />
methicillin, 78<br />
penicillin G, 78<br />
piperacillin, 78<br />
rifampin, 78<br />
ticarcillin, 78<br />
trimethoprim-sulfamethoxazole, 78<br />
vancomycin, 78<br />
E1040<br />
Acinetobacter spp., 693<br />
Bacteroides spp., 1666<br />
P-lactamases, 1666<br />
C. freundii, 693<br />
Citrobacter spp., 1666<br />
comparative activity<br />
cefazolin, cefmenoxime, cefotiam,<br />
ceftazidime, <strong>and</strong> methicillin,<br />
693<br />
cefepime, cefpirome, ceftazidime,<br />
gentamicin, <strong>and</strong> imipenem,<br />
1666<br />
E. aerogenes, 693<br />
E. cloacae, 693<br />
E. coli, 693<br />
Enterobacter spp., 1666<br />
Enterobacteriaceae, 693, 1666<br />
Haemophilus spp., 1666<br />
Morganella spp., 1666<br />
Neisseria spp., 1666<br />
P. aeruginosa, 693, 1666<br />
P. cepacia, 1666<br />
Pseudomonas spp., 1666<br />
Serratia spp., 1666<br />
Staphylococcus spp., 1666<br />
Streptococcus spp., 1666<br />
X. maltophilia, 1666<br />
E-3846<br />
comparative activity<br />
ciprofloxacin <strong>and</strong> norfloxacin, 636<br />
cystitis, 636<br />
E. coli, 636<br />
Enterobacteriaceae, 636<br />
K. pneumoniae, 636<br />
P. aeruginosa, 636<br />
P. mirabilis, 636<br />
pyelonephritis, 636<br />
S. faecalis, 636<br />
Staphylococcus spp., 636<br />
Ehrlichia risticii<br />
demeclocycline, 986<br />
doxycycline, 986<br />
erythromycin, 986<br />
minocycline, 986<br />
nalidixic acid, 986<br />
oxytetracycline, 986<br />
rifampin, 986<br />
tetracycline, 986<br />
Eikenella corrodens<br />
clindamycin, 1521<br />
neutrophil killing, 1521<br />
R plasmid, 765<br />
tetracycline resistance, 765<br />
Encephalomyocarditis virus<br />
P-536, 1257<br />
Endocarditis<br />
amikacin-ceftazidime, 231<br />
cefam<strong>and</strong>ole, 63<br />
cefazolin, 63, 262<br />
ceftazidime-amikacin, 231<br />
ciprofloxacin, 747<br />
daptomycin, 63, 141, 877<br />
daptomycin-gentamicin, 877<br />
difloxacin, 262<br />
enoxacin, 262<br />
fosfomycin, 919<br />
fosfomycin-pefloxacin, 919<br />
gentamicin-daptomycin, 877<br />
gentamicin-penicillin G procaine, 877<br />
gentamicin-vancomycin, 877<br />
P. aeruginosa, 231<br />
pefloxacin, 231, 919<br />
pefloxacin-fosfomycin, 919<br />
penicillin G, 141<br />
penicillin G procaine, 877<br />
penicillin G procaine-gentamicin, 877<br />
S. aureus, 262, 747, 919<br />
S. epidermidis, 63<br />
S. faecalis, 877<br />
Streptococcus spp., 141<br />
vancomycin, 63, 877<br />
vancomycin-gentamicin, 877<br />
Endomyometritis<br />
cesarean section, 853<br />
clindamycin-gentamicin, 853<br />
gentamicin-clindamycin, 853<br />
moxalactam, 853<br />
treatment cost analysis, 853<br />
Enoxacin<br />
B. fragilis, 1437<br />
bite wound bacteria, 1143<br />
SUBJECT INDEX xvii<br />
Bordetella spp., 137<br />
C. trachomatis, 1080<br />
comparative activity<br />
amifloxacin, ciprofloxacin, norfloxacin,<br />
<strong>and</strong> ofloxacin, 928<br />
cefazolin <strong>and</strong> difloxacin, 262<br />
endocarditis, 262<br />
Haemophilus spp., 147<br />
high-pressure liquid chromatography,<br />
834<br />
Nocardia spp., 1078<br />
osteomyelitis, 834<br />
P. falciparum, 1182<br />
P. pseudomallei, 928<br />
prostatic tissue concentrations, 1433<br />
S. aureus, 262<br />
Shigella spp., 20<br />
Entamoeba histolytica<br />
B. javanica, 1725<br />
quassinoids, 1725<br />
S. amara, 1725<br />
Enterobacter aerogenes<br />
E1040, 693<br />
R-3746, 671<br />
R plasmid, 9<br />
tigemonam, 84<br />
Enterobacter cloacae<br />
amdinocillin, 1632<br />
ceftazidime, 1632<br />
resistance, 1632<br />
ceftazidime-amdinocillin, 1632<br />
E1040, 693<br />
R-3746, 671<br />
tigemonam, 84<br />
YTR 830, 925<br />
Enterobacter spp.<br />
E-1040, 1666<br />
lomefloxacin, 656<br />
PD 117,596, 1450<br />
tigemonam, 84<br />
Enterobacteriaceae<br />
A-61827, 27<br />
6'-N-acetyltransferase type 4, 1289<br />
amikacin, 873<br />
resistance, 1289<br />
aminoglycoside resistance, 1289<br />
amoxicillin-clavulanic acid, 873<br />
ampicillin, 873<br />
P-lactamases, 1365<br />
carumonam, 1593<br />
cefixime, 1896<br />
cefotaxime, 873<br />
cefoxitin, 873<br />
cefpodoxime, 1896<br />
ceftibuten, 1576<br />
ceftriaxone, 1896<br />
cephalothin, 873<br />
chloramphenicol, 873<br />
chlorhexidine digluconate, 873<br />
ciprofloxacin, 1327<br />
colistin, 873<br />
CS-807, 1082<br />
doxycycline, 873<br />
DuP 105, 580<br />
DuP 721, 580<br />
E1040, 693, 1666<br />
E-3846, 636<br />
fluoroquinolone resistance, 1285<br />
gentamicin, 873<br />
iodine alcohol, 873<br />
lomefloxacin, 617<br />
PD 127,391, 1251<br />
polyvinylpyrrolidone, 873
xviii SUBJECT INDEX<br />
R plasmid, 1289<br />
sodium hypochlorite, 873<br />
susceptibility testing, 1365<br />
T-3262, 663, 827<br />
ticarcillin, 873<br />
ticarcillin-potassium clavulanate resistance,<br />
1365<br />
tigemonam, 84<br />
tobramycin, 873<br />
trimethoprim, 873<br />
trimethoprim-sulfamethoxazole, 1327<br />
trospectomycin, 216<br />
U-76,252, 1082<br />
U-76,253A, 443<br />
urinary tract infections, 1327<br />
Enterococcus faecalis<br />
CS-807, 1082<br />
daptomycin, 24<br />
DuP 105, 580<br />
DuP 721, 580<br />
fluoroquinolone resistance, 1285<br />
T-3262, 663<br />
U-76,252, 1082<br />
Enterococcus faecium<br />
daptomycin, 24<br />
norfloxacin, 1869<br />
Enterococcus spp.<br />
Campylobacter resistance gene, 1793<br />
cefixime, 18%<br />
cefpodoxime, 1896<br />
ceftriaxone, 18%<br />
clindamycin, 1769<br />
clindamycin-streptomycin, 1769<br />
daptomycin, 279<br />
DuP 105, 150<br />
DuP 721, 150<br />
intestinal colonization <strong>and</strong> translocation,<br />
1769<br />
metronidazole, 1769<br />
metronidazole-streptomycin, 1769<br />
PD 117,5%, 1450<br />
R-3746, 671<br />
R plasmids, 1793<br />
S-6123, 1341<br />
T-3262, 827<br />
tigemonam, 84<br />
translocation, 1769<br />
U-76,253A, 443<br />
Enviroxime<br />
aerosol, 890<br />
liposomes, 890<br />
rhinoviruses, 890<br />
toxicity, 890<br />
Enzyme immunoassays<br />
Chlamydiazyme, 1350<br />
Enzyme-linked immunosorbent assays<br />
T. gondii, 303<br />
Epidermophyton floccosum<br />
G2, 1586<br />
Epstein-Barr virus<br />
acyclovir, 1068<br />
acyclovir-AZT, 265<br />
1-P-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil,<br />
1068<br />
3'-azido-3'-deoxythymidine, 265<br />
3'-azido-3'-deoxythymidine-acyclovir,<br />
265<br />
AZT, 265<br />
AZT-acyclovir, 265<br />
E-5-(2-bromovinyl)-2'-deoxyuridine, 1068<br />
bromovinyl nucleoside analogs, 1068<br />
Ergosterol<br />
C. albicans, 702<br />
Erythromycin<br />
acistrate<br />
tonsillar <strong>and</strong> plasma concentrations,<br />
1019<br />
Arthrobacter spp., 420<br />
B. bronchiseptica, 1891<br />
B. catarrhalis, 259<br />
Bacillus spp., 642<br />
base<br />
toxicity, 1541<br />
uptake <strong>and</strong> distribution, 1541<br />
Bordetella spp., 137<br />
C. trachomatis, 1350<br />
Chlamydia sp. strain TWAR, 257<br />
combinations<br />
ciprofloxacin, 1392<br />
ethambutol, 1392<br />
M. avium complex, 1392<br />
rifampin, 1392<br />
comparative activity, 1710<br />
clarithromycin <strong>and</strong> roxithromycin,<br />
1758<br />
demeclocycline, doxycycline, minocycline,<br />
nalidixic acid, oxytetracycline,<br />
rifampin, <strong>and</strong> tetracycline,<br />
986<br />
mupirocin, 1780<br />
dysgonic fermenter 2, 78<br />
E. risticii, 986<br />
H. ducreyi, 1458<br />
H. influenzae, 180<br />
impetigo, 1780<br />
M. leprae, 1758<br />
N. asteroides, 1776<br />
P. multocida, 213<br />
R. conorii, 255<br />
R. rickettsii, 255<br />
S. faecalis resistance, 547<br />
Staphylococcus spp., 420<br />
stearate<br />
tonsillar <strong>and</strong> plasma concentrations,<br />
1019<br />
T. pallidum, resistant, 164<br />
Erythromycin estolate<br />
B. catarrhalis, 1227<br />
comparative activity<br />
erythromycin ethylsuccinate, 1227<br />
high-pressure liquid chromatography,<br />
561<br />
pharmacokinetics, 561<br />
plasma bactericidal activity, 1227<br />
Streptococcus spp., 1227<br />
toxicity, 1541<br />
uptake <strong>and</strong> distribution, 1541<br />
Erythromycin ethylsuccinate<br />
B. catarrhalis, 1227<br />
comparative activity<br />
erythromycin estolate, 1227<br />
high-pressure liquid chromatography,<br />
561<br />
pharmacokinetics, 561<br />
plasma bactericidal activity, 1227<br />
Streptococcus spp., 1227<br />
Erythromycin-sulfisoxazole<br />
B. catarrhalis, 259<br />
Erythromycylamine<br />
comparative activity, 1710<br />
Escherichia coli<br />
A-61827, 27<br />
ampicillin, 450, 552<br />
aztreonam, 552<br />
berberine sulfate, 1274<br />
,-lactamase, 1243<br />
ANTIMICROB. AGENTS CHEMOTHER.<br />
biofilms<br />
radiochemical method, 770<br />
2-bromo-2-nitropropane-1,3-diol, 1693<br />
bronopol, 1693<br />
cefotaxime-chloramphenicol, 1375<br />
cefoxitin, 1511<br />
cefpirome, 13%<br />
ceftizoxime, 1511<br />
ceftriaxone, 552<br />
ceftriaxone-chloramphenicol, 1375<br />
cephalosporins<br />
catechol substituted, 1879<br />
3-chlorodiaminopimelic acid, 1119<br />
ciprofloxacin, 450<br />
cloning of P. maltophilia ,B-lactamase<br />
operon, 819<br />
CS-807, 1082<br />
cystitis, 636, 1640<br />
diaminopimelic acid epimerase, 1119<br />
DNA synthesis, 1113<br />
E1040, 693<br />
E-3846, 636<br />
etoposide, 1456<br />
gentamicin, 552<br />
hypersusceptible<br />
gentamicin, 308<br />
lipopolysaccharide polycation affinity<br />
<strong>and</strong> binding, 308<br />
polymyxin, 308<br />
spermine, 308<br />
imipenem sub-MICs<br />
killing, 1012<br />
phagocytosis, 1012<br />
serum sensitivity, 1012<br />
in vitro simulation of serious infections,<br />
552<br />
lipopolysaccharide<br />
amikacin, 1247<br />
gentamicin, 1247<br />
kanamycin, 1247<br />
spectinomycin, 1247<br />
tobramycin, 1247<br />
lomefloxacin, 656<br />
LY163892, 268<br />
M14659, 1648<br />
ME1207, 1421<br />
mixed infection with B. fragilis<br />
amoxicillin-clavulanic acid, 1830<br />
ampicillin-sulbactam, 1830<br />
norfloxacin, 1292<br />
endogenous active efflux, 1187<br />
ofloxacin, 1640<br />
outer membrane proteins<br />
iron regulated, 1879<br />
oxyimino-cephalosporins, 1243<br />
Pap fimbrial adhesion, 1274<br />
PD 117,5%, 1450<br />
permeability, increased<br />
anesthetics, 153<br />
chlorpronmazine, 153<br />
dibucaine, 153<br />
procaine, 153<br />
quinine, 153<br />
tetracaine, 153<br />
postantibiotic effect, 450<br />
pyelonephritis, 636<br />
quinolone permeation, 438<br />
quinolones, 1113<br />
R-3746, 671<br />
R plasmids, 9, 1243, 1552<br />
S-6123, 1341<br />
sensitization by heat treatment<br />
chloramphenicol, 1680
VOL. 32, 1988<br />
crystal violet, 1680<br />
fatty acids, 1680<br />
malachite green, 1680<br />
p-hydroxybenzoic acid, 1680<br />
rifampin, 1680<br />
tylosin, 1680<br />
vancomycin, 1680<br />
T-3262, 663, 827<br />
tigemonam, 84, 346<br />
tobramycin, 450<br />
trimethoprim-sulfamethoxazole,<br />
1640<br />
U-76,252, 1082<br />
urinary tract infections, 1274<br />
YTR 830, 925<br />
Ethambutol<br />
combinations<br />
ciprofloxacin, 1392<br />
clofazimine, 1392<br />
erythromycin, 1392<br />
M. avium complex, 1392<br />
rifabutin, 1392<br />
rifampin, 1392<br />
M. tuberculosis, 1208, 1441<br />
Ethidium<br />
P. carinii, 896<br />
Ethidium bromide<br />
S. aureus resistance, 932<br />
Ethionamide<br />
M. avium, 1131<br />
Etoposide<br />
B. stearothermophilus, 1456<br />
B. subtilis, 1456<br />
comparative activity<br />
cloxacillin, 1456<br />
E. coli, 1456<br />
K. pneumoniae, 1456<br />
P. aeruginosa, 1456<br />
S. aureus, 1456<br />
S. lutea, 1456<br />
S. sanguis, 1456<br />
Eubacterium spp.<br />
daptomycin, 788<br />
paldimycin, 788<br />
tetracycline<br />
resistance, 1271<br />
Fagara zanthoxyloides<br />
B. gingivalis, 598<br />
B. melaninogenicus, 598<br />
Fatty acids<br />
E. coli<br />
heat treatment, 1680<br />
M. avium complex, 400<br />
Fecal flora<br />
antimicrobial resistance, 1801<br />
Feces<br />
norfloxacin binding, 1869<br />
quinolone binding, 1869<br />
Fibronectin<br />
S. pyogenes, 1370<br />
Fleroxacin<br />
C. trachomatis, 1080<br />
high-pressure liquid chromatography,<br />
1515<br />
letter to the editor, 791<br />
pharmacokinetics, 1515<br />
S. typhimurium, 791<br />
Flucloxacillin<br />
open-heart surgery, 930<br />
Fluconazole<br />
C. albicans, 209, 1859<br />
coccidioidal meningitis, 369<br />
comparative activity<br />
ketoconazole, 209, 646<br />
denture stomatitis, 1859<br />
meningitis, coccidioidal, 369<br />
pharmacokinetics, 209, 369<br />
stomatitis, denture, 1859<br />
testosterone, 646<br />
2-Fluoro-L-histidine<br />
P. falciparum, 1655<br />
Fluoroquinolones<br />
B. fragilis, 1437<br />
resistance, development of, 1285<br />
Fluorovinylglycine<br />
comparative activity, 319<br />
gram-positive bacteria, 319<br />
Staphylococcus spp., 319<br />
Flurithromycin<br />
comparative activity, 1710<br />
pharmacokinetics, 1875<br />
Folate pathway<br />
bacterial adhesion, 1609<br />
minireview, 1609<br />
Folic acid antagonists<br />
T. vaginalis, 144<br />
Foscarnet<br />
guinea pig embryonic fibroblasts, 1533<br />
herpes simplex virus type 1, 1533<br />
human immunodeficiency virus type 1,<br />
1733<br />
human immunodeficiency virus type 2,<br />
1733<br />
simian immunodeficiency virus, 1733<br />
Fosfomycin<br />
calcium<br />
pharmacokinetics, 938<br />
young <strong>and</strong> elderly adults, 938<br />
combinations<br />
endocarditis, 919<br />
pefloxacin, 919<br />
S. aureus, 919<br />
endocarditis, 919<br />
glutathione adduct, 1552<br />
plasmid-borne resistance, 1552<br />
S. aureus, 919<br />
tromethamine<br />
pharmacokinetics, 938<br />
young <strong>and</strong> elderly adults, 938<br />
Fucoidan<br />
cytomegalovirus, 1742<br />
herpes simplex virus, 1742<br />
human immunodeficiency virus, 1742<br />
vesicular stomatitis virus, 1742<br />
Furazolidone<br />
T. vaginalis, 144<br />
Fusobacterium nucleatum<br />
tetracycline<br />
resistance, 1271<br />
G2 E. floccosum, 1586<br />
Microsporum spp., 1586<br />
structure, 1586<br />
toxicity, 1586<br />
Trichophyton spp., 1586<br />
GABA receptor<br />
diclofenac, 1624<br />
quinolones, 1624<br />
theophylline, 1624<br />
f-Galactosidase<br />
P. chryosogenum<br />
glucokinase-deficient mutant, 1061<br />
SUBJECT INDEX xix<br />
y-Aminobutyric acid receptor<br />
diclofenac, 1624<br />
quinolones, 1624<br />
theophylline, 1624<br />
Ganciclovir<br />
cochlear pathophysiology, 865<br />
cytomegalovirus, 865<br />
high-pressure liquid chromatography,<br />
865<br />
labyrinthitis, 865<br />
marrow transplantation, 271<br />
pharmacokinetics, 1899<br />
Gene probes<br />
3-V-acetyltransferase, 1834<br />
Gentamicin<br />
A. denitrificans subsp. xylosoxidans, 276<br />
B. bronchiseptica, 1891<br />
B. catarrhalis, 259<br />
Bacillus spp., 642<br />
cerebrospinal fluid penetration, 1034<br />
cochlear binding sites, 467<br />
combinations<br />
ciprofloxacin, 782<br />
clindamycin, 853<br />
cost analysis, 853<br />
daptomycin, 81<br />
endomyometritis, 853<br />
P. maltophilia, 782<br />
pyelonephritis, 81<br />
S. faecalis, 81<br />
comparative activity<br />
carumonam, 473<br />
chloramphenicol <strong>and</strong> ciprofloxacin,<br />
285<br />
dysgonic fermenter 2, 78<br />
E. coli, 308, 552<br />
lipopolysaccharide, 1247<br />
Enterobacteriaceae, 873<br />
fecal flora resistance, 1801<br />
H. influenzae, 1034<br />
in vitro simulation of serious infections,<br />
552<br />
K. pneumoniae resistance, 1379<br />
meningitis, 1034<br />
N. asteroides, 1776<br />
nephrotoxicity<br />
hydrocortisone, influence of, 992<br />
piperacillin protective effect, 912<br />
P. aeruginosa, 552<br />
P. carinii, 896<br />
P. maltophilia, 782<br />
pharmacokinetics, 467, 736<br />
pyelonephritis, 81, 736<br />
S. aureus resistance, 932, 1174<br />
S. faecalis, 81, 736<br />
resistance, 547, 1528<br />
S. marcescens resistance, 1379<br />
S. pneumoniae, 552<br />
scrub typhus, 285<br />
Shigella spp., 20<br />
sodium hydroxide digestion method, 595<br />
T. vaginalis, 1323<br />
urinary tract infections, 473<br />
Gentamicin-clindamycin<br />
comparative activity<br />
cost analysis, 853<br />
moxalactam, 853<br />
endomyometritis, 853<br />
Giardia lamblia<br />
5-methylthioribose analogs, 1904<br />
(1-3)-p-D-Glucan synthase<br />
C. albicans, 1901<br />
cilofungin, 1901
xx SUBJECT INDEX<br />
Glucose<br />
avermectin production, 282<br />
Glutathione<br />
adduct formation, 1552<br />
fosfomycin modification, 1552<br />
GMP<br />
guinea pig embryonic fibroblasts, 1533<br />
herpes simplex virus type 1, 1533<br />
Gonorrhea<br />
cefodizime, 426<br />
cefotaxime, 426<br />
imipenem-cilastatin, 773<br />
spectinomycin<br />
disk zone diameter as predictor of outcome,<br />
775<br />
Gram-negative bacteria<br />
cefotaxime-chloramphenicol, 1375<br />
ceftriaxone-chloramphenicol, 1375<br />
cephalexin hydrochloride, 882<br />
cephalexin monohydrate, 882<br />
norfloxacin, 1292<br />
PD 127,391, 1278<br />
S-6123, 1341<br />
susceptibility testing, 385<br />
Gram-positive bacteria<br />
cyclohexane triones, 814<br />
DuP 721, 1218<br />
halovinylglycine compounds, 319<br />
L-norvalyl peptide derivatives, 319<br />
norfloxacin, 1292<br />
PD 127,391, 1278<br />
Guanosine analogs<br />
guinea pig embryonic fibroblasts, 1533<br />
herpes simplex virus type 1, 1533<br />
Haemophilus ducreyi<br />
A-56268, 1458<br />
amoxicillin, 1458<br />
amoxicillin-clavulanic acid, 1458<br />
cefotaxime, 1458<br />
cefoxitin, 1458<br />
ceftetrame, 1458<br />
ceftriaxone, 1458<br />
chloramphenicol, 1458<br />
ciprofloxacin, 723, 1458<br />
co-trimoxazole, 1458<br />
difloxacin, 1458<br />
doxycycline, 1458<br />
erythromycin, 1458<br />
kanamycin, 1458<br />
minocycline, 1458<br />
penicillin, 1458<br />
rifampin, 1458<br />
rosoxacin, 1458<br />
spectinomycin, 1458<br />
sulfamethoxazole, 1458<br />
tetracycline, 1458<br />
thiamphenicol, 1458<br />
trimethoprim, 1458<br />
trimethoprim-sulfamethoxazole, 1458<br />
Haemophilus influenzae<br />
A-61827, 27<br />
ampicillin, 180<br />
azithromycin, 752<br />
P-lactamase, 180<br />
cefaclor, 180<br />
cefam<strong>and</strong>ole, 180<br />
cefixime, 1896<br />
cefpodoxime, 1896<br />
ceftibuten, 1576<br />
ceftriaxone, 1896<br />
cephalexin, 180<br />
cephalothin, 180<br />
chloramphenicol<br />
acetyltransferase, 180<br />
conjunctivitis, 1820<br />
CS-807, 1082<br />
cyclohexane triones, 814<br />
erythromycin, 180<br />
gentamicin, 1034<br />
lomefloxacin, 617, 656<br />
LY163892, 131, 268<br />
ME1207, 1421<br />
meningitis, 1034<br />
minireview, 1747<br />
norfloxacin, 1820<br />
ocular infections, 1820<br />
PD 127,391, 1251<br />
penicillin G, 498<br />
penicillin-binding proteins, 498<br />
R-3746, 671<br />
rifampin, 180<br />
S-6123, 1341<br />
sulfisoxazole, 180<br />
susceptibility testing, 1747<br />
chloramphenicol, 1484<br />
T-3262, 663<br />
tetracycline, 180<br />
tobramycin, 1820<br />
trimethoprim resistance, 477<br />
trimethoprim-sulfamethoxazole, 180<br />
trospectomycin, 216<br />
U-76,252, 1082<br />
U-76,253A, 443<br />
Haemophilus spp.<br />
ciprofloxacin, 147<br />
E-1040, 1666<br />
enoxacin, 147<br />
norfloxacin, 147<br />
ofloxacin, 147<br />
PD 117,596, 1450<br />
pefloxacin, 147<br />
tigemonam, 84<br />
Halovinylglycine compounds<br />
alanine racemase, 319<br />
comparative activities, 319<br />
gram-positive bacteria, 319<br />
L-norvalyl peptide derivatives, 319<br />
Staphylococcus spp., 319<br />
Head <strong>and</strong> neck surgery<br />
cancer patients, 1557<br />
clindamycin-amikacin, 1557<br />
ticarcillin-clavulanic acid, 1557<br />
Herpes simplex virus<br />
carrageenans, 1742<br />
dextran sulfate, 1742<br />
fucoidan, 1742<br />
pentosan polysulfate, 1742<br />
sulfated polysaccharides, 1742<br />
Herpes simplex virus type I<br />
A723U, 1100<br />
acyclovir, 1100, 1533<br />
monophosphate, 1533<br />
9-p-D-arabinofuranosyladenine, 1046<br />
I -,-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil,<br />
1547<br />
1-0-D-arabinofuranosyl-E-(2-bromovinyl)<br />
uracil, 1046<br />
I-P-D-arabinofuranosylthymine, 1046<br />
3-azido-3'-deoxythymidine, 265<br />
AZT, 265<br />
B-220, 1720<br />
BRL 39123, 358<br />
bromovinyldeoxyuridine, 1533<br />
buciclovir, 1533<br />
ANTIMICROB. AGENTS CHEMOTHER.<br />
monophosphate, 1533<br />
2,3,dimethyl(dimethylaminoethyl)SHindolo-(2,3-b)quinoxaline,<br />
1720<br />
foscarnet, 1533<br />
GMP, 1533<br />
guanosine analogs, 1533<br />
9-4-(hydroxy-3-hydroxymethylbut-1 -yl)<br />
guanine, 358<br />
9-(2-hydroxyethoxymethyl)guanine, 1046<br />
indoloquinoxaline derivatives, 1720<br />
5-iodo-2'-deoxyuridine, 1046<br />
iododeoxyuridine, 1533<br />
P-536, 1257<br />
pyrimidine deoxynucleotide metabolism,<br />
1100<br />
ribonucleotide reductase inhibition,<br />
1100<br />
Herpes simplex virus type 2<br />
1-P-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil,<br />
1547<br />
3'-azido-3'-deoxythymidine, 265<br />
AZT, 265<br />
BRL 39123, 358<br />
9-4-(hydroxy-3-hydroxymethylbut-1-yl)<br />
guanine, 358<br />
phosphonoacetate, 858<br />
phosphonoformate, 858<br />
Hexadecane<br />
S. pyogenes, 1370<br />
High-performance liquid chromatography<br />
amphotericin B, 1103<br />
carbapenem labeling, 186<br />
cefonicid, 485<br />
cefpiramide, 1360<br />
cefpirome, 1481<br />
ceftazidime, 1845<br />
clindamycin, 1825<br />
itraconazole, 1310<br />
lomefloxacin, 1503, 1508<br />
reuterin, 1854<br />
High-pressure liquid chromatography<br />
carumonam, 354<br />
cefoperazone-ceftazidime, 298<br />
ceftazidime-cefoperazone, 298<br />
ciprofloxacin, 1537<br />
enoxacin, 834<br />
erythromycin estolate, 561<br />
erythromycin ethylsuccinate, 561<br />
fleroxacin, 1515<br />
ganciclovir, 865<br />
trimetrexate, 324<br />
Histidine analogs<br />
P. falciparum, 1655<br />
±2HM-HBG<br />
pharmacokinetics, 1807<br />
simian varicella-zoster virus, 1807<br />
Home parenteral therapy<br />
ceftriaxone, 1439<br />
HPA-23<br />
acquired immune deficiency syndrome,<br />
1300<br />
(S)-HPMPA<br />
influenza viruses, 906<br />
(S)-HPMPC<br />
cytomegalovirus, 1839<br />
HRE 664<br />
comparative activity<br />
aztreonam, ceftazidime, ceftriaxone,<br />
imipenem, piperacillin, <strong>and</strong> Sch<br />
34343, 1090<br />
Human granulocytes<br />
P. aeruginosa<br />
moxalactam-induced filamentous
VOL. 32, 1988<br />
forms, 1565<br />
Human immunodeficiency virus<br />
carrageenans, 1742<br />
dextran sulfate, 1742<br />
fucoidan, 1742<br />
pentosan polysulfate, 1742<br />
phosphonylmethoxyethyl purines, 1025<br />
reverse transcriptase, 1887<br />
sulfated polysaccharides, 1742<br />
Human immunodeficiency virus type 1<br />
3'-azido-3'-deoxythymidine, 1784<br />
triphosphate, 1733<br />
AZT, 1784<br />
triphosphate, 1733<br />
AZT-isoprinosine, 1784<br />
cell cultures, 684<br />
foscarnet, 1733<br />
isoprinosine, 1784<br />
isoprinosine-AZT, 1784<br />
reverse transcriptase, 684, 1733<br />
rifabutin, 684<br />
virus-antigen assay, 684<br />
Human immunodeficiency virus type 2<br />
3'-azido-3'-deoxythymidine triphosphate,<br />
1733<br />
AZT triphosphate, 1733<br />
foscarnet, 1733<br />
reverse transcriptase, 1733<br />
Human renal dehydropeptidase I<br />
purification <strong>and</strong> characterization, 587<br />
Hydrocortisone<br />
nephrotoxicity, gentamicin induced, 992<br />
9-[4-Hydroxy-2(hydroxymethyl)butyl]<br />
guanine triphosphate<br />
DNA polymerases, 1137<br />
varicella-zoster virus, 1137<br />
(R,S)-9-[4-Hydroxy-2-(hydroxymethyl)<br />
butyl]guanine<br />
pharmacokinetics, 1807<br />
simian varicella-zoster virus, 1807<br />
(S)-9-(3-Hydroxy-2-phosphonylmethoxypropyl)adenine<br />
influenza viruses, 906<br />
(S)- 1-(3-Hydroxy-2-phosphonylmethoxypropyl)cytosine<br />
comparative activity<br />
9-(1,3-dihydroxy-2-propoxymethyl)<br />
guanine, (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine,<br />
<strong>and</strong> phosphonoformate, 1839<br />
cytomegalovirus, 1839<br />
9-(4-Hydroxy-3-hydroxymethyl-1-yl)guanine<br />
comparative activity<br />
acyclovir, 358<br />
herpes simplex virus type 1, 358<br />
herpes simplex virus type 2, 358<br />
p-Hydroxybenzoic acids<br />
E. coli<br />
heat treatment, 1680<br />
2-Hydroxybenzoylglycine<br />
hyperbilirubinemia<br />
centrifugal ultrafiltration, 1571<br />
9-(2-hydroxyethoxymethyl)guanine<br />
herpes simplex virus type 1, 1046<br />
9-(2-Hydroxyethoxymethyl)guanine triphosphate<br />
DNA polymerases, 1137<br />
varicella-zoster virus, 1137<br />
Hyperbilirubinemia<br />
aztreonam, 1571<br />
carbenicillin, 1571<br />
cefoperazone, 1571<br />
ceftriaxone, 1571<br />
cefuroxime, 1571<br />
dicloxacillin, 1571<br />
2-hydroxybenzoylglycine, 1571<br />
kanamycin, 1571<br />
mezlocillin, 1571<br />
moxalactam, 1571<br />
nafcillin, 1571<br />
sulfamethoxazole, 1571<br />
sulfisoxazole, 1571<br />
Imidazoles<br />
T. vaginalis, 1323<br />
Imidocarb<br />
P. carinii, 896<br />
Imipenem<br />
A. denitrificans subsp. xylosoxidans, 276<br />
B. catarrhalis, 259<br />
Bacillus spp., 642<br />
combinations<br />
ciprofloxacin, 782<br />
P. maltophilia, 782<br />
comparative activity<br />
piperacillin, 1012<br />
dysgonic fermenter 2, 78<br />
M. morganii, 1385<br />
M. tuberculosis, 1441<br />
N. asteroides, 1776<br />
Nocardia spp., 1078<br />
P. aeruginosa resistance, 1267<br />
P. maltophilia, 782<br />
P. pseudomallei, 1435<br />
P. vulgaris, 1385<br />
sub-MICs<br />
E. coli, 1012<br />
killing, 1012<br />
phagocytosis, 1012<br />
S. aureus, 1012<br />
serum sensitivity, 1012<br />
Imipenem-cilastatin<br />
-y-aminobutyric acid binding, 758<br />
C. trachomatis, 773<br />
gonorrhea, 773<br />
N. gonorrhoeae, 773<br />
pentylenetetrazole convulsive threshold,<br />
758<br />
pharmacokinetics, 530<br />
Immunoblotting<br />
P. aeruginosa, 649<br />
Immunoglobulin, intravenous<br />
respiratory syncytial virus, 1269<br />
Impetigo<br />
erythromycin, 1780<br />
mupirocin, 1780<br />
Indoloquinoxaline<br />
derivatives, 1720<br />
herpes simplex virus type 1, 1720<br />
Influenza A virus<br />
alpha-2b interferon, 47<br />
Influenza B virus<br />
alpha-2b interferon, 47<br />
ribavirin small-particle aerosol, 761<br />
Influenza viruses<br />
(RS)-3-adenin-9-yl-2-hydroxypropanoic<br />
acid, 906<br />
(RS)-AHPA, 906<br />
carbocyclin 3-deazaadenosine, 906<br />
carbodine, 906<br />
5-chlorotubercidin, 906<br />
5-cyanoimidazole-4-carboxamide, 906<br />
5-cyano-1-,-D-ribofuranosyl-imidazole-4carboxamide,<br />
906<br />
cyclopentenyl cytosine, 906<br />
SUBJECT INDEX xxi<br />
3-deazaguanine, 906<br />
3-deazauridine, 906<br />
5'-deoxy-5-fluorouridine, 906<br />
(S)-DHIPA, 906<br />
(S)-9-(2,3-dihydroxypropyl)adenine, 906<br />
(S)-HPMPA, 906<br />
(S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine,<br />
906<br />
3-methylhypoxanthine, 906<br />
3'-C-methyluridine, 906<br />
neplanocin A, 900<br />
neplanocin C, 906<br />
P-536, 1257<br />
pyrazofurin, 906<br />
ribavirin, 906<br />
T-25, 906<br />
T-26, 906<br />
tubercidin, 906<br />
xylotubercidin, 906<br />
Inositol hexaphosphate<br />
B. microti, 391<br />
P. falciparum, 391<br />
Interferon<br />
alfa-2b, recombinant<br />
rhinovirus, 224<br />
alpha-2a, recombinant<br />
respiratory syncytial virus, 589<br />
cytomegalovirus, 678<br />
S26308, 678<br />
Intra-abdominal infections<br />
cefoperazone-sulbactam, 730<br />
Intravenous immunoglobulin<br />
respiratory syncytial virus, 1269<br />
Iodine alcohol<br />
Enterobacteriaceae, 873<br />
5-Iodo-2'-deoxyuridine<br />
herpes simplex virus type 1, 1046<br />
Iododeoxyuridine<br />
guinea pig embryonic fibroblasts, 1533<br />
herpes simplex virus type 1, 1533<br />
2-Iodo-L-histidine<br />
P. falciparum, 1655<br />
lontophoresis<br />
tobramycin, 978<br />
Ipratropium bromide<br />
rhinovirus, 1644<br />
Isoelectric focusing<br />
,B-lactamases, 397, 1730<br />
comparative studies, 397<br />
PhastSystem, 1730<br />
Isometamidium<br />
P. carinii, 896<br />
Isoniazid<br />
M. avium, 1131<br />
M. tuberculosis, 1208, 1441<br />
Isoprinosine<br />
combinations<br />
3'-azido-3'-deoxythymidine, 1784<br />
AZT, 1784<br />
human immunodeficiency virus type 1,<br />
1984<br />
human immunodeficiency virus type 1,<br />
1984<br />
Itraconazole<br />
high-performance liquid chromatography,<br />
1310<br />
pharmacokinetics, 1310, 1595<br />
renal dysfunction, 1595<br />
S. schenckii, 1619<br />
sporotrichosis, 1619
xxii SUBJECT INDEX<br />
Jasplakinolide<br />
antifungal agents, 1154<br />
C. albicans, 1154<br />
C<strong>and</strong>ida spp., 1154<br />
comparative activity<br />
clotrimazole <strong>and</strong> miconazole, 1154<br />
Josamycin<br />
Arthrobacter spp., 420<br />
C. trachomatis, 1350<br />
comparative activity, 1710<br />
R. conorii, 255<br />
R. rickettsii, 255<br />
Staphylococcus spp., 420<br />
Kanamycin<br />
B. bronchiseptica, 1891<br />
C. coli resistance, 1170<br />
C. jejuni resistance, 1170<br />
Campylobacter resistance, 945<br />
E. coli<br />
lipopolysaccharide, 1247<br />
fecal flora resistance, 1801<br />
H. ducreyi, 1458<br />
hyperbilirubinemia<br />
centrifugal ultrafiltration, 1571<br />
K. pneumoniae resistance, 1379<br />
M. avium, 1131<br />
N. asteroides, 1776<br />
S. aureus resistance, 932<br />
S. marcescens resistance, 1379<br />
Shigella spp., 20<br />
Keratitis<br />
P. aeruginosa, 978<br />
tobramycin, 978<br />
Ketoconazole<br />
C. albicans, 209<br />
combinations<br />
SF 86-327, 1237<br />
T. (S.) cruzi, 1237<br />
comparative activity<br />
fluconazole, 209<br />
pharmacokinetics, 209<br />
T. (S.) cruzi, 1237<br />
T. vaginalis, 1323<br />
testosterone, 646<br />
Kingella denitrificans<br />
R plasmid, 765<br />
tetracycline resistance, 765<br />
Klebsiella aerogenes<br />
YTR 830, 925<br />
Klebsiella pneumoniae<br />
amikacin resistance, 1379<br />
transposon mediated, 1416<br />
P-lactam resistance, 1660<br />
,-lactamases, 626, 1660<br />
cephaloridine, 364<br />
cephalosporin resistance, 1660<br />
CGP 17520, 364<br />
cystitis, 636<br />
E-3846, 636<br />
etoposide, 1456<br />
gentamicin resistance, 1379<br />
kanamycin resistance, 1379<br />
lomefloxacin, 656<br />
meningitis, 1705<br />
netilmicin resistance, 1379<br />
plasmids, 1660<br />
pyelonephritis, 636<br />
R-3746, 671<br />
R plasmid, 9, 626, 1379, 1416<br />
surface protein antigens, 364<br />
temocillin, 1705<br />
tobramycin resistance, 1379<br />
Klebsiella spp.<br />
CS-807, 1082<br />
PD 117,596, 1450<br />
tigemonam, 84<br />
U-76,252, 1082<br />
Labyrinthitis<br />
cytomegalovirus, 865<br />
ganciclovir, 865<br />
Lactobacillus reuteri<br />
production <strong>and</strong> isolation of reuterin,<br />
1854<br />
Lactobacillus spp.<br />
daptomycin, 788<br />
paldimycin, 788<br />
Legionella pneumophila<br />
A-61827, 27<br />
azithromycin, 752<br />
carumonam, 1593<br />
PD 117,596, 1450<br />
Legionella spp.<br />
NY-198, 1427<br />
Legionnaires disease<br />
NY-198, 1427<br />
Letters to the editor<br />
antacids<br />
ciprofloxacin pharmacokinetics, 949<br />
B. subtilis<br />
streptomycin adenylyltransferase, 949<br />
ciprofloxacin<br />
antacids, 949<br />
pharmacokinetics, 949<br />
common cold therapy, 605, 606, 608<br />
Cryptosporidium sp., 1907<br />
fleroxacin, 791<br />
in vitro simulation of serious infections,<br />
1600<br />
M. tuberculosis, 287<br />
N. gonorrhoeae<br />
P-lactamase, 158<br />
R plasmid, 158<br />
tetracycline resistance, 951<br />
pharmacokinetics<br />
ciprofloxacin, 949<br />
puerperal infections, 407<br />
pyrazinamide, 287<br />
S. aureus, 1464<br />
S. typhimurium, 791<br />
streptomycin<br />
B. subtilis adenylyltransferase, 949<br />
sulfadimethoxine, 1907<br />
susceptibility testing, 1464<br />
tetracycline<br />
N. gonorrhoeae resistance, 951<br />
ticarcillin-clavulanic acid, 407<br />
zinc for common cold, 605, 606, 608<br />
pH <strong>and</strong> free ion concentration, 608<br />
stability constants, 606<br />
Lidocaine<br />
ceftriaxone reconstitution, 1439<br />
Lincomycin<br />
Arthrobacter spp., 420<br />
Staphylococcus spp., 420<br />
Lincosamides<br />
Arthrobacter resistance, 420<br />
Staphylococcus resistance, 420<br />
Lipid X<br />
pharmacokinetics, 37<br />
Lipopolysaccharides<br />
E. coli<br />
amikacin, 1247<br />
ANTIMICROB. AGENTS CHEMOTHER.<br />
gentamicin, 1247<br />
kanamycin, 1247<br />
spectinomycin, 1247<br />
tobramycin, 1247<br />
Liposomes<br />
amikacin<br />
M. avium-M. intracellulare, 1404<br />
ampicillin, 1560<br />
enviroxime, 890<br />
L. monocytogenes, 1560<br />
lipid composition, 1560<br />
phosphonoacetate, 858<br />
phosphonoformate, 858<br />
stearylamine-phosphatidylcholine, 966<br />
T. b. gambiense, 966<br />
Liposome-swelling assay<br />
P. aeruginosa, 1267<br />
Listeria monocytogenes<br />
ampicillin, 1204<br />
nanoparticle polyisohexylcyanoacrylate-bound,<br />
1204<br />
ampicillin, liposome entrapped<br />
lipid composition, 1560<br />
azithromycin, 752<br />
DuP 105, 150, 580<br />
DuP 721, 150, 580<br />
Listeria spp.<br />
tigemonam, 84<br />
Lomefloxacin<br />
B. fragilis, 617<br />
Branhamella spp., 656<br />
comparative activity<br />
amoxicillin, ciprofloxacin, cefuroxime,<br />
fleroxacin, ofloxacin, <strong>and</strong> trimethoprim,<br />
617<br />
ciprofloxacin, enoxacin, norfloxacin,<br />
<strong>and</strong> ofloxacin, 656<br />
E. coli, 656<br />
Enterobacter spp., 656<br />
Enterobacteriaceae, 617<br />
H. influenzae, 617, 656<br />
high-performance liquid chromatography,<br />
1503, 1508<br />
K. pneumoniae, 656<br />
Neisseria spp., 617<br />
P. aeruginosa, 617<br />
pharmacokinetics, 1503, 1508<br />
Pseudomonas spp., 656<br />
Salmonella spp., 656<br />
Shigella spp., 656<br />
Staphylococcus spp., 617, 656<br />
Streptococcus spp., 617<br />
tolerance, 1503<br />
LY163892<br />
B. catarrhalis, 268<br />
chemical stability in storage, 1477<br />
comparative activity<br />
amoxicillin, amoxicillin-clavulanic<br />
acid, <strong>and</strong> cefaclor, 268<br />
cefaclor <strong>and</strong> cefuroxime, 131<br />
cefaclor, cephalexin, cephalothin, <strong>and</strong><br />
cefuroxime, 1477<br />
E. coli, 268<br />
H. influenzae, 131, 268<br />
pediatric infections, 268<br />
pharmacokinetics, 1738<br />
S. aureus, 131<br />
Streptococcus spp., 268<br />
susceptibility test conditions, 1477<br />
M14659<br />
comparative activity
VOL. 32, 1988<br />
ceftazidime <strong>and</strong> ceftriaxone, 1648<br />
E. coli, 1648<br />
low-iron environment, 1648<br />
Macrolides<br />
comparative activity, 1710<br />
T. vaginalis, 144<br />
Malachite green<br />
E. coli<br />
heat treatment, 1680<br />
Malaria<br />
antimalarial agents<br />
mechanisms of action, 793<br />
minireview, 793<br />
chemoprophylaxis, 953<br />
chloroquine resistance, 799<br />
minireviews, 793, 799, 953, 957<br />
treatment, 957<br />
Marrow transplantation<br />
ganciclovir, 271<br />
Massularia accuminata<br />
B. gingivalis, 598<br />
B. melaninogenicus, 598<br />
ME1207<br />
,-lactamases, 1421<br />
comparative activity<br />
cefaclor, cefixime, <strong>and</strong> T-2525, 1421<br />
E. coli, 1421<br />
H. influenzae, 1421<br />
N. gonorrhoeae, 1421<br />
P. cepacia, 1421<br />
P. rettgeri, 1421<br />
S. pneumoniae, 1421<br />
Staphylococcus spp., 1421<br />
Measles virus<br />
P-536, 1257<br />
Mebendazole<br />
T. vaginalis, 144<br />
Mefloquine<br />
polymorphonuclear neutrophils, 1124<br />
Meningitis<br />
coccidioidal<br />
fluconazole, 369<br />
gentamicin<br />
cerebrospinal fluid penetration,<br />
1034<br />
H. influenzae, 1034<br />
K. pneumoniae, 1705<br />
temocillin, 1705<br />
Methicillin<br />
dysgonic fermenter 2, 78<br />
Methylenepenams<br />
antibacterial properties, 1005<br />
Methylglyoxal bis(guanylhydrazone)<br />
P. carinii, 896<br />
3-Methylhypoxanthine<br />
influenza viruses, 906<br />
5-Methylthioribose analogs<br />
G. lamblia, 1904<br />
0. malhamensis, 1904<br />
P. falciparum, 1904<br />
3'-C-Methyluridine<br />
influenza viruses, 906<br />
Metronidazole<br />
combinations<br />
enterococci, 1769<br />
streptomycin, 1769<br />
enterococci, 1769<br />
T. vaginalis, 144, 1323<br />
Mezlocillin<br />
B. catarrhalis, 259<br />
Bacillus spp., 642<br />
combinations<br />
ciprofloxacin, 782<br />
P. maltophilia, 782<br />
hyperbilirubinemia<br />
centrifugal ultrafiltration, 1571<br />
M. morganii, 1385<br />
P. maltophilia, 782<br />
P. vulgaris, 1385<br />
pharmacokinetics, 777<br />
Miconazole<br />
comparative activity<br />
amphotericin B, 1864<br />
polymorphonuclear leukocytes, 1864<br />
T. vaginalis, 1323<br />
Microsporum spp.<br />
G2, 1586<br />
Minireviews<br />
antibiotic biosynthetic genes, 1472<br />
antifungal agents, 1<br />
antimalarial agents<br />
mechanisms of action, 793<br />
azoles, I<br />
B. catarrhalis<br />
susceptibility testing, 1747<br />
bacterial adhesion, 1603, 1609<br />
biosynthetic genes, 1472<br />
C. trachomatis<br />
antibodies, monoclonal, 1295<br />
susceptibility testing, 1295<br />
Campylobacter spp.<br />
resistance mechanisms, 1107<br />
chloroquine<br />
mechanism of resistance, 799<br />
H. influenzae<br />
susceptibility testing, 1747<br />
malaria, 793, 799<br />
chemoprophylaxis, 953<br />
treatment, 957<br />
mixed aerobic-anaerobic infections, 611<br />
N. gonorrhoeae<br />
susceptibility testing, 1747<br />
P. falciparum, 799<br />
pharmacokinetics<br />
outcome of infections, 289<br />
Plasmodium spp., 793<br />
rhinovirus colds chemotherapy, 409<br />
Streptomyces spp.<br />
cloned genes, 1465, 1472<br />
recombinant DNA systems, 1465<br />
susceptibility testing<br />
B. catarrhalis, 1747<br />
H. influenzae, 1747<br />
N. gonorrhoeae, 1747<br />
triazoles, I<br />
Minocycline<br />
C. trachomatis, 1080, 1350<br />
comparative activity<br />
demeclocycline, doxycycline, erythromycin,<br />
nalidixic acid, oxytetracycline,<br />
rifampin, <strong>and</strong> tetracycline,<br />
986<br />
E. risticii, 986<br />
H. ducreyi, 1458<br />
N. asteroides, 1776<br />
P. multocida, 213<br />
Miocamycin<br />
comparative activity, 1710<br />
Mixed infections<br />
aerobic-anaerobic, 611<br />
minireview, 611<br />
Morganella morganii<br />
ampicillin, 1385<br />
P-lactam resistance, 1385<br />
P-lactamase, 1385<br />
carbenicillin, 1385<br />
SUBJECT INDEX xxiii<br />
cefotaxime, 1385<br />
cefoxitin, 1385<br />
ceftriaxone, 1385<br />
cephaloridine, 1385<br />
imipenem, 1385<br />
mezlocillin, 1385<br />
Morganella spp.<br />
E-1040, 1666<br />
R-3746, 671<br />
tigemonam, 84<br />
Moxalactam<br />
B. catarrhalis, 259<br />
comparative activity<br />
clindamycin-gentamicin, 853<br />
cost analysis, 853<br />
endomyometritis, 853<br />
hyperbilirubinemia<br />
centrifugal ultrafiltration, 1571<br />
P. aeruginosa filamentous forms<br />
human granulocytes, 1565<br />
P. vulgaris, 1073<br />
Shigella spp., 20<br />
Mtr phenotype<br />
N. gonorrhoeae, 971<br />
Mucor racemosus<br />
cycloheximide efflux, 341<br />
trichodermin, 341<br />
Mupirocin<br />
comparative activity<br />
erythromycin, 1780<br />
impetigo, 1780<br />
Mycobacterium avium<br />
amikacin, 1131<br />
capreomycin, 1131<br />
ethionamide, 1131<br />
isoniazid, 1131<br />
kanamycin, 1131<br />
rifampin, 1131<br />
streptomycin, 1131<br />
susceptibility testing, 1131<br />
Mycobacterium avium complex<br />
acquired immune deficiency syndrome,<br />
1392<br />
amikacin, 886, 1149, 1400<br />
amikacin-clofazimine, 1400<br />
amikacin-clofazimine-rifabutin, 1400<br />
amikacin-rifabutin, 1400<br />
amikacin-tumor necrosis factor, 1149<br />
azithromycin, 1149<br />
azithromycin-tumor necrosis factor,<br />
1149<br />
clofazime-ethambutol, 1392<br />
clofazimine-ciprofloxacin, 1392<br />
ethambutol-ciprofloxacin, 1392<br />
ethambutol-erythromycin, 1392<br />
ethambutol-rifampin, 1392<br />
ethambutol-rifampin-ciprofloxacin, 1392<br />
ethambutol-rifampin-ciprofloxacin-erythromycin,<br />
1392<br />
ethambutol-rifampin-erythromycin, 1392<br />
fatty acids, 400<br />
model man, 886<br />
rifabutin-ciprofloxacin, 1392<br />
rifabutin-clofazimine, 1392<br />
rifabutin-ethambutol, 1392<br />
rifampin-ciprofloxacin, 1392<br />
rifampin-erythromycin, 1392<br />
roxithromycin, 1149<br />
roxithromycin-tumor necrosis factor,<br />
1149<br />
Mycobacterium avium-M. intracellulare<br />
amikacin, 1404<br />
liposome encapsulated, 1404
xxiv SUBJECT INDEX<br />
Mycobacterium leprae<br />
clarithromycin, 1758<br />
clofazimine, 1583<br />
erythromycin, 1758<br />
phenazines, 1583<br />
roxithromycin, 1758<br />
Mycobacterium smegmatis<br />
cyclohexane triones, 814<br />
Mycobacterium spp.<br />
dihydromycoplanecin A, 110<br />
Mycobacterium tuberculosis<br />
A-56620, 1441<br />
ATP bioluminescence assay, 1208<br />
cefonicid, 1441<br />
ceforanide, 1441<br />
cefotaxime, 1441<br />
cefpirome, 1441<br />
ceftizoxime, 1441<br />
cephapirin, 1441<br />
difloxacin, 1441<br />
ethambutol, 1208, 1441<br />
imipenem, 1441<br />
isoniazid, 1208, 1441<br />
letter to the editor, 287<br />
PD 127,391, 1251<br />
pyrazinamide, 125, 287<br />
pHs, different, 1002<br />
radiometric method, 1002<br />
rifampin, 1208, 1441<br />
SK&F 88070, 1441<br />
streptomycin, 1208, 1441<br />
susceptibility testing, 125<br />
Mycoplasma hominis<br />
A-63075, 1500<br />
clarithromycin, 1500<br />
difloxacin, 1500<br />
erythromycin, 1500<br />
temafloxacin, 1500<br />
Mycoplasma pneumoniae<br />
A-63075, 1500<br />
clarithromycin, 1500<br />
difloxacin, 1500<br />
erythromycin, 1500<br />
temafloxacin, 1500<br />
Naegleria fowleri<br />
acrolein, 962<br />
cyclophosphamide, 962<br />
Nafcillin<br />
hyperbilirubinemia<br />
centrifugal ultrafiltration, 1571<br />
Nalidixic acid<br />
B. bronchiseptica, 1891<br />
cleavable-complex assay, 1086<br />
comparative activity<br />
ciprofloxacin, enoxacin, norfloxacin,<br />
<strong>and</strong> ofloxacin, 1285<br />
demeclocycline, doxycycline, erythromycin,<br />
minocycline, oxytetracycline,<br />
rifampin, <strong>and</strong> tetracycline,<br />
986<br />
E. faecalis resistance, 1285<br />
E. risticii, 986<br />
Enterobacteriaceae resistance, 1285<br />
fecal flora resistance, 1801<br />
GABA receptor, 1624<br />
P. aeruginosa resistance, 1285<br />
P. falciparum, 1182<br />
S. aureus, 1192<br />
resistance, 1285<br />
Shigella spp., 20<br />
Nauclea latifolia<br />
B. gingivalis, 598<br />
B. melaninogenicus, 598<br />
Neisseria gonorrhoeae<br />
A-61827, 27<br />
azithromycin, 752<br />
,B-lactamases, 158, 1430<br />
cefodizime, 426<br />
cefotaxime, 426<br />
DNA gyrase inhibitors, 1788<br />
genetic transformation, 1788<br />
imipenem-cilastatin, 773<br />
letters to the editor, 158, 951<br />
ME1207, 1421<br />
minireview, 1747<br />
Mtr phenotype, 971<br />
PD 117,596, 1450<br />
R-3746, 671<br />
R plasmids, 158, 488<br />
transfer to Neisseria spp., 1430<br />
susceptibility testing, 1747<br />
T-3262, 663<br />
tetracycline resistance, 488, 951<br />
trospectomycin, 216<br />
Neisseria meningitidis<br />
azithromycin, 752<br />
cefixime, 1896<br />
cefpodoxime, 1896<br />
ceftriaxone, 18%<br />
ciprofloxacin, 1740<br />
penicillin resistance, 706<br />
R plasmid<br />
transfer from N. gonorrhoeae, 1430<br />
Neisseria perflava-N. sicca<br />
tetracycline<br />
resistance, 1271<br />
Neisseria spp.<br />
ceftibuten, 1576<br />
E-1040, 1666<br />
lomefloxacin, 617<br />
PD 127,391, 1251<br />
R plasmid, 488, 765<br />
transfer from N. gonorrhoeae, 1430<br />
tetracycline resistance, 488, 765<br />
tigemonam, 84<br />
U-76,253A, 443<br />
Neomycin<br />
B. bronchiseptica, 1891<br />
Nephrotoxicity<br />
apalcillin, 942<br />
cefazolin, 314<br />
cefoperazone, 314<br />
ceftazidime, 314<br />
cephaloglycin, 314<br />
cephaloridine, 314, 912<br />
cephalothin, 314<br />
gentamicin, 912<br />
hydrocortisone, influence of, 992<br />
Neplanocin A<br />
influenza viruses, 906<br />
Neplanocin C<br />
influenza viruses, 906<br />
Netilmicin<br />
A. denitrificans subsp. xylosoxidans,<br />
276<br />
B. catarrhalis, 259<br />
cardiopulmonary bypass, 631<br />
K. pneumoniae resistance, 1379<br />
pharmacokinetics, 631<br />
S. marcescens resistance, 1379<br />
Neutrophils<br />
clindamycin<br />
periodontal bacteria, 1521<br />
ANTIMICROB. AGENTS CHEMOTHER.<br />
Nifurtimox<br />
immune response, effect on, 241<br />
T. cruzi, 241<br />
Nigerian chewing sticks<br />
B. gingivalis, 598<br />
B. melaninogenicus, 598<br />
Nitrosoureas<br />
amphQtericin B<br />
C. albicans, 327<br />
Nocardia asteroides<br />
amikacin, 1776<br />
ampicillin, 1776<br />
1-lactamase, 1776<br />
carbenicillin, 1776<br />
cefotaxime, 1776<br />
ceftriaxone, 1776<br />
ciprofloxacin, 1776<br />
erythromycin, 1776<br />
gentamicin, 1776<br />
imipenem, 1776<br />
kanamycin, 1776<br />
minocycline, 1776<br />
sulfamethoxazole, 1776<br />
susceptibility patterns, 1776<br />
Nocardia spp.<br />
A-56620, 1078<br />
A-62254, 1078<br />
amifloxacin, 1078<br />
cefepime, 1078<br />
cefpirome, 1078<br />
ciprofloxacin, 1078<br />
difloxacin, 1078<br />
enoxacin, 1078<br />
imipenem, 1078<br />
PD-1 17558, 1078<br />
RO 23-6240, 1078<br />
S-25930, 1078<br />
S-25932, 1078<br />
Nonoxynol-9<br />
T. vaginalis, 1323<br />
Norfloxacin<br />
A. denitrificans subsp. xylosoxidans, 276<br />
B.fragilis, 1437, 1869<br />
binding to feces, 1869<br />
Bordetella spp., 137<br />
C. trachomatis, 1080, 1350, 1735<br />
C. freundii resistance, 922<br />
cleavable-complex assay, 1086<br />
comparative activity<br />
amifloxacin, ciprofloxacin, enoxacin,<br />
<strong>and</strong> ofloxacin, 928<br />
doxycycline <strong>and</strong> minocycline, 1735<br />
tobramycin, 1820<br />
conjunctivitis, 1820<br />
E. coli, 1292<br />
endogenous active efflux, 1187<br />
E. faecium, 1869<br />
fecal binding, 1869<br />
gram-negative bacteria, 1292<br />
gram-positive bacteria, 1292<br />
H. influenzae, 1820<br />
Haemophilus spp., 147<br />
ocular infections, 1820<br />
P. aeruginosa, 1292<br />
P. falciparum, 1182<br />
P. maltophilia, 782<br />
P. pseudomallei, 928, 1435<br />
S. aureus, 1192, 1820<br />
S. pneumoniae, 1820<br />
Shigella spp., 20<br />
Staphylococcus spp., 1820<br />
streptococci, alpha-hemolytic, 1820<br />
theophylline pharmacokinetics, 510
VOL. 32, 1988<br />
urinary tract infections, 1292<br />
L-Norvalyl-L-chlorovinylglycine<br />
comparative activity, 319<br />
gram-positive bacteria, 319<br />
Staphylococcus spp., 319<br />
Nosocomial infections<br />
Staphylococcus spp., 202<br />
Novobiocin<br />
A. lignieresii, 1354<br />
B. bronchiseptica, 1891<br />
P. falciparum, 1182<br />
P. multocida, 1354<br />
Nucleic acid synthesis<br />
bacterial adhesion, 1609<br />
minireview, 1609<br />
NY-198<br />
B. fragilis, 1437<br />
C. trachomatis, 1080, 1735<br />
comparative activity<br />
ciprofloxacin, 1427<br />
doxycycline <strong>and</strong> minocycline, 1735<br />
Legionella spp., 1427<br />
Legionnaires disease, 1427<br />
pharmacokinetics, 156, 1427<br />
Ochromonas malhamensis<br />
5-methylthioribose analogs, 1904<br />
Ocular infections<br />
H. influenzae, 1820<br />
norfloxacin, 1820<br />
S. aureus, 1820<br />
S. pneumoniae, 1820<br />
Staphylococcus spp., 1820<br />
streptococci, alpha-hemolytic, 1820<br />
tobramycin, 1820<br />
Ofloxacin<br />
A. denitrificans subsp. xylosoxidans,<br />
276<br />
B. fragilis, 1437<br />
bite wound bacteria, 1143<br />
Bordetella spp., 137<br />
C. trachomatis, 1080, 1350, 1735<br />
C. freundii resistance, 922<br />
cleavable-complex assay, 1086<br />
comparative activity<br />
amifloxacin, ciprofloxacin, enoxacin,<br />
<strong>and</strong> norfloxacin, 928<br />
doxycycline <strong>and</strong> minocycline, 1735<br />
cystitis, 1640<br />
cytogenetic effects, 936<br />
DR-3355 isomer, 1336<br />
E. coli, 1640<br />
GABA receptor, 1624<br />
Haemophilus spp., 147<br />
P. falciparum, 1182<br />
P. pseudomallei, 928<br />
pharmacokinetics, 1590, 1640<br />
S. aureus, 1192<br />
Shigella spp., 20<br />
Ole<strong>and</strong>omycin<br />
Arthrobacter spp., 420<br />
Staphylococcus spp., 420<br />
Oligonucleotide probes<br />
,3-lactamases, 397<br />
comparative studies, 397<br />
Open-heart surgery<br />
flucloxacillin, 930<br />
Oral bacteria<br />
tetracycline resistance, 1271<br />
Ornithine decarboxylase inhibitors<br />
T. gondii, 303<br />
Osteomyelitis<br />
enoxacin, 834<br />
vancomycin bone concentrations, 1320<br />
Outer membrane<br />
permeability<br />
P. aeruginosa, 1267<br />
P. cepacia, 1636<br />
proteins<br />
E. coli, 1879<br />
iron regulated, 1879<br />
Oxacillin<br />
Bacillus spp., 642<br />
bactericidal testing, 1614<br />
coagulase-negative staphylococcal susceptibility,<br />
1754<br />
P. multocida, 213<br />
S. aureus, 1614<br />
MBCs, 374<br />
susceptibility, 1754<br />
Oxetanocin G<br />
cytomegalovirus, 1053<br />
Oxolinic acid<br />
B. bronchiseptica, 1891<br />
cleavable-complex assay, 1086<br />
P. falciparum, 1182<br />
Oxyimino-cephalosporins<br />
,B-lactamase, 1243<br />
E. coli, 1243<br />
Oxytetracycline<br />
B. bronchiseptica, 1891<br />
comparative activity<br />
demeclocycline, doxycycline, erythromycin,<br />
minocycline, nalidixic<br />
acid, rifampin, <strong>and</strong> tetracycline,<br />
986<br />
E. risticii, 986<br />
P-536<br />
encephalomyocarditis virus, 1257<br />
influenza virus, 1257<br />
measles virus, 1257<br />
poliovirus type 1, 1257<br />
T. cruzi, 1412<br />
type 5, 1257<br />
herpes simplex virus type 1, 1257<br />
UDP-glucose analog, 1257<br />
vaccinia virus, 1257<br />
vesicular stomatitis virus, 1257<br />
PADAC<br />
P-lactamase assay, 1040<br />
Paldimycin<br />
Actinomyces spp., 788<br />
Bifidobacterium spp., 788<br />
Clostridium spp., 788<br />
comparative activity<br />
daptomycin, penicillin, <strong>and</strong> vancomycin,<br />
788<br />
Eubacterium spp., 788<br />
Lactobacillus spp., 788<br />
Peptostreptococcus spp., 788<br />
Propionibacterium spp., 788<br />
Pap fimbrial adhesion<br />
berberine sulfate, 1274<br />
Paradoxical effect<br />
P-lactams, 1073<br />
P. vulgaris, 1073<br />
Parainfluenza virus<br />
sulfated polysaccharides, 1742<br />
Pasteurella multocida<br />
actinomycin D, 1354<br />
amoxicillin-clavulanic acid, 213<br />
ampicillin, 213<br />
SUBJECT INDEX xxv<br />
cefaclor, 213<br />
cefadroxil, 213<br />
cefuroxime, 213<br />
cephalexin, 213<br />
chloramphenicol, 213<br />
clindamycin, 213<br />
daptomycin, 1354<br />
erythromycin, 213<br />
minocycline, 213<br />
novobiocin, 1354<br />
oxacillin, 213<br />
penicillin, 213<br />
phospholipid composition, 1354<br />
polymyxin, 1354<br />
rifamycin, 1354<br />
tetracycline, 213<br />
trimethoprim-sulfamethoxazole, 213<br />
Pasteurella spp.<br />
P-lactamase, 1282<br />
R plasmid, 1282<br />
PD-1 17558<br />
Nocardia spp., 1078<br />
PD 117,596<br />
Acinetobacter spp., 1450<br />
B. catarrhalis, 1450<br />
C. jejuni, 1450<br />
comparative activity<br />
amikacin, aztreonam, cephalothin, CI<br />
934, ciprofloxacin, imipenem, <strong>and</strong><br />
piperacillin, 1450<br />
Corynebacterium spp., 1450<br />
E. coli, 1450<br />
Enterobacter spp., 1450<br />
Enterococcus spp., 1450<br />
Haemophilus spp., 1450<br />
Klebsiella spp., 1450<br />
L. pneumophila, 1450<br />
N. gonorrhoeae, 1450<br />
P. mirabilis, 1450<br />
Pseudomonas spp., 1450<br />
S. aureus, 1450<br />
S. marcescens, 1450<br />
Streptococcus spp., 1450<br />
PD 127,391<br />
B. fragilis, 1251<br />
C. trachomatis, 1251<br />
comparative activity<br />
ceftazidime, ciprofloxacin, gentamicin,<br />
<strong>and</strong> imipenem, 1278<br />
cefuroxime, ciprofloxacin, gentamicin,<br />
nalidixic acid, <strong>and</strong> ofloxacin, 1251<br />
Enterobacteriaceae, 1251<br />
gram-negative aerobes, 1278<br />
gram-positive aerobes, 1278<br />
H. influenzae, 1251<br />
M. tuberculosis, 1251<br />
Neisseria spp., 1251<br />
P. aeruginosa, 1251, 1278<br />
Pseudomonas spp., 1278<br />
S. pneumoniae, 1251<br />
Staphylococcus spp., 1251<br />
Pediatric infections<br />
LY163892, 268<br />
Pefloxacin<br />
A. denitrificans subsp. xylosoxidans,<br />
276<br />
B. catarrhalis, 259<br />
C. trachomatis, 1350<br />
combinations<br />
endocarditis, 919<br />
fosfomycin, 919<br />
S. aureus, 919<br />
comparative activity
xxvi SUBJECT INDEX<br />
amikacin-ceftazidime, 231<br />
ceftazidime-amikacin, 231<br />
endocarditis, 231, 919<br />
GABA receptor, 1624<br />
Haemophilus spp., 147<br />
P. aeruginosa, 231<br />
resistance, development of, 231<br />
P. falciparum, 1182<br />
S. aureus, 919<br />
Shigella spp., 20<br />
Penems<br />
protein binding, 159<br />
spectrophotometric assay, 159<br />
Penicillin<br />
B. catarrhalis, 259<br />
Bacillus spp., 642<br />
biosynthesis<br />
P. chrysogenum glucokinase-deficient<br />
mutant, 1061<br />
Chlamydia sp. strain TWAR, 257<br />
dysgonic fermenter 2, 78<br />
H. ducreyi, 1458<br />
H. influenzae, 498<br />
N. meningitidis resistance, 706<br />
P. multocida, 213<br />
S. aureus resistance, 1164<br />
T. vaginalis, 1323<br />
Penicillin G<br />
bite wound bacteria, 1143<br />
methylene analogs<br />
antibacterial properties, 1005<br />
Penicillinase<br />
P. cepacia, 838<br />
Penicillin-binding proteins<br />
B. fragilis, 1848<br />
H. influenzae, 498<br />
Penicillium chrysogenum<br />
P-galactosidase activity, 1061<br />
glucokinase-deficient mutant, 1061<br />
penicillin biosynthesis, 1061<br />
Pentamidine<br />
comparative activity<br />
dapsone, trimethoprim-dapsone, <strong>and</strong><br />
trimethoprim-sulfamethoxazole,<br />
623<br />
P. carinii, 623, 896, 1490<br />
pharmacokinetics, 1490<br />
pneumonia, 623, 1490<br />
Pentosan polysulfate<br />
cytomegalovirus, 1742<br />
herpes simplex virus, 1742<br />
human immunodeficiency virus, 1742<br />
vesicular stomatitis virus, 1742<br />
Pentostam<br />
P. carinii, 896<br />
Pentylenetetrazole<br />
BMY-26225, 758<br />
cefazolin, 758<br />
convulsive threshold, 758<br />
imipenem-cilastatin, 758<br />
rat model, 758<br />
Peptidoglycan synthesis<br />
bacterial adhesion, 1609<br />
minireview, 1609<br />
Peptococcus spp.<br />
DR-3355, 1336<br />
Peptostreptococcus anaerobius<br />
tetracycline<br />
resistance, 1271<br />
Peptostreptococcus spp.<br />
daptomycin, 788<br />
paldimycin, 788<br />
Percutaneous transhepatic biliary drainage<br />
cefotiam, 726<br />
sulbenicillin, 726<br />
ursodeoxycholate, 726<br />
Periodontal disease<br />
A. actinomycetemcomitans, 1521<br />
C. ochracea, 1521<br />
clindamycin, 1521<br />
E. corrodens, 1521<br />
tetracycline resistance, 1271<br />
Pharmacokinetics<br />
A40926, 246<br />
amdinocillin pivoxil<br />
influence of food, 592<br />
amikacin, 236<br />
amopyroquin, 568<br />
apalcillin, 942<br />
calcium fosfomycin, 938<br />
carumonam, 354<br />
cefazolin, 33<br />
cefetamet, 573<br />
cefetamet pivoxil, 573<br />
cefonicid, 485<br />
protein binding, 128<br />
cefoperazone, 42<br />
cefoperazone-sulbactam, 42, 503, 730<br />
continuous ambulatory peritoneal dialysis,<br />
51<br />
cefotaxime<br />
protein binding, 128<br />
cefpiramide, 33, 1360<br />
cefpirome, 13%<br />
ceftazidime, 1845<br />
ceftazidime-vancomycin, 92<br />
ceftizoxime<br />
protein binding, 128<br />
ciprofloxacin, 949, 982, 1537<br />
clindamycin, 1825<br />
dihydromycoplanecin A, 110<br />
erythromycin estolate, 561<br />
erythromycin ethylsuccinate, 561<br />
fleroxacin, 1515<br />
fluconazole, 209, 369<br />
flurithromycin, 1875<br />
ganciclovir, 1899<br />
gentamicin, 467, 736<br />
±2HM-HBG, 1807<br />
(R,S)-9-[4-hydroxy-2(hydroxymethyl)<br />
butyl]guanine, 1807<br />
imipenem-cilastatin, 530<br />
itraconazole, 1310<br />
renal dysfunction, 1595<br />
ketoconazole, 209<br />
letter to the editor, 949<br />
lipid X, 37<br />
lomefloxacin, 1503, 1508<br />
LY163892, 1738<br />
mezlocillin, 777<br />
minireview, 289<br />
monoclonal anti-lipid A antibody, 710<br />
netilmicin, 631<br />
NY-198, 156, 1427<br />
ofloxacin, 1590, 1640<br />
outcome of infections, 289<br />
pentamidine, 1490<br />
ribavirin aerosol, 117<br />
rimantadine, 1699, 1813<br />
roxithromycin, 1461<br />
sulbactam, 42<br />
teicoplanin, 1223<br />
temocillin, 1705<br />
theophylline<br />
ciprofloxacin, effect of, 75<br />
ANTIMICROB. AGENTS CHEMOTHER.<br />
norfloxacin, 510<br />
tobramycin<br />
charcoal, effect of, 274<br />
trimethoprim-sulfamethoxazole, 1640<br />
trimetrexate, 324<br />
tromethamine fosfomycin, 938<br />
vancomycin, 92, 631, 848<br />
vancomycin-ceftazidime, 92<br />
PhastSystem<br />
13-lactamases, 1730<br />
Phenazines<br />
M. leprae, 1583<br />
structure-activity relationships, 1583<br />
Pheromones<br />
S. faecalis, 547<br />
Phlebovirus<br />
ribavirin, 331<br />
Phosphatidylcholine<br />
liposomes, 966<br />
T. b. gambiense, 966<br />
Phospholipids<br />
A. lignieresii, 1354<br />
P. multocida, 1354<br />
Phosphonoacetate<br />
herpes simplex virus type 2, 858<br />
liposomes, 858<br />
Phosphonoformate<br />
herpes simplex virus type 2, 858<br />
liposomes, 858<br />
Phosphonylmethoxyethyl purines<br />
human immunodeficiency virus, 1025<br />
Pipemidic acid<br />
C. trachomatis, 1080<br />
Piperacillin<br />
A. denitrificans subsp. xylosoxidans, 276<br />
B. catarrhalis, 259<br />
cephaloridine nephrotoxicity, 912<br />
combinations<br />
ciprofloxacin, 782<br />
P. maltophilia, 782<br />
dysgonic fermenter 2, 78<br />
gentamicin nephrotoxicity, 912<br />
P. maltophilia, 782<br />
P. pseudomallei, 1435<br />
P. vulgaris, 1073<br />
Piritrexim<br />
P. carinii, 430<br />
T. gondii, 430<br />
Plasma bactericidal activity<br />
erythromycin estolate, 1227<br />
erythromycin ethylsuccinate, 1227<br />
Plasmids<br />
1-lactamases, 175, 1730<br />
DNA probes, 175<br />
resistance<br />
Acinetobacter spp., 15<br />
C. coli, 1170<br />
C. difficile, 1213<br />
C. freundii, 9<br />
C. jejuni, 1170<br />
E. aerogenes, 9<br />
E. coli, 9, 1243, 1552<br />
E. corrodens, 765<br />
Enterobacteriaceae, 1289<br />
Enterococcus spp., 1793<br />
K. denitrificans, 765<br />
K. pneumoniae, 9, 626, 1379, 1416,<br />
1660<br />
letter to the editor, 158<br />
N. gonorrhoeae, 158, 488, 1430<br />
Neisseria spp., 488, 765<br />
P. morganii, 9<br />
Pasteurella spp., 1282
VOL. 32, 1988<br />
S. aureus, 932, 1164, 1174<br />
S. faecalis, 547, 1528<br />
S. marcescens, 9, 1289, 1379, 1834<br />
S. sonnei, 1598<br />
S. wien, 1262<br />
Staphylococcus spp., 1494<br />
Streptococcus spp., 1793<br />
sulfonamides, 1684<br />
Plasmodium berghei<br />
cyclosporine, 462<br />
stage-selective inhibition, 462<br />
Plasmodium falciparum<br />
amifloxacin, 1182<br />
amopyroquin, 568<br />
B. javanica, 1725<br />
2-bromo-L-histidine, 1655<br />
2-chloro-L-histidine, 1655<br />
chloroquine resistance, 799<br />
cinchonidine, 250<br />
cinchonine, 250<br />
ciprofloxacin, 1182<br />
coumermycin A, 1182<br />
enoxacin, 1182<br />
2-fluoro-L-histidine, 1655<br />
histidine analogs, 1655<br />
inositol hexaphosphate, 391<br />
2-iodo-L-histidine, 1655<br />
5-methylthioribose analogs, 1904<br />
minireview, 799<br />
nalidixic acid, 1182<br />
norfloxacin, 1182<br />
novobiocin, 1182<br />
ofloxacin, 1182<br />
oxolinic acid, 1182<br />
pefloxacin, 1182<br />
quassinoids, 1725<br />
quinidine, 250<br />
quinine, 250<br />
S. amara, 1725<br />
WR 194,965 phosphate, 540<br />
Plasmodium spp.<br />
antimalarial agents<br />
mechanisms of action, 793<br />
minireview, 793<br />
minireview, 793<br />
Pneumococci<br />
U-76,253A, 443<br />
Pneumocystis carinii<br />
acquired immunodeficiency syndrome,<br />
1057<br />
amicarbalide, 896<br />
ampicillin, 896<br />
Astiban, 896<br />
chloramphenicol, 896<br />
chlorpromazine, 896<br />
clind4mycin, 807<br />
clindamycin-primaquine, 807<br />
dapsone, 96, 623, 1057, 1158<br />
dapsone-trimethoprim, 623<br />
dehydroemetine, 896<br />
diaveridine, 96<br />
difluoromethylornithine, 896<br />
DL-a-difluoromethylornithine, 1158<br />
diminazene, 896<br />
aceturate, 1158<br />
ethidium, 896<br />
gentamicin, 896<br />
imidocarb, 896<br />
isom.etamidium, 896<br />
methylglyoxal bis(guanylhydrazone), 896<br />
pentamidine, 623, 896, 1490<br />
Pentostam, 896<br />
piritrexim, 430<br />
pneumonia, 623, 896, 1057, 1490<br />
primaquine, 807<br />
primaquine-clindamycin, 807<br />
pyrimethamine, 96<br />
quinacrine, 896<br />
quinapyramine, 896<br />
quinidine, 896<br />
quinine, 896<br />
spectinomycin, 896<br />
spiramycin, 896<br />
sulfadiazine, 96<br />
sulfadoxine, 96<br />
sulfamethoxazole, 96<br />
suramin, 1158<br />
trimethoprim, 96<br />
trimethoprim-dapsone, 623<br />
trimethoprimn-sulfamethoxazole, 623,<br />
1158<br />
trimetrexate, 324<br />
Pneumonia<br />
dapsone, 1057<br />
P. carinii, 1057, 1490<br />
dosages <strong>and</strong> intervals, 623<br />
pentamidine, 1490<br />
Poliovirus<br />
sulfated polysaccharides, 1742<br />
type I<br />
P-536, 1257<br />
Polycystic kidney disease<br />
ciprofloxacin, 844<br />
Polyisohexylcyanoacrylate<br />
ampicillin binding<br />
L. monocytogenes, 1204<br />
Polymorphonuclear leukocytes<br />
amphotericin B, 1864<br />
miconazole, 1864<br />
P. aeruginosa<br />
moxalactam-induced filamentous<br />
forms, 1565<br />
Polymorphonuclear neutrophils<br />
amodiaquine, 1124<br />
chloroquine, 1124<br />
mefloquine, 1124<br />
Polymyxin<br />
A. lignieresii, 1354<br />
E. coli, 308<br />
P. multocida, 1354<br />
Polymyxin B<br />
B. bronchiseptica, 1891<br />
Polyvinylpyrrolidone<br />
Enterobacteriaceae, 873<br />
Porins<br />
P. cepacia, 1636<br />
Postantibiotic effect<br />
ampicillin, 450<br />
ciprofloxarin, 450<br />
E. coli, 450<br />
tobramycin, 450<br />
Primaquine<br />
combinations<br />
clindamycin, 807<br />
P. carinii, 807<br />
P. carinii, 807<br />
Pristinamycin<br />
aerobic bacteria, 1094<br />
comparative activity<br />
cefoxitin, chloramphenicol, clindamycin,<br />
metronidazole, penicillin,<br />
pristinamnycin group IA, <strong>and</strong><br />
pristinamycin group IIA, 1094<br />
Procaine<br />
E. coli permeability, 153<br />
SUBJECT INDEX xxvii<br />
Propionibacterium spp.<br />
daptomycin, 788<br />
paldimycin, 788<br />
Prostatic tissue<br />
enoxacin concentrations, 1433<br />
Protein synthesis<br />
bacterial adhesion, 1603<br />
minireyiew, 1603<br />
Proteus mirabilis<br />
CS-807, 1082<br />
cystitis, 636<br />
E-3846, 636<br />
PD 117,596, 1450<br />
pyelonephritis, 636<br />
R-3746, 671<br />
U-76,252, 1082<br />
YTR 830, 925<br />
Proteus morganii<br />
R plasmids, 9<br />
Proteus spp.<br />
tigenionam, 84<br />
trospectomycin, 216<br />
Proteus vulgaris<br />
ampicillin, 1385<br />
f-lactamases, 1073, 1385<br />
1-lactams<br />
paradoxical effect, 1073<br />
resistance, 1385<br />
carbenicillin, 1385<br />
cefbuperazone, 1073<br />
cefmenoxime, 1073<br />
cefmetazole, 1073<br />
cefoperazone, 1073<br />
cefotaxime, 1073, 1385<br />
cefotiam, 1073<br />
cefoxitin, 1385<br />
ceftazidime, 1073<br />
ceftizoxime, 1073<br />
ceftriaxone, 1073, 1385<br />
cefuroxime, 1073<br />
cefuzonam, 1073<br />
cephaloridine, 1073, 1385<br />
cephalothin, 1073<br />
imipenem, 1385<br />
mezlocillin, 1385<br />
moxalactam, 1073<br />
piperacillin, 1073<br />
R-3746, 671<br />
Prothrombin<br />
cefotetan effect, 1446<br />
cefoxitin effect, 1446<br />
Providencia rettgeri<br />
ME1207, 1421<br />
Providencia spp.<br />
R-3746, 671<br />
tigemonam, 84<br />
PSE-2<br />
sequence, 134<br />
Pseudomonas aeruginosa<br />
A-61827, 27<br />
amikacin-ceftazidime, 231<br />
resistance, development of, 231<br />
aminoglycoside resistance, 689<br />
ampicillin, 552<br />
antibodies<br />
monoclonal, 649<br />
aztreonam, 552<br />
P-lactamases, 1443<br />
heterogeneity, 1893<br />
carumonam, 1593<br />
cefepime resistance, 1443<br />
cefixime, 1896<br />
cefoperazone-ceftazidime, 298
xxviii SUBJECT INDEX<br />
cefotaxime resistance, 1443<br />
cefpirome, 1396<br />
cefpodoxime, 1896<br />
ceftazidime resistance, 1443<br />
ceftazidime-amikacin, 231<br />
resistance, development of, 231<br />
ceftazidime-cefoperazone, 298<br />
ceftriaxone, 552, 1896<br />
ciprofloxacin resistance, 535<br />
CS-807, 1082<br />
cystitis, 636<br />
DuP 105, 580<br />
DuP 721, 580<br />
E1040, 693, 1666<br />
E-3846, 636<br />
endocarditis, 231<br />
enhanced antibiotic binding, 649<br />
etoposide, 1456<br />
fluoroquinolone resistance, 1285<br />
gentamicin, 552<br />
imipenem resistance, 1267<br />
immunoblotting, 649<br />
in vitro simulation of serious infections,<br />
552<br />
keratitis, 978<br />
liposome-swelling assay, 1267<br />
lomefloxacin, 617<br />
moxalactam-induced filamentous forms<br />
human granulocytes, 1565<br />
norfloxacin, 1292<br />
outer membrane<br />
permeability, 1267<br />
proteins, 785<br />
PD 127,391, 1251, 1278<br />
pefloxacin, 231<br />
pyelonephritis, 636<br />
quinolone resistance, 785<br />
T-3262, 663, 827<br />
tobramycin, 978<br />
binding to alginate, 518<br />
tolA mutant, 649<br />
U-76,252, 1082<br />
Pseudomonas cepacia<br />
,B-lactam resistance, 1636<br />
P-lactamase, 838<br />
cystic fibrosis, 1636<br />
E-1040, 1666<br />
ME1207, 1421<br />
outer membrane permeability, 1636<br />
penicillinase, 838<br />
porins, 1636<br />
T-3262, 663<br />
Pseudomonas maltophilia<br />
A-56620, 782<br />
amikacin, 782<br />
aztreonam, 782<br />
P-lactamase<br />
cloning of operon on E. coli, 819<br />
carbenicillin, 782<br />
cefoperazone, 782<br />
cefsulodin, 782<br />
ceftazidime, 782<br />
ciprofloxacin, 782<br />
ciprofloxacin-amikacin, 782<br />
ciprofloxacin-aztreonam, 782<br />
ciprofloxacin-cefoperazone, 782<br />
ciprofloxacin-cefsulodin, 782<br />
ciprofloxacin-ceftazidime, 782<br />
ciprofloxacin-gentamicin, 782<br />
ciprofloxacin-imipenem, 782<br />
ciprofloxacin-mezlocillin, 782<br />
ciprofloxacin-piperacillin, 782<br />
ciprofloxacin-tobramycin, 782<br />
difloxacin, 782<br />
gentamicin, 782<br />
imipenem, 782<br />
mezlocillin, 782<br />
norfloxacin, 782<br />
piperacillin, 782<br />
Sch 34343, 782<br />
T-3262, 663<br />
ticarcillin, 782<br />
tobramycin, 782<br />
Pseudomonas pseudomallei<br />
amifloxacin, 928<br />
amoxicillin, 1435<br />
amoxicillin-clavulanic acid, 1435<br />
carumonam, 1435<br />
cefotaxime, 1435<br />
ceftazidime, 1435<br />
ceftriaxone, 1435<br />
ciprofloxacin, 928, 1435<br />
enoxacin, 928<br />
imipenem, 1435<br />
norfloxacin, 928, 1435<br />
ofloxacin, 928<br />
piperacillin, 1435<br />
ticarcillin, 1435<br />
ticarcillin-clavulanic acid, 1435<br />
Pseudomonas spp.<br />
amiloride, 395<br />
cystic fibrosis, 395<br />
E-1040, 1666<br />
lomefloxacin, 656<br />
PD 117,5%, 1450<br />
PD 127,391, 1278<br />
R-3746, 671<br />
tigemonam, 84, 346<br />
tobramycin, 395<br />
U-76,253A, 443<br />
Puerperal infections<br />
letter to the editor, 407<br />
ticarcillin-clavulanic acid, 407<br />
Pulmonary aspergillosis<br />
amphotericin B, 1676<br />
Punta Toro virus<br />
ribavirin, 331<br />
Pyelonephritis<br />
daptomycin, 81<br />
daptomycin-gentamicin, 81<br />
E-3846, 636<br />
gentamicin, 81, 736<br />
gentamicin-daptomycin, 81<br />
S. faecalis, 81<br />
Pyrazinamide<br />
letter to the editor, 285<br />
M. tuberculosis, 125, 285<br />
pHs, different, 1002<br />
radiometric method, 1002<br />
susceptibility testing, 125<br />
Pyrazofurin<br />
influenza viruses, 906<br />
Pyridinium-2-azo-p-dimethylaniline chromophore<br />
P-lactamase assay, 1040<br />
Pyrimethamine<br />
P. carinii, 96<br />
T. gondii, 303<br />
Pyrimidine deoxynucleotide metabolism<br />
herpes simplex virus type 1, 1100<br />
Quassinoids<br />
E. histolytica, 1725<br />
P. falciparum, 1725<br />
ANTIMICROB. AGENTS CHEMOTHER.<br />
Quinacrine<br />
P. carinii, 896<br />
Quinapyramine<br />
P. carinii, 896<br />
Quinidine<br />
P. carinii, 8%<br />
P. falciparum, 250<br />
Quinine<br />
E. coli permeability, 153<br />
P. carinii, 896<br />
P. falciparum, 250<br />
Quinolones<br />
C. freundii resistance, 922<br />
cleavable-complex assay, 1086<br />
DNA gyrase resistance, 104<br />
DNA synthesis, 1113<br />
E. coli, 1113<br />
permeation, 438<br />
fecal binding, 1869<br />
GABA receptor, 1624<br />
y-aminobutyric acid receptor, 1624<br />
inhibition of y-aminobutyric acid binding<br />
to receptor sites, 190<br />
P. aeruginosa resistance, 785<br />
R-3746<br />
Bacteroides spp., 671<br />
Branhamella spp., 671<br />
C. diversus, 671<br />
C. freundii, 671<br />
Clostridium spp., 671<br />
comparative activity<br />
amoxicillin-clavulanic acid, cefaclor,<br />
cefixime, cephalexin, <strong>and</strong> trimethoprim-sulfamethoxazole,<br />
671<br />
E. aerogenes, 671<br />
E. cloacae, 671<br />
E. coli, 671<br />
Enterococcus spp., 671<br />
H. influenzae, 671<br />
K. pneumoniae, 671<br />
Morganella spp., 671<br />
N. gonorrhoeae, 671<br />
P. mirabilis, 671<br />
P. vulgaris, 671<br />
Providencia spp., 671<br />
Pseudomonas spp., 671<br />
S. marcescens, 671<br />
S. pneumoniae, 671<br />
Salmonella spp., 671<br />
Shigella spp., 671<br />
streptococci, 671<br />
Yersinia spp., 671<br />
Radiochemical method<br />
E. coli biofilms, 770<br />
Radiometric method<br />
M. tuberculosis, 125<br />
pyrazinamide, 125<br />
Rat granuloma pouch<br />
cefpirome, 1396<br />
Recombinant DNA<br />
minireview, 1465<br />
Streptomyces spp., 1465<br />
Renal cyst infection<br />
ciprofloxacin, 844<br />
Reovirus<br />
sulfated polysaccharides, 1742<br />
Respiratory syncytial virus<br />
immunoglobulin, intravenous, 1269<br />
interferon alpha-2a, recombinant, 589<br />
intravenous immunoglobulin, 1269
VOL. 32, 1988<br />
Reuterin<br />
high-performance liquid chromatography,<br />
1854<br />
isolation, 1854<br />
production, 1854<br />
Reverse transcriptases<br />
human immunodeficiency virus, 1887<br />
human immunodeficiency virus type 1,<br />
684, 1733<br />
human immunodeficiency virus type 2,<br />
1733<br />
simian immunodeficiency virus, 1733,<br />
1887<br />
Rhinovirus<br />
alpha-2b interferon, 47<br />
colds chemotherapy, 409<br />
enviroxime, 890<br />
interferon, recombinant alfa-2b, 224<br />
ipratropium bromide, 1644<br />
minireview, 409<br />
Ribavirin<br />
aerosol<br />
pharmacokinetics, 117<br />
Argentine hemorrhagic fever, 1304<br />
influenza B virus, 761<br />
influenza viruses, 906<br />
Phlebovirus, 331<br />
Punta Toro virus, 331<br />
small-particle aerosol, 761<br />
vesicular stomatitis virus transcription,<br />
492<br />
Ribonucleotide reductase<br />
herpes simplex virus type 1, 1100<br />
Rickettsia conorii<br />
erythromycin, 255<br />
josamycin, 255<br />
spiramycin, 255<br />
Rickettsia rickettsii<br />
erythromycin, 255<br />
josamycin, 255<br />
spiramycin, 255<br />
Rifabutin<br />
combinations<br />
amikacin, 1400<br />
ciprofloxacin, 1392<br />
clofazimine, 1392<br />
ethambutol, 1392<br />
M. avium complex, 1392, 1400<br />
human immunodeficiency virus type 1,<br />
684<br />
Rifampin<br />
B. bronchiseptica, 1891<br />
B. catarrhalis, 259<br />
Bordetella spp., 137<br />
C. trachomatis, 1350<br />
combinations<br />
ciprofloxacin, 1392<br />
erythromycin, 1392<br />
ethambutol, 1392<br />
M. avium complex, 1392<br />
trimethoprim, 802<br />
urinary tract infections, 802<br />
comparative activity<br />
demeclocycline, doxycycline, erythromycin,<br />
minocycline, nalidixic<br />
acid, oxytetracycline, <strong>and</strong> tetracycline,<br />
986<br />
dysgonic fermenter 2, 78<br />
E. coli<br />
heat treatment, 1680<br />
E. risticii, 986<br />
H. ducreyi, 1458<br />
H. influenzae, 180<br />
M. avium, 1131<br />
M. tuberculosis, 1208, 1441<br />
Rifampin-trimethoprim<br />
comparative activity<br />
sulfamethoxazole-trimethoprim, 802<br />
urinary tract infections, 802<br />
Rifamycin<br />
A. lignieresii, 1354<br />
P. multocida, 1354<br />
Rikamycin<br />
C. trachomatis, 1350<br />
Rimantadine<br />
metabolism, 1699<br />
pharmacokinetics, 1699, 1813<br />
RO 23-6240<br />
C. trachomatis, 1080<br />
Nocardia spp., 1078<br />
Rokitamycin<br />
comparative activity, 1710<br />
Rosaramicin<br />
Arthrobacter spp., 420<br />
Staphylococcus spp., 420<br />
Rosoxacin<br />
C. trachomatis, 1350<br />
H. ducreyi, 1458<br />
Roxithromycin<br />
Bordetella spp., 137<br />
C. trachomatis, 1350<br />
combinations<br />
M. avium complex, 1149<br />
tumor necrosis factor, 1149<br />
comparative activity, 1710<br />
clarithromycin <strong>and</strong> erythromycin, 1758<br />
M. avium complex, 1149<br />
M. leprae, 1758<br />
pharmacokinetics, 1461<br />
T. gondii, 524<br />
T. pallidum, resistant, 164<br />
tonsillectomy, 1461<br />
toxicity, 1541<br />
uptake <strong>and</strong> distribution, 1541<br />
S-6123<br />
comparative activity<br />
ampicillin, ciprofloxacin, clindamycin,<br />
tetracycline, <strong>and</strong> trimethoprimsulfamethoxazole,<br />
1341<br />
E. coli, 1341<br />
Enterococcus spp., 1341<br />
gram-negative bacteria, 1341<br />
H. influenzae, 1341<br />
mechanism of action, 1341<br />
Staphylococcus spp., 1341<br />
Streptococcus spp., 1341<br />
S-25930<br />
Nocardia spp., 1078<br />
S-25932<br />
Nocardia spp., 1078<br />
S26308<br />
cytomegalovirus, 678<br />
interferon, 678<br />
Saccharomyces cerevisiae<br />
cilofungin, 1331<br />
Salmonella paratyphi A<br />
ampicillin resistance, 195<br />
cross-resistant mutant, 195<br />
mutation, pleiotropic, 195<br />
Salmonella spp.<br />
lomefloxacin, 656<br />
R-3746, 671<br />
tigemonam, 84<br />
SUBJECT INDEX xxix<br />
Salmonella typhimurium<br />
A-61827, 27<br />
allicin, 1763<br />
ampicillin, 57<br />
chloramphenicol, 57<br />
ciprofloxacin, 57<br />
diallyl thiosulfinate, 1763<br />
fleroxacin, 791<br />
letter to the editor, 791<br />
Salmonella wien<br />
FIme plasmid, 1262<br />
R plasmid, 1262<br />
tetracycline resistance, class B, 1262<br />
TnJO-like transposon, 1262<br />
Sarcina lutea<br />
etoposide, 1456<br />
Scrub typhus<br />
chloramphenicol, 285<br />
ciprofloxacin, 285<br />
gentamicin, 285<br />
SDZ 89-485<br />
S. schenckii, 1619<br />
sporotrichosis, 1619<br />
Sedecamycin<br />
comparative activity<br />
carbadox, lincomycin, <strong>and</strong> tiamulin,<br />
458<br />
T. hyodysenteriae, 458<br />
Serindeia werneckei<br />
B. gingivalis, 598<br />
B. melaninogenicus, 598<br />
Serratia marcescens<br />
6'-N-acetyltransferase type 4, 1289<br />
amikacin resistance, 1289, 1379<br />
gentamicin resistance, 1379<br />
kanamycin resistance, 1379<br />
netilmicin resistance, 1379<br />
PD 117,596, 1450<br />
R-3746, 671<br />
R plasmid, 9, 1289, 1379, 1834<br />
tigemonam, 84<br />
tobramycin resistance, 1379<br />
Serratia spp.<br />
E-1040, 1666<br />
Serum bactericidal activity<br />
cefoxitin, 1511<br />
ceftizoxime, 1511<br />
SF 86-327<br />
combinations<br />
ketoconazole, 1237<br />
T. (S.) cruzi, 1237<br />
T. (S.) cruzi, 1237<br />
Shigella sonnei<br />
R plasmids, 1598<br />
trimethoprim resistance, 1598<br />
Shigella spp.<br />
amikacin, 20<br />
ampicillin, 20<br />
ampicillin-sulbactam, 20<br />
cefam<strong>and</strong>ole, 20<br />
cefoperazone, 20<br />
cefotaxime, 20<br />
ceftazidime, 20<br />
ceftriaxone, 20<br />
cefuroxime, 20<br />
cephalothin, 20<br />
chloramphenicol, 20<br />
ciprofloxacin, 20<br />
enoxacin, 20<br />
gentamicin, 20<br />
kanamycin, 20<br />
lomefloxacin, 656<br />
moxalactam, 20
xxx SUBJECT INDEX<br />
nalidixic acid, 20<br />
norfloxacin, 20<br />
ofloxacin, 20<br />
pefloxacin, 20<br />
R-3746, 671<br />
streptomycin, 20<br />
sulfanmethoxazole, 20<br />
tetracycline, 20<br />
tigemonam, 84<br />
trimethoprimn, 20<br />
trimethoprim-sulfamethoxazole,<br />
20<br />
Simarouba amara<br />
E. histolytica, 1725<br />
P. falciparum, 1725<br />
quassinoids, 1725<br />
Simian immunodeficiency virus<br />
3'-azido-3'-deoxythyiidine triphosphate,<br />
1733<br />
AZT triphosphate, 1733<br />
foscarnet, 1733<br />
reverse transcriptase, 1733, 1887<br />
Simian varicella-zoster virus<br />
+2HM-HBG, 1807<br />
(R,S)-9-[4-hydroxy-2(hydroxymethyl)<br />
butyl]guanite, 1807<br />
Sindbis virus<br />
carrageenans, 1742<br />
dextran sulfate, 1742<br />
fucoidan, 1742<br />
pentosan polysulfate, 1742<br />
sulfated polysaccharides, 1742<br />
SK&F 88070<br />
M. tuberculosis, 1441<br />
Skin infections<br />
cefonicid, 485<br />
cephalexin hydrochloride, 882<br />
cephalexin monohydrate, 882<br />
Skin structure infections<br />
cefonicid, 485<br />
Sodium hydroxide digestion method<br />
gentamicin, 595<br />
SodiUim hypochlorite<br />
Enterobacteriaceae, 873<br />
Soft tissue infections<br />
cephalexin hydrochloride, 882<br />
cephalexin monohydrate, 882<br />
Spectinomycin<br />
E. coli<br />
lipopolysaccharide, 1247<br />
gonorrhea<br />
disk zone diameter as predictor of outcome,<br />
775<br />
f. ducreyi, 1458<br />
P. carinii, 896<br />
Spectrophotometric assay<br />
protein binding of penems, 159<br />
Spermine<br />
E. coli, 308<br />
Spiramycin<br />
Arthrobacter spp., 420<br />
comparative activity, 1710<br />
P. carinii, 896<br />
R. conorii, 255<br />
R. rickettsii, 255<br />
Staphylococcus spp., 420<br />
T. gondii, 303, 524<br />
Sporothrix schenckii<br />
amphotericin B, 1619<br />
itraconazole, 1619<br />
SDZ 89-485, 1619<br />
terbinafine, 1619<br />
Sporotrichosis<br />
amphotericin B, 1619<br />
itraconazole, 1619<br />
SDZ 89-485, 1619<br />
terbinafine, 1619<br />
Staphylococcus aureus<br />
A-61827, 27<br />
acriflavin resistance, 932<br />
acrinol resistance, 932<br />
amikacin resistance, 932<br />
bactericidal testing, 1614<br />
benzalkonium chloride resistance, 932<br />
,-lactamase, 1614, 1754<br />
transposon, 1164<br />
cefazolin, 262<br />
cefotaxime-chloramphenicol, 1375<br />
cefpirome, 13%<br />
ceftriaxone-chloramphenicol, 1375<br />
cephalexin hydrochloride, 882<br />
cephalexin monohydrate, 882<br />
cephalosporins, 170<br />
cephalothin, 374<br />
chlorhexidine resistance, 932<br />
cinoxacin, 1192<br />
ciprofloxacin, 747, 1192<br />
conjunctivitis, 1820<br />
daptomycin, 279, 454<br />
difloxacin, 262<br />
DNA gyrase, 1192<br />
DuP 105, 580<br />
DuP 721, 580<br />
endocarditis, 262, 747, 919<br />
enoxacin, 262<br />
ethidium bromide resistance, 932<br />
etoposide, 1456<br />
fluoroquinolone resistance, 1285<br />
fosfomycin, 919<br />
fosfomycin-pefloxacin, 919<br />
gentamicin resistance, 932, 1174<br />
imipenem sub-MICs<br />
killing, 1012<br />
phagocytosis, 1012<br />
serum sensitivity, 1012<br />
kanamycin resistance, 932<br />
letter to the editor, 1464<br />
LY163892, 131<br />
MBC reproducibility, 374<br />
nalidixic acid, 1192<br />
norfloxacin, 1192, 1820<br />
ocular infections, 1820<br />
ofloxacin, 1192<br />
oxacillin, 374, 1614<br />
susceptibility, 1754<br />
PD 117,596, 1450<br />
pefloxacin, 919<br />
pefloxacin-fosfomycin, 919<br />
penicillin resistance, 1164<br />
R plasmids, 932, 1164, 1174<br />
resistance phenotype, 170<br />
susceptibility testing, 1464<br />
T-3262, 663<br />
tobramycin, 1820<br />
resistance, 932<br />
U-76,253A, 443<br />
vancomycin, 374, 454<br />
Staphylococcus carnosus<br />
methicillin resistance.<br />
cloning from S. epidermidis,<br />
1494<br />
Staphylococcus epidermidis<br />
catheters, 1627<br />
cefam<strong>and</strong>ole, 63<br />
cefazolin, 63<br />
ANTIMICROB. AGENTS CHEMOTHER.<br />
daptomycin, 63, 279<br />
disodium EDTA, 1627<br />
DuP 105, 580<br />
DuP 721, 580<br />
endocarditis, 63<br />
methicillin resistance<br />
cloning in S. carnosus, 1494<br />
R plasmid, 1494<br />
T-3262, 661<br />
vancomycin, 63, 1627<br />
Staphylococcus spp.<br />
A-61827, 27<br />
carbomycin, 420<br />
cefixime, 18%<br />
cefpodoxime, 18%<br />
ceftriaxone, 1896<br />
celesticetin, 420<br />
cephalexin hydrochloride, 882<br />
cephalexin monohydrate, 882<br />
clindamycin, 420<br />
coagulase negative<br />
P-lactamase, 1754<br />
oxacillin susceptibility, 1754<br />
conjunctivitis, 1820<br />
CS-807, 1082<br />
daptomycin, 24, 279<br />
DR-3355, 1336<br />
DuP 105, 150<br />
DuP 721, 150<br />
E-1040, 1666<br />
E-3846, 636<br />
erythromycin, 420<br />
halovinylglycine compounds, 319<br />
L-norvalyl peptide derivatives,<br />
319<br />
josamycin, 420<br />
lincomycin, 420<br />
resistance, 420<br />
lomefloxacin, 617, 656<br />
ME1207, 1421<br />
norfloxacin, 1820<br />
nosocomial infections<br />
cardiac surgery, 202<br />
coronary angioplasty, 202<br />
ocular infections, 1820<br />
ole<strong>and</strong>omycin, 420<br />
PD 127,391, 1251<br />
rosaramicin, 420<br />
S-6123, 1341<br />
spiramycin, 420<br />
T-3262, 827<br />
tobramycin, 1820<br />
trospectomycin, 216<br />
tylosin, 420<br />
U-76,252, 1082<br />
U-76,253A, 443<br />
vernamycin B, 420<br />
Stearylamine<br />
liposomes, %6<br />
T. b. gambiense, 966<br />
Stomatitis, denture<br />
C. albicans, 1859<br />
fluconazole, 1859<br />
Streptococci<br />
alpha-hemolytic<br />
conjunctivitis, 1820<br />
norfloxacin, 1820<br />
ocular infections, 1820<br />
tobramycin, 1820<br />
group B<br />
cefotaxime-chloramphenicol, 1375<br />
ceftriaxone-chloramphenicol, 1375
VOL . 32, 1988<br />
Streptococcus faecalis<br />
P-lactamase, 122, 547, 768<br />
cystitis, 636<br />
daptomycin, 81, 877<br />
effect on translocation, 337<br />
daptomycin-gentamicin, 81, 877<br />
E-3846, 636<br />
endocarditis, 877<br />
erythromycin resistance, 547<br />
gentamicin, 81, 736<br />
resistance, 547<br />
gentamicin-daptomycin, 81, 877<br />
gentamicin-penicillin G procaine, 877<br />
gentamicin-vancomycin, 877<br />
penicillin G procaine, 877<br />
penicillin G procaine-gentamicin, 877<br />
pheromones, 547<br />
pyelonephritis, 81, 636<br />
R plasmid, 547<br />
vancomycin, 877<br />
vancomycin-gentamicin, 877<br />
Streptococcus faecium<br />
aminoglycoside resistance, 1528<br />
gentamicin resistance, 1528<br />
R plasmids, 1528<br />
Streptococcus pneumoniae<br />
ampicillin, 552<br />
aztreonam, 552<br />
ceftriaxone, 552<br />
conjunctivitis, 1820<br />
daptomycin, 24<br />
gentamicin, 552<br />
in vitro simulation of serious infections,<br />
552<br />
ME1207, 1421<br />
norfloxacin, 1820<br />
ocular infections, 1820<br />
PD 127,391, 1251<br />
R-3746, 671<br />
tigemonam, 84<br />
tobramycin, 1820<br />
Streptococcus pyogenes<br />
A-61827, 27<br />
berberine sulfate<br />
fibronectin, 1370<br />
hexadecane, 1370<br />
host cell adherence, 1370<br />
cephalexin hydrochloride, 882<br />
cephalexin monohydrate, 882<br />
Streptococcus sanguis<br />
etoposide, 1456<br />
Streptococcus sobrinus<br />
C31G, 350<br />
Streptococcus spp.<br />
A-61827, 27<br />
C31G, 350<br />
Campylobacter resistance gene, 1793<br />
ceftibuten, 1576<br />
CS-807, 1082<br />
daptomycin, 141<br />
DuP 105, 150, 580<br />
DuP 721, 150, 580<br />
E-1040, 1666<br />
endocarditis, 141<br />
erythromycin estolate, 1227<br />
erythromycin ethylsuccinate, 1227<br />
lomefloxacin, 617<br />
LY163892, 268<br />
PD 117,596, 1450<br />
penicillin G, 141<br />
R-3746, 671<br />
R plasmids, 1793<br />
S-6123, 1341<br />
T-3262, 827<br />
tetracycline<br />
resistance, 1271<br />
tigemonam, 84, 346<br />
trospectomycin, 216<br />
U-76,252, 1082<br />
U-76,253A, 443<br />
Streptomyces avermitilis<br />
avermectin production<br />
glucose metabolism, 282<br />
Streptomyces spp.<br />
antibiotic biosynthetic genes, 1472<br />
biosynthetic genes, 1472<br />
cloned genes, 1465, 1472<br />
minireviews, 1465, 1472<br />
recombinant DNA, 1465<br />
Streptomycin<br />
adenylyltransferase<br />
B. subtilis, 949<br />
letter to the editor, 949<br />
combinations<br />
enterococci, 1769<br />
streptomycin, 1769<br />
enterococci, 1769<br />
fecal flora resistance, 1801<br />
M. avium, 1131<br />
M. tuberculosis, 1208, 1441<br />
Shigella spp., 20<br />
Sulbactam<br />
bioassay, 1347<br />
combinations<br />
ampicillin, 1830<br />
B. fragilis, 403<br />
B. fragilis-E. coli, 1830<br />
cefoperazone, 403<br />
pharmacokinetics, 42<br />
Sulbenicillin<br />
biliary excretion<br />
ursodeoxycholate, 726<br />
percutaneous transhepatic biliary drainage,<br />
726<br />
Sulfadiazine<br />
P. carinii, 96<br />
Sulfadimethoxine<br />
B. bronchiseptica, 1891<br />
Cryptosporidium sp., 1907<br />
letter to the editor, 1907<br />
Sulfadoxine<br />
P. carinii, 96<br />
T. gondii, 303<br />
Sulfamethoxazole<br />
C. trachomatis, 1350<br />
combinations<br />
trimethoprim, 802<br />
urinary tract infections, 802<br />
H. ducreyi, 1458<br />
hyperbilirubinemia<br />
centrifugal ultrafiltration, 1571<br />
N. asteroides, 1776<br />
P. carinii, 96<br />
Shigella spp., 20<br />
Sulfamethoxazole-trimethoprim<br />
Bordetella spp., 137<br />
comparative activity<br />
rifampin-trimethoprim, 802<br />
urinary tract infections, 802<br />
Sulfamonomethoxine<br />
B. bronchiseptica, 1891<br />
Sulfated polysaccharides<br />
adenovirus, 1742<br />
coxsackievirus, 1742<br />
cytomegalovirus, 1742<br />
herpes simplex virus, 1742<br />
SUBJECT INDEX xxxi<br />
human immunodeficiency virus, 1742<br />
parainfluenza virus, 1742<br />
poliovirus, 1742<br />
reovirus, 1742<br />
Sindbis virus, 1742<br />
vaccinia virus, 1742<br />
vesicular stomatitis virus, 1742<br />
Sulfisoxazole<br />
B. catarrhalis, 259<br />
Chlamydia sp. strain TWAR, 257<br />
H. influenzae, 180<br />
hyperbilirubinemia<br />
centrifugal ultrafiltration, 1571<br />
Sulfonamides<br />
dihydropteroate synthase (sullI) gene,<br />
1684<br />
resistance plasmids, 1684<br />
sulII gene<br />
nucleotide sequence, 1684<br />
Suramin<br />
P. carinii, 1158<br />
Susceptibility testing<br />
B. catarrhalis, 1747<br />
C. trachomatis, 1350<br />
minireview, 1295<br />
monoclonal antibodies, 1295<br />
ceftibuten, 1576<br />
Enterobacteriaceae, 1365<br />
gram-negative bacteria, 385<br />
H. influenzae, 1747<br />
chloramphenicol, 1484<br />
letter to the editor, 1464<br />
LY163892, 1477<br />
M. avium, 1131<br />
M. tuberculosis, 125<br />
minireview, 1747<br />
N. gonorrhoeae, 1747<br />
pyrazinamide, 125<br />
S. aureus, 1464<br />
T. pallidum subsp. pallidum, 68<br />
T-25<br />
influenza viruses, 906<br />
T-26<br />
influenza viruses, 906<br />
T-3262<br />
B. catarrhalis, 663<br />
B. fragilis, 663, 1437<br />
C. trachomatis, 1080<br />
comparative activity<br />
ceftazidime, ciprofloxacin, gentamicin,<br />
imipenem, <strong>and</strong> ofloxacin, 663<br />
ciprofloxacin, ofloxacin, norfloxacin,<br />
<strong>and</strong> pipemidic acid, 827<br />
E. coli, 663, 827<br />
E. faecalis, 663<br />
Enterobacteriaceae, 663, 827<br />
Enterococcus spp., 827<br />
H. influenzae, 663<br />
N. gonorrhoeae, 663<br />
P. aeruginosa, 663, 827<br />
P. cepacia, 663<br />
P. maltophilia, 663<br />
S. aureus, 663<br />
S. epidermidis, 663<br />
Staphylococcus spp., 827<br />
Streptococcus spp., 827<br />
Talampicillin<br />
dental granuloma, 566<br />
Teicoplanin<br />
combinations<br />
Corynebacterium group JK, 434
xxxii SUBJECT INDEX<br />
gentamicin <strong>and</strong> tobramycin, 434<br />
Corynebacterium group JK, 434<br />
pharmacokinetics, 1223<br />
Temafloxacin<br />
comparative activity<br />
erythromycin, 1500<br />
M. hominis, 1500<br />
M. pneumoniae, 1500<br />
U. urealyticum, 1500<br />
Temocillin<br />
A. denitrificans subsp. xylosoxidans,<br />
276<br />
infusion system, 1705<br />
K. pneumoniae, 1705<br />
meningitis, 1705<br />
pharmacokinetics, 1705<br />
Terbinafine<br />
Aspergillus spp., 780<br />
comparative activity<br />
amphotericin B <strong>and</strong> ketoconazole, 780<br />
S. schenckii, 1619<br />
sporotrichosis, 1619<br />
Terminalia glaucescens<br />
B. gingivalis, 598<br />
B. melaninogenicus, 598<br />
Testosterone<br />
fluconazole, 646<br />
ketoconazole, 646<br />
Tetracaine<br />
E. coli permeability, 153<br />
Tetracycline<br />
B. bronchiseptica, 1891<br />
B. catarrhalis, 259<br />
B. fragilis resistance, 1271<br />
Bacillus spp., 642<br />
bite wound bacteria, 1143<br />
Bordetella spp., 137<br />
C. trachomatis, 1350<br />
Campylobacter resistance, 1793<br />
Chlamydia sp. strain TWAR, 257<br />
comparative activity<br />
demeclocycline, doxycycline, erythromycin,<br />
minocycline, nalidixic<br />
acid, oxytetracycline, <strong>and</strong> rifampin,<br />
986<br />
cryptic resistance determinant on<br />
Tn4400, 1797<br />
detoxification, 1797<br />
E. risticii, 986<br />
efflux, 1797<br />
Eubacterium spp. resistance, 1271<br />
F. nucleatum resistance, 1271<br />
fecal flora resistance, 1801<br />
H. ducreyi, 1458<br />
H. influenzae, 180<br />
letter to the editor, 951<br />
N. gonorrhoeae resistance, 488, 951<br />
N. perflava-N. sicca resistance, 1271<br />
Neisseria resistance, 488<br />
oral bacteria, 1271<br />
P. anaerobius resistance, 1271<br />
P. multocida, 213<br />
periodontal disease, 1271<br />
resistance<br />
degradation, 1797<br />
E. corrodens, 765<br />
efflux, 1797<br />
K. denitrificans, 765<br />
Neisseria spp., 765<br />
S. wien resistance, 1262<br />
Shigella spp., 20<br />
Streptococcus spp. resistance, 1271<br />
V. parvula resistance, 1271<br />
Theophylline<br />
GABA receptor, 1624<br />
y-aminobutyric acid receptor, 1624<br />
pharmacokinetics<br />
ciprofloxacin, effect of, 75<br />
norfloxacin, 510<br />
Thiamphenicol<br />
H. ducreyi, 1458<br />
Ticarcillin<br />
B. catarrhalis, 259<br />
dysgonic fermenter 2, 78<br />
Enterobacteriaceae, 873<br />
P. maltophilia, 782<br />
P. pseudomallei, 1435<br />
Ticarcillin-clavulanic acid<br />
A. denitrificans subsp. xylosoxidans, 276<br />
B. catarrhalis, 259<br />
Bacillus spp., 642<br />
comparative activity<br />
clindamycin-amikacin, 1557<br />
head <strong>and</strong> neck surgery in cancer<br />
patients, 1557<br />
letter to the editor, 407<br />
P. pseudomallei, 1435<br />
puerperal infections, 407<br />
wound infections, 1557<br />
Ticarcillin-potassium clavulanate<br />
Enterobacteriaceae resistance, 1365<br />
Tigemonam<br />
A. hydrophila, 84<br />
Acinetobacter spp., 84<br />
B. catarrhalis, 84<br />
Bacteroides spp., 84<br />
C. diversus, 84<br />
comparative activity<br />
aztreonam, cefaclor, <strong>and</strong> trimethoprim-sulfamethoxazole,<br />
346<br />
E. aerogenes, 84<br />
E. cloacae, 84<br />
E. coli, 84, 346<br />
Enterobacter spp., 84<br />
Enterobacteriaceae, 84<br />
Enterococcus spp., 84<br />
Haemophilus spp., 84<br />
Klebsiella spp., 84<br />
Listeria spp., 84<br />
Morganella spp., 84<br />
Neisseria spp., 84<br />
Proteus spp., 84<br />
Providencia spp., 84<br />
Pseudomonas spp., 84, 346<br />
S. marcescens, 84<br />
S. pneumoniae, 84<br />
Salmonella spp., 84<br />
Shigella spp., 84<br />
Streptococcus spp., 84, 346<br />
Y. enterocolitica, 84<br />
Tinidazole<br />
T. vaginalis, 144<br />
Tobramycin<br />
A. denitrificans subsp. xylosoxidans,<br />
276<br />
B. catarrhalis, 259<br />
combinations<br />
amiloride, 395<br />
ampicillin, 1231<br />
biliary tract infections, 1231<br />
ciprofloxacin, 782<br />
P. maltophilia, 782<br />
Pseudomonas spp., 395<br />
comparative activity<br />
norfloxacin, 1820<br />
conjunctivitis, 1820<br />
ANTIMICROB. AGENTS CHEMOTHER.<br />
E. coli, 450<br />
lipopolysaccharide, 1247<br />
Enterobacteriaceae, 873<br />
H. influenzae, 1820<br />
iontophoretic application, 978<br />
K. pneumoniae resistance, 1379<br />
keratitis, 978<br />
ocular infections, 1820<br />
P. aeruginosa, 978<br />
alginate binding, 518<br />
P. maltophilia, 782<br />
pharmacokinetics<br />
charcoal, effect of, 274<br />
postantibiotic effect, 450<br />
Pseudomonas spp., 395<br />
S. aureus, 1820<br />
resistance, 932<br />
S. marcescens resistance, 1379<br />
S. pneumoniae, 1820<br />
Staphylococcus spp., 1820<br />
streptococci, alpha-hemolytic, 1820<br />
Tobramycin-ampicillin<br />
biliary tract infections, 1231<br />
comparative activity<br />
cefoperazone, 1231<br />
Tonsillectomy<br />
erythromycin<br />
acistrate, 1019<br />
stearate, 1019<br />
tissue <strong>and</strong> plasma concentrations,<br />
1019<br />
roxithromycin, 1461<br />
Torulopsis glabrata<br />
cilofungin, 1331<br />
Total hip arthroplasty<br />
vancomycin bone concentrations, 1320<br />
Toxoplasma gondii<br />
A-56268, 524<br />
azithromycin, 524, 755<br />
enzyme-linked immunosorbent assay,<br />
303<br />
ornithine decarboxylase inhibitors, 303<br />
piritrexim, 430<br />
pyrimethamine, 303<br />
roxithromycin, 524<br />
spiramycin, 303, 524<br />
sulfadoxine, 303<br />
Translocation<br />
enterococci, 1769<br />
Treponema hyodysenteriae<br />
sedecamycin, 458<br />
Treponema pallidum<br />
erythromycin resistance, 164<br />
roxithromycin resistance, 164<br />
Treponema pallidum subsp. pallidum<br />
susceptibility testing, 68<br />
Triazoles<br />
minireview, 1<br />
Trichodermin<br />
M. racemosus, 341<br />
Trichomonas vaginalis<br />
aminoglycosides, 144<br />
amphotericin B, 1323<br />
anisomycin, 144<br />
antifungal agents, 144<br />
P-lactams, 144<br />
chemotaxis, 1323<br />
folic acid antagonists, 144<br />
furazolidone, 144<br />
gentamicin, 1323<br />
imidazoles, 1323<br />
ketoconazole, 1323<br />
macrolides, 144
VOL. 32, 1988<br />
mebendazole, i44<br />
metronidazole, 144, 1323<br />
miconazole, 1323<br />
Nonoxynol-9, 1323<br />
penicillin, 1323<br />
tinidazole, 144<br />
Trichophyton spp.<br />
G2, 1586<br />
Trimethoprim<br />
combinations<br />
dapsone, 623<br />
P. carinii, 623<br />
pneumonia, 623<br />
rifampin <strong>and</strong> sulfamethoxazole, 802<br />
urinary tract infections, 802<br />
Enterobacteriaceae, 873<br />
H. ducreyi, 1458<br />
H. influenzae resistance, 477<br />
P. carinii, 96<br />
S. sonnei resistance, 1598<br />
Shigella spp., 20<br />
Trimethoprim-sulfamnethoxazole<br />
A. denitrificans subsp. xylosoxidans,<br />
276<br />
B. catarrhalis, 259<br />
Bacillus spp., 642<br />
comparative activity<br />
ciprofloxacin, 1327<br />
dapsone, pentamidine, <strong>and</strong> trimethoprim-dapsone,<br />
623<br />
cystitis, 1640<br />
dysgonic fermenter 2, 78<br />
E. coli, 1640<br />
Enterobacteriaceae, 1327<br />
H. ducreyi, 1458<br />
H. influenzae, 180<br />
P. carinii, 623, 1158<br />
P. multocida, 213<br />
pharmacokinetics, 1640<br />
pneumonia, 623<br />
Shigella spp., 20<br />
urinary tract infections, 1327<br />
Trimetrexate<br />
high-pressure liquid chromatography,<br />
324<br />
P. carinii, 324<br />
pharmacokinetics, 324<br />
Tromethamine fosfomycin<br />
pharmacokinetics, 938<br />
young <strong>and</strong> elderly adults, 938<br />
Trospectomycin<br />
B. catarrhalis, 216<br />
B. fragilis, 584<br />
Bacteroides spp., 216, 584<br />
C. trachomatis, 216<br />
C. difficile, 216<br />
Chlamydia sp. strain TWAR, 257<br />
Clostridium spp., 216<br />
comparatiVe activity<br />
ampicillin, cefaclor, cefoxitin, clindamycin,<br />
<strong>and</strong> doxycycline, 584<br />
ampicillin, gentamicin, <strong>and</strong><br />
spectinomycin, 216<br />
Enterobacteriaceae, 216<br />
H. influenzae, 216<br />
N. gonorrhoeae, 216<br />
Proteus spp., 216<br />
Staphylococcus spp., 216<br />
Streptococcus spp., 216<br />
Trypanosoma brucei gambiense<br />
stearylamine- <strong>and</strong> phosphatidylcholineliposomes,<br />
966<br />
Trypanosoma cruzi<br />
nifurtimox, 241<br />
immune response, effect on, 241<br />
P536, 1412<br />
UDP-glucose analog, 1412<br />
Trypanosoma (Schizotrypanum) cruzi<br />
ketoconazole, 1237<br />
ketoconazole-SF 86-327, 1237<br />
SF 86-327, 1237<br />
Tubercidin<br />
influenza viruses, 906<br />
Tumor necrosis factor<br />
combinations<br />
amikacin, azithronycin, <strong>and</strong><br />
roxithromycin, 1149<br />
M. avium complex, 1149<br />
Tylosin<br />
Arthrobacter spp., 420<br />
E. coli<br />
heat treatment, 1680<br />
Staphylococcus spp., 420<br />
U-76,252<br />
A. hydrophila, 1082<br />
B. catarrhalis, 1082<br />
C. diversus, 1082<br />
comparative activity<br />
amoxicillin, amoxicillin-clavulanic<br />
acid, cefaclor, cefuroxime, cephalexin,<br />
<strong>and</strong> erythromycin, 1082<br />
E. coli, 1082<br />
E. faecalis, 1082<br />
Enterobacteriaceae; 1082<br />
H. influenzae, 1082<br />
Klebsiella spp., 1082<br />
P. aeruginosa, 1082<br />
P. mirabilis, 1082<br />
Staphylococcus spp., 1082<br />
Streptococcus spp., 1082<br />
U-76,253A<br />
Acinetobacter spp., 443<br />
B. catarrhalis, 443<br />
comparative activity<br />
amoxicillin, amoxicillin-clavulanic<br />
acid, cefaclor, cefixime, <strong>and</strong> cefuroxime,<br />
443<br />
Enterobacteriaceae, 443<br />
enterococci, 443<br />
H. influenzae, 443<br />
Neisseria spp., 443<br />
pneumococci, 443<br />
Pseudomonas spp., 443<br />
S. aareus, 443<br />
Staphylococcus spp., 443<br />
Streptococcus spp., 443<br />
UDP-glucose analogs<br />
herpes simplex virus type 1, 1257<br />
P-536, 1257, 1412<br />
T. cruzi, 1412<br />
Ureaplasma urealyticum<br />
A-63075, 1500<br />
clarithromycin, 1500<br />
difloxacin; 1500<br />
erythromycin, 1500<br />
temafloxacin, 1500<br />
Uridine<br />
3'-azido-3'-deoxythymidine toxicity,<br />
997<br />
AZT toxicity, 997<br />
Urinary tract infections<br />
berberine sulfate, 1274<br />
carumonam, 473, 1031<br />
SUBJECT INDEX xxxiii<br />
ceftazidime, 1031<br />
ciprofloxacin, 1327<br />
Enterobacteriaceae, 1327<br />
gentamicin, 473<br />
norfloxacin, 1292<br />
rifampin-trimethoprim, 802<br />
sulfamethoxazole-trimethoprim, 802<br />
trimethoprim-sulfamethoxazole, 1327<br />
Ursodeoxycholate<br />
biliary excretion<br />
cefotiam, 726<br />
sulbenicillin, 726<br />
Vaccinia virus<br />
P-536, 1257<br />
sulfated polysaccharides, 1742<br />
Vancomycin<br />
Bacillus spp., 642<br />
bone concentrations<br />
osteomyelitis, 1320<br />
total hip arthroplasty, 1320<br />
cardiopulmonary bypass, 631<br />
catheters, 1627<br />
combinations<br />
Corynebacterium group JK, 434<br />
gentamicin <strong>and</strong> tobramycin, 434<br />
comparative activity<br />
cefam<strong>and</strong>ole, cefazolin, <strong>and</strong> daptomycin,<br />
63<br />
daptomycin, 454<br />
Corynebacterium group JK, 434<br />
dysgonic fermenter 2, 78<br />
E. coli<br />
heat treatment, 1680<br />
endocarditis, 63<br />
pharmacokinetics, 92, 631, 848<br />
S. aureus, 454<br />
MBCs, 374<br />
S. epidermidis, 63, 1627<br />
Vancomycin-ceftazidime<br />
pharmacokinetics, 92<br />
Varicella-zoster virus<br />
acyclovir triphosphate, 1137<br />
3'-azido-3'-deoxythymidine, 265<br />
AZT, 265<br />
B-220, 1720<br />
buciclovir triphosphate, 1137<br />
9-(3,4-dihydroxybutyl)guanine triphosphate,<br />
1137<br />
DNA polymerases, 1137<br />
9-[4-hydroxy-2(hydroxymethyl)butyl]<br />
guanine triphosphate, 1137<br />
9-(2-hydroxyethoxymethyl)guanine triphosphate,<br />
1137<br />
Veillonella parvula<br />
tetracycline<br />
resistance, 1271<br />
Vernamycin B<br />
Arthrobacter spp., 420<br />
Staphylococcus spp., 420<br />
Vernonia amygdalina<br />
B. gingivalis, 598<br />
B. melaninogenicus, 598<br />
Vesicular stomatitis virus<br />
carrageenans, 1742<br />
dextran sulfate, 1742<br />
fucoidan, 1742<br />
P-536, 1257<br />
pentosan polysulfate, 1742<br />
ribavirin, phosphorylated, 492<br />
sulfated polysaccharides, 1742<br />
transcription, 492
xxxiv SUBJECT INDEX ANTIMICROB. AGENTS CHEMOTHER.<br />
Virus-antigen assays<br />
human immunodeficiency virus type 1,<br />
684<br />
Vitamin K<br />
cefotetan effect on metabolism, 1446<br />
cefoxitin effect on metabolism, 1446<br />
Wound infections<br />
clindamycin-amikacin, 1557<br />
ticarcillin-clavulanic acid, 1557<br />
WR 194,965 phosphate<br />
crystal <strong>and</strong> molecular structure, 540<br />
Xanthomonas maltophilia<br />
E-1040, 1666<br />
Xylotubercidin<br />
influenza viruses, 906<br />
Yersinia enterocolitica<br />
tigemonam, 84<br />
Yersinia spp.<br />
R-3746, 671<br />
YTR 830<br />
1-lactamases, 925<br />
C. freundii, 925<br />
comparative activity<br />
clavulanic acid <strong>and</strong> sulbactam,<br />
925<br />
E. cloacae, 925<br />
E. coli, 925<br />
K. aerogenes, 925<br />
mechanisms of action, 925<br />
P. mirabilis, 925<br />
Zinc<br />
common cold, 605, 606, 608<br />
letters to the editor, 605, 606, 608