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Robert C. Moellering, Jr.,<br />

Editor in Chief (1990)<br />

New Engl<strong>and</strong> Deaconess Hospital<br />

Boston, Mass.<br />

Michael Barza, Editor (1990)<br />

New Engl<strong>and</strong> Medical Center<br />

Hospitals<br />

Boston, Mass.<br />

Lawrence E. Bryan, Editor (1992)<br />

University of Calgary<br />

Calgary, Alberta, Canada<br />

Vincent T. Andriole (1990)<br />

Bascom F. Anthony (1988)<br />

Gordon L. Archer (1989)<br />

George R. Aronoff (1989)<br />

Rashmi H. Barbhaiya (1989)<br />

Arthur L. Barry (1989)<br />

John G. Bartlett (1990)<br />

Arnold S. Bayer (1988)<br />

William M. Bennett (1990)<br />

Michel G. Bergeron (1989)<br />

Richard F. Bergstrom (1988)<br />

Karen K. Biron (1990)<br />

Gerald P. Bodey (1989)<br />

Ward Bullock (1990)<br />

Tsun Chang (1989)<br />

Anthony Chow (1988)<br />

C. Glenn Cobbs (1989)<br />

Paul S. Cohen (1989)<br />

William A. Craig (1990)<br />

Naomi Datta (1990)<br />

Lawrence E. Day (1989)<br />

William E. Dismukes (1990)<br />

Gary V. Doern (1990)<br />

Susan M. Dorrbecker (1989)<br />

R. Gordon Douglas, Jr. (1989)<br />

John C. Drach (1990)<br />

George L. Drusano (1990)<br />

Theodore Eickhoff (1988)<br />

Gertrude B. Elion (1990)<br />

George M. Eliopoulos (1988)<br />

Arthur English (1989)<br />

ANTIMICROBIAL AGENTS AND<br />

CHEMOTHERAPY<br />

VOLUME 32 DECEMBER 1988 NUMBER 12<br />

Jack M. Gwaltney, Jr., Editor (1990)<br />

University of Virginia School of<br />

Medicine<br />

Charlottesville<br />

George A. Jacoby, Jr., Editor (1990)<br />

Massachusetts General Hospital<br />

Boston<br />

EDITORIAL BOARD<br />

Robert J. Fass (1988)<br />

Stuart Feldman (1988)<br />

Sydney Finegold (1988)<br />

Martin Forbes (1989)<br />

John N. Galgiani (1990)<br />

Dale N. Gerding (1988)<br />

Allan Godfrey (1990)<br />

Irving H. Goldberg (1988)<br />

Thomas D. Gootz (1988)<br />

Stephen B. Greenberg (1989)<br />

Scott M. Hammer (1989)<br />

Margaret R. Hammerschlag (1989)<br />

Robert E. W. Hancock (1989)<br />

W. Lee H<strong>and</strong> (1989)<br />

H. Hunter H<strong>and</strong>sfield (1989)<br />

Frederick G. Hayden (1990)<br />

Leonid B. Heifets (1990)<br />

Michael L. Higgins (1989)<br />

David C. Hooper (1990)<br />

Richard Hornick (1989)<br />

George Gee Jackson (1989)<br />

Michael R. Jacobs (1990)<br />

James H. Jorgensen (1990)<br />

William J. Jusko (1989)<br />

A. W. Karchmer (1988)<br />

Donald Kaye (1988)<br />

Mark S. Klempner (1989)<br />

George S. Kobayashi (1988)<br />

Jeffrey R. Koup (1990)<br />

Donald J. Krogstad (1989)<br />

Philip Todd Lavin (1989)<br />

Stephen A. Lerner (1989)<br />

Stuart B. Levy (1989)<br />

David R. Luke (1990)<br />

Joan Lusk (1989)<br />

R. Luthy (1989)<br />

Gerald L. M<strong>and</strong>ell (1989)<br />

Gary R. Matzke (1989)<br />

George H. McCracken (1990)<br />

Antone A. Medeiros (1990)<br />

Michael Miller (1990)<br />

Barbara E. Murray (1990)<br />

Henry W. Murray (1990)<br />

John D. Nelson (1989)<br />

Harold C. Neu (1989)<br />

Lawrence A. Pachla (1990)<br />

Joseph S. Pagano (1990)<br />

James E. Pennington (1989)<br />

T. J. Perun (1989)<br />

Lance R. Peterson (1988)<br />

W. H. G. Richards (1989)<br />

Douglas D. Richman (1990)<br />

Glenn D. Roberts (1989)<br />

Richard Roberts (1988)<br />

Ian M. Rollo (1988)<br />

Allan Ronald (1990)<br />

John P. Rosazza (1989)<br />

Jon E. Rosenblatt (1988)<br />

Robert H. Rubin (1990)<br />

Merle S<strong>and</strong>e (1988)<br />

W. Eugene S<strong>and</strong>ers, Jr. (1990)<br />

W. Michael Scheld (1989)<br />

Christine C. S<strong>and</strong>ers, Editor (1989)<br />

Creighton University School of<br />

Medicine<br />

Omaha, Neb.<br />

John A. Washington II, Editor (1991)<br />

Clevel<strong>and</strong> Clinic Foundation<br />

Clevel<strong>and</strong>, Ohio<br />

Peter G. Welling, Editor (1988)<br />

Warner-Lambert Co.<br />

Ann Arbor, Mich.<br />

Jerome J. Schentag (1988)<br />

Raymond F. Schinazi (1989)<br />

Fritz D. Schoenknecht (1989)<br />

Robert T. Schooley (1990)<br />

F. C. Sciavolino (1988)<br />

William M. Shannon (1989)<br />

Charles Shipman, Jr. (1988)<br />

David M. Shlaes (1988)<br />

Robert W. Sidwell (1990)<br />

Herbert M. Sommers (1989)<br />

P. Frederick Sparling (1990)<br />

Harold St<strong>and</strong>iford (1988)<br />

David A. Stevens (1989)<br />

Stephen E. Straus (1990)<br />

R. Sutherl<strong>and</strong> (1988)<br />

Morton N. Swartz (1988)<br />

Richard B. Sykes (1988)<br />

Francis P. Tally (1990)<br />

Fred C. Tenover (1988)<br />

Alex<strong>and</strong>er Tomasz (1988)<br />

Roger D. Toothaker (1988)<br />

Francis L. S. Tse (1989)<br />

Michael Waring (1990)<br />

Bernard Weisblum (1988)<br />

Peter F. Weller (1989)<br />

Richard Wise (1989)<br />

John S. Wolfson (1990)<br />

David J. Wyler (1989)<br />

Lowell Young (1988)<br />

Pauline K. W. Yu (1988)<br />

Helen R. Whiteley, Chairman, Publications Board Kirk Jensen, Director of Publications<br />

Linda M. Illig, Managing Editor, Journals<br />

Carol J. Neff, Production Editor<br />

<strong>Antimicrobial</strong> <strong>Agents</strong> <strong>and</strong> <strong>Chemotherapy</strong> (ISSN 0066-4804), an interdisciplinary publication of the American Society for Microbiology,<br />

1913 I St., N.W., Washington, DC 20006, is devoted to the dissemination of knowledge relating to all aspects of antimicrobial, antiparasitic,<br />

<strong>and</strong> anticancer agents <strong>and</strong> chemotherapy. Instructions to authors are published in the January issue each year; reprints are available from the<br />

editors <strong>and</strong> the Publications Department. <strong>Antimicrobial</strong> <strong>Agents</strong> <strong>and</strong> <strong>Chemotherapy</strong> is published monthly, one volume per year. The<br />

nonmember subscription price is $220 per year; single copies are $30. The member subscription price is $35 (foreign, $56 [air drop shipping])<br />

per year; single copies are $8. Correspondence relating to subscriptions, reprints, defective copies, availability of back issues, lost or late<br />

proofs, disposition of submitted manuscripts, <strong>and</strong> general editorial matters should be directed to the ASM Publications Department, 1913 I<br />

St., N.W., Washington, DC 20006 (phone: 202 833-9680).<br />

Claims for missing issues from residents of the United States, Canada, <strong>and</strong> Mexico must be submitted within 3 months after publication<br />

of the issues; residents of all other countries must submit claims within 6 months of publication of the issues. Claims for issues missing<br />

because of failure to report an address change or for issues "missing from files" will not be allowed.<br />

Second-class postage paid at Washington, DC 20006, <strong>and</strong> at additional mailing offices.<br />

POSTMASTER: Send address changes to <strong>Antimicrobial</strong> <strong>Agents</strong> <strong>and</strong> <strong>Chemotherapy</strong>, ASM, 1913 I St., N.W., Washington, DC 20006.<br />

Made in the United States of America.<br />

Copyright C) 1988, American Society for Microbiology. 43*:I^ &'iAK,J L Um{f,1; ( I13'f<br />

All Rights Reserved.<br />

The code at the top of the first page of an article in this journal indicates the copyright owner's consent that copies of the article may be<br />

made for personal use or for personal use of specific clients. This consent is given on the condition, however, that the copier pay the stated<br />

per-copy fee through the Copyright Clearance Center, Inc., 21 Congress St., Salem, MA 01970, for copying beyond that permitted by Sections<br />

107 <strong>and</strong> 108 of the U.S. Copyright Law. This consent does not extend to other kinds of copying, such as copying for general distribution, for<br />

advertising or promotional purposes, for creating new collective works, or for resale.

Abele, Gunnar, 1807<br />

Akabane, Taro, 1864<br />

Arnold, Barbara H., 1784<br />

Barg, Neil L., 1834<br />

Beale, Angela S., 1830<br />

Benoni, G., 1875<br />

Bertr<strong>and</strong>, G., 1875<br />

Blumer, Jeffrey L., 1780<br />

Boehme, Richard E., 1887<br />

Brown, David C., 1899<br />

Bubrick, Melvin P., 1845<br />

Budtz-J0rgensen, Ejvind, 1859<br />

Call, N. Branson, 1820<br />

Cannon, Deborah L., 1784<br />

Casas, Ivan A., 1854<br />

Chang, Stephen C., 1763<br />

Chen, Ming S., 1887<br />

Chernow, Marlene, 1887<br />

Chuang, Ronald Y., 1887<br />

Chung, Tung C., 1854<br />

Cocchetto, David M., 1845<br />

Consolo, U., 1875<br />

Cornford, Richard J., 1879<br />

Courvalin, Patrice, 1793<br />

Crenshaw, Deborah, 1780<br />

Cunningham, Eloise, 1788<br />

Curtis, Nigel A. C., 1879<br />

Cuzzolin, L., 1875<br />

Datema, Roelf, 1807<br />

Davis, Joanne, 1801<br />

de Clercq, Erik, 1839<br />

Dirks, Monte S., 1820<br />

Dobrogosz, Walter J., 1854<br />

Doern, Gary V., 1747<br />

East, Simon J., 1879<br />

Edlund, Charlotta, 1869<br />

Eisenstadt, Rosemary L.,<br />

1879<br />

Feldberg, Ross S., 1763<br />

Ferro, Adolph J., 1904<br />

Ferronato, G., 1875<br />

Fitchen, John H., 1904<br />

Flaherty, John F., 1825<br />

Fleishaker, Joseph C., 1825<br />

Fletcher, Courtney V., 1899<br />

Fracasso, M. E., 1875<br />

Franzblau, Scott G., 1758<br />

Gambertoglio, John G., 1825<br />

Gates, Mark L., 1893<br />

Gisby, John, 1830<br />

Goldfarb, Johanna, 1780<br />

Guglielmo, B. Joseph, 1825<br />

Gustavson, Linda E., 1813<br />

Hastings, Robert C., 1758<br />

Hayden, Frederick G., 1813<br />

Heim-Duthoy, Karen L., 1845<br />

Holmstrup, Palle, 1859<br />

Holy, Antonin, 1839<br />

Hori, Ritsuko, 1848<br />

Inoue, Matsuhisa, 1848<br />

Isayama, Yasuro, 1891<br />

Ishikawa, Hitoshi, 1891<br />

Jacobson, Jay A., 1820<br />

Jechorek, Robert P., 1769<br />

Jones, Ronald N., 1747<br />

Joyce, Lyle D., 1899<br />

Karaffa, Camile, 1754<br />

Kasworm, Evelyn M., 1820<br />

Knapp, Cynthia, 1754, 1896<br />

Komiyama, Atsushi, 1864<br />

Kotik, Alan N., 1763<br />

Krogh, Palle, 1859<br />

Lake, Kathleen D., 1899<br />

Lake-Bakaar, Desmond M.,<br />

1807<br />

Author Index<br />

Lemon, Eloise, 1780<br />

Leone, R., 1875<br />

Levy, Stuart B., 1797, 1801<br />

Lindborg, Bjorn, 1807<br />

Lindqvist, Lennart, 1869<br />

Love, Kathryn R., 1899<br />

Maddaus, Michael A., 1769<br />

Marshall, Bonnie, 1801<br />

Martino-Saltzman, David,<br />

1784<br />

Marx, Preston A., 1887<br />

Masuda, Midori, 1864<br />

Matsuoka, Takafumi, 1864<br />

Matthews, Thomas R., 1887<br />

Matzke, Gary R., 1845<br />

McGinnis, E., 1788<br />

McRoberts, Mary Jane, 1887<br />

Mitsuhashi, Susumu, 1848<br />

Mitsuyama, Junichi, 1848<br />

Murata, Kenjiro, 1864<br />

Nadler, Marcus, 1763<br />

Neuwirth, Zeev, 1763<br />

Nord, Carl Erik, 1869<br />

Ohmae, Kenichi, 1891<br />

O'Horo, Jennifer, 1780<br />

Papadopoulou, Barbara, 1793<br />

Parham, Christine, 1788<br />

Park, Britt H., 1797<br />

Prisbe, Ernest J., 1887<br />

Pritzker, Marc R., 1899<br />

Puchetti, V., 1875<br />

Riscoe, Michael K., 1904<br />

Rodondi, Lisa C., 1825<br />

Rosenberg, Ivan, 1839<br />

Rowse, Deborah, 1801<br />

Saikawa, Isamu, 1848<br />

Sakuma, Takashi, 1839<br />

S<strong>and</strong>ers, Christine C., 1893<br />

S<strong>and</strong>ers, W. Eugene, Jr., 1893<br />

Schinazi, Raymond F., 1784<br />

Schluederberg, Susan, 1801<br />

Selitrennikoff, Claude P., 1901<br />

Sierra-Madero, Juan, 1754,<br />

1896<br />

Simmons, Richard L., 1769<br />

Smith, John M., 1776<br />

Snoeck, Robert, 1839<br />

Soike, Kenneth F., 1807<br />

Stark, Tracey, 1901<br />

Steele, Lorraine C., 1776<br />

Sumter, Gwendolyn, 1776<br />

Sundstrom, David C., 1763<br />

Suttmann, Rebecca T., 1887<br />

Taft, Cathy S., 1901<br />

Talarico, Todd L., 1854<br />

Thompson, Nathan H., 1763<br />

Tominack, Rebecca L., 1813<br />

Townsend, Raymond J., 1825<br />

Turner, Ronald B., 1820<br />

Walker, Linda A., 1879<br />

Wallace, Richard J., Jr., 1776<br />

Washington, John A., 1754,<br />

1896<br />

Wells, Carol L., 1769<br />

White, Anthony J., 1879<br />

Wills, Robert J., 1813<br />

Wu, John C., 1887<br />

Yamazaki, Munehiro, 1864<br />

Yasuda, Takashi, 1848<br />

Yasui, Kozo, 1864<br />

Yotsuji, Akira, 1848<br />

Zilhao, Rita, 1793

ACKNOWLEDGMENT<br />

The following persons served as invited special reviewers for the journal during 1988, <strong>and</strong> their help is greatly appreciated.<br />

Charles A. Alford, Jr.<br />

J. Davis Allen<br />

R. Anderson<br />

F. S. Archibald<br />

Devron Averett<br />

Johan S. Bakken<br />

Robert M. Bannatyne<br />

Jules Baum<br />

Robert Beahner<br />

Michael Bennish<br />

J. D. Berman<br />

Robert F. Betts<br />

A. Bock<br />

John M. Boyce<br />

Volkman Braun<br />

Sam Broder<br />

Kenneth Brown<br />

Karen Bush<br />

Peter Canonico<br />

Stephen J. Cavalier<br />

Henry Chambers<br />

John Chapman<br />

Stephen A. Chartr<strong>and</strong><br />

Ming S. Chen<br />

Yung-Chi Cheng<br />

Ian Chopra<br />

Gordon Christensen<br />

Richard B. Clark<br />

Donald Coen<br />

Patrice Courvalin<br />

W. A. Cramer<br />

Lawrence R. Crane<br />

Jorge Crosa<br />

Clyde Crumpacker<br />

George Cuchural, Jr.<br />

Thomas Curran<br />

Richard Davey<br />

Bernard Davis<br />

Eric De Clercq<br />

David Diuguid<br />

Thomas Dougherty<br />

Kathleen M. Downey<br />

Richard Duma<br />

Paul H. Edelstein<br />

Roslyn Eisenberg<br />

Suzanne U. Emerson<br />

Richard H. K. Eng<br />

Lawrence Eron<br />

J. 0. Falkinham<br />

Barry M. Farr<br />

David Feingold<br />

Robert Fekety<br />

A. Ferrante<br />

A. Kirk Field<br />

Cay Fitch<br />

Robert J. Fitzgerald<br />

Cecil W. Forsberg<br />

A. Forsgren<br />

Eben Fox<br />

I. Fridovich<br />

K. P. Fu<br />

Philip Furman<br />

James Fyfe<br />

Denise Galloway<br />

Peter Gemski<br />

Nafsika Georgopapadakou<br />

Donald K. Giger<br />

David Gilbert<br />

Michael Glauser<br />

Joseph Glorioso<br />

Richard V. Goering<br />

Myles Gombert<br />

Robert C. Good<br />

John E. Greenlee<br />

Jerome E. Groopman<br />

Gerri S. Hall<br />

J. Owen Hendley<br />

Martin Hirsch<br />

Jan V. Hirschmann<br />

Glen R. Hodger<br />

B. Houwen<br />

Walter Hughes<br />

Pentti Huovinen<br />

J. Michael J<strong>and</strong>a<br />

Susan Jensen<br />

Dave Johns<br />

Allen Kaiser<br />

Earl R. Kern<br />

A. Kerr<br />

W. M. M. Kirby<br />

Saul Kit<br />

T. R. Klaenhammer<br />

Vernon Knight<br />

M. Kozak<br />

Donald Leblanc<br />

William Ledger<br />

Tim Lee<br />

Rol<strong>and</strong> A. Lev<strong>and</strong>owski<br />

J. J. Lipsky<br />

L. F. Liu<br />

David Livermore<br />

G. Lopez-Berestein<br />

Lionel A. M<strong>and</strong>ell<br />

Joseph Marr<br />

J. R. Martin<br />

Kenneth Mayer<br />

J. K. McClatchy<br />

Mark A. McKinlay<br />

Colin McLaren<br />

Cody Meissner<br />

Miklos H. Muller<br />

William N. Murphy<br />

Kenrad E. Nelson<br />

R. H. Neubauer<br />

Franklin Neva<br />

Ernest Newbrun<br />

Thalia Nicas<br />

H. Nikaido<br />

Carl-Erik Nord<br />

Richard Novick<br />

Paul O'Keefe<br />

Andrew Onderdonk<br />

Michael Otto<br />

W. Paranchych<br />

Roberta Parente<br />

J. T. Parisi<br />

T. Parr<br />

Robert Pass<br />

Gerald Peir<br />

L. Piddock<br />

Philip Pizzo<br />

Laurel C. Preheim<br />

Alice Prince<br />

Peter J. Quesenberry<br />

Jonathan I. Ravdin<br />

D. J. Reed<br />

Jack Remington<br />

K. L. Rinhart, Jr.<br />

Marilyn Roberts<br />

William Robinson<br />

Hans G. Sahl<br />

Irving Salit<br />

K. S<strong>and</strong>erson<br />

Prem Sarin<br />

Priscilla Schaeffer<br />

Charles J. Schleupner<br />

A. Schryvers<br />

Warren Shaw<br />

G. Shockman<br />

Robert Shoemaker<br />

Robert E. Shope<br />

Simon Silver<br />

John Sixbey<br />

Craig A. Smith<br />

Thomas Smith<br />

Jack Sobel<br />

Kenneth F. Soike<br />

Pam Sokol<br />

Tom Specter<br />

David Speert<br />

Magel Spitz<br />

Brian Spratt<br />

Walter Stamm<br />

Victor Stollar<br />

Barbara Styrt<br />

J. W. Suttie<br />

Richard L. Sweet<br />

Francis P. Szoka<br />

H. Taber<br />

Janson M. Tanzer<br />

Martin Tauber<br />

Raymond Testa<br />

Charles Thoen<br />

Clyde Thornsberry<br />

Richard Tidwell<br />

Carmelita Tuazon<br />

E. Tuomanen<br />

Ronald B. Turner<br />

M. Vaara<br />

Leo Vining<br />

Edward E. Walsh<br />

Richard J. Whitley<br />

Kirk Wilhelmis<br />

Murray Wittner<br />

Emanuel Wolinsky<br />

Brian Wong<br />

D. E. Woods<br />

Philip Wyde<br />

Robert Yarchoan<br />

Stephen Zinner<br />

M. Zweerink

Abele, G., 1137, 1807<br />

Abraham, Soman N., 1274<br />

Acar, J. F., 9, 195<br />

Adinolfi, Luigi E., 1012<br />

Adloff, M., 1360<br />

Aguirre, Tania, 1237<br />

Aikawa, M., 1655<br />

Aizawa, Noboru, 1648<br />

Akabane, Taro, 1864<br />

Akerfeldt, Stig, 1720<br />

Akimoto, Yoshiaki, 566<br />

Alarc6n, Balbino, 1257, 1412<br />

Albrecht, Janice K., 47, 224<br />

Alcina, Antonio, 1412<br />

Aidridge, Kenneth, 717<br />

Allais, Jean M., 1327, 1740<br />

Allegra, Carmen J., 324, 430<br />

Allison, Patricia E., 137<br />

Alonso, Marie-Jose, 1204<br />

Alvarez, Emilio, 1061<br />

An, Florence Y., 547<br />

An<strong>and</strong>, Rita, 684<br />

Andrade, J., 780<br />

Andremont, Antoine, 1204<br />

Andrews, J. M., 617, 1251, 1508<br />

Andrews, Kenneth J. M., 814<br />

Andry, G., 1557<br />

Ansehn, Steffan, 1208<br />

Antikainen, Riitta, 1019<br />

Anwar, Hosmin, 364<br />

Aoyagi, Teruo, 110<br />

Aoyama, Hiroshi, 104, 922<br />

Apicella, Michael A., 777<br />

Appelbaum, Frederick R., 271<br />

Arai, Mamoru, 110<br />

Arai, Susumu, 1040, 1396<br />

Arai, Toshihiko, 110<br />

Arakawa, Soichi, 1080<br />

Arathoon, Eduardo G., 369<br />

Araujo, Fausto G., 755<br />

Arca, Pilar, 1552<br />

Armstrong, D., 780, 1676<br />

Arnold, Barbara H., 1784<br />

Arnold, John, 42<br />

Aronoff, Stephen C., 395, 1636<br />

Ashby, J. P., 617, 1251, 1508<br />

Ashdown, Leslie R., 1435<br />

Asmar, Basim I., 1375<br />

Auclair, Pierre, 736<br />

Azuma, Masanobu, 1547<br />

Baba, Masanori, 1025, 1742<br />

Babin-Chevaye, C., 1124<br />

Bachmann, Kenneth, 75, 730<br />

Bacon, Teresa H., 358<br />

Baker, Cynthia B., 374<br />

Baker, Pamela J., 1521<br />

Baker, Richard H., 462<br />

Bakken, Johan S., 1314<br />

Bakker, Leendert J., 473<br />

Bakker-Woudenberg, Irma A.J.M., 1560<br />

Balis, Frank M., 324<br />

Baltch, Aldona L., 1450, 1565<br />

Balzarini, Jan, 1025<br />

Baqar, Shahida, 462<br />

Barber, William E., 814<br />

Barg, Neil L., 202, 1834<br />

Barnett, Bill B., 331<br />

Baron, Patricia A., 1269<br />

Barredo, Jose L., 1061<br />

AUTHOR INDEX<br />

VOLUME 32<br />

Barriere, Steven L., 298<br />

Barry, Arthur L., 150, 346, 443, 752, 1576<br />

Bartlett, J. C., 598<br />

Bartlett, Karen H., 782<br />

Bartlett, Marilyn S., 897<br />

Bartosek, IVan, 1541<br />

Bartucci, F., 1461<br />

Bassford, Philip J., Jr., 164<br />

Baumann, Russell J., 1119<br />

Bayer, Arnold S., 141, 231<br />

Beachey, Edwin H., 1274, 1370, 1603,<br />

1609<br />

Beale, Angela S., 1830<br />

Beauchamp, Denis, 992<br />

Beckman, Howard B., 510<br />

Beggs, William H., 209<br />

Bellin, Eran Y., 1113<br />

Bemis, A. Todd, 63<br />

Bennett, D. B., 758<br />

Bennett, John E., 1619<br />

Bennett, Renee L., 209<br />

Bennett, William M., 844<br />

Benoni, G., 1875<br />

Berger-Bachi, Brigitte, 1494<br />

Bergeron, Michel G., 354, 561, 736, 1227,<br />

1231, 1433, 1515<br />

Bergman, Jan, 1720<br />

Berk, Shirley, 78<br />

Berk, Steven, 78<br />

Berkey, Peter, 1078<br />

Bermudez, Luiz Eduardo M., 1149<br />

Bernard, E. M., 780, 1676<br />

Bernareggi, Alberto, 246, 1223<br />

Bernstein, David I., 761<br />

Berthe, Jackie, 250<br />

Bertino, Joseph S., Jr., 236, 1446<br />

Bertr<strong>and</strong>, G., 1875<br />

Berube, Denise, 354, 1227<br />

Beyer, Jill M., 1710<br />

Bia, Frank J., 1182<br />

Bianchi, A., 1350<br />

Billot-Klein, D., 9, 195<br />

Biron, Karen, 265<br />

Biron, Simon, 1231<br />

Bishop, Monica, 1565<br />

Bittner, Marvin J., 1327<br />

Black, William A., 1441<br />

Blasecki, John W., 1699<br />

Blickens, Donald, 42<br />

Blickle, J. F., 1360<br />

Blum, Robert A., 848<br />

Blumer, Jeffrey L., 1780<br />

Bocquet, V., 1590<br />

Bodey, Gerald P., 1365<br />

Bodhidatta, Ladaporn, 723<br />

Boeckh, Michael, 92<br />

Boehm, Diane M., 137<br />

Boehme, Richard, 1154, 1887<br />

Boelaert, J., 1595<br />

Bohme, Ekkehard H., 1119<br />

Bongaerts, Ger P. A., 740<br />

B3onventre, Peter F., 1012<br />

Boot, J. M., 426<br />

Bornemann, L. D., 592<br />

Borner, Klaus, 92<br />

Borsa, Francoise, 938<br />

Boscia, Jerome A., 262, 877<br />

Boslego, John W., 775<br />

Bottner, Wayne A., 1446<br />

Bower, Robert R., 27<br />

Bowles, Susan K., 510<br />

Boyd, James C., 1644<br />

Boyd, Malcolm R., 358<br />

Bradley, S. G., 962<br />

Brajtburg, Janina, 327, 702<br />

Brafia, Alfredo F., 1552<br />

Br<strong>and</strong>icourt, Olivier, 250<br />

Br<strong>and</strong>t, Roger, 573<br />

Broadhurst, Anne V., 814<br />

Brogard, J. M., 1360<br />

Brown, David C., 1899<br />

Brown, Michael R. W., 364<br />

Brown, Robert, 1269<br />

Brown, S. Anthony, 595<br />

Brown, William J., 385<br />

Brunner, H., 57<br />

Brust, Paula, 1640<br />

Bryan, L. E., 498<br />

Bubrick, Melvin P., 1845<br />

Budtz-J0rgensen, Ejvind, 1859<br />

Bull, Herbert G., 319<br />

Bundy, J. McCall, 882<br />

Bush, Larry M., 877<br />

Byrne, Sean K., 1441<br />

Cabeza Meckert, Patricia, 241<br />

Cacalano, Grace Soong, 838<br />

Cafarell, Robert F., 777<br />

Calame, Wim, 1456<br />

Call, N. Branson, 182Q<br />

Campos, Jos4, 477, 706<br />

Canawati, Hanna N., 81<br />

Cannon, Deborah L., 1784<br />

Cantoral, Jesus M., 1061<br />

Canupp, Kay C., 1500<br />

Carbon, C., 1590<br />

Carlet, J., 9<br />

Carlisle, Ricarda, 997<br />

Carr, Mary E., 844<br />

Carrasco, Luis, 1257<br />

Carret, G., 454<br />

Casadaban, Malcolm, 1379<br />

Casalino, Mariassunta, 1262<br />

Casas, Ivan A., 1854<br />

Casey, Sharon W., 337<br />

Casin, I., 1350<br />

Cassano, Karen, 1031<br />

,Cassell, Gail H., 1500<br />

Castellano, S., 592<br />

Catherall, Elaine J., 1705<br />

Catlin, B. Wesley, 971<br />

Cattier, Bl<strong>and</strong>ine, 147<br />

Cavenaghi, Luigi, 246, 1223<br />

Chabner, Bruce A., 324, 430<br />

Chaffin, Donald O., 706<br />

Chalkley, Lynda J., 24<br />

Chamb6, Jorge G., 241<br />

Chamorro, Roxana M., 1416<br />

Champlin, Franklin R., 1354<br />

Chan, gobert, 1231<br />

Chanal, Catherine M., 626, 1660<br />

Chang, Hernan R., 524<br />

Chang, Stephen C., 1763<br />

Chanock, Robert M., 1269<br />

Chantrain, G., 1557<br />

Chapman, John S., 438<br />

Chastang, Claude, 303<br />

Chen, Man, 678<br />

Chen, Ming S., 1887<br />

Cheng, Nick, 788<br />

Chernow, Marlene, 1887

ii AUTHORINDEX<br />

Chin, Nai Xing, 838<br />

Chin, Nai-Xun, 84, 580, 656, 663, 671,<br />

1666<br />

Chitwarakorn, Anupong, 723<br />

Chongsuphajaisiddhi, T., 250<br />

Chow, AnthonyNW., 782, 788<br />

Chow, Raymond T., 1113<br />

Christenson, James G., 1005<br />

Chu, Chun-Jung, 858<br />

Chu, D. T. W., 27<br />

Chuang, Ronald Y., 1887<br />

Chung, Menger, 42<br />

Chung, Tung C., 1854<br />

Citron, Diane M., 213, 1143<br />

Clark, Richard B., 689, 1314<br />

Clarkson, Allen B., Jr., 1158<br />

Clavier, Francoise, 568<br />

Clayton, Christopher, 1213<br />

Cleary, Timothy, 717<br />

Cleel<strong>and</strong>, Roy, 770<br />

Clewell, Don B., 547<br />

Cluzel, Roger A., 626, 1660<br />

Cocchetto, David M., 1845<br />

Cohen, L. A., 1655<br />

Cohen, Paul S., 770<br />

Cohen, Seth P., 1187<br />

Cohn, Robert C., 395<br />

Cole, Gerald A., 462<br />

Coll, Ram6n, 636<br />

Collaborative <strong>Antimicrobial</strong> Susceptibility<br />

Testing Group, 346<br />

Collatz, E., 195, 1289<br />

Comereski, C. R., 758<br />

Conroy, Joseph V., 1450, 1565<br />

Consolo, U., 1875<br />

Conte, John E., Jr., 1490<br />

Cook, S<strong>and</strong>ra, 1439<br />

Corada, Monica, 1541<br />

Cornaglia, Giuseppe, 552<br />

Corner, Anne-Marie, 350<br />

Cormford, Richard J., 1879<br />

Courtney, Harry S., 1370<br />

Courvalin, Patrice, 15, 945, 1107, 1174,<br />

1793<br />

Couvreur, Patrick, 1204<br />

Craig, William A., 51<br />

Crawford, Carol E., 1441<br />

Crenshaw, Deborah, 1780<br />

Crokaert, F., 1632<br />

Crook, Derrick, 717<br />

Crosa, Jorge H., 1416<br />

Crossley, Kent B., 848<br />

Croteau, Daniel, 561, 1227<br />

Cuchural, George J., Jr., 717<br />

Cuevas, Thomas A., 1327<br />

Cullmann, Wolfgang, 1090<br />

Cunningham, Eloise, 1788<br />

Curran, James W., 684<br />

Curtis, Nigel A. C., 1879<br />

Cushion, Melanie T., 96, 896<br />

Cuzzolin, L., 1875<br />

Daghlian, Charles P., 1627<br />

Daikos, George L., 785<br />

Dajani, Adnan S., 1375<br />

Daly, Jennifer S., 1341<br />

Daneau, D., 1557<br />

Daneels, R., 1595<br />

Danese, Antonio, 246, 1223<br />

Dangor, Y., 1458<br />

Darfeuille-Richaud, Arlette, 1282<br />

Daschner, F. D., 930<br />

Datema, Roelf, 1807<br />

Daum, Robert S., 1034<br />

Davis, Joanne, 1801<br />

Davis, Robin L., 274<br />

Debbia, Eugenio, 279<br />

De Beule, K., 1595<br />

Debs, Robert J., 1404<br />

de Clercq, Erik, 906, 1025, 1742, 1839<br />

Deeg, H. Joachim, 271<br />

Deffrennes, Dominique, 467<br />

de Groot, Ronald, 477<br />

de las Heras, Federico G., 1257<br />

Delgado, Rafael, 1598<br />

Deloron, Philippe, 391<br />

Derouin, Francis, 303<br />

Desmyter, Jan, 1025<br />

Diez, Bruno, 1061<br />

DiGiovanni, Maria A., 982<br />

DiMattia, Arthur, 882<br />

Dirks, Monte S., 1820<br />

Dismukes, William E., I<br />

Divo, Alan A., 1182<br />

Dix, Barbara A., 770<br />

Dobrogosz, Walter J., 1854<br />

Doern, Gary V., 180, 259, 1747<br />

Dohtsu, Yasumasa, 1427<br />

Dolan, Margaret M., 350<br />

Dolan, Stephen A., 928<br />

Dor, P., 1557<br />

Dornbusch, Katherine, 1484<br />

Dorrington, Susan M., 518<br />

Dougherty, Steven H., 337<br />

Dougherty, Thomas J., 1113<br />

Douwes-Idema, Nora, 1456<br />

Draft, Kenneth, 773<br />

Drake, James C., 324, 430<br />

Drucker, William R., 882<br />

Druilhe, Pierre, 250<br />

Drusano, George L., 289, 1537<br />

Dubach, Ulrich C., 573<br />

Dudley, Michael N., 128<br />

Dufresne, Julien, 819<br />

Durica, David, 391<br />

Durkin, Michelle M., 807<br />

Durnell, Monty, 882<br />

Duroux, Michel H., 298<br />

Duzgunes, Nejat, 1404<br />

Dworzack, David L., 1740<br />

East, Simon J., 1879<br />

Ebert, S., 37<br />

Echeverria, Peter, 723<br />

Edelstein, Howard, 1031<br />

Edlund, Charlotta, 1869<br />

Edmondson, Diane G., 68<br />

Edwards, David J., 510<br />

Edwards, F., 780<br />

Ehret, Josephine M., 773, 1295<br />

Eisenstadt, Rosemary L., 1879<br />

Elberg, Svetlana, 327, 702<br />

Eliopoulos, G. M., 434, 1341, 1528<br />

Elvrum, Patricia M., 1170<br />

Elwell, Lynn P., 1086<br />

Elzinga, Lawrence W., 844<br />

Enthoven, D., 592<br />

Eriksson, B., 1137<br />

Escajadillo, A., 1655<br />

Espinoza, Ana Maria, 663<br />

Esteve, Montserrat, 636<br />

Eustice, D. C., 1218<br />

Everett, E. Dale, 928<br />

Evron, Ruth, 1586<br />

ANTIMICROB. AGENTS CHEMOTHER.<br />

Exposto, F. da L., 1458<br />

Fardel, G., 454<br />

Farinotti, R., 1590<br />

Fasco, Michael J., 1446<br />

Fass, Robert J., 1082<br />

Fattal, Elias, 1204<br />

Faurisson, Francois, 568<br />

Feld, Ron, 1231<br />

Feldberg, Ross S., 1763<br />

Feldman, P. A., 1218<br />

Fern<strong>and</strong>es, Prabhavathi B., 27, 1500, 1710<br />

Fern<strong>and</strong>ez-Guerrero, Manuel, 747<br />

Ferraro, Frank M., 1740<br />

Ferrea, Giuseppe, 1223<br />

Ferro, Adolph J., 1904<br />

Ferronato, G., 1875<br />

Fesik, Stephen W., 308<br />

Fetchick, Richard, 1310<br />

Fidalgo, S., 420<br />

Fillastre, Jean-Paul, 919, 938, 942<br />

Finegold, Sydney M., 403, 601, 611, 717<br />

Finnerty, Edmund F., 882<br />

Fischer, James H., 848<br />

Fitchen, John H., 1904<br />

Flaherty, John F., 1825<br />

Fl<strong>and</strong>rois, J. P., 454<br />

Fleishaker, Joseph C., 1825<br />

Fletcher, Courtney V., 1899<br />

Fleurette, J., 873<br />

Foddis, Giovanni, 552<br />

Folan, David W., Jr., 882<br />

Fong, Ignatius W., 834, 1231<br />

Forrest, Alan, 1537<br />

Foster, Timothy J., 1174<br />

Foucault, Paule, 1433<br />

Fourgeaud, M., 1094<br />

Foxall, Carrol, 710<br />

Foy, Jilanna, %, 896<br />

Fracasso, M. E., 1875<br />

Fraimow, Henry S., 1113<br />

Frances, Cathy A., 773<br />

Frank, U., 930<br />

Franzblau, Scott G., 1583, 1758<br />

Franzus, Bettylene, 78<br />

Freimer, E. H., 530<br />

Frelon, Jean-Hughes, 942<br />

French, G. L., 20<br />

Freney, J., 276, 873<br />

Fresno, Manuel, 1412<br />

Fuchs, Peter C., 346<br />

Fujii, Akira, 566, 1080<br />

Fujii, Tadashi, 104, 922<br />

Fujimaki, Kazuo, 104, 827, 922<br />

Fujimoto, Teruo, 1336<br />

Fung-Tomc, Joan, 1443<br />

Fuse, Aisaku, 587<br />

Gadebusch, Hans, 319<br />

Gaffey, Michael J., 1644<br />

Galioto, G. B., 1461<br />

Gambertoglio, John G., 298, 1825<br />

Gangadharam, Pattisapu R. J., 886, 1400,<br />

1404<br />

Garcia-Lopez, M. Teresa, 1257<br />

Gargallo, Domingo, 636<br />

Garry, Franklyn B., 595<br />

Gates, Mark L., 1893<br />

Gaudebout, Claude, 568<br />

Gavignet, Martine, 147

VOL . 32, 1988<br />

Gavini, F., 873<br />

Gaylord, Janet C., 1699<br />

Gaynes, Robert, 1379<br />

Geddes, Glenna L., 1441<br />

Georgopapadakou, Nafsika H., 438<br />

Gerard, M., 1557<br />

Gerbaud, Guy, 15, 626<br />

Gibbs, Ronald S., 853<br />

Gibson, Gene A., 1320<br />

Gilbert, Brian E., 117, 890<br />

Gilbert, Peter, 1693<br />

Ginunas, Virginia J., 81<br />

Girard, Arthur E., 1347<br />

Gisby, John, 1830<br />

Glupczynski, Y., 276, 1632<br />

Godin, Michel, 938, 942<br />

Goering, Richard V., 1164<br />

Golden, Jeffrey A., 1490<br />

Goldfarb, Johanna, 1780<br />

Goldmann, D., 1528<br />

Goldspiel, Barry R., 853<br />

Goldstein, Ellie J. C., 213, 1143<br />

Goldstein, F. W., 9, 195<br />

Goldstein, Jayne A., 1404<br />

Golenbock, D. T., 37<br />

Golper, Thomas A., 844<br />

Gonzalez, M. Eugenia, 1257<br />

Gootz, Thomas D., 159<br />

Goransson, Evelyn, 1484<br />

Gorbach, Sherwood L., 1439<br />

Gordin, Ariel, 1019<br />

Goudeau, Alain, 147<br />

Graham, Theodore, 271<br />

Graybill, John R., 1310<br />

Grayston, J. Thomas, 257<br />

Graziani, Amy L., 1320<br />

Greenberg, Richard, 710<br />

Gresser-Burns, Mary E., 513<br />

Griffith, Brigitte P., 678<br />

Griggs, D., 1508<br />

Groisman, Eduardo, 1379<br />

Gross, M. L., 530<br />

Guay, D. R. P., 485<br />

Guglielmo, B. Joseph, 298, 1511, 1825<br />

Guinea, Jesus, 636<br />

Guizie, Miriam, 1586<br />

Guptill, Douglas R., 755<br />

Gurwith, Dorothy, 802<br />

Gurwith, Marc, 802<br />

Gustavson, Linda E., 1813<br />

Gutmann, L., 9, 195<br />

Gwaltney, Jack M., Jr., 1644<br />

Haase, David A., 1292<br />

Hadley, W. K., 1392<br />

Hall, Gerti S., 1331<br />

Hall, Michael J., 814<br />

Hamati, Fawwaz, 78<br />

Hammer, Mark C., 1450, 1565<br />

Hancock, Robert E. W., 649<br />

H<strong>and</strong>sfield, H. Hunter, 773<br />

Haneishi, Tatsuo, 110<br />

Hanger, D. P., 646<br />

Hanna, Charles B., 882<br />

Hansen, W., 276<br />

Hanson, Charles W., 27<br />

Hanson, Linda H., 369<br />

Hara, Kohei, 1427<br />

Hardin, Thomas C., 1310<br />

Harding, Godfrey K., 1231, 1292<br />

Hardisson, C., 420, 1552<br />

Hardy, Dwight J., 27, 1710<br />

Harkonen, Scott, 710<br />

Harmenberg, J., 1100, 1137, 1533, 1720<br />

Harris, Jeffrey P., 865<br />

Hart, Mark E., 1354<br />

Hartstein, Alan I., 369<br />

Hastings, Robert C., 1758<br />

Haug, Alfred, 308, 649<br />

Hauser, M., 1676<br />

Hayakawa, Tomihiro, 726<br />

Hayasaka, Hiroshi, 1588<br />

Hayashi, Shoryo, 1040, 1396<br />

Hayashi, Toshiaki, 1427<br />

Hayashi, Toshikatsu, 458<br />

Hayashi, Toshio, 912<br />

Hayden, Frederick G., 224, 409, 1644,<br />

1813<br />

Hecht, David, 717<br />

Heeres-Weststrate, P. L., 426<br />

Heifets, Leonid, 1002, 1131<br />

Heim-Duthoy, K. L., 485, 1845<br />

Helsel, Valerie L., 1082<br />

Hemming, Val G., 1269<br />

Hengstler, Bruno, 364<br />

Henry, Nancy, 747<br />

Hensey, Dena M., 1710<br />

Hentges, David J., 337<br />

Herwaldt, Barbara L., 793, 799, 953, 957<br />

Heykants, J., 1595<br />

Hicks, R., 589<br />

Higashi, Katsuyoshi, 726<br />

Higgins, J. T., Jr., 530<br />

Hill, Carter D., 882<br />

Hill, Gale, 717<br />

Hill, James M., 978<br />

Hill, Lori, 1565<br />

Hirai, Keiji, 922<br />

Hirano, Lance, 141, 231<br />

Hirata, Koichi, 1588<br />

Hirota, Masaki, 1427<br />

Hitchcock, Michael J. M., 186<br />

Hoban, Daryl J., 1292<br />

Hobden, Jeffery A., 978<br />

Hoepelman, Andy I. M., 473<br />

Hoffken, Gert, 92<br />

Hoffman, Howard E., 1699<br />

Hoffner, Sven E., 1208<br />

Hohl, P., 1593<br />

Holden, Patricia, 450<br />

Holmstrup, Palle, 1859<br />

Holy, Antonin, 1025, 1839<br />

Hook, Edward W., III, 773<br />

Hooper, David C., 1187<br />

Hooton, Thomas M., 1640<br />

Hopewell, Philip C., 1057<br />

Hori, Michael, 1314<br />

Hori, Ritsuko, 1097, 1848<br />

Horowitz, Edward A., 1740<br />

Hoshino, Makoto, 726<br />

Hosotsubo, Hideo, 1103<br />

Hosotsubo, Kikumi, 1103<br />

Hostetter, Marcia K., 689<br />

Hottendorf, G. H., 314<br />

Howard, R. J., 1655<br />

HPA-23 Cooperative Study Group, 1300<br />

Hsiung, G. D., 678<br />

Huczko, Elizabeth, 1443<br />

Huffman, John H., 331<br />

Huggins, John W., 1304<br />

Hughes, Carolyn E., 209<br />

Hughes, Walter T., 623, 1057<br />

Hull, Richard, 768<br />

Humbert, Guy, 919<br />

Huovinen, Pentti, 134, 175<br />

AUTHOR INDEX iii<br />

Huovinen, Saara, 134, 175, 1730<br />

Hussoh, M. O., 873<br />

Iaconis, Joseph P., 1365<br />

Iannini, Paul, 717<br />

Ihler, Garret M., 391<br />

Ikeda, Fumiaki, 1243<br />

Ikeda, Haruo, 282<br />

Ikeda, Yasushi, 1073<br />

Inoue, Matsuhisa, 104, 587, 827, 922, 1097,<br />

1421, 1848<br />

Isayama, Yasuro, 1891<br />

Iseman, Michael D., 886, 1400<br />

Ishiguro, Edward E., 1247<br />

Ishiguro, Junzo, 1648<br />

Ishii, Junko, 378<br />

Ishikawa, Hitoshi, 1891<br />

Ito, Kazuyuki, 726<br />

Ito, Yasuo, 156<br />

Izard, D., 873<br />

Jackson, George Gee, 785<br />

Jacobs, Michael, 395<br />

Jacobs, Nicholas J., 1627<br />

Jacobs, Richard F., 1481<br />

Jacobson, Jay A., 1820<br />

Jacobson, Kirk D., 882<br />

Jacobus, Nilda V., 584, 717<br />

Jacoby, George A., 134, 175<br />

Janicke, David M., 777<br />

Jauregui, Luis, 75, 730<br />

Jay, Margaret A., 807<br />

Jechorek, Robert P., 1769<br />

Jehl, F., 1360<br />

Jevons, S., 646<br />

Jiang, Baoming M., 986<br />

Johnson, Carolyn R., 1640<br />

Johnson, Curtis A., 51<br />

Johnson, Steven R., 765<br />

Johnston, Michael, 1196<br />

Joly, Bernard H., 1282<br />

Jones, Ronald N., 346, 443, 752, 1576,<br />

1747<br />

Jonsson, Monica, 1278<br />

Jorgensen, James H., 180, 1477<br />

Joshi, Bharati, 285<br />

Joyce, Lyle D., 1899<br />

Judson, Franklyn N., 773, 1295<br />

Junakovic, Nikolaj, 1262<br />

Jusko, William J., 777<br />

Kadurugamuwa, Jagath L., 364<br />

Kaiser, Allen B., 202<br />

Kaiser, Donald L., 224<br />

Kam, K. M., 20<br />

Kamidono, Sadao, 1080<br />

Kamimura, Toshiaki, 1243<br />

Kan, Virginia L., 1619<br />

Kane, James G., 882<br />

Kaneda, Yoshimasa, 966<br />

Kaneko, Kenji, 566<br />

Karaffa, Camile, 1754<br />

Karasawa, Gakuyo, 1588<br />

Karchmer, Adolf W., 434<br />

Karle, Isabella L., 540<br />

Karle, Jean M., 540<br />

Karlsson, A., 1100<br />

Karlsson, Inga, 1484<br />

Kasworm, Evelyn M., 1820<br />

Katagiri, Kenji, 726<br />

Katahira, Junichi, 912<br />

Katayama, Toshiaki, 110

iv AUTHOR INDEX<br />

Kato, Hideo, 190<br />

Kato, Naoki, 1437<br />

Katsu, Kanemasa, 693<br />

Kawahapa, Yukinori, 110<br />

Kaye, Donald, 262, 877<br />

Kayser, Fritz H., 1494<br />

Kearns, Gregory L., 148i<br />

Keeler, Girard H., 1347<br />

Keith, Dennis D., 1005<br />

Kennedy, Donald, 710<br />

Kennedy, James K., 1292<br />

Kernodle, Douglas S., 202<br />

Kernutt, Ian, 1705<br />

Kesavalu, L., 886, 1400, 1404<br />

Kessler, Robert E., 1443<br />

Khan, Waheed N., 775<br />

Kim, C. Kurtis, 96, 8%<br />

Kimura, Hiromichi, 1588<br />

Kirihara, Jean, 1392<br />

Kirk, K. L., 1655<br />

Kirouac, Daniel, 1227<br />

Kitayama, Rieko, 912<br />

Kitoh, Kyosuke, 693<br />

Kitzis, M. D., 9<br />

Klamerus, Karen J., 631<br />

Klastersky, J., 1557<br />

Knapp, Cynthia, 131, 170, 1754, 1896<br />

Knapp, J. S., 426, 488, 765, 1430<br />

K'night, Vernon, 890<br />

Knodel, Leroy C., 853<br />

Kobasa, William D., 262<br />

Kobayashi, George S., 327, 702<br />

Kobayashi, Shinzo, 1046, 13%<br />

Kdeppe, Peter, 92<br />

Koga, Hironobu, 1427<br />

Kohno,'Shigeru, 1427<br />

Kokkonen, Paula, 1019<br />

Kolnig, Anne-Marie, 936<br />

Komiya, Masamichi, 566<br />

Komiyama, Atsushi, 1864<br />

Kondo, Eiko, 110<br />

Kondo, Sinichi, 1421<br />

Konno, Kenji, 906<br />

Koornhof, H. J., 24, 1458<br />

Koseki, Yuichi, 110<br />

Kosuzume, Hiroshi, 1648<br />

Kotaki, Hiromichi, 282<br />

Kotik, Alan N., 1763<br />

Koubaa, Nedra, 147<br />

Koup, Jeffrey R., 274, 573<br />

Kovacs, Joseph A., 430<br />

Kreindler, Thdmas G., 882<br />

Kresken, M.; 1285<br />

Krogh, Palle, 1859<br />

Krogstad, Donald J., 793, 799, 953, 957<br />

Kromann-Andersen, Bjarne, 936<br />

Kronvall, G6ran, 1484<br />

Kuhn, Jbhn G., 1310<br />

Kumada, Teppei, 912<br />

Kumano, Katsuhiko, 912<br />

Kumar, Ashir, 882<br />

Kume, Yothihiro, 190<br />

Kunka, R. L., 1503<br />

Kunz, Samuel, 364<br />

Kuo, Cho-chou, 257<br />

Kurihara, Kozo, 110<br />

Kurth, Reinhard, 1733<br />

Kurzynski, Terrence A., 137<br />

kusmiesz, Helen, 1738<br />

Kusser, Wolfgang C., 1247<br />

Kuvanont, Krit, 723<br />

Labedan, Bernard, 153<br />

Labia, Roger, 626, 1660<br />

Labro, M. T., 1124<br />

Labroo, V. M., 1655<br />

Laforest, H., 1094<br />

Lagrange, P. H., 1094<br />

Laguens, Ruben P., 241<br />

Lake, Kathleen D., 1899<br />

Lake-Bakaar, Desmond M., 1807<br />

Lally, Richard T., 513<br />

Lam, A. W., 20<br />

Lam, Y. W. Francis, 298<br />

Lambert, Thierry, 15<br />

Lane, H. Clifford, 324<br />

Laska, D. A., 314<br />

Laughon, B. E., 598<br />

Laux, David C., 770<br />

Lawson, Lisa A., 1320<br />

Lazardi, Keyla, 1237<br />

LeBel, Marc, 354, 561, 1227, 1515<br />

Leclerc, H., 873<br />

Lee, A. T., 1655<br />

Leggett, James E., 51<br />

Lemel<strong>and</strong>, Jean-Francois, 919<br />

Lemon, Eloise, 1780<br />

Leone, R., 1875<br />

Leoung, Gifford, 1057<br />

Lerner, Stephen A., 1196, 1379<br />

Leroy, Annie, 938<br />

Leslie, James, 1537<br />

Lessard, Celine, 736, 1433<br />

Lettieri, John, 75<br />

Levesque, Roger C., 819<br />

Levine, Bernard E., 369<br />

Levitsky, Sidney, 63i<br />

Levy, Mordekhai, 1586<br />

Levy, Stuart B., 1187, 1797, 1801<br />

Liebowitz, Lynne D., 24<br />

Lin, A. H., 592<br />

Lin, Jung-Chung, 265, 1068<br />

Lindborg, Bjorn, 1807<br />

Lindner, David L., 159<br />

Lindqvist, Lennart, 1869<br />

Ling, Julia, 20<br />

Linke, Michael J., 96, 98%<br />

Lismont, M. J., 1632<br />

Livermore, David M., 1385<br />

Livrelli, Valerie 0., 1282<br />

Lloyd, William J., 814<br />

Lode, Hartmut, 92<br />

Lokerse, A. F., 1560<br />

Lolans, Valentina T., 785<br />

London, William T., 1269<br />

Love, Kathryn R., 1899<br />

Lower, Johannes, 1733<br />

Loy, Anna, 1223<br />

Lucia, Helen L., 678<br />

Lundblad, Leif, 1720<br />

MacGregor, Rob Roy, 1320<br />

Machida, H., 1046, 1068, 1547<br />

Maddaus, Michael A., 1769<br />

Madier, S., 873<br />

Maeda, Hiroshi, 1080<br />

Maher, Louise A., 180, 1477<br />

Mahl<strong>and</strong>t, Bill G., 1304<br />

Maimorie, Francesco, 1262<br />

MalamUld, Daniel, 350<br />

Malouin, F., 498<br />

M<strong>and</strong>ell, Lionel, 1231<br />

Mannisto, Pekka T., 1019<br />

Mant, T. G. K., 1503<br />

ANTIMICROB. AGENTS CHEMOTHER.<br />

Marble, Dwight A., 503<br />

Marciano-Cabral, F., 962<br />

Marini, Patricia M., 1416<br />

Marshall, Bonnie, 1801<br />

Martel, Jean-Louis, 1282<br />

Martin, Juan F., 1061<br />

Martin, Mary E., 730<br />

Martino-Saltzman, David, 1784<br />

Martra, A., 873<br />

Marx, Preston A., 1887<br />

Masecar, Barbara L., 122<br />

Masuda, Midori, 1864<br />

Masur, Henry, 324, 430<br />

Mateos-Mora, Miguel, 170<br />

Matsui, Hidefumi, 33<br />

Matsumoto, Y., 1243, 1655<br />

Matsuoka, Takafumi, 1864<br />

Matthews, R. S., 617<br />

Matthews, Thomas R., 1154, 1887<br />

Matthys, E., 1595<br />

Mattie, Herman, 1456<br />

Matzke, G. R., 485, 1845<br />

McCabe, Robert, 1031<br />

McChesney, Daniel G., 775<br />

McClain, J. Bruce, 285<br />

McCormack, William M., 773<br />

McDonald, Edith'J., 1710<br />

McGinnis, E., 1788<br />

McGroarty, Estelle J., 308, 649<br />

McIntyre, 0. Ross, 1627<br />

McKee, Kelly T., Jr., 1304<br />

McMurry, Laura M., 1187<br />

McRoberts, Mary Jane, 1887<br />

Medina, Ileana, 1057<br />

Medoff, Gerald, 327, 702<br />

Mellencamp, Martha A., 1327<br />

Mendelman, Paul M., 706<br />

Mendelson, Jack, 1231<br />

Mendez, F. J., 420<br />

Mendez-Castrill6n, Paloma P., 1257<br />

Meunier, F., 1557<br />

Mevio, E., 1461<br />

Meyers, Joel D., 271<br />

Michel, M. F., 426<br />

Michelsen, Phyllis, 1565<br />

Mikami, Hidetada, 587<br />

Miller, Michael H., 1113<br />

Miller, S. D., 1458<br />

Mills, John, 1057<br />

Mine, Yasuhiro, 1243<br />

Mintzer, C. L., 391<br />

Mischak, Ronald P., 710<br />

Mitelman, Felix, 936<br />

Mitsuhashi, Susumu, 104, 587, 827, 922,<br />

1097, 1421, 1848<br />

Mitsuyama, Junichi, 1097, 1848<br />

Miyaji, Makoto, 726<br />

Miyauchi, Masayuki, i437<br />

Mizen, Linda, 1705<br />

Mobashery, Shahriar, 1196<br />

Mochida, Ei, 1648<br />

Mochizuki, Hidenori, 1648<br />

Moellering, R. C., Jr., 434, 1341, 1528<br />

Moncla, Bernard J., 1271<br />

Monteil; H., 1360<br />

Montgomerie, John Z., 81<br />

Monto, Arnold S., 47<br />

Moore, pavid, 1078<br />

Moore, Jennifer L., 684<br />

Moosdeen, F., 925<br />

Mor<strong>and</strong>, Annick, 1660<br />

Moriyama, Megumi, 693<br />

Moros, Mariano, 636

VOL. 32, 1988<br />

Morrison, P. J., 1503<br />

Morse, Stephen A., 765<br />

Mosadomi, H. A., 598<br />

Moseley, Steve L., 477<br />

Moskovitz, Bruce L., 1300<br />

Moulin, Bruno, 938, 942<br />

Mounier, J., 195<br />

Mullany, Peter, 1213<br />

Mummaw, Nancy, 1323<br />

Murakami, Kimihiro, 1648<br />

Murata, Kenjiro, 1864<br />

Murphy, James R., 462<br />

Murphy, Robert F., 324<br />

Murray, Barbara E., 547, 768<br />

Murray, Dennis L., 882<br />

Muto, Yoshinori, 1437<br />

Myles, Camille, 1331<br />

Nadler, Marcus, 1763<br />

Nagata, Osamu, 156, 190<br />

Nagayama, Ariaki, 1735<br />

Nakae, Taiji, 378, 966<br />

Nakajima, Mutsuo, 110<br />

Nakamura, Kiyoto, 906<br />

Nakao, Tomokazu, 1735<br />

Nakata, Katsuhisa, 1080<br />

Narukawa, Noriaki, 458<br />

Nassos, Patricia, 1392<br />

Nelson, Eric, 1379<br />

Nelson, John D., 268, 1738<br />

Neu, Harold C., 84, 580, 656, 663, 671,<br />

1666<br />

Neuwirth, Zeev, 1763<br />

Nichols, James S., 1119<br />

Nichols, Wright W., 518<br />

Nickell, Steven P., 462<br />

Nicolau, Claude, 391<br />

Nicoletti, Mauro, 1262<br />

Nightingale, Charles H., 128<br />

Nilsson, Lennart E., 1208<br />

Nishimura, Hitoshi, 566<br />

Nishino, Takeshi, 1073, 1192<br />

Nishiyama, Yukihiro, 1053<br />

Nix, David E., 450<br />

Nord, Carl Erik, 1869<br />

Norman, G. T. 1503<br />

Norrby, Ragnar, 936<br />

Norrby, S. Ragnar, 1278<br />

Norris, Steven J., 68<br />

Norton, James A., 63<br />

Noumi, Toshihiko, 827<br />

Novelli, Andrea, 580, 656, 663, 1666<br />

Oberg, Bo, 1733<br />

O'Callaghan, Richard J., 978<br />

Ochi, James W., 865<br />

O'Connell, Kevin, 492<br />

Ogborne, Kevin T., 186<br />

O'Hara, Denise, 1494<br />

O'Hare, J., 144<br />

Ohmae, Kenichi, 1891<br />

O'Horo, Jennifer, 1780<br />

Oikawa, Yoshihiro, 1648<br />

Okamoto, Ryoichi, 1421<br />

O'Keefe, J. Paul, 717<br />

Okezaki, Eiichi, 156, 190<br />

Okuda, Takao, 33<br />

Olson, L., 589<br />

Omnes, Anne, 1204<br />

Omura, Satoshi, 282<br />

O'Neill, Melanie J., 1725<br />

Opheim, Kent, 274, 1640<br />

Ortisi, G., 1461<br />

Osada, Yasuaki, 1336<br />

Oster, Sharon, 1031<br />

O'Sullivan, John F., 1583<br />

Otero, Joaquin R., 1598<br />

Ouellette, Marc, 397<br />

Pacheco, F., 589<br />

Pagano, Joseph S., 265<br />

Pakiz, Cathy B., 689<br />

Panneton, Anne-Claire, 354, 1515<br />

Panton, L. J., 1655<br />

Papadopoulou, Barbara, 945, 1793<br />

Pares, Juan, 636<br />

Parham, Christine, 1788<br />

Park, Britt H., 1797<br />

Parker, Steven W., 777<br />

Parrillo, Joseph E., 324, 430<br />

Parry, Michael F., 982<br />

Patchett, Arthur A., 319<br />

Patel, I. H., 592<br />

Patterson, Jan Evans, 122<br />

Patterson, Jean L., 492<br />

Patton, Curtis L., 1182<br />

Paul, Gerard C., 397<br />

Pauwels, Rudi, 1025, 1742<br />

Pearce, Maria, 1443<br />

Pechere, Jean-Claude F., 524<br />

Pelletier, Lawrence L., Jr., 374<br />

Peltier, G. L., 485<br />

Perol, Y., 1350<br />

Perumal, Veluchamy K., 886, 1400, 1404<br />

Pesce, Adelaide, 279<br />

Petit, Agnes, 626, 1660<br />

Pettigrew, Martine, 992<br />

Philippon, Alain M., 397<br />

Phillipson, J. David, 1725<br />

Pierson, Carl, 717<br />

Pifat, Dominique Y., 331<br />

Piras, Marta M., 1237<br />

Piras, Romano, 1237<br />

Plaisance, Karen I., 1537<br />

Podapati, N. Rao, 1400<br />

Polacheck, Itzhack, 1586<br />

Pompei, Raffaello, 552<br />

Poplack, David G., 324<br />

Popovski, Zagorka, 510<br />

Portnoy, J., 589<br />

Prainito, Marie, 1375<br />

Pratt, Kathleen J., 1331<br />

Preheim, Laurel C., 1327<br />

Preston, David A., 180<br />

Prince, Alice, 838<br />

Prince, Gregory A., 1269<br />

Prisbe, Ernest J., 1887<br />

Pritzker, Marc R., 1899<br />

Privitera, G., 1461<br />

Proctor, R. A., 37<br />

Pruess, David L., 1005<br />

Puchetti, V., 1875<br />

Pussard, Eric, 568<br />

Queener, Sherry F., 807<br />

Quentin, Rol<strong>and</strong>, 147<br />

Quinn, John P., 1267<br />

Quintiliani, Richard, 128<br />

Quiros, L. M., 420<br />

Rachlis, Anita, 1231<br />

Radstrom, Peter, 1684<br />

Ramer, Nancy R., 27<br />

Rao, Podapati N. R., 886<br />

AUTHOR INDEX v<br />

Raoult, D., 255<br />

Rash, Jay J., 1347<br />

Rashad, Abdel L., 844<br />

Rauramaa, Veikko, 1019<br />

Redding, Judith S., 180, 1477<br />

Rehavi, M., 1624<br />

Reiszner, E., 1528<br />

Reitberg, Donald P., 42, 51, 503, 730<br />

Remington, Jack S., 755<br />

Rescott, Denise L., 450<br />

Reuman, Peter D., 761<br />

Reynolds, Janet, 63<br />

Reynolds, Peter, 1494<br />

Rice, Robert, 285<br />

Rice-Ficht, Allison, 391<br />

Rich, Chantal D., 1282<br />

Richardson, James D., 807<br />

Richet, H., 1094<br />

Richman, Douglas D., 865<br />

Richwald, Gary A., 213<br />

Rico, Manuel, 1552<br />

Riff, Louise J., 848<br />

Rikihisa, Yasuko, 986<br />

Rinaldi, Michael G., 1310<br />

Ringertz, Signe, 1484<br />

Riscoe, Michael K., 1904<br />

Rittenhouse, Brian R., 834<br />

Rivera, Mildred, 649<br />

Roberts, Elizbeth, 462<br />

Roberts, Marilyn C., 488, 765, 1271, 1430<br />

Robillard, Norman J., 535<br />

Robinson, J., 1503<br />

Roblot-Treupel, Liliane, 1204<br />

Roccaforte, Jane S., 1327<br />

Rocque, Warren J., 308<br />

Rodondi, Lisa C., 1511, 1825<br />

Rodvold, Keith A., 631, 848<br />

Roerdink, F. H., 1560<br />

Roessner, Charles A., 391<br />

Rogers, Paul, 324<br />

Rolston, Kenneth, 1078<br />

Ronald Allan R., 1292<br />

Roon, Richard A., 274<br />

Root, Carol J., 773<br />

Root, Jennifer L., 1627<br />

Rootman, David S., 978<br />

Rosenberg, Carl, 1158<br />

Rosenberg, Ivan, 1025, 1839<br />

Rosina, Rita, 1223<br />

Rossan, R. N., 1655<br />

Rotimi, V. O., 598<br />

Rotschafer, John C., 848<br />

Rott-Petri, Jean A., 137<br />

Rouse, Mark, 747<br />

Roussellier, P., 255<br />

Rowse, Deborah, 1801<br />

Roy, Paul H., 397<br />

Roy, Rejean, 1433<br />

Rubinstein, E., 1624<br />

Russo, T., 717, 1439<br />

Rutala, William A., 642<br />

Rybak, Michael J., 510<br />

Saag, Michael S., I<br />

Saez-Nieto, Juan A., 706<br />

Saha, Gita, 580<br />

Saikawa, Isamu, 827, 912, 1097, 1848<br />

Saino, Yushi, 587<br />

Saito, Akira, 156<br />

Saito, Atsushi, 1427<br />

Saito, Hajime, 400<br />

Sakaguchi, Takashi, 1040, 1396

Vi AUTHOR INDEX<br />

Sakuma, Takashi, 1046, 1547, 1839<br />

Salas, J. A., 420<br />

Salfinger, Max, 1002<br />

Salmeron, C. M., 1350<br />

Samonis, George, 1365<br />

S<strong>and</strong>ers, Christine C., 689, 1314, 1365,<br />

1740, 1893<br />

S<strong>and</strong>ers, Cynthia, 1392<br />

S<strong>and</strong>ers, W. Eugene, Jr., 1740, 1893<br />

Sapico, Francisco L., 81<br />

Sartorelli, Alan C., 1182<br />

Sassella, D., 1461, 1541<br />

Sato, Hitoshi, 190<br />

Sato, Kenichi, 104, 922, 1336<br />

Satta, Giuseppe, 552<br />

Saunders, Jean, 24<br />

Sauzieres, Jacques, 1204<br />

Saviteer, Susan M., 642<br />

Savolainen, Seppo, 1019<br />

Sawyer, Janet G., 649<br />

Scannon, Patrick, 710<br />

Scarpa, Alphonse L., 535<br />

Schalla, W. O., 426<br />

Scheifele, David W., 1034<br />

Schell, Ronald F., 137<br />

Schentag, Jerome J., 450, 503<br />

Schiff, Gilbert M., 761<br />

Schifferli, Dieter M., 1603, 1609<br />

Schinazi, Raymond F., 997, 1784<br />

Schindler, M., 930<br />

Schito, Gian Carlo, 279<br />

Schlesinger, Paul H., 793, 799, 953, 957<br />

Schlosser, V., 930<br />

Schluederberg, Susan, 1801<br />

Schmidt-Eisenlohr, E., 930<br />

Schmitt, B., 780<br />

Schmitt, H. J., 780, 1676<br />

Schols, Dominique, 1025<br />

Schuening, Friedrich, 271<br />

Schultz, Robert W., 503<br />

Schurgers, M., 1595<br />

Schwartz, Jules, 75, 730<br />

Schwartz, Stanley A., 47<br />

Schwartzman, Michael S., 236<br />

Scieux, C., 1350<br />

Scott, Virginia R., 1154<br />

Sears, S. D., 144<br />

Segal, Neil B., 1231<br />

Segev, S., 1624<br />

Selitrennikoff, Claude P., 1901<br />

Serfass, Debra A., 706<br />

Shalaby, Lamaat M., 1699<br />

Sh<strong>and</strong>s, Joseph W., 773<br />

Sharp, Patricia A., 865<br />

Shaw, J. T. B., 646<br />

Shearer, Glenmore, Jr., 341<br />

Sheehan, Gerard J., 1292<br />

Shelton, Sharon, 268, 1738<br />

Shepherd, Julia A., 1693<br />

Sherwood, James R., 761<br />

Shigeta, Shiro, 906<br />

Shimada, Nobuyoshi, 1053<br />

Shimizu, Kihachiro, 912<br />

Shinners, Elizabeth N., 971<br />

Shiraishi, Akio, 110<br />

Shiramatsu, Koji, 1588<br />

Shyu, Wen Chyi, 128<br />

Siber, George R., 1034<br />

Sidwell, Robert W., 331<br />

Sieradzan, Raymond R., 1446<br />

Sierra-Madero, Juan, 1754, 1896<br />

Silva, Eric J., 865<br />

Silverman, Norman A., 631<br />

Simbul, Moises, 834<br />

Simmons, Richard L., 1769<br />

Simon, Francois, 568<br />

Sirot, Danielle L., 626, 1660<br />

Sirot, Jacques L., 626, 1660<br />

Six, Howard R., 890<br />

Slack, Mary P. E., 518<br />

Slee, A. M., 1218<br />

Sligh, James E., Jr., 702<br />

Smego, Douglas A., 982<br />

Smeltzer, Brian D., 236<br />

Smith, Arnold L., 477, 706, 1034<br />

Smith, Arnold N., 274<br />

Smith, Gary G., 595<br />

Smith, J. Kelly, 78<br />

Smith, James W., 63, 807<br />

Smith, John M., 1776<br />

Smith, M. Carolyn, 265<br />

Smith, Raymond P., 1450, 1565<br />

Smithwick, Ronald W., 125<br />

Snoeck, Robert, 1742, 1839<br />

Soike, Kenneth F., 1807<br />

Sokol-Anderson, Marcia, 702<br />

Somani, P., 530<br />

Someya, Tetsufumi, 1588<br />

Sommadossi, Jean-Pierre, 997<br />

Sommer, Peter, 936<br />

Sookpranee, Mondej, 1740<br />

Souza, Kathleen S., 1187<br />

Sperber, Steven J., 409<br />

Spillner, G., 930<br />

Spitler, Lynn E., 710<br />

Spitzer, Peter G., 434<br />

Srinivasan, A., 684<br />

Stamm, John M., 27<br />

Stamm, Lola V., 164<br />

Stamm, Walter E., 1640<br />

St<strong>and</strong>iford, Harold C., 1537<br />

Stankewich, Joseph P., 1347<br />

Stapleton, Jack T., 164<br />

Stark, Tracey, 1901<br />

Steele, Lorraine C., 1776<br />

Stein, Gary E., 802<br />

Steinberg, Marvin A., 1320<br />

Stenberg, Kjell, 1533<br />

Stevens, David A., 369<br />

Stieglitz, Michaela, 1090<br />

Stoeckel, Klaus, 573<br />

Stolz, E., 426<br />

Stone, J. W., 1508<br />

Storb, Rainer, 271<br />

Storrs, Michele J., 1174<br />

Strassle, Anni, 1494<br />

Strombeck, Bodil, 936<br />

Struck, Douglas K., 391<br />

Studemeister, Alex E., 1267<br />

Suarez, Juan E., 1552<br />

Subashi, Timothy A., 159<br />

Suenaga, Itaru, 458<br />

Sugarman, Barrett, 1323<br />

Sugimoto, Kyoko, 595<br />

Suh, Byungse, 1571<br />

Sumter, Gwendolyn, 1776<br />

Sun, Daxi, 1274, 1370<br />

Sundstrom, David C., 1763<br />

Suttmann, Rebecca T., 1887<br />

Sutton, David, 358<br />

Suzutani, Tatsuo, 1046, 1547<br />

Swan, Judith C., 430<br />

Swanson, Robert N., 27<br />

Swarz, Herbert, 42<br />

Swedberg, Gote, 1684<br />

Sypherd, Paul S., 341<br />

ANTIMICROB. AGENTS CHEMOTHER.<br />

Syriopoulou, Vassiliki P., 1034<br />

Szoka, Francis C., Jr., 858<br />

Tabaqchali, Soad, 1213<br />

Tachibana, Hiroshi, 966<br />

Taen, Haruko, 1735<br />

Taenaka, Nobuyuki, 1103<br />

Taft, Cathy S., 1901<br />

Takahara, Yoshio, 156<br />

Takahash, Katsutoshi, 1053<br />

Takahata, Masahiro, 1192<br />

Takano, Mitsuo, 1680<br />

Takeuchi, Toshihiko, 726<br />

Takezawa, Jun, 1103<br />

Talarico, Todd L., 1854<br />

Talbot, M. Kelly, 1005<br />

Tally, Francis P., 584, 717<br />

Tamai, Ikumi, 190<br />

Tamalet, J., 255<br />

Tamura, Atsushi, 1421<br />

Tamura, Toyoyuki, 566<br />

Tamura, Yuka, 932<br />

Tanaka, Haruo, 282<br />

Tancrede, Cyrille, 1204<br />

Tartaglione, Teresa A., 1640<br />

Taub, David, 319<br />

Tay, L. K., 314<br />

Taylor, David N., 723<br />

Taylor, Diane E., 1107<br />

Tenover, Fred C., 1170<br />

Terragna, Alberto, 1223<br />

Tesch, Wolfgang, 1494<br />

Thal, Wendy R., 337<br />

Thauvin, Claudie, 919<br />

Thomann, Charlotte A., 642<br />

Thompson, Nathan H., 1763<br />

Thomson, Margaret J., 1292<br />

Thomberry, Nancy A., 319<br />

Thornsberry, Clyde, 180, 752<br />

Tokunaga, Tohru, 110<br />

Tolmasky, Marcelo E., 1416<br />

Toltzis, Philip, 492<br />

Tomich, Paul K., 1465, 1472<br />

Tominack, Rebecca L., 1813<br />

Tomioka, Haruaki, 400<br />

Torikata, Akio, 110<br />

Townsend, Raymond J., 1825<br />

Trahan, Creighton J., 1304<br />

Tran Ba Huy, Patrice, 467<br />

Tran Van Nhieu, G., 9, 1289<br />

Treger, Thomas, 63<br />

Trouvin, J. H., 1590<br />

Tsuchido, Tetsuaki, 1680<br />

Tsuji, Akira, 190<br />

Tsukada, Katsuhiko, 726<br />

Tubert, Tracey, 180, 259<br />

Tucker, Richard M., 369<br />

Tuna, Ishik C., 209<br />

Turley, C. Patrick, 1481<br />

Turner, Ronald B., 1820<br />

Ueno, Kazue, 1437<br />

Une, Tsutomu, 1336<br />

Urbina, Julio A., 1237<br />

Urias, Barbara, 1292<br />

Usuki, Toshihiro, 1588<br />

Vaal, Mark, 1119<br />

Valiant, Mary E., 319<br />

Vall6e, Francois, 354<br />

V<strong>and</strong>enbroucke, Arthur C., 834<br />

Van der Auwera, P., 1557

VOL. 32, 1988<br />

van der Linden, M. P., 1632<br />

van der Waals, Ron, 1456<br />

van der Willigen, A. H., 426<br />

van Furth, Ralph, 1456<br />

van Klingeren, B., 426<br />

Van Peer, A., 1595<br />

Vavra, James J., 216<br />

Verdier, Francoise, 568<br />

Verdon, Michael S., 773<br />

Verghese, Abraham, 78<br />

Verhoef, Jan, 473<br />

Vermerie, N., 1590<br />

Vezina, Guy, 819<br />

Villa, Pia, 1541<br />

Villar, Claudio J., 1552<br />

Vliegenthart, John S., 740<br />

Vojtko, Charlene, 1710<br />

von Graevenitz, A., 1593<br />

Vrang, Lotta, 1733<br />

Wadstein, Jan, 936<br />

Wadsworth, S<strong>and</strong>ra J., 1571<br />

Wagenvoort, J. H. T., 426<br />

Wagner, Jutta, 92<br />

Wahren, B., 1137, 1720<br />

Waigh, Roger D., 1693<br />

Waites, Ken B., 1500<br />

Walker, Linda A., 1879<br />

Wallace, Richard J., Jr., 1776<br />

Walmsley, Harold L., 518<br />

Walton, Leslie, 1086<br />

Walzer, Peter D., 96, 8%<br />

Warhurst, David C., 1725<br />

Washington, John A., 131, 170, 1331, 1754,<br />

1896<br />

Watanabe, Kunitomo, 1437<br />

Watanabe, Nao-Aki, 693<br />

Watanabe, Yasuo, 912<br />

Waxman, Kenneth, 882<br />

Weber, David A., 1164<br />

Weber, David J., 642<br />

Weir, Matthew, 1537<br />

Weissberger, Barbara, 319<br />

Wells, Carol L., 1769<br />

Wennersten, C., 1528<br />

Wentworth, Berttina B., 216<br />

Wexler, Hannah M., 403, 601, 611<br />

Whall, Thomas J., 42, 51, 503<br />

Wheat, Lawrence J., 63<br />

White, Anthony J., 1879<br />

Whitney, Charles C., Jr., 1699<br />

Wiedemann, B., 1285<br />

Will, J. A., 37<br />

Willey, S<strong>and</strong>ra, 1341<br />

Williams, Deborah E., 1158<br />

Williams, J. D., 925<br />

Williams, P. D., 314, 758<br />

Williams, Paul L., 369<br />

Williamson, R., 9, 195<br />

Wills, Robert J., 1813<br />

Wilson, Mark E., 1521<br />

Wilson, Samuel Z., 890<br />

Wilson, Walter, 747<br />

Winton, Mark D., 928<br />

Wise, R., 617, 1251, 1508<br />

Wiseman, Jeffrey S., 1119<br />

Woestenborghs, R., 1310, 1595<br />

Wofsy, Constance, 1057<br />

Wolfson, John S., 1187<br />

Wong, Justina, 782<br />

Wong-Kai-In, Philippe, 814<br />

Wood, Mark S., 838<br />

Woodley, Charles L., 125<br />

Woodnutt, Gary, 1705<br />

Woods, Gail L., 1614<br />

Woolf, Nigel K., 865<br />

Woolfrey, Bert F., 513<br />

Wren, Brendan W., 1213<br />

Wright, Colin W., 1725<br />

Wu, John C., 1887<br />

Wyde, Philip R., 117, 890<br />

Wyss, Ronald, 573<br />

Xicota, M. Angels, 636<br />

Yagi, Betty Hannon, 216<br />

Yajko, David M., 1392<br />

Yam, Paul, 1614<br />

Yamabe, S., 925<br />

AUTHOR INDEX vii<br />

Yamada, Hidehiko, 1648<br />

Yamada, Takehisa, 156<br />

Yamada, Takeshi, 1588<br />

Yamaguchi, Keizo, 1427<br />

Yamamoto, Haruo, 1421<br />

Yamamoto, Naohiko, 1053<br />

Yamamoto, Tatsuo, 932<br />

Yamamoto, Toshiyuki, 726<br />

Yamazaki, Munehiro, 1864<br />

Yamazaki, Toshiyuki, 458<br />

Yang, Youjun, 1385<br />

Yankell, Samuel L., 350<br />

Yasuda, Takashi, 912, 1097, 1848<br />

Yasui, Kozo, 1864<br />

Yih, Jennifer, 141, 231<br />

Ylikoski, Jukka, 1019<br />

Yokota, Takeshi, 932<br />

Yokota, Tomoyuki, 906<br />

Yokota, Yoshiko, 1243<br />

Yoshida, Takashi, 1421<br />

Yoshihara, Eisaku, 966<br />

Yoshiya, Ikuto, 1103<br />

Yotsuji, Akira, 1097, 1848<br />

Young, Elizabeth C., 761<br />

Young, Lowell S., 1149<br />

Yourassowsky, E., 276, 1632<br />

Youssef, Mohammad, 1204<br />

Zajac, I., 1218<br />

Zak, Oto, 364<br />

Zehavi, Uri, 1586<br />

Zeiler, H.-J., 57<br />

Zenilman, Jonathan M., 765<br />

Zervos, Marcus J., 122<br />

Zhang, Lei, 962<br />

Zhang, Zhen-Xi, 265<br />

Zhou, Zhu, 997<br />

Zighelboim-Daum, S., 1528<br />

Zilhao, Rita, 1793<br />

Zimmerman, Stephen W., 51<br />

Zokufa, Humphrey Z., 848<br />

Zollinger-Iten, J., 1593<br />

Zscheck, Karen K., 768<br />

Zurenko, Gary E., 216

A723U<br />

herpes simplex virus type 1, 1100<br />

A40926<br />

pharmacokinetics, 246<br />

A-56268<br />

H. ducreyi, 1458<br />

T. gondii, 524<br />

A-56620<br />

M. tuberculosis, 1441<br />

Nocardia spp., 1078<br />

P. maltophilia, 782<br />

A-61827<br />

B. fragilis, 27<br />

C. jejuni, 27<br />

E. coli, 27<br />

Enterobacteriaceae, 27<br />

H. influenzae, 27<br />

L. pneumophila, 27<br />

N. gonorrhoeae, 27<br />

P. aeruginosa, 27<br />

S. aureus, 27<br />

S. pyogenes, 27<br />

S. typhimurium, 27<br />

Staphylococcus spp., 27<br />

Streptococcus spp., 27<br />

A-62254<br />

Nocardia spp., 1078<br />

A-62671<br />

comparative activity, 1710<br />

A-63075<br />

comparative activity<br />

erythromycin, 1500<br />

M. hominis, 1500<br />

M. pneumoniae, 1500<br />

U. urealyticum, 1500<br />

Acetyltransferase<br />

chloramphenicol<br />

C. difficile, 1213<br />

3-V-acetyltransferase<br />

gene probe, 1834<br />

6'-N-Acetyltransferase type 4<br />

Enterobacteriaceae, 1289<br />

S. marcescens, 1289<br />

Acinetobacter spp.<br />

3'-aminoglycoside phosphotransferase,<br />

15<br />

E1040, 693<br />

PD 117,596, 1450<br />

R plasmid, 15<br />

tigemonam, 84<br />

U-76,253A, 443<br />

Acquired immunodeficiency syndrome<br />

HPA-23, 1300<br />

M. avium complex, 1392<br />

P. carinii, 1057<br />

Acriflavin<br />

S. aureus resistance, 932<br />

Acrinol<br />

S. aureus resistance, 932<br />

Acrolein<br />

amoebic meningoencephalitis, 962<br />

N. fowleri, 962<br />

Actinobacillus actinomycetemcomitans<br />

clindamycin, 1521<br />

neutrophil killing, 1521<br />

Actinobacillus lignieresii<br />

actinomycin D, 1354<br />

daptomycin, 1354<br />

novobiocin, 1354<br />

phospholipid composition, 1354<br />

polymyxin, 1354<br />

SUBJECT INDEX<br />

VOLUME 32<br />

rifamycin, 1354<br />

Actinomyces spp.<br />

daptomycin, 788<br />

paldimycin, 788<br />

Actinomycin D<br />

A. lignieresii, 1354<br />

P. multocida, 1354<br />

Acyclovir<br />

combinations<br />

3'-azido-3'-deoxythymidine, 265<br />

AZT, 265<br />

Epstein-Barr virus, 265<br />

comparative activity<br />

I-3-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil<br />

<strong>and</strong><br />

E-5(2-bromovinyl)-2'-deoxyuridine,<br />

1068<br />

Epstein-Barr virus, 1068<br />

guinea pig embryonic fibroblasts, 1533<br />

herpes simplex virus type 1, 1100, 1533<br />

monophosphate<br />

guinea pig embryonic fibroblasts, 1533<br />

herpes simplex virus type 1, 1533<br />

triphosphate<br />

DNA polymerases, 1137<br />

varicella-zoster virus, 1137<br />

(RS)-3-Adenin-9-yl-2-hydroxypropanoic<br />

acid<br />

influenza viruses, 906<br />

Adenovirus<br />

sulfated polysaccharides, 1742<br />

type 5<br />

P-536, 1257<br />

Adhesion, bacterial<br />

antibiotic modulation, 1603, 1609<br />

folate pathway, 1609<br />

membrane structures, 1609<br />

nucleic acid synthesis, 1609<br />

peptidoglycan synthesis, 1609<br />

protein synthesis, 1603<br />

minireviews, 1603, 1609<br />

Aerobic bacteria<br />

pristinamycin, 1094<br />

Aerobic-anaerobic infections<br />

minireview, 611<br />

Aeromonas hydrophila<br />

CS-807, 1082<br />

tigemonam, 84<br />

U-76,252, 1082<br />

Aeromonas spp.<br />

,B-lactam resistance, 1314<br />

13-lactamases, 1314<br />

Agar dilution plate count method<br />

effect of temperature on inoculum, 513<br />

errors, 513<br />

(RS)-AHPA<br />

influenza viruses, 906<br />

Alanine racemase<br />

halovinylglycine compounds, 319<br />

L-norvalyl peptide derivatives, 319<br />

Alcaligenes denitrificans subsp. xylosoxidans<br />

amdinocillin, 276<br />

amikacin, 276<br />

amoxicillin-clavulanic acid, 276<br />

ampicillin, 276<br />

cefam<strong>and</strong>ole, 276<br />

cefazolin, 276<br />

ceforanide, 276<br />

cefotaxime, 276<br />

cefotetan, 276<br />

viii<br />

ceftazidime, 276<br />

ceftriaxone, 276<br />

cefuroxime, 276<br />

ciprofloxacin, 276<br />

gentamicin, 276<br />

imipenem, 276<br />

netilmicin, 276<br />

norfloxacin, 276<br />

ofloxacin, 276<br />

pefloxacin, 276<br />

piperacillin, 276<br />

temocillin, 276<br />

ticarcillin-clavulanic acid, 276<br />

tobramycin, 276<br />

trimethoprim-sulfamethoxazole, 276<br />

Alcaligenes faecalis<br />

diffusion pore, 378<br />

Alginate<br />

P. aeruginosa<br />

tobramycin binding, 518<br />

Allicin<br />

mechanism of action, 1763<br />

S. typhimurium, 1763<br />

Alpha-2b interferon<br />

influenza A virus, 47<br />

influenza B virus, 47<br />

rhinovirus, 47<br />

AM-833<br />

C. trachomatis, 1080, 1735<br />

comparative activity<br />

doxycycline <strong>and</strong> minocycline, 1735<br />

Amdinocillin<br />

A. denitrificans subsp. xylosoxidans, 276<br />

combinations<br />

ceftazidime, 1632<br />

E. cloacae, 1632<br />

E. cloacae, 1632<br />

Amdinocillin pivoxil<br />

pharmacokinetics<br />

influence of food, 592<br />

Amicarbalide<br />

P. carinii, 896<br />

Amifloxacin<br />

comparative activity<br />

ciprofloxacin, enoxacin, norfloxacin,<br />

<strong>and</strong> ofloxacin, 928<br />

Nocardia spp., 1078<br />

P. falciparum, 1182<br />

P. pseudomallei, 928<br />

Amikacin<br />

A. denitrificans subsp. xylosoxidans, 276<br />

B. catarrhalis, 259<br />

combinations<br />

ceftazidime, 231<br />

ciprofloxacin, 782<br />

clindamycin, 1557<br />

clofazimine, 1400<br />

endocarditis, 231<br />

head <strong>and</strong> neck surgery in cancer patients,<br />

1557<br />

M. avium complex, 1149, 1400<br />

P. aeruginosa, 231<br />

P. maltophilia, 782<br />

resistance, development of, 231<br />

rifabutin, 1400<br />

tumor necrosis factor, 1149<br />

wound infections, 1557<br />

dysgonic fermenter 2, 78<br />

E. coli<br />

lipopolysaccharide, 1247<br />

Enterobacteriaceae, 873

VOL. 32, 1988<br />

resistance, 1289<br />

K. pneumoniae resistance, 1379, 1416<br />

liposome encapsulated<br />

M. avium-M. intracellulare, 1404<br />

M. avium, 1131<br />

M. avium complex, 886, 1149, 1400<br />

M. avium-M. intracellulare, 1404<br />

N. asteroides, 1776<br />

P. maltophilia, 782<br />

pharmacokinetics, 236<br />

S. aureus resistance, 932<br />

S. marcescens resistance, 1289, 1379<br />

Shigella spp., 20<br />

Amikacin-ceftazidime<br />

comparative activity<br />

pefloxacin, 23i<br />

endocarditis, 231<br />

P. aeruginosa, 231<br />

resistance, development of, 231<br />

Amiloride<br />

combinations<br />

Pseudomonas spp., 395<br />

tobramycin, 395<br />

Pseudomonas spp., 395<br />

y-Aminobutyric acid binding<br />

BMY-262252 758<br />

cefazolin, 758<br />

imipenem-cilastatin, 758<br />

inhibition of<br />

quiholones, 190<br />

rat model, 758,<br />

Aminoglycoside 3-V-acetyltransferase<br />

gene probe, 1834<br />

3'-Aminoglycoside phosphotransferase<br />

Acinetobacter spp., 15<br />

Aminoglycoside-modifying enzymes<br />

reaction rates, 740<br />

Aminoglycosides<br />

cochlear binding sites, 467<br />

P. aeruginosa resistance, 689<br />

S. faecalis resistance, 1528<br />

T. vaginalis, 144<br />

Amodiaquine<br />

polymorphonuclear neutrophils, 1124<br />

Ainoebic meningoencephalitis<br />

acrolein, 962<br />

cyclophosphamide, 962<br />

Amopyroquin<br />

comparative activity<br />

chloroquine <strong>and</strong> monodesethylamodiaquine,<br />

568<br />

P. falciparum, 568<br />

pharmacokinetics, 568<br />

Amooxicillin<br />

Bordetella spp., 137<br />

H. ducreyi, 1458<br />

P. pseudomallei, 1435<br />

Amoxicillin-clavulanic acid<br />

A. denitrificans subsp. xylosoxidans, 276<br />

B. catarrhalis, 259<br />

B. fragilis-E. coli, 1830<br />

bite wound bacteria, 1143<br />

comparative activity<br />

ampicillin-sulbactam, 1830<br />

Enterobacteriaceae, 873<br />

H. ducreyi, 1458<br />

P. multocida, 213<br />

P. pseudomallei, 1435<br />

Amphotericin B<br />

Aspergillus spp'., 1676<br />

C. albicans<br />

2-chloroethyl-1-nitrosoureas, 327<br />

resistance, 702<br />

comparative activity<br />

miconazole, 1864<br />

high-performance liquid chromatography,<br />

1103<br />

polymorphonuclear leukocytes, 1864<br />

pulmonary aspergillosis, 1676<br />

S. schenckii, 1619<br />

sporotrichosis, 1619<br />

T. vaginalis, 1323<br />

Ampicillin<br />

A. denitrificans subsp. xylosoxidans, 276<br />

B. bronchiseptica, 1891<br />

B. catarrhalis, 259<br />

bite wound bacteria, 1143<br />

Chlamydia sp. strain TWAR, 257<br />

combinations<br />

B. fragilis-E. coli, 1830<br />

biliary tract infections, 1231<br />

sulbactam, 1830<br />

tobramycin, 1231<br />

dental granuloma, 566<br />

E. coli, 450, 552<br />

Enterobacteriaceae, 873<br />

fecal flora resistance, 1801<br />

H. influenzae, 180<br />

in vitro simulation of serious infections,<br />

552<br />

L. monocytogenes, 1204, 1560<br />

liposome entrapped<br />

L. monocytogenes, 1560<br />

lipid composition, 1560<br />

M. morganii, 1385<br />

N. asteroides, 1776<br />

nanoparticle polyisohexylcyanoacrylate<br />

bound<br />

L. monocytogenes, 1204<br />

P. aeruginosa, 552<br />

P. carinii, 896<br />

P. multocida, 213<br />

P. vulgaris, 1385<br />

postantibiotic effect, 450<br />

S. paratyphi A, resistant, 195<br />

S. pneumoniae, 552<br />

Shigella spp., 20<br />

Ampicillin-gulbactam<br />

B. catarrhalis, 259<br />

B. fragilis-E. coli, 1830<br />

comparative activity<br />

amoxicillin-clavulanic acid, 1830<br />

Shigella spp., 20<br />

Ampicillin-tobramycin<br />

biliary tract infections, 1231<br />

comparative activity<br />

cefoperazone, 1231<br />

Anesthetics<br />

E. coli permeability, 153<br />

Anisomycin<br />

T. vaginalis, 144<br />

Anogeissus leiocurpus<br />

B. gingivalis, 598<br />

B. melaninogenicus, 598<br />

Antacids<br />

ciprofloxacin, 949<br />

letter to the editor, 949<br />

Antibiotic biosynthetic genes<br />

minireview, 1472<br />

Streptomyces spp., 1472<br />

Antibodies<br />

monoclonal<br />

C. trachomatis, 1295<br />

minireview, 1295<br />

P. aeruginosa, 649<br />

monoclonal anti-lipid A<br />

SUBJECT INDEX<br />

bacteremia, 710<br />

immunogenicity, 710<br />

pharmacokinetics, 710<br />

toxicity, 710<br />

Antifungal agents<br />

jasplakinolide, 1154<br />

minireview, I<br />

T. vaginalis, 144<br />

Antimalarial drugs<br />

polymorphonuclear neutrophils, 1124<br />

Apalcillin<br />

nephrotoxicity, 942<br />

pharmacokinetics, 942<br />

9-p-D-Arabinofuranosyladenine<br />

herpes simplex virus type 1, 1046<br />

1- ,-D-Arabinofuranosyl-E-5-(2-bromovinyl)<br />

uracil<br />

comparative activity<br />

acyclovir <strong>and</strong> E-5-(2-bromovinyl)-2'deoxyuridine,<br />

1068<br />

Epstein-Barr virus, 1068<br />

herpes simplex virus type 1, 1547<br />

herpes simplex virus type 2, 1547<br />

nucleosides, effect of, 1547<br />

1-4-D-Arabinofuranosyl-E-(2-bromovinyl)<br />

uracil<br />

herpes simplex virus type 1, 1046<br />

1-P-D-Arabinofuranosylthymine<br />

herpes simplex virus type 1, 1046<br />

Argentine hemorrhagic fever<br />

ribavirin, 1304<br />

Arthrobacter spp,<br />

carbomycin, 420<br />

celesticetin, 420<br />

clindamycin, 420<br />

erythromycin, 420<br />

josamycin, 420<br />

lincomycin, 420<br />

lincosamide resistance, 420<br />

ole<strong>and</strong>omycin, 420<br />

rosaramicin, 420<br />

spiramycin, 420<br />

tylosin, 420<br />

vernamycin B, 420<br />

Aspergillus spp.<br />

amphotericin B, 1676<br />

terbinafine, 780<br />

Astiban<br />

P. carinii, 896<br />

ATP<br />

M. tuberculosis bioluminescence assay,<br />

1208<br />

Avermectins<br />

glucose metabolism, 282<br />

3'-Azido-3'-deoxythymidine<br />

combinations<br />

acyclovir, 265<br />

Epstein-Barr virus, 265<br />

human immunodeficiency virus type 1,<br />

1784<br />

isoprinosine, 1784<br />

cytomegalovirus, 265<br />

Epstein-Barr virus, 265<br />

herpes simplex virus type 1, 265<br />

herpes simplex virus type 2, 265<br />

human immunodeficiency virus type 1,<br />

1784<br />

toxicity<br />

uridine, 997<br />

varicella-zoster virus, 265<br />

3'-Azido-3'-deoxythymidine triphosphate<br />

human immunodeficiency virus type 1,<br />

1733<br />

ix

x SUBJECT INDEX<br />

human immunodeficiency virus type 2,<br />

1733<br />

simian immunodeficiency virus, 1733<br />

Azithromycin<br />

B. catarrhalis, 752<br />

combinations<br />

M. avium complex, 1149<br />

tumor necrosis factor, 1149<br />

comparative activity, 1710<br />

clarithromycin, clindamycin, erythromycin,<br />

<strong>and</strong> roxithromycin, 752<br />

H. influenzae, 752<br />

L. monocytogenes, 752<br />

L. pneumophila, 752<br />

M. avium complex, 1149<br />

N. gonorrhoeae, 752<br />

N. meningitidis, 752<br />

T. gondii, 524, 755<br />

Azlocillin<br />

B. catarrhalis, 259<br />

Azoles<br />

minireview, 1<br />

AZT<br />

combinations<br />

acyclovir, 265<br />

Epstein-Barr virus, 265<br />

human immunodeficiency virus type 1,<br />

1784<br />

isoprinosine, 1784<br />

cytomegalovirus, 265<br />

Epstein-Barr virus, 265<br />

herpes simplex virus type 1, 265<br />

herpes simplex virus type 2, 265<br />

human immunodeficiency virus type 1,<br />

1784<br />

toxicity<br />

uridine, 997<br />

triphosphate<br />

human immunodeficiency virus type 1,<br />

1733<br />

human immunodeficiency virus type 2,<br />

1733<br />

simian immunodeficiency virus, 1733<br />

varicella-zoster virus, 265<br />

Aztreonam<br />

B. catarrhalis, 259<br />

combinations<br />

ciprofloxacin, 782<br />

P. maltophilia, 782<br />

dysgonic fermenter 2, 78<br />

E. coli, 552<br />

hyperbilirubinemia<br />

centrifugal ultrafiltration, 1571<br />

in vitro simulation of serious infections,.<br />

552<br />

P. aeruginosa, 552<br />

P. maltophilia, 782<br />

S. pneumoniae, 552<br />

B-220<br />

cytomegalovirus, 1720<br />

herpes simplex virus type 1, 1720<br />

mechanism of action, 1720<br />

varicella-zoster virus, 1720<br />

Babesia microti<br />

inositol hexaphosphate, 391<br />

Bacillus spp.<br />

cefazolin, 642<br />

cefotaxime, 642<br />

cefoxitin, 642<br />

cefuroxime, 642<br />

chloramphenicol, 642<br />

ciprofloxacin, 642<br />

clindamycin, 642<br />

daptomycin, 642<br />

erythromycin, 642<br />

gentamicin, 642<br />

imipenem, 642<br />

mezlocillin, 642<br />

oxacillin, 642<br />

penicillin, 642<br />

tetracycline, 642<br />

ticarcillin-clavulanate, 642<br />

trimethoprim-sulfamethoxazole, 642<br />

vancomycin, 642<br />

Bacillus stearothermophilus<br />

etoposide, 1456<br />

Bacillus subtilis<br />

etoposide, 1456<br />

letter to the editor, 949<br />

streptomycin adenylyltransferase, 949<br />

Bacteremia<br />

monoclonal anti-lipid A antibody, 710<br />

Bacterial adhesion<br />

antibiotic modulation, 1603, 1609<br />

folate pathway, 1609<br />

membrane structures, 1609<br />

nucleic acid synthesis, 1609<br />

peptidoglycan synthesis, 1609<br />

protein synthesis, 1603<br />

minireviews, 1603, 1609<br />

Bactericidal testing<br />

oxacillin, 1614<br />

S. aureus, 1614<br />

Bacteroides fragilis<br />

A-61827, 27<br />

P-lactam resistance, 1437<br />

P-lactamase, 1848<br />

cefam<strong>and</strong>ole, 1097, 1848<br />

cefazolin, 1097, 1848<br />

cefoperazone, 1097, 1848<br />

cefoperazone-sulbactam, 403<br />

cefotetan, 601<br />

cefoxitin, 1511<br />

ceftezole, 1097, 1848<br />

ceftizoxime, 1511<br />

cephalosporins<br />

outer membrane permeation, 1097<br />

resistance, 1848<br />

cephalothin, 1097, 1848<br />

ciprofloxacin, 1437<br />

clindamycin, 1825<br />

DR-3355, 1336<br />

DuP 105, 580<br />

DuP 721, 580<br />

enoxacin, 1437<br />

fluoroquinolone resistance, 1437<br />

lomefloxacin, 617<br />

mixed infection with E. coli<br />

amoxicillin-clavulanic acid, 1830<br />

ampicillin-sulbactam, 1830<br />

norfloxacin, 1437, 1869<br />

NY-198, 1437<br />

ofloxacin, 1437<br />

PD 127,391, 1251<br />

penicillin-binding proteins, 1848<br />

susceptibility patterns<br />

analysis by site of isolation, 717<br />

T-3262, 663, 1437<br />

tetracycline<br />

resistance, 1271<br />

trospectomycin, 584<br />

Bacteroides gingivalis<br />

A. leiocarpus, 598<br />

B. paradoxum, 598<br />

ANTIMICROB. AGENTS CHEMOTHER.<br />

chewing sticks, 598<br />

D. benthamianus, 598<br />

F. zanthoxyloides, 598<br />

M. accuminata, 598<br />

N. latifolia, 598<br />

Nigerian chewing sticks, 598<br />

S. werneckei, 598<br />

T. glaucescens, 598<br />

V. amygdalina, 598<br />

Bacteroides melaninogenicus<br />

A. leiocarpus, 598<br />

B. paradoxum, 598<br />

chewing sticks, 598<br />

D. benthamianus, 598<br />

F. zanthoxyloides, 598<br />

M. accuminata, 598<br />

N. latifolia, 598<br />

Nigerian chewing sticks, 598<br />

S. werneckei, 598<br />

T. glaucescens, 598<br />

V. amygdalina, 598<br />

Bacteroides spp.<br />

E-1040, 1666<br />

R-3746, 671<br />

tigemonam, 84<br />

trospectomycin, 216, 584<br />

Benzalkonium chloride<br />

S. aureus resistance, 932<br />

Berberine sulfate<br />

E. coli Pap fimbrial adhesion, 1274<br />

S. pyogenes<br />

fibronectin, 1370<br />

hexadecane, 1370<br />

host cell adherence, 1370<br />

P-Lactamases<br />

Aeromonas spp., 1314<br />

B. fragilis, 1848<br />

13C nuclear magnetic resonance spectroscopy,<br />

1196<br />

CTX-1, 9<br />

DNA probes, 175<br />

E-1040, 1666<br />

E. coli, 1243<br />

Enterobacteriaceae, 1365<br />

H. influenzae, 180<br />

isoelectric focusing, 397, 1730<br />

K. pneumoniae, 626, 1660<br />

letter to the editor, 158<br />

M. morganii, 1385<br />

ME1207, 1421<br />

N. asteroides, 1776<br />

N. gonorrhoeae, 158, 1430<br />

oligonucleotide probes, 397<br />

oxacillin susceptibility, 1754<br />

oxyimino-cephalosporins, 1243<br />

P. aeruginosa, 1443<br />

heterogeneity, 1893<br />

P. cepacia, 838<br />

P. maltophilia<br />

cloning of operon in E. coli, 819<br />

P. vulgaris, 1073, 1385<br />

PADAC assay, 1040<br />

Pasteurella spp., 1282<br />

PhastSystem, 1730<br />

plasmid mediated, 175<br />

PSE-2 sequence, 134<br />

pyridinium-2-azo-p-dimethylaniline chromophore<br />

assay, 1040<br />

S. aureus, 1614, 1754<br />

transposon, 1164<br />

S.faecalis, 122, 547<br />

hybridization studies, 768<br />

restriction mapping, 768

VOL. 32, 1988<br />

staphylococci, coagulase negative, 1754<br />

YTR 830, 925<br />

P-Lactams<br />

Aeromonas resistance, 1314<br />

-y-aminobutyric acid binding, 758<br />

B. fragilis, 1437<br />

K. pneumoniae resistance, 1660<br />

M. morganii, 1385<br />

P. cepacia resistance, 1636<br />

P. vulgaris, 1385<br />

paradoxical effect, 1073<br />

pentylenetetrazole convulsive threshold,<br />

758<br />

T. vaginalis, 144<br />

Bifidobacterium spp.<br />

daptomycin, 788<br />

paldimycin, 788<br />

Biliary drainage<br />

cefotiam, 726<br />

sulbenicillin, 726<br />

ursodeoxycholate, 726<br />

Biliary tract infections<br />

ampicillin-tobramycin, 1231<br />

cefoperazone, 1231<br />

ceftazidime, 1588<br />

tobramycin-ampicillin, 1231<br />

Bioassay<br />

sulbactam, 1347<br />

Biofilms<br />

E. coli, 770<br />

radiochemical method, 770<br />

Bioluminescence assay<br />

M. tuberculosis ATP, 1208<br />

Biosynthetic genes<br />

minireview, 1472<br />

Streptomyces spp., 1472<br />

Bite wound bacteria<br />

amoxicillin-clavulanic acid, 1143<br />

ampicillin, 1143<br />

cefadroxil, 1143<br />

cefuroxime, 1143<br />

cephalexin, 1143<br />

ciprofloxacin, 1143<br />

enoxacin, 1143<br />

ofloxacin, 1143<br />

penicillin G, 1143<br />

tetracycline, 1143<br />

BMY-26225<br />

y-aminobutyric acid binding, 758<br />

pentylenetetrazole convulsive threshold,<br />

758<br />

Bordetella bronchiseptica<br />

ampicillin, 1891<br />

antigenic modulation, 1891<br />

carbenicillin, 1891<br />

cephalothin, 1891<br />

chloramphenicol, 1891<br />

chlortetracycline, 1891<br />

colistin, 1891<br />

doxycycline, 1891<br />

erythromycin, 1891<br />

gentamicin, 1891<br />

kanamycin, 1891<br />

nalidixic acid, 1891<br />

neomycin, 1891<br />

novobiocin, 1891<br />

oxolinic acid, 1891<br />

oxytetracycline, 1891<br />

phase variation, 1891<br />

polymyxin B, 1891<br />

rifampin, 1891<br />

sulfadimethoxine, 1891<br />

sulfamonomethoxine, 1891<br />

tetracycline, 1891<br />

Bordetella spp.<br />

amoxicillin, 137<br />

ciprofloxacin, 137<br />

enoxacin, 137<br />

erythromycin, 137<br />

norfloxacin, 137<br />

ofloxacin, 137<br />

rifampin, 137<br />

roxithromycin, 137<br />

sulfamethoxazole-trimethoprim, 137<br />

tetracycline, 137<br />

Branhamella catarrhalis<br />

amikacin, 259<br />

amoxicillin-clavulanic acid, 259<br />

ampicillin, 259<br />

ampicillin-sulbactam, 259<br />

azithromycin, 752<br />

azlocillin, 259<br />

aztreonam, 259<br />

carbenicillin, 259<br />

cefaclor, 259<br />

cefam<strong>and</strong>ole, 259<br />

cefixime, 259, 1896<br />

cefonicid, 259<br />

cefoperazone, 259<br />

cefotaxime, 259<br />

cefoxitin, 259<br />

cefpodoxime, 1896<br />

ceftazidime, 259<br />

ceftibuten, 1576<br />

ceftizoxime, 259<br />

ceftriaxone, 259, 1896<br />

cefuroxime, 259<br />

cephalexin, 259<br />

cephalothin, 259<br />

chloramphenicol, 259<br />

ciprofloxacin, 259<br />

CS-807, 1082<br />

erythromycin, 259<br />

erythromycin estolate, 1227<br />

erythromycin ethylsuccinate, 1227<br />

erythromycin-sulfisoxazole, 259<br />

gentamicin, 259<br />

imipenem, 259<br />

LY163892, 268<br />

mezlocillin, 259<br />

minireview, 1747<br />

moxalactam, 259<br />

netilmicin, 259<br />

PD 117,596, 1450<br />

pefloxacin, 259<br />

penicillin, 259<br />

piperacillin, 259<br />

rifampin, 259<br />

sulfisoxazole, 259<br />

susceptibility testing, 1747<br />

T-3262, 663<br />

tetracycline, 259<br />

ticarcillin, 259<br />

ticarcillin-clavulanic acid, 259<br />

tigemonam, 84<br />

tobramycin, 259<br />

trimethoprim-sulfamethoxazole, 259<br />

trospectomycin, 216<br />

U-76,252, 1082<br />

U-76,253A, 443<br />

Branhamella spp.<br />

lomefloxacin, 656<br />

R-3746, 671<br />

BRL 39123<br />

comparative activity<br />

acyclovir, 358<br />

SUBJECT INDEX xi<br />

herpes simplex virus type 1, 358<br />

herpes simplex virus type 2, 358<br />

2-Bromo-2-nitropropane-1,3-diol<br />

E. coli, 1693<br />

mechanism of action, 1693<br />

2-Bromo-L-histidine<br />

P. falciparum, 1655<br />

E-5-(2-Bromovinyl)-2'-deoxyuridine<br />

comparative activity<br />

acyclovir <strong>and</strong> l-P-D-arabinofuranosyl-<br />

E-5-(2-bromovinyl)uracil, 1068<br />

Epstein-Barr virus, 1068<br />

Bromovinyl nucleoside analogs<br />

comparative activity<br />

acyclovir, 1068<br />

Epstein-Barr virus, 1068<br />

Bromovinyldeoxyuridine<br />

guinea pig embryonic fibroblasts, 1533<br />

herpes simplex virus type 1, 1533<br />

Bronopol<br />

E. coli, 1693<br />

mechanism of action, 1693<br />

Brucea javanica<br />

B. javanica, 1725<br />

E. histolytica, 1725<br />

quassinoids, 1725<br />

Buciclovir<br />

DNA polymerases, 1137<br />

guinea pig embryonic fibroblasts, 1533<br />

herpes simplex virus type 1, 1533<br />

monophosphate<br />

guinea pig embryonic fibroblasts, 1533<br />

herpes simplex virus type 1, 1533<br />

varicella-zoster virus, 1137<br />

4-(tert-Butyl)2-(tert-butylaminomethyl)-6-<br />

(4-chlorophenyl)phenol dihydrogen<br />

phosphate<br />

crystal <strong>and</strong> molecular structure, 540<br />

BW A855U<br />

cleavable-complex assay, 1086<br />

Bytyrospermum paradoxum<br />

B. gingivalis, 598<br />

B. melaninogenicus, 598<br />

C31G<br />

C. albicans, 350<br />

comparative activities<br />

chlorhexidine, Fluorigard, Listerine,<br />

<strong>and</strong> Viadent, 350<br />

S. sobrinus, 350<br />

Streptococcus spp., 350<br />

13C nuclear magnetic resonance spectroscopy<br />

P-lactamases, 1196<br />

Calcium fosfomycin<br />

pharmacokinetics, 938<br />

young <strong>and</strong> elderly adults, 938<br />

Campylobacter coli<br />

kanamycin resistance, 1170<br />

R plasmid, 1170<br />

Campylobacter jejuni<br />

A-61827, 27<br />

kanamycin resistance, 1170<br />

PD 117,596, 1450<br />

R plasmid, 1170<br />

Campylobacter spp.<br />

DNA annealing, 945<br />

kanamycin resistance, 945<br />

minireview, 1107<br />

resistance mechanisms, 1107<br />

tetracycline resistance gene, 1793

xii SUBJECT INDEX<br />

Cancer patients<br />

clindamycin-amikacin, 1557<br />

head <strong>and</strong> neck surgery, 1557<br />

ticarcillin-clavulanic acid, 1557<br />

wound infections, 1557<br />

C<strong>and</strong>ida albicans<br />

amphotericin B, 327<br />

resistance, 702<br />

C31G, 350<br />

2-chloroethyl-1-nitrosoureas, 327<br />

cilofungin, 1331, 1901<br />

denture stomatitis, 1859<br />

ergosterol, 702<br />

fluconazole, 209, 1859<br />

(1-3)-3-D-glucan synthase<br />

cilofungin, 1901<br />

jasplakinolide, 1154<br />

ketoconazole, 209<br />

stomatitis, denture, 1859<br />

C<strong>and</strong>ida parapsilosis<br />

cilofungin, 1331<br />

C<strong>and</strong>ida spp.<br />

jasplakinolide, 1154<br />

C<strong>and</strong>ida tropicalis<br />

cilofungin, 1331<br />

Capnocytophaga ochracea<br />

clindamycin, 1521<br />

neutrophil killing, 1521<br />

Capreomycin<br />

M. avium, 1131<br />

Carbapenems<br />

[14C]dimethyl sulfate labeling, 186<br />

high-performance liquid chromatography,<br />

186<br />

Carbenicillin<br />

B. bronchiseptica, 1891<br />

B. catarrhalis, 259<br />

hyperbilirubinemia<br />

centrifugal ultrafiltration, 1571<br />

M. morganii, 1385<br />

N. asteroides, 1776<br />

P. maltophilia, 782<br />

P. vulgaris, 1385<br />

Carbocyclin 3-deazaadenosine<br />

influenza viruses, 906<br />

Carbodine<br />

influenza viruses, 906<br />

Carbomycin<br />

Arthrobacter spp., 420<br />

Staphylococcus spp., 420<br />

Cardiac surgery<br />

Staphylococcus infection, 202<br />

Cardiopulmonary bypass<br />

netilmicin, 631<br />

vancomycin, 631<br />

Caromonam<br />

comparative activity<br />

ceftazidime, 1031<br />

urinary tract infections, 1031<br />

Carrageenans<br />

cytomegalovirus, 1742<br />

herpes simplex virus, 1742<br />

human immunodeficiency virus, 1742<br />

vesicular stomatitis virus, 1742<br />

Carumonam<br />

comparative activity<br />

gentamicin, 473<br />

Enterobacteriaceae, 1593<br />

high-pressure liquid chromatography,<br />

354<br />

L. pneumophila, 1593<br />

P. aeruginosa, 1593<br />

P. pseudomallei, 1435<br />

pharmacokinetics, 354<br />

urinary tract infections, 473<br />

Catechol-cephalosporins<br />

mechanisms of action, 1879<br />

Catheters<br />

disodium EDTA, 1627<br />

S. epidermidis, 1627<br />

vancomycin, 1627<br />

Cefaclor<br />

B. catarrhalis, 259<br />

H. influenzae, 180<br />

P. multocida, 213<br />

Cefadroxil<br />

bite wound bacteria, 1143<br />

P. maltocida, 213<br />

Cefam<strong>and</strong>ole<br />

A. denitrificans subsp. xylosoxidans, 276<br />

B. catarrhalis, 259<br />

B. fragilis, 1848<br />

outer membrane permeation, 1097<br />

comparative activity<br />

cefazolin, daptomycin, <strong>and</strong> vancomycin,<br />

63<br />

dysgonic fermenter 2, 78<br />

endocarditis, 63<br />

H. influenzae, 180<br />

S. epidermidis, 63<br />

Shigella spp., 20<br />

Cefazolin<br />

A. denitrificans subsp. xylosoxidans, 276<br />

y-aminobutyric acid binding, 758<br />

B. fragilis, 1848<br />

outer membrane permeation, 1097<br />

Bacillus spp., 642<br />

comparative activity<br />

cefam<strong>and</strong>ole, daptomycin, <strong>and</strong> vancomycin,<br />

63<br />

difloxacin <strong>and</strong> enoxacin, 262<br />

dysgonic fermenter 2, 78<br />

endocarditis, 63, 262<br />

nephrotoxicity, 314<br />

pentylenetetrazole convulsive threshold,<br />

758<br />

pharmacokinetics, 33<br />

S. aureus, 262<br />

S. epidermidis, 63<br />

Cefbuperazone<br />

P. vulgaris, 1073<br />

Cefepime<br />

Nocardia spp., 1078<br />

P. aeruginosa resistance, 1443<br />

Cefetamet<br />

pharmacokinetics, 573<br />

Cefetamet pivoxil<br />

pharmacokinetics, 573<br />

Cefixime<br />

B. catarrhalis, 259, 18%<br />

comparative activity<br />

cefpodoxime <strong>and</strong> ceftriaxone, 18%<br />

Enterobacteriaceae, 18%<br />

Enterococcus spp., 18%<br />

H. influenzae, 18%<br />

N. meningitidis, 18%<br />

P. aeruginosa, 18%<br />

Staphylococcus spp., 18%<br />

Cefmenoxime<br />

P. vulgaris, 1073<br />

Cefmetazole<br />

P. vulgaris, 1073<br />

Cefodizime<br />

comparative activity<br />

cefotaxime, 426<br />

gonorrhea, 426<br />

ANTIMICROB. AGENTS CHEMOTHER.<br />

N. gonorrhoeae, 426<br />

Cefonicid<br />

B. catarrhalis, 259<br />

high-performance liquid chromatography,<br />

485<br />

M. tuberculosis, 1441<br />

pharmacokinetics, 485<br />

protein binding, 128<br />

skin infections, 485<br />

skin structure infections, 485<br />

Cefoperazone<br />

B. catarrhalis, 259<br />

B. fragilis, 403, 1848<br />

outer membrane permeation, 1097<br />

biliary tract infections, 1231<br />

combinations<br />

B. fragilis, 403<br />

ceftazidime, 298<br />

ciprofloxacin, 782<br />

intra-abdominal infections, 730<br />

P. aeruginosa, 298<br />

P. maltophilia, 782<br />

pharmacokinetics, 730<br />

sulbactam, 403, 730<br />

comparative activity<br />

ampicillin-tobramycin, 1231<br />

dysgonic fermenter 2, 78<br />

high-pressure liquid chromatography,<br />

298<br />

hyperbilirubinemia<br />

centrifugal ultrafiltration, 1571<br />

nephrotoxicity, 314<br />

P. maltophilia, 782<br />

P. vulgaris, 1073<br />

pharmacokinetics, 42<br />

protein binding, 298<br />

Shigella spp., 20<br />

Cefoperazone-sulbactam<br />

B. fragilis, 403<br />

comparative activity<br />

cefoperazone, cefoxitin, chloramphenicol,<br />

clindamycin, imipenem, metronidazole,<br />

<strong>and</strong> penicillin G, 403<br />

pharmacokinetics, 42, 503<br />

continuous ambulatory peritoneal dialysis,<br />

51<br />

renal failure, 503<br />

Ceforanide<br />

A. denitrificans subsp. xylosoxidans, 276<br />

M. tuberculosis, 1441<br />

Cefotaxime<br />

A. denitrificans subsp. xylosoxidans, 276<br />

B. catarrhalis, 259<br />

Bacillus spp., 642<br />

combinations<br />

chloramphenicol, 1375<br />

E. coli, 1375<br />

gram-negative bacteria, 1375<br />

S. aureus, 1375<br />

streptococci, group B, 1375<br />

comparative activity<br />

cefodizime, 426<br />

dysgonic fermenter 2, 78<br />

Enterobacteriaceae, 873<br />

gonorrhea, 426<br />

H. ducreyi, 1458<br />

M. morganii, 1385<br />

M. tubetculosis, 1441<br />

N. asteroides, 1776<br />

N. gonorrhoeae, 426<br />

P. aerugindsa resistance, 1443<br />

P. pseudomallei, 1435<br />

P. vulgaris, 1073, 1385

VOL. 32, 1988<br />

pharmacokinetics<br />

protein binding, 128<br />

Shigella spp., 20<br />

Cefotetan<br />

A. denitrificans subsp. xylosoxidans, 276<br />

B. fragilis, 601<br />

C. difficile, 601<br />

comparative activity<br />

cefoxitin, ceftizoxime, chloramphenicol,<br />

clindamycin, <strong>and</strong> metronidazole,<br />

601<br />

prothrombin, 1446<br />

vitamin K metabolism, 1446<br />

Cefotiam<br />

biliary excretion<br />

ursodeoxycholate, 726<br />

P. vulgaris, 1073<br />

percutaneous transhepatic biliary drainage,<br />

726<br />

Cefoxitin<br />

B. catarrhalis, 259<br />

B. fragilis, 1511<br />

Bacillus spp., 642<br />

comparative activity<br />

ceftizoxime, 1511<br />

E. coli, 1511<br />

Enterobacteriaceae, 873<br />

H. ducreyi, 1458<br />

M. morganii, 1385<br />

P. vulgaris, 1385<br />

prothrombin, 1446<br />

serum bactericidal activity, 1511<br />

vitamin K metabolism, 1446<br />

Cefpiramide<br />

hepatic excretion, 1360<br />

high-performance liquid chromatography,<br />

1360<br />

pharmacokinetics, 33, 1360<br />

Cefpirome<br />

comparative activity<br />

cefoperazone, cefotaxime,<br />

ceftazidime, <strong>and</strong> moxalactam,<br />

1396<br />

croton oil-induced rat granuloma pouch,<br />

1396<br />

E. coli, 1396<br />

high-performance liquid chromatography,<br />

1481<br />

M. tuberculosis, 1441<br />

Nocardia spp., 1078<br />

P. aeruginosa, 1396<br />

pharmacokinetics, 1396<br />

S. aureus, 1396<br />

Cefpodoxime<br />

B. catarrhalis, 1896<br />

comparative activity<br />

cefixime <strong>and</strong> ceftriaxone, 1896<br />

Enterobacteriaceae, 1896<br />

Enterococcus spp., 1896<br />

H. influenzae, 1896<br />

N. meningitidis, 1896<br />

P. aeruginosa, 1891<br />

Staphylococcus spp., 1896<br />

Cefsulodin<br />

combinations<br />

ciprofloxacin, 782<br />

P. maltophilia, 782<br />

P. maltophilia, 782<br />

Ceftazidime<br />

A. denitrificans subsp. xylosoxidans, 276<br />

B. catarrhalis, 259<br />

biliary tract infections, 1588<br />

cholelithiasis, 1588<br />

combinations<br />

amdinocillin, 1632<br />

amikacin, 231<br />

cefoperazone, 298<br />

ciprofloxacin, 782<br />

E. cloacae, 1632<br />

endocarditis, 231<br />

P. aeruginosa, 231, 298<br />

P. maltophilia, 782<br />

resistance, development of, 231<br />

comparative activity<br />

carumonam, 1031<br />

concentrations in bile <strong>and</strong> gallbladder<br />

wall, 1588<br />

dysgonic fermenter 2, 78<br />

E. cloacae, 1632<br />

resistance, 1632<br />

high-performance liquid chromatography,<br />

1845<br />

high-pressure liquid chromatography,<br />

298<br />

nephrotoxicity, 314<br />

P. aeruginosa resistance, 1443<br />

P. maltophilia, 782<br />

P. pseudomallei, 1435<br />

P. vulgaris, 1073<br />

pharmacokinetics, 1845<br />

protein binding, 298<br />

Shigella spp., 20<br />

urinary tract infections, 1031<br />

Ceftazidime-amikacin<br />

comparative activity<br />

pefloxacin, 231<br />

endocarditis, 231<br />

P. aeruginosa, 231<br />

resistance, development of, 231<br />

Ceftazidime-vancomycin<br />

pharmacokinetics, 92<br />

Ceftetrame<br />

H. ducreyi, 1458<br />

Ceftezole<br />

B. fragilis, 1848<br />

outer membrane permeation, 1097<br />

Ceftibuten<br />

B. catarrhalis, 1576<br />

comparative activity<br />

amoxicillin, amoxicillin-clavulanic<br />

acid, cefaclor, cefixime, <strong>and</strong> cefuroxime,<br />

1576<br />

Enterobacteriaceae, 1576<br />

H. influenzae, 1576<br />

Neisseria spp., 1576<br />

Streptococcus spp., 1576<br />

susceptibility testing, 1576<br />

Ceftizoxime<br />

B. catarrhalis, 259<br />

B. fragilis, 1511<br />

comparative activity<br />

cefoxitin, 1511<br />

E. coli, 1511<br />

M. tuberculosis, 1441<br />

P. vulgaris, 1073<br />

pharmacokinetics<br />

protein binding, 128<br />

serum bactericidal activity, 1511<br />

Ceftriaxone<br />

A. denitrificans subsp. xylosoxidans, 276<br />

B. catarrhalis, 259, 1896<br />

combinations<br />

chloramphenicol, 1375<br />

E. coli, 1375<br />

gram-negative bacteria, 1375<br />

S. aureus, 1375<br />

SUBJECT INDEX xiii<br />

streptococci, group B, 1375<br />

comparative activity<br />

cefixime <strong>and</strong> cefpodoxime, 1896<br />

E. coli, 552<br />

Enterobacteriaceae, 1896<br />

Enterococcus spp., 1896<br />

H. ducreyi, 1458<br />

H. influenzae, 1896<br />

home parenteral therapy, 1439<br />

hyperbilirubinemia<br />

centrifugal ultrafiltration, 1571<br />

in vitro simulation of serious infections,<br />

552<br />

lidocaine reconstitution, 1439<br />

M. morganii, 1385<br />

N. asteroides, 1776<br />

N. meningitidis, 1896<br />

P. aeruginosa, 552, 1896<br />

P. pseudomallei, 1435<br />

P. vulgaris, 1073, 1385<br />

S. pneumoniae, 552<br />

Shigella spp., 20<br />

Staphylococcus spp., 1896<br />

Cefuroxime<br />

A. denitrificans subsp. xylosoxidans, 276<br />

B. catarrhalis, 259<br />

Bacillus spp., 642<br />

bite wound bacteria, 1143<br />

hyperbilirubinemia<br />

centrifugal ultrafiltration, 1571<br />

P. multocida, 213<br />

P. vulgaris, 1073<br />

Shigella spp., 20<br />

Cefuzonam<br />

P. vulgaris, 1073<br />

Celesticetin<br />

Arthrobacter spp., 420<br />

Staphylococcus spp., 420<br />

Cell cultures<br />

human immunodeficiency virus type 1,<br />

684<br />

Cephalexin<br />

B. catarrhalis, 259<br />

bite wound bacteria, 1143<br />

H. influenzae, 180<br />

P. multocida, 213<br />

Cephalexin hydrochloride<br />

comparative activity<br />

cephalexin monohydrate, 882<br />

gram-negative bacteria, 882<br />

S. aureus, 882<br />

S. pyogenes, 882<br />

skin infections, 882<br />

soft tissue infections, 882<br />

Staphylococcus spp., 882<br />

Cephalexin monohydrate<br />

comparative activity<br />

cephalexin hydrochloride, 882<br />

gram-negative bacteria, 882<br />

S. aureus, 882<br />

S. pyogenes, 882<br />

skin infections, 882<br />

soft tissue infections, 882<br />

Siaphylococcus spp., 882<br />

Cephaloglycin<br />

nephrotoxicity, 314<br />

Cephaloridine<br />

K. pneumoniae, 364<br />

M. morganii, 1385<br />

nephrotoxicity, 314<br />

piperacillin protective effect, 912<br />

P. vulgaris, 1073, 1385

xiv SUBJECT INDEX<br />

Cephalosporins<br />

B. fragilis, 1848<br />

outer membrane permeation, 1097<br />

catechol substituted<br />

mechanism of action, 1879<br />

K. pneumoniae resistance, 1660<br />

oxyimino<br />

3-lactamase, 1243<br />

E. coli, 1243<br />

S. aureus, 170<br />

Cephalothin<br />

B. bronchiseptica, 1891<br />

B. catarrhalis, 259<br />

B. fragilis, 1848<br />

outer membrane permeation, 1097<br />

Enterobacteriaceae, 873<br />

H. influenzae, 180<br />

nephrotoxicity, 314<br />

P. vulgaris, 1073<br />

S. aureus MBCs, 374<br />

Shigella spp., 20<br />

Cephapirin<br />

M. tuberculosis, 1441<br />

CGP 17520<br />

K. pneumoniae, 364<br />

Chagas' disease<br />

ketoconazole, 1237<br />

SF 86-327, 1237<br />

Charcoal<br />

tobramycin clearance, effect on, 274<br />

Chemotaxis<br />

T. vaginalis, 1323<br />

Chewing sticks<br />

B. gingivalis, 598<br />

B. melaninogenicus, 598<br />

Chlamydia trachomatis<br />

AM-833, 1080, 1735<br />

antibodies<br />

monoclonal, 1295<br />

Chlamydiazyme, 1350<br />

chloramphenicol, 1350<br />

ciprofloxacin, 1080, 1350, 1735<br />

doxycycline, 1350, 1735<br />

enoxacin, 1080<br />

erythromycin, 1350<br />

fleroxacin, 1080<br />

imipenem-cilastatin, 773<br />

josamycin, 1350<br />

minireview, 1295<br />

minocycline, 1080, 1350, 1735<br />

norfloxacin, 1080, 1350, 1735<br />

NY-198, 1080, 1735<br />

ofloxacin, 1080, 1350, 1735<br />

PD 127,391, 1251<br />

pefloxacin, 1350<br />

pipemidic acid, 1080<br />

rifampin, 1350<br />

rikamycin, 1350<br />

RO 23-6240, 1080<br />

rosoxacin, 1350<br />

roxithromycin, 1350<br />

sulfamethoxazole, 1350<br />

susceptibility testing, 1295, 1350<br />

T-3262, 1080<br />

tetracycline, 1350<br />

trospectomycin, 216<br />

Chlamydia sp. strain TWAR<br />

ampicillin, 257<br />

erythromycin, 257<br />

penicillin, 257<br />

sulfisoxazole, 257<br />

tetracycline, 257<br />

trospectomycin, 257<br />

Chlamydiazyme<br />

evaluation, 1350<br />

Chloramphenicol<br />

acetyltransferase<br />

C. difficile, 1213<br />

H. influenzae, 180<br />

B. bronchiseptica, 1891<br />

B. catarrhalis, 259<br />

Bacillus spp., 642<br />

C. trachomatis, 1350<br />

combinations<br />

cefotaxime, 1375<br />

ceftriaxone, 1375<br />

E. coli, 1375<br />

gram-negative bacteria, 1375<br />

S. aureus, 1375<br />

streptococci, group B, 1375<br />

comparative activity<br />

ciprofloxacin <strong>and</strong> gentamicin, 285<br />

dysgonic fermenter 2, 78<br />

E. coli<br />

heat treatment, 1680<br />

Enterobacteriaceae, 873<br />

fecal flora resistance, 1801<br />

H. ducreyi, 1458<br />

H. influenzae, 180<br />

susceptibility testing, 1484<br />

P. carinii, 8%<br />

P. multocida, 213<br />

scrub typhus, 285<br />

Shigella spp., 20<br />

Chlorhexidine<br />

S. aureus resistance, 932<br />

Chlorhexidine digluconate<br />

Enterobacteriaceae, 873<br />

3-Chlorodiaminopimelic acid<br />

diaminopimelic acid epimerase, 1119<br />

E. coli, 1119<br />

2-Chloroethyl- I -nitrosoureas<br />

amphotericin B<br />

C. albicans, 327<br />

2-Chloro-L-histidine<br />

P. falciparum, 1655<br />

Chloroquine<br />

malaria, 799<br />

minireview, 799<br />

P. falciparum, 799<br />

polymorphonuclear neutrophils, 1124<br />

resistance, 799<br />

5-Chlorotubercidin<br />

influenza viruses, 906<br />

Chlorovinylglycine<br />

comparative activity, 319<br />

gram-positive bacteria, 319<br />

Staphylococcus spp., 319<br />

Chlorpromazine<br />

E. coli permeability, 153<br />

P. carinii, 8%<br />

Chlortetracycline<br />

B. bronchiseptica, 1891<br />

Cholelithiasis<br />

ceftazidime, 1588<br />

CI-934<br />

cleavable-complex assay, 1086<br />

Cilofungin<br />

C. albicans, 1331<br />

(1-3)-p-D-glucan synthase, 1901<br />

C. parapsilosis, 1331<br />

C. tropicalis, 1331<br />

comparative activity<br />

amphotericin B, flucytosine, <strong>and</strong> ketoconazole,<br />

1331<br />

Cryptococcus spp., 1331<br />

ANTIMICROB. AGENTS CHEMOTHER.<br />

S. cerevisiae, 1331<br />

T. glabrata, 1331<br />

Cinchonidine<br />

P. falciparum, 250<br />

Cinchonine<br />

P. falciparum, 250<br />

Cinoxacin<br />

S. aureus, 1192<br />

Ciprofloxacin<br />

A. denitrificans subsp. xylosoxidans, 276<br />

antacids, 949<br />

B. catarrhalis, 259<br />

B. fragilis, 1437<br />

Bacillus spp., 642<br />

biliary excretion <strong>and</strong> metabolism, 982<br />

bite wound bacteria, 1143<br />

Bordetella spp., 137<br />

C. trachomatis, 1080, 1350, 1735<br />

chancroid, 723, 723<br />

cleavable-complex assay, 1086<br />

combinations<br />

amikacin, aztreonam, cefoperazone,<br />

cefsulodin, ceftazidime, gentamicin,<br />

imipenem, mezlocillin, piperacillin,<br />

<strong>and</strong> tobramycin, 782<br />

clofazimine, 1392<br />

erythromycin, 1392<br />

ethambutol, 1392<br />

M. avium complex, 1392<br />

P. maltophilia, 782<br />

rifabutin, 1392<br />

rifampin, 1392<br />

comparative activity<br />

A-56620, amikacin, aztreonam, carbenicillin,<br />

cefoperazone, cefsulodin,<br />

ceftazidime, difloxacin, gentamicin,<br />

imipenem, mezlocillin,<br />

norfloxacin, piperacillin, Sch<br />

34343, ticarcillin, <strong>and</strong> tobramycin,<br />

782<br />

amifloxacin, enoxacin, norfloxacin,<br />

<strong>and</strong> ofloxacin, 928<br />

ampicillin <strong>and</strong> chloramphenicol, 57<br />

chloramphenicol <strong>and</strong> gentamicin, 285<br />

doxycycline <strong>and</strong> minocycline, 1735<br />

gentamicin, imipenem, nafcillin, <strong>and</strong><br />

vancomycin, 747<br />

trimethoprim-sulfamethoxazole, 1327<br />

cytogenetic effects, 936<br />

dysgonic fermenter 2, 78<br />

E. coli, 450<br />

endocarditis, 747<br />

Enterobacteriaceae, 1327<br />

GABA receptor, 1624<br />

H. ducreyi, 723, 723, 1458<br />

Haemophilus spp., 147<br />

high-pressure liquid chromatography,<br />

1537<br />

letter to the editor, 949<br />

N. asteroides, 1776<br />

N. meningitidis, 1740<br />

Nocardia spp., 1078<br />

P. aeruginosa resistance, 535<br />

P. falciparum, 1182<br />

P. maltophilia, 782<br />

P. pseudomallei, 928, 1435<br />

pharmacokinetics, 949, 982, 1537<br />

polycystic kidney disease, 844<br />

postantibiotic effect, 450<br />

renal cyst infection, 844<br />

S. aureus, 747, 1192<br />

S. typhimurium, 57<br />

scrub typhus, 285

VOL. 32, 1988<br />

Shigella spp., 20<br />

theophylline pharmacokinetics, effect<br />

on, 75<br />

urinary tract infections, 1327<br />

Citrobacter diversus<br />

CS-807, 1082<br />

R-3746, 671<br />

tigemonam, 84<br />

U-76,252, 1082<br />

Citrobacter freundii<br />

DNA gyrase, 922<br />

E1040, 693<br />

norfloxacin resistance, 922<br />

ofloxacin resistance, 922<br />

quinolone resistance, 922<br />

R-3746, 671<br />

R plasmid, 9<br />

YTR 830, 925<br />

Citrobacter spp.<br />

E-1040, 1666<br />

Clarithromycin<br />

comparative activity, 1710<br />

erythromycin, 1500<br />

erythromycin <strong>and</strong> roxithromycin,<br />

1758<br />

M. hominis, 1500<br />

M. leprae, 1758<br />

M. pneumoniae, 1500<br />

U. urealyticum, 1500<br />

Cleavable-complex assay<br />

BW A855U, 1086<br />

CI-934, 1086<br />

ciprofloxacin, 1086<br />

nalidixic acid, 1086<br />

norfloxacin, 1086<br />

ofloxacin, 1086<br />

oxolinic acid, 1086<br />

quinolones, 1086<br />

Clindamycin<br />

A. actinomycetemcomitans, 1521<br />

Arthrobacter spp., 420<br />

B. fragilis, 1825<br />

Bacillus spp., 642<br />

C. ochracea, 1521<br />

combinations<br />

amikacin, 1557<br />

cost analysis, 853<br />

endomyometritis, 853<br />

enterococci, 1769<br />

gentamicin, 853<br />

head <strong>and</strong> neck surgery in cancer patients,<br />

1557<br />

P. carinii, 807<br />

primaquine, 807<br />

streptomycin, 1769<br />

wound infections, 1557<br />

dysgonic fermenter 2, 78<br />

E. corrodens, 1521<br />

enterococci, 1769<br />

high-performance liquid chromatography,<br />

1825<br />

neutrophil killing, 1521<br />

P. carinii, 807<br />

P. multocida, 213<br />

periodontal bacteria, 1521<br />

pharmacokinetics, 1825<br />

serum inhibitory activity, 1825<br />

Staphylococcus spp., 420<br />

Clindamycin-amikacin<br />

comparative activity<br />

ticarcillin-clavulanic acid, 1557<br />

head <strong>and</strong> neck surgery in cancer<br />

patients, 1557<br />

wound infections, 1557<br />

Clindamycin-gentamicin<br />

comparative activity<br />

cost analysis, 853<br />

moxalactam, 853<br />

endomyometritis, 853<br />

Clofazimine<br />

combinations<br />

amikacin, 1400<br />

ciprofloxacin, 1392<br />

ethambutol, 1392<br />

M. avium complex, 1392, 1400<br />

rifabutin, 1392<br />

M. leprae, 1583<br />

structure-activity relationship, 1583<br />

Cloning<br />

antibiotic biosynthetic genes, 1472<br />

biosynthetic genes, 1472<br />

minireviews, 1465, 1472<br />

Streptomyces spp., 1465, 1472<br />

Clostridium difficile<br />

cefotetan, 601<br />

chloramphenicol acetyltransferase determinant<br />

genetic analysis, 1213<br />

molecular cloning, 1213<br />

R plasmid, 1213<br />

trospectomycin, 216<br />

Clostridium spp.<br />

daptomycin, 788<br />

DuP 105, 580<br />

DuP 721, 580<br />

paldimycin, 788<br />

R-3746, 671<br />

trospectomycin, 216<br />

13C nuclear magnetic resonance spectroscopy<br />

P-lactamases, 1196<br />

Coccidioidal meningitis<br />

fluconazole, 369<br />

Colistin<br />

B. bronchiseptica, 1891<br />

Enterobacteriaceae, 873<br />

Common colds<br />

letters to the editor, 605, 606, 608<br />

zinc, 605, 606, 608<br />

Conjunctivitis<br />

H. influenzae, 1820<br />

norfloxacin, 1820<br />

S. aureus, 1820<br />

S. pneumoniae, 1820<br />

Staphylococcus spp., 1820<br />

streptococci, alpha-hemolytic, 1820<br />

tobramycin, 1820<br />

Coronary angioplasty<br />

Staphylococcus infection, 202<br />

Corynebacterium group JK<br />

DuP 105, 580<br />

DuP 721, 580<br />

gentamicin-teicoplanin, 434<br />

gentamicin-vancomycin, 434<br />

teicoplanin, 434<br />

teicoplanin-gentamicin, 434<br />

teicoplanin-tobramycin, 434<br />

tobramycin-teicoplanin, 434<br />

tobramycin-vancomycin, 434<br />

vancomycin, 434<br />

vancomycin-gentamicin, 434<br />

vancomycin-tobramycin, 434<br />

Corynebacterium spp.<br />

PD 117,596, 1450<br />

Co-trimoxazole<br />

H. ducreyi, 1458<br />

SUBJECT INDEX xv<br />

Coumermycin A<br />

P. falciparum, 1182<br />

Coxsackievirus<br />

sulfated polysaccharides, 1742<br />

Cryptococcus spp.<br />

cilofungin, 1331<br />

Cryptosporidium sp.<br />

letter to the editor, 1907<br />

sulfadimethoxine, 1907<br />

Crystal violet<br />

E. coli<br />

heat treatment, 1680<br />

CS-807<br />

A. hydrophila, 1082<br />

B. catarrhalis, 1082<br />

C. diversus, 1082<br />

comparative activity<br />

amoxicillin, amoxicillin-clavulanic<br />

acid, cefaclor, cefuroxime, cephalexin,<br />

<strong>and</strong> erythromycin, 1082<br />

E. coli, 1082<br />

E. faecalis, 1082<br />

Enterobacteriaceae, 1082<br />

H. influenzae, 1082<br />

Klebsiella spp., 1082<br />

P. aeruginosa, 1082<br />

P. mirabilis, 1082<br />

Staphylococcus spp., 1082<br />

Streptococcus spp., 1082<br />

5-Cyano- I -P-D-ribofuranosyl-imidazole-4carboxamide<br />

influenza viruses, 906<br />

5-Cyanoimidazole-4-carboxamide<br />

influenza viruses, 906<br />

Cyclohexane triones<br />

comparative activity<br />

cetrimide, chlorohexidine, FCCP, hexachlorophene,<br />

<strong>and</strong> tribromosalan,<br />

814<br />

gram-positive bacteria, 814<br />

H. influenzae, 814<br />

M. smegmatis, 814<br />

mechanisms of action, 814<br />

Cycloheximide<br />

M. racemosus, 341<br />

Cyclopentenyl cytosine<br />

influenza viruses, 906<br />

Cyclophosphamide<br />

amoebic meningoencephalitis, 962<br />

N. fowleri, 962<br />

Cyclosporine<br />

P. berghei, 462<br />

Cystic fibrosis<br />

P. cepacia, 1636<br />

Cystitis<br />

E-3846, 636<br />

E. coli, 1640<br />

ofloxacin, 1640<br />

trimethoprim-sulfamethoxazole, 1640<br />

Cytogenetic effects<br />

ciprofloxacin, 936<br />

ofloxacin, 936<br />

Cytomegalovirus<br />

3'-azido-3'-deoxythymidine, 265<br />

AZT, 265<br />

B-220, 1720<br />

carrageenans, 1742<br />

cochlear pathophysiology, 865<br />

dextran sulfate, 1742<br />

fucoidan, 1742<br />

ganciclovir, 865<br />

(S)-HPMPC, 1839<br />

(S)- 1-(3-hydroxy-2-phosphonylmethoxy-

xvi SUBJECT INDEX<br />

propyl)cytosine, 1839<br />

interferon, 678<br />

labyrinthitis, 865<br />

oxetanocin G, 1053<br />

pentosan polysulfate, 1742<br />

S26308, 678<br />

sulfated polysaccharides, 1742<br />

Dapsone<br />

combinations<br />

P. carinii, 623<br />

pneumonia, 623<br />

trimethoprim, 623<br />

comparative activity<br />

pentamidine, trimethoprim-dapsone,<br />

<strong>and</strong> trimethoprim-sulfamethoxazole,<br />

623<br />

P. carinii, 96, 623, 1057, 1158<br />

pneumonia, 623, 1057<br />

Daptomycin<br />

A. lignieresii, 1354<br />

Actinomyces spp., 788<br />

Bacillus spp., 642<br />

Bifidobacterium spp., 788<br />

Clostridium spp., 788<br />

combinations<br />

amikacin, fosfomycin, imipenem, netilmicin,<br />

rifampin, teicoplanin, <strong>and</strong><br />

vancomycin, 279<br />

endocarditis, 877<br />

Enterococcus spp., 279<br />

gentamicin, 81, 877<br />

pyelonephritis, 81<br />

S. aureus, 279<br />

S. epidermidis, 279<br />

S. faecalis, 81, 877<br />

Staphylococcus spp., 279<br />

comparative activity<br />

cefam<strong>and</strong>ole, cefazolin, <strong>and</strong> vancomycin,<br />

63<br />

daptomycin-gentamicin, penicillin G<br />

procaine, penicillin G procainegentamicin,<br />

vancomycin, vancomycin-gentamicin,<br />

877<br />

paldimycin, penicillin, <strong>and</strong> vancomycin,<br />

788<br />

penicillin G, 141<br />

vancomycin, 454<br />

E. faecalis, 24<br />

E. faecium, 24<br />

endocarditis, 63, 141, 877<br />

Enterococcus spp., 279<br />

Eubacterium spp., 788<br />

Lactobacillus spp., 788<br />

P. multocida, 1354<br />

Peptostreptococcus spp., 788<br />

Propionibacterium spp., 788<br />

pyelonephritis, 81<br />

S. aureus, 279, 454<br />

S. epidermidis, 63, 279<br />

S. faecalis, 81, 877<br />

translocation, 337<br />

S. pneumoniae, 24<br />

Staphylococcus spp., 24, 279<br />

Streptococcus spp., 141<br />

3-Deazaguanine<br />

influenza viruses, 906<br />

3-Deazauridine<br />

influenza viruses, 906<br />

Dehydroemetine<br />

P. carinii, 896<br />

Dehydropeptidase I<br />

purification <strong>and</strong> characterization, 587<br />

Demeclocycline<br />

comparative activity<br />

doxycycline, erythromycin, minocycline,<br />

nalidixic acid, oxytetracycline,<br />

rifampin, <strong>and</strong> tetracycline,<br />

986<br />

E. risticii, 986<br />

Dental granuloma<br />

ampicillin, 566<br />

talampicillin, 566<br />

Denture stomatitis<br />

C. albicans, 1859<br />

fluconazole, 1859<br />

5'-Deoxy-5-fluorouridine<br />

influenza viruses, 906<br />

Dermatophytes<br />

G2, 1586<br />

Dextran sulfate<br />

cytomegalovirus, 1742<br />

herpes simplex virus, 1742<br />

human immunodeficiency virus,<br />

1742<br />

vesicular stomatitis virus, 1742<br />

(S)-DHPA<br />

influenza viruses, 906<br />

Diallyl thiosulfinate<br />

mechanism of action, 1763<br />

S. typhimurium, 1763<br />

Diaminopimelic acid epimerase<br />

3-chlorodiaminopimelic acid, 1119<br />

E. coli, 1119<br />

Diaveridine<br />

P. carinii, 96<br />

Dibucaine<br />

E. coli permeability, 153<br />

Diclofenac<br />

GABA receptor, 1624<br />

y-aminobutyric acid receptor, 1624<br />

Dicloxacillin<br />

hyperbilirubinemia<br />

centrifugal ultrafiltration, 1571<br />

Difloxacin<br />

comparative activity<br />

cefazolin <strong>and</strong> enoxacin, 262<br />

erythromycin, 1500<br />

endocarditis, 262<br />

H. ducreyi, 1458<br />

M. hominis, 1500<br />

M. pneumoniae, 1500<br />

M. tuberculosis, 1441<br />

Nocardia spp., 1078<br />

P. maltophilia, 782<br />

S. aureus, 262<br />

U. urealyticum, 1500<br />

Difluoromethylornithine<br />

P. carinii, 896<br />

DL-a-Difluoromethylornithine<br />

combinations<br />

P. carinii, 1158<br />

suramin, 1158<br />

comparative activity<br />

dapsone, diminazene aceturate, suramin,<br />

<strong>and</strong> trimethoprim-sulfamethoxazole,<br />

1158<br />

P. carinii, 1158<br />

Dihydromycoplanecin A<br />

comparative activity<br />

isoniazid, ofloxacin, rifampin, <strong>and</strong><br />

streptomycin, 110<br />

Mycobacterium spp., 110<br />

pharmacokinetics, 110<br />

ANTIMICROB. AGENTS CHEMOTHER.<br />

Dihydropteroate synthase gene<br />

nucleotide sequence, 1684<br />

9-(3,4-Dihydroxybutyl)guanine<br />

triphosphate<br />

DNA polymerases, 1137<br />

varicella-zoster virus, 1137<br />

(S)-9-(2,3-Dihydroxypropyl)adenine<br />

influenza viruses, 906<br />

2,3,Dimethyl(dimethylaminoethyl)5H-indolo-(2,3-b)quinoxaline<br />

cytomegalovirus, 1720<br />

herpes simplex virus type 1, 1720<br />

mechanism of action, 1720<br />

varicella-zoster virus, 1720<br />

['4C]dimethyl sulfate<br />

carbapenem labeling, 186<br />

Diminazene<br />

P. carindi, 8%<br />

Diminazene aceturate<br />

P. carinii, 1158<br />

Dirithromycin<br />

comparative activity, 1710<br />

Disodium EDTA<br />

catheters, 1627<br />

S. epidermidis, 1627<br />

Distemonanthus benthamianus<br />

B. gingivalis, 598<br />

B. melaninogenicus, 598<br />

DNA gyrase<br />

C. freundii, 922<br />

cleavable-complex assay, 1086<br />

inhibitors<br />

N. gonorrhoeae, 1788<br />

quinolones, 1086<br />

resistance, 104<br />

S. aureus, 1192<br />

DNA polymerases<br />

varicella-zoster virus, 1137<br />

DNA probes<br />

,B-lactamases, 175<br />

DNA synthesis<br />

E. coli, 1113<br />

quinolones, 1113<br />

Doxycycline<br />

B. bronchiseptica, 1891<br />

C. trachomatis, 1350<br />

comparative activity<br />

demeclocycline, erythromycin, minocycine,<br />

nalidixic acid,<br />

oxytetracycline, rifampin, <strong>and</strong><br />

tetracycline, 986<br />

E. risticii, 986<br />

Enterobacteriaceae, 873<br />

H. ducreyi, 1458<br />

DR-3355<br />

B. fragilis, 1336<br />

comparative activity<br />

ciprofloxacin, fleroxacin, methicillin,<br />

NY-198, <strong>and</strong> ofloxacin, 1336<br />

Peptococcus spp., 1336<br />

Staphylococcus spp., 1336<br />

DuP 105<br />

B. fragilis, 580<br />

Clostridium spp., 580<br />

comparative activity<br />

amoxicillin-clavulanic acid,<br />

cephalexin, teicoplanin, <strong>and</strong> vancomycin,<br />

580<br />

ampicillin, cefaclor, ciprofloxacin,<br />

erythromycin, <strong>and</strong> vancomycin,<br />

150<br />

Corynebacterium group JK, 580<br />

E. faecalis, 580

VOL. 32, 1988<br />

Enterobacteriaceae, 580<br />

Enterococcus spp., 150<br />

L. monocytogenes, 150, 580<br />

P. aeruginosa, 580<br />

S. aureus, 580<br />

S. epidermidis, 580<br />

Staphylococcus sop., 150<br />

Streptococcus spp., 150, 580<br />

DuP 721<br />

B. fragilis, 580<br />

Clostridium spp., 580<br />

comparative activity<br />

amoxicillin-clavulanic acid,<br />

cephalexin, teicoplanin, <strong>and</strong> vancomycin,<br />

580<br />

ampicillin, cefaclor, ciprofloxacin,<br />

erythromycin, <strong>and</strong> vancomycin,<br />

150<br />

Corynebacterium group JK, 580<br />

E. faecalis, 580<br />

Enterobacteriaceae, 580<br />

Enterococcus spp., 150<br />

gram-positive bacteria, 1218<br />

L. monocytogenes, 150, 580<br />

mechanism of action, 1218<br />

P. aeruginosa, 580<br />

protein synthesis, 1218<br />

S. aureus, 580<br />

S. epidermidis, 580<br />

Staphylococcus spp., 150<br />

Streptococcus spp., 150, 580<br />

Dysgonic fermenter 2<br />

amikacin, 78<br />

aztreonam, 78<br />

cefam<strong>and</strong>ole, 78<br />

cefazolin, 78<br />

cefoperazone, 78<br />

cefotaxime, 78<br />

ceftazidime, 78<br />

chloramphenicol, 78<br />

ciprofloxacin, 78<br />

clindamycin, 78<br />

erythromycin, 78<br />

gentamicin, 78<br />

imipenem, 78<br />

methicillin, 78<br />

penicillin G, 78<br />

piperacillin, 78<br />

rifampin, 78<br />

ticarcillin, 78<br />

trimethoprim-sulfamethoxazole, 78<br />

vancomycin, 78<br />

E1040<br />

Acinetobacter spp., 693<br />

Bacteroides spp., 1666<br />

P-lactamases, 1666<br />

C. freundii, 693<br />

Citrobacter spp., 1666<br />

comparative activity<br />

cefazolin, cefmenoxime, cefotiam,<br />

ceftazidime, <strong>and</strong> methicillin,<br />

693<br />

cefepime, cefpirome, ceftazidime,<br />

gentamicin, <strong>and</strong> imipenem,<br />

1666<br />

E. aerogenes, 693<br />

E. cloacae, 693<br />

E. coli, 693<br />

Enterobacter spp., 1666<br />

Enterobacteriaceae, 693, 1666<br />

Haemophilus spp., 1666<br />

Morganella spp., 1666<br />

Neisseria spp., 1666<br />

P. aeruginosa, 693, 1666<br />

P. cepacia, 1666<br />

Pseudomonas spp., 1666<br />

Serratia spp., 1666<br />

Staphylococcus spp., 1666<br />

Streptococcus spp., 1666<br />

X. maltophilia, 1666<br />

E-3846<br />

comparative activity<br />

ciprofloxacin <strong>and</strong> norfloxacin, 636<br />

cystitis, 636<br />

E. coli, 636<br />

Enterobacteriaceae, 636<br />

K. pneumoniae, 636<br />

P. aeruginosa, 636<br />

P. mirabilis, 636<br />

pyelonephritis, 636<br />

S. faecalis, 636<br />

Staphylococcus spp., 636<br />

Ehrlichia risticii<br />

demeclocycline, 986<br />

doxycycline, 986<br />

erythromycin, 986<br />

minocycline, 986<br />

nalidixic acid, 986<br />

oxytetracycline, 986<br />

rifampin, 986<br />

tetracycline, 986<br />

Eikenella corrodens<br />

clindamycin, 1521<br />

neutrophil killing, 1521<br />

R plasmid, 765<br />

tetracycline resistance, 765<br />

Encephalomyocarditis virus<br />

P-536, 1257<br />

Endocarditis<br />

amikacin-ceftazidime, 231<br />

cefam<strong>and</strong>ole, 63<br />

cefazolin, 63, 262<br />

ceftazidime-amikacin, 231<br />

ciprofloxacin, 747<br />

daptomycin, 63, 141, 877<br />

daptomycin-gentamicin, 877<br />

difloxacin, 262<br />

enoxacin, 262<br />

fosfomycin, 919<br />

fosfomycin-pefloxacin, 919<br />

gentamicin-daptomycin, 877<br />

gentamicin-penicillin G procaine, 877<br />

gentamicin-vancomycin, 877<br />

P. aeruginosa, 231<br />

pefloxacin, 231, 919<br />

pefloxacin-fosfomycin, 919<br />

penicillin G, 141<br />

penicillin G procaine, 877<br />

penicillin G procaine-gentamicin, 877<br />

S. aureus, 262, 747, 919<br />

S. epidermidis, 63<br />

S. faecalis, 877<br />

Streptococcus spp., 141<br />

vancomycin, 63, 877<br />

vancomycin-gentamicin, 877<br />

Endomyometritis<br />

cesarean section, 853<br />

clindamycin-gentamicin, 853<br />

gentamicin-clindamycin, 853<br />

moxalactam, 853<br />

treatment cost analysis, 853<br />

Enoxacin<br />

B. fragilis, 1437<br />

bite wound bacteria, 1143<br />

SUBJECT INDEX xvii<br />

Bordetella spp., 137<br />

C. trachomatis, 1080<br />

comparative activity<br />

amifloxacin, ciprofloxacin, norfloxacin,<br />

<strong>and</strong> ofloxacin, 928<br />

cefazolin <strong>and</strong> difloxacin, 262<br />

endocarditis, 262<br />

Haemophilus spp., 147<br />

high-pressure liquid chromatography,<br />

834<br />

Nocardia spp., 1078<br />

osteomyelitis, 834<br />

P. falciparum, 1182<br />

P. pseudomallei, 928<br />

prostatic tissue concentrations, 1433<br />

S. aureus, 262<br />

Shigella spp., 20<br />

Entamoeba histolytica<br />

B. javanica, 1725<br />

quassinoids, 1725<br />

S. amara, 1725<br />

Enterobacter aerogenes<br />

E1040, 693<br />

R-3746, 671<br />

R plasmid, 9<br />

tigemonam, 84<br />

Enterobacter cloacae<br />

amdinocillin, 1632<br />

ceftazidime, 1632<br />

resistance, 1632<br />

ceftazidime-amdinocillin, 1632<br />

E1040, 693<br />

R-3746, 671<br />

tigemonam, 84<br />

YTR 830, 925<br />

Enterobacter spp.<br />

E-1040, 1666<br />

lomefloxacin, 656<br />

PD 117,596, 1450<br />

tigemonam, 84<br />

Enterobacteriaceae<br />

A-61827, 27<br />

6'-N-acetyltransferase type 4, 1289<br />

amikacin, 873<br />

resistance, 1289<br />

aminoglycoside resistance, 1289<br />

amoxicillin-clavulanic acid, 873<br />

ampicillin, 873<br />

P-lactamases, 1365<br />

carumonam, 1593<br />

cefixime, 1896<br />

cefotaxime, 873<br />

cefoxitin, 873<br />

cefpodoxime, 1896<br />

ceftibuten, 1576<br />

ceftriaxone, 1896<br />

cephalothin, 873<br />

chloramphenicol, 873<br />

chlorhexidine digluconate, 873<br />

ciprofloxacin, 1327<br />

colistin, 873<br />

CS-807, 1082<br />

doxycycline, 873<br />

DuP 105, 580<br />

DuP 721, 580<br />

E1040, 693, 1666<br />

E-3846, 636<br />

fluoroquinolone resistance, 1285<br />

gentamicin, 873<br />

iodine alcohol, 873<br />

lomefloxacin, 617<br />

PD 127,391, 1251<br />

polyvinylpyrrolidone, 873

xviii SUBJECT INDEX<br />

R plasmid, 1289<br />

sodium hypochlorite, 873<br />

susceptibility testing, 1365<br />

T-3262, 663, 827<br />

ticarcillin, 873<br />

ticarcillin-potassium clavulanate resistance,<br />

1365<br />

tigemonam, 84<br />

tobramycin, 873<br />

trimethoprim, 873<br />

trimethoprim-sulfamethoxazole, 1327<br />

trospectomycin, 216<br />

U-76,252, 1082<br />

U-76,253A, 443<br />

urinary tract infections, 1327<br />

Enterococcus faecalis<br />

CS-807, 1082<br />

daptomycin, 24<br />

DuP 105, 580<br />

DuP 721, 580<br />

fluoroquinolone resistance, 1285<br />

T-3262, 663<br />

U-76,252, 1082<br />

Enterococcus faecium<br />

daptomycin, 24<br />

norfloxacin, 1869<br />

Enterococcus spp.<br />

Campylobacter resistance gene, 1793<br />

cefixime, 18%<br />

cefpodoxime, 1896<br />

ceftriaxone, 18%<br />

clindamycin, 1769<br />

clindamycin-streptomycin, 1769<br />

daptomycin, 279<br />

DuP 105, 150<br />

DuP 721, 150<br />

intestinal colonization <strong>and</strong> translocation,<br />

1769<br />

metronidazole, 1769<br />

metronidazole-streptomycin, 1769<br />

PD 117,5%, 1450<br />

R-3746, 671<br />

R plasmids, 1793<br />

S-6123, 1341<br />

T-3262, 827<br />

tigemonam, 84<br />

translocation, 1769<br />

U-76,253A, 443<br />

Enviroxime<br />

aerosol, 890<br />

liposomes, 890<br />

rhinoviruses, 890<br />

toxicity, 890<br />

Enzyme immunoassays<br />

Chlamydiazyme, 1350<br />

Enzyme-linked immunosorbent assays<br />

T. gondii, 303<br />

Epidermophyton floccosum<br />

G2, 1586<br />

Epstein-Barr virus<br />

acyclovir, 1068<br />

acyclovir-AZT, 265<br />

1-P-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil,<br />

1068<br />

3'-azido-3'-deoxythymidine, 265<br />

3'-azido-3'-deoxythymidine-acyclovir,<br />

265<br />

AZT, 265<br />

AZT-acyclovir, 265<br />

E-5-(2-bromovinyl)-2'-deoxyuridine, 1068<br />

bromovinyl nucleoside analogs, 1068<br />

Ergosterol<br />

C. albicans, 702<br />

Erythromycin<br />

acistrate<br />

tonsillar <strong>and</strong> plasma concentrations,<br />

1019<br />

Arthrobacter spp., 420<br />

B. bronchiseptica, 1891<br />

B. catarrhalis, 259<br />

Bacillus spp., 642<br />

base<br />

toxicity, 1541<br />

uptake <strong>and</strong> distribution, 1541<br />

Bordetella spp., 137<br />

C. trachomatis, 1350<br />

Chlamydia sp. strain TWAR, 257<br />

combinations<br />

ciprofloxacin, 1392<br />

ethambutol, 1392<br />

M. avium complex, 1392<br />

rifampin, 1392<br />

comparative activity, 1710<br />

clarithromycin <strong>and</strong> roxithromycin,<br />

1758<br />

demeclocycline, doxycycline, minocycline,<br />

nalidixic acid, oxytetracycline,<br />

rifampin, <strong>and</strong> tetracycline,<br />

986<br />

mupirocin, 1780<br />

dysgonic fermenter 2, 78<br />

E. risticii, 986<br />

H. ducreyi, 1458<br />

H. influenzae, 180<br />

impetigo, 1780<br />

M. leprae, 1758<br />

N. asteroides, 1776<br />

P. multocida, 213<br />

R. conorii, 255<br />

R. rickettsii, 255<br />

S. faecalis resistance, 547<br />

Staphylococcus spp., 420<br />

stearate<br />

tonsillar <strong>and</strong> plasma concentrations,<br />

1019<br />

T. pallidum, resistant, 164<br />

Erythromycin estolate<br />

B. catarrhalis, 1227<br />

comparative activity<br />

erythromycin ethylsuccinate, 1227<br />

high-pressure liquid chromatography,<br />

561<br />

pharmacokinetics, 561<br />

plasma bactericidal activity, 1227<br />

Streptococcus spp., 1227<br />

toxicity, 1541<br />

uptake <strong>and</strong> distribution, 1541<br />

Erythromycin ethylsuccinate<br />

B. catarrhalis, 1227<br />

comparative activity<br />

erythromycin estolate, 1227<br />

high-pressure liquid chromatography,<br />

561<br />

pharmacokinetics, 561<br />

plasma bactericidal activity, 1227<br />

Streptococcus spp., 1227<br />

Erythromycin-sulfisoxazole<br />

B. catarrhalis, 259<br />

Erythromycylamine<br />

comparative activity, 1710<br />

Escherichia coli<br />

A-61827, 27<br />

ampicillin, 450, 552<br />

aztreonam, 552<br />

berberine sulfate, 1274<br />

,-lactamase, 1243<br />

ANTIMICROB. AGENTS CHEMOTHER.<br />

biofilms<br />

radiochemical method, 770<br />

2-bromo-2-nitropropane-1,3-diol, 1693<br />

bronopol, 1693<br />

cefotaxime-chloramphenicol, 1375<br />

cefoxitin, 1511<br />

cefpirome, 13%<br />

ceftizoxime, 1511<br />

ceftriaxone, 552<br />

ceftriaxone-chloramphenicol, 1375<br />

cephalosporins<br />

catechol substituted, 1879<br />

3-chlorodiaminopimelic acid, 1119<br />

ciprofloxacin, 450<br />

cloning of P. maltophilia ,B-lactamase<br />

operon, 819<br />

CS-807, 1082<br />

cystitis, 636, 1640<br />

diaminopimelic acid epimerase, 1119<br />

DNA synthesis, 1113<br />

E1040, 693<br />

E-3846, 636<br />

etoposide, 1456<br />

gentamicin, 552<br />

hypersusceptible<br />

gentamicin, 308<br />

lipopolysaccharide polycation affinity<br />

<strong>and</strong> binding, 308<br />

polymyxin, 308<br />

spermine, 308<br />

imipenem sub-MICs<br />

killing, 1012<br />

phagocytosis, 1012<br />

serum sensitivity, 1012<br />

in vitro simulation of serious infections,<br />

552<br />

lipopolysaccharide<br />

amikacin, 1247<br />

gentamicin, 1247<br />

kanamycin, 1247<br />

spectinomycin, 1247<br />

tobramycin, 1247<br />

lomefloxacin, 656<br />

LY163892, 268<br />

M14659, 1648<br />

ME1207, 1421<br />

mixed infection with B. fragilis<br />

amoxicillin-clavulanic acid, 1830<br />

ampicillin-sulbactam, 1830<br />

norfloxacin, 1292<br />

endogenous active efflux, 1187<br />

ofloxacin, 1640<br />

outer membrane proteins<br />

iron regulated, 1879<br />

oxyimino-cephalosporins, 1243<br />

Pap fimbrial adhesion, 1274<br />

PD 117,5%, 1450<br />

permeability, increased<br />

anesthetics, 153<br />

chlorpronmazine, 153<br />

dibucaine, 153<br />

procaine, 153<br />

quinine, 153<br />

tetracaine, 153<br />

postantibiotic effect, 450<br />

pyelonephritis, 636<br />

quinolone permeation, 438<br />

quinolones, 1113<br />

R-3746, 671<br />

R plasmids, 9, 1243, 1552<br />

S-6123, 1341<br />

sensitization by heat treatment<br />

chloramphenicol, 1680

VOL. 32, 1988<br />

crystal violet, 1680<br />

fatty acids, 1680<br />

malachite green, 1680<br />

p-hydroxybenzoic acid, 1680<br />

rifampin, 1680<br />

tylosin, 1680<br />

vancomycin, 1680<br />

T-3262, 663, 827<br />

tigemonam, 84, 346<br />

tobramycin, 450<br />

trimethoprim-sulfamethoxazole,<br />

1640<br />

U-76,252, 1082<br />

urinary tract infections, 1274<br />

YTR 830, 925<br />

Ethambutol<br />

combinations<br />

ciprofloxacin, 1392<br />

clofazimine, 1392<br />

erythromycin, 1392<br />

M. avium complex, 1392<br />

rifabutin, 1392<br />

rifampin, 1392<br />

M. tuberculosis, 1208, 1441<br />

Ethidium<br />

P. carinii, 896<br />

Ethidium bromide<br />

S. aureus resistance, 932<br />

Ethionamide<br />

M. avium, 1131<br />

Etoposide<br />

B. stearothermophilus, 1456<br />

B. subtilis, 1456<br />

comparative activity<br />

cloxacillin, 1456<br />

E. coli, 1456<br />

K. pneumoniae, 1456<br />

P. aeruginosa, 1456<br />

S. aureus, 1456<br />

S. lutea, 1456<br />

S. sanguis, 1456<br />

Eubacterium spp.<br />

daptomycin, 788<br />

paldimycin, 788<br />

tetracycline<br />

resistance, 1271<br />

Fagara zanthoxyloides<br />

B. gingivalis, 598<br />

B. melaninogenicus, 598<br />

Fatty acids<br />

E. coli<br />

heat treatment, 1680<br />

M. avium complex, 400<br />

Fecal flora<br />

antimicrobial resistance, 1801<br />

Feces<br />

norfloxacin binding, 1869<br />

quinolone binding, 1869<br />

Fibronectin<br />

S. pyogenes, 1370<br />

Fleroxacin<br />

C. trachomatis, 1080<br />

high-pressure liquid chromatography,<br />

1515<br />

letter to the editor, 791<br />

pharmacokinetics, 1515<br />

S. typhimurium, 791<br />

Flucloxacillin<br />

open-heart surgery, 930<br />

Fluconazole<br />

C. albicans, 209, 1859<br />

coccidioidal meningitis, 369<br />

comparative activity<br />

ketoconazole, 209, 646<br />

denture stomatitis, 1859<br />

meningitis, coccidioidal, 369<br />

pharmacokinetics, 209, 369<br />

stomatitis, denture, 1859<br />

testosterone, 646<br />

2-Fluoro-L-histidine<br />

P. falciparum, 1655<br />

Fluoroquinolones<br />

B. fragilis, 1437<br />

resistance, development of, 1285<br />

Fluorovinylglycine<br />

comparative activity, 319<br />

gram-positive bacteria, 319<br />

Staphylococcus spp., 319<br />

Flurithromycin<br />

comparative activity, 1710<br />

pharmacokinetics, 1875<br />

Folate pathway<br />

bacterial adhesion, 1609<br />

minireview, 1609<br />

Folic acid antagonists<br />

T. vaginalis, 144<br />

Foscarnet<br />

guinea pig embryonic fibroblasts, 1533<br />

herpes simplex virus type 1, 1533<br />

human immunodeficiency virus type 1,<br />

1733<br />

human immunodeficiency virus type 2,<br />

1733<br />

simian immunodeficiency virus, 1733<br />

Fosfomycin<br />

calcium<br />

pharmacokinetics, 938<br />

young <strong>and</strong> elderly adults, 938<br />

combinations<br />

endocarditis, 919<br />

pefloxacin, 919<br />

S. aureus, 919<br />

endocarditis, 919<br />

glutathione adduct, 1552<br />

plasmid-borne resistance, 1552<br />

S. aureus, 919<br />

tromethamine<br />

pharmacokinetics, 938<br />

young <strong>and</strong> elderly adults, 938<br />

Fucoidan<br />

cytomegalovirus, 1742<br />

herpes simplex virus, 1742<br />

human immunodeficiency virus, 1742<br />

vesicular stomatitis virus, 1742<br />

Furazolidone<br />

T. vaginalis, 144<br />

Fusobacterium nucleatum<br />

tetracycline<br />

resistance, 1271<br />

G2 E. floccosum, 1586<br />

Microsporum spp., 1586<br />

structure, 1586<br />

toxicity, 1586<br />

Trichophyton spp., 1586<br />

GABA receptor<br />

diclofenac, 1624<br />

quinolones, 1624<br />

theophylline, 1624<br />

f-Galactosidase<br />

P. chryosogenum<br />

glucokinase-deficient mutant, 1061<br />

SUBJECT INDEX xix<br />

y-Aminobutyric acid receptor<br />

diclofenac, 1624<br />

quinolones, 1624<br />

theophylline, 1624<br />

Ganciclovir<br />

cochlear pathophysiology, 865<br />

cytomegalovirus, 865<br />

high-pressure liquid chromatography,<br />

865<br />

labyrinthitis, 865<br />

marrow transplantation, 271<br />

pharmacokinetics, 1899<br />

Gene probes<br />

3-V-acetyltransferase, 1834<br />

Gentamicin<br />

A. denitrificans subsp. xylosoxidans, 276<br />

B. bronchiseptica, 1891<br />

B. catarrhalis, 259<br />

Bacillus spp., 642<br />

cerebrospinal fluid penetration, 1034<br />

cochlear binding sites, 467<br />

combinations<br />

ciprofloxacin, 782<br />

clindamycin, 853<br />

cost analysis, 853<br />

daptomycin, 81<br />

endomyometritis, 853<br />

P. maltophilia, 782<br />

pyelonephritis, 81<br />

S. faecalis, 81<br />

comparative activity<br />

carumonam, 473<br />

chloramphenicol <strong>and</strong> ciprofloxacin,<br />

285<br />

dysgonic fermenter 2, 78<br />

E. coli, 308, 552<br />

lipopolysaccharide, 1247<br />

Enterobacteriaceae, 873<br />

fecal flora resistance, 1801<br />

H. influenzae, 1034<br />

in vitro simulation of serious infections,<br />

552<br />

K. pneumoniae resistance, 1379<br />

meningitis, 1034<br />

N. asteroides, 1776<br />

nephrotoxicity<br />

hydrocortisone, influence of, 992<br />

piperacillin protective effect, 912<br />

P. aeruginosa, 552<br />

P. carinii, 896<br />

P. maltophilia, 782<br />

pharmacokinetics, 467, 736<br />

pyelonephritis, 81, 736<br />

S. aureus resistance, 932, 1174<br />

S. faecalis, 81, 736<br />

resistance, 547, 1528<br />

S. marcescens resistance, 1379<br />

S. pneumoniae, 552<br />

scrub typhus, 285<br />

Shigella spp., 20<br />

sodium hydroxide digestion method, 595<br />

T. vaginalis, 1323<br />

urinary tract infections, 473<br />

Gentamicin-clindamycin<br />

comparative activity<br />

cost analysis, 853<br />

moxalactam, 853<br />

endomyometritis, 853<br />

Giardia lamblia<br />

5-methylthioribose analogs, 1904<br />

(1-3)-p-D-Glucan synthase<br />

C. albicans, 1901<br />

cilofungin, 1901

xx SUBJECT INDEX<br />

Glucose<br />

avermectin production, 282<br />

Glutathione<br />

adduct formation, 1552<br />

fosfomycin modification, 1552<br />

GMP<br />

guinea pig embryonic fibroblasts, 1533<br />

herpes simplex virus type 1, 1533<br />

Gonorrhea<br />

cefodizime, 426<br />

cefotaxime, 426<br />

imipenem-cilastatin, 773<br />

spectinomycin<br />

disk zone diameter as predictor of outcome,<br />

775<br />

Gram-negative bacteria<br />

cefotaxime-chloramphenicol, 1375<br />

ceftriaxone-chloramphenicol, 1375<br />

cephalexin hydrochloride, 882<br />

cephalexin monohydrate, 882<br />

norfloxacin, 1292<br />

PD 127,391, 1278<br />

S-6123, 1341<br />

susceptibility testing, 385<br />

Gram-positive bacteria<br />

cyclohexane triones, 814<br />

DuP 721, 1218<br />

halovinylglycine compounds, 319<br />

L-norvalyl peptide derivatives, 319<br />

norfloxacin, 1292<br />

PD 127,391, 1278<br />

Guanosine analogs<br />

guinea pig embryonic fibroblasts, 1533<br />

herpes simplex virus type 1, 1533<br />

Haemophilus ducreyi<br />

A-56268, 1458<br />

amoxicillin, 1458<br />

amoxicillin-clavulanic acid, 1458<br />

cefotaxime, 1458<br />

cefoxitin, 1458<br />

ceftetrame, 1458<br />

ceftriaxone, 1458<br />

chloramphenicol, 1458<br />

ciprofloxacin, 723, 1458<br />

co-trimoxazole, 1458<br />

difloxacin, 1458<br />

doxycycline, 1458<br />

erythromycin, 1458<br />

kanamycin, 1458<br />

minocycline, 1458<br />

penicillin, 1458<br />

rifampin, 1458<br />

rosoxacin, 1458<br />

spectinomycin, 1458<br />

sulfamethoxazole, 1458<br />

tetracycline, 1458<br />

thiamphenicol, 1458<br />

trimethoprim, 1458<br />

trimethoprim-sulfamethoxazole, 1458<br />

Haemophilus influenzae<br />

A-61827, 27<br />

ampicillin, 180<br />

azithromycin, 752<br />

P-lactamase, 180<br />

cefaclor, 180<br />

cefam<strong>and</strong>ole, 180<br />

cefixime, 1896<br />

cefpodoxime, 1896<br />

ceftibuten, 1576<br />

ceftriaxone, 1896<br />

cephalexin, 180<br />

cephalothin, 180<br />

chloramphenicol<br />

acetyltransferase, 180<br />

conjunctivitis, 1820<br />

CS-807, 1082<br />

cyclohexane triones, 814<br />

erythromycin, 180<br />

gentamicin, 1034<br />

lomefloxacin, 617, 656<br />

LY163892, 131, 268<br />

ME1207, 1421<br />

meningitis, 1034<br />

minireview, 1747<br />

norfloxacin, 1820<br />

ocular infections, 1820<br />

PD 127,391, 1251<br />

penicillin G, 498<br />

penicillin-binding proteins, 498<br />

R-3746, 671<br />

rifampin, 180<br />

S-6123, 1341<br />

sulfisoxazole, 180<br />

susceptibility testing, 1747<br />

chloramphenicol, 1484<br />

T-3262, 663<br />

tetracycline, 180<br />

tobramycin, 1820<br />

trimethoprim resistance, 477<br />

trimethoprim-sulfamethoxazole, 180<br />

trospectomycin, 216<br />

U-76,252, 1082<br />

U-76,253A, 443<br />

Haemophilus spp.<br />

ciprofloxacin, 147<br />

E-1040, 1666<br />

enoxacin, 147<br />

norfloxacin, 147<br />

ofloxacin, 147<br />

PD 117,596, 1450<br />

pefloxacin, 147<br />

tigemonam, 84<br />

Halovinylglycine compounds<br />

alanine racemase, 319<br />

comparative activities, 319<br />

gram-positive bacteria, 319<br />

L-norvalyl peptide derivatives, 319<br />

Staphylococcus spp., 319<br />

Head <strong>and</strong> neck surgery<br />

cancer patients, 1557<br />

clindamycin-amikacin, 1557<br />

ticarcillin-clavulanic acid, 1557<br />

Herpes simplex virus<br />

carrageenans, 1742<br />

dextran sulfate, 1742<br />

fucoidan, 1742<br />

pentosan polysulfate, 1742<br />

sulfated polysaccharides, 1742<br />

Herpes simplex virus type I<br />

A723U, 1100<br />

acyclovir, 1100, 1533<br />

monophosphate, 1533<br />

9-p-D-arabinofuranosyladenine, 1046<br />

I -,-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil,<br />

1547<br />

1-0-D-arabinofuranosyl-E-(2-bromovinyl)<br />

uracil, 1046<br />

I-P-D-arabinofuranosylthymine, 1046<br />

3-azido-3'-deoxythymidine, 265<br />

AZT, 265<br />

B-220, 1720<br />

BRL 39123, 358<br />

bromovinyldeoxyuridine, 1533<br />

buciclovir, 1533<br />

ANTIMICROB. AGENTS CHEMOTHER.<br />

monophosphate, 1533<br />

2,3,dimethyl(dimethylaminoethyl)SHindolo-(2,3-b)quinoxaline,<br />

1720<br />

foscarnet, 1533<br />

GMP, 1533<br />

guanosine analogs, 1533<br />

9-4-(hydroxy-3-hydroxymethylbut-1 -yl)<br />

guanine, 358<br />

9-(2-hydroxyethoxymethyl)guanine, 1046<br />

indoloquinoxaline derivatives, 1720<br />

5-iodo-2'-deoxyuridine, 1046<br />

iododeoxyuridine, 1533<br />

P-536, 1257<br />

pyrimidine deoxynucleotide metabolism,<br />

1100<br />

ribonucleotide reductase inhibition,<br />

1100<br />

Herpes simplex virus type 2<br />

1-P-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil,<br />

1547<br />

3'-azido-3'-deoxythymidine, 265<br />

AZT, 265<br />

BRL 39123, 358<br />

9-4-(hydroxy-3-hydroxymethylbut-1-yl)<br />

guanine, 358<br />

phosphonoacetate, 858<br />

phosphonoformate, 858<br />

Hexadecane<br />

S. pyogenes, 1370<br />

High-performance liquid chromatography<br />

amphotericin B, 1103<br />

carbapenem labeling, 186<br />

cefonicid, 485<br />

cefpiramide, 1360<br />

cefpirome, 1481<br />

ceftazidime, 1845<br />

clindamycin, 1825<br />

itraconazole, 1310<br />

lomefloxacin, 1503, 1508<br />

reuterin, 1854<br />

High-pressure liquid chromatography<br />

carumonam, 354<br />

cefoperazone-ceftazidime, 298<br />

ceftazidime-cefoperazone, 298<br />

ciprofloxacin, 1537<br />

enoxacin, 834<br />

erythromycin estolate, 561<br />

erythromycin ethylsuccinate, 561<br />

fleroxacin, 1515<br />

ganciclovir, 865<br />

trimetrexate, 324<br />

Histidine analogs<br />

P. falciparum, 1655<br />

±2HM-HBG<br />

pharmacokinetics, 1807<br />

simian varicella-zoster virus, 1807<br />

Home parenteral therapy<br />

ceftriaxone, 1439<br />

HPA-23<br />

acquired immune deficiency syndrome,<br />

1300<br />

(S)-HPMPA<br />

influenza viruses, 906<br />

(S)-HPMPC<br />

cytomegalovirus, 1839<br />

HRE 664<br />

comparative activity<br />

aztreonam, ceftazidime, ceftriaxone,<br />

imipenem, piperacillin, <strong>and</strong> Sch<br />

34343, 1090<br />

Human granulocytes<br />

P. aeruginosa<br />

moxalactam-induced filamentous

VOL. 32, 1988<br />

forms, 1565<br />

Human immunodeficiency virus<br />

carrageenans, 1742<br />

dextran sulfate, 1742<br />

fucoidan, 1742<br />

pentosan polysulfate, 1742<br />

phosphonylmethoxyethyl purines, 1025<br />

reverse transcriptase, 1887<br />

sulfated polysaccharides, 1742<br />

Human immunodeficiency virus type 1<br />

3'-azido-3'-deoxythymidine, 1784<br />

triphosphate, 1733<br />

AZT, 1784<br />

triphosphate, 1733<br />

AZT-isoprinosine, 1784<br />

cell cultures, 684<br />

foscarnet, 1733<br />

isoprinosine, 1784<br />

isoprinosine-AZT, 1784<br />

reverse transcriptase, 684, 1733<br />

rifabutin, 684<br />

virus-antigen assay, 684<br />

Human immunodeficiency virus type 2<br />

3'-azido-3'-deoxythymidine triphosphate,<br />

1733<br />

AZT triphosphate, 1733<br />

foscarnet, 1733<br />

reverse transcriptase, 1733<br />

Human renal dehydropeptidase I<br />

purification <strong>and</strong> characterization, 587<br />

Hydrocortisone<br />

nephrotoxicity, gentamicin induced, 992<br />

9-[4-Hydroxy-2(hydroxymethyl)butyl]<br />

guanine triphosphate<br />

DNA polymerases, 1137<br />

varicella-zoster virus, 1137<br />

(R,S)-9-[4-Hydroxy-2-(hydroxymethyl)<br />

butyl]guanine<br />

pharmacokinetics, 1807<br />

simian varicella-zoster virus, 1807<br />

(S)-9-(3-Hydroxy-2-phosphonylmethoxypropyl)adenine<br />

influenza viruses, 906<br />

(S)- 1-(3-Hydroxy-2-phosphonylmethoxypropyl)cytosine<br />

comparative activity<br />

9-(1,3-dihydroxy-2-propoxymethyl)<br />

guanine, (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine,<br />

<strong>and</strong> phosphonoformate, 1839<br />

cytomegalovirus, 1839<br />

9-(4-Hydroxy-3-hydroxymethyl-1-yl)guanine<br />

comparative activity<br />

acyclovir, 358<br />

herpes simplex virus type 1, 358<br />

herpes simplex virus type 2, 358<br />

p-Hydroxybenzoic acids<br />

E. coli<br />

heat treatment, 1680<br />

2-Hydroxybenzoylglycine<br />

hyperbilirubinemia<br />

centrifugal ultrafiltration, 1571<br />

9-(2-hydroxyethoxymethyl)guanine<br />

herpes simplex virus type 1, 1046<br />

9-(2-Hydroxyethoxymethyl)guanine triphosphate<br />

DNA polymerases, 1137<br />

varicella-zoster virus, 1137<br />

Hyperbilirubinemia<br />

aztreonam, 1571<br />

carbenicillin, 1571<br />

cefoperazone, 1571<br />

ceftriaxone, 1571<br />

cefuroxime, 1571<br />

dicloxacillin, 1571<br />

2-hydroxybenzoylglycine, 1571<br />

kanamycin, 1571<br />

mezlocillin, 1571<br />

moxalactam, 1571<br />

nafcillin, 1571<br />

sulfamethoxazole, 1571<br />

sulfisoxazole, 1571<br />

Imidazoles<br />

T. vaginalis, 1323<br />

Imidocarb<br />

P. carinii, 896<br />

Imipenem<br />

A. denitrificans subsp. xylosoxidans, 276<br />

B. catarrhalis, 259<br />

Bacillus spp., 642<br />

combinations<br />

ciprofloxacin, 782<br />

P. maltophilia, 782<br />

comparative activity<br />

piperacillin, 1012<br />

dysgonic fermenter 2, 78<br />

M. morganii, 1385<br />

M. tuberculosis, 1441<br />

N. asteroides, 1776<br />

Nocardia spp., 1078<br />

P. aeruginosa resistance, 1267<br />

P. maltophilia, 782<br />

P. pseudomallei, 1435<br />

P. vulgaris, 1385<br />

sub-MICs<br />

E. coli, 1012<br />

killing, 1012<br />

phagocytosis, 1012<br />

S. aureus, 1012<br />

serum sensitivity, 1012<br />

Imipenem-cilastatin<br />

-y-aminobutyric acid binding, 758<br />

C. trachomatis, 773<br />

gonorrhea, 773<br />

N. gonorrhoeae, 773<br />

pentylenetetrazole convulsive threshold,<br />

758<br />

pharmacokinetics, 530<br />

Immunoblotting<br />

P. aeruginosa, 649<br />

Immunoglobulin, intravenous<br />

respiratory syncytial virus, 1269<br />

Impetigo<br />

erythromycin, 1780<br />

mupirocin, 1780<br />

Indoloquinoxaline<br />

derivatives, 1720<br />

herpes simplex virus type 1, 1720<br />

Influenza A virus<br />

alpha-2b interferon, 47<br />

Influenza B virus<br />

alpha-2b interferon, 47<br />

ribavirin small-particle aerosol, 761<br />

Influenza viruses<br />

(RS)-3-adenin-9-yl-2-hydroxypropanoic<br />

acid, 906<br />

(RS)-AHPA, 906<br />

carbocyclin 3-deazaadenosine, 906<br />

carbodine, 906<br />

5-chlorotubercidin, 906<br />

5-cyanoimidazole-4-carboxamide, 906<br />

5-cyano-1-,-D-ribofuranosyl-imidazole-4carboxamide,<br />

906<br />

cyclopentenyl cytosine, 906<br />

SUBJECT INDEX xxi<br />

3-deazaguanine, 906<br />

3-deazauridine, 906<br />

5'-deoxy-5-fluorouridine, 906<br />

(S)-DHIPA, 906<br />

(S)-9-(2,3-dihydroxypropyl)adenine, 906<br />

(S)-HPMPA, 906<br />

(S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine,<br />

906<br />

3-methylhypoxanthine, 906<br />

3'-C-methyluridine, 906<br />

neplanocin A, 900<br />

neplanocin C, 906<br />

P-536, 1257<br />

pyrazofurin, 906<br />

ribavirin, 906<br />

T-25, 906<br />

T-26, 906<br />

tubercidin, 906<br />

xylotubercidin, 906<br />

Inositol hexaphosphate<br />

B. microti, 391<br />

P. falciparum, 391<br />

Interferon<br />

alfa-2b, recombinant<br />

rhinovirus, 224<br />

alpha-2a, recombinant<br />

respiratory syncytial virus, 589<br />

cytomegalovirus, 678<br />

S26308, 678<br />

Intra-abdominal infections<br />

cefoperazone-sulbactam, 730<br />

Intravenous immunoglobulin<br />

respiratory syncytial virus, 1269<br />

Iodine alcohol<br />

Enterobacteriaceae, 873<br />

5-Iodo-2'-deoxyuridine<br />

herpes simplex virus type 1, 1046<br />

Iododeoxyuridine<br />

guinea pig embryonic fibroblasts, 1533<br />

herpes simplex virus type 1, 1533<br />

2-Iodo-L-histidine<br />

P. falciparum, 1655<br />

lontophoresis<br />

tobramycin, 978<br />

Ipratropium bromide<br />

rhinovirus, 1644<br />

Isoelectric focusing<br />

,B-lactamases, 397, 1730<br />

comparative studies, 397<br />

PhastSystem, 1730<br />

Isometamidium<br />

P. carinii, 896<br />

Isoniazid<br />

M. avium, 1131<br />

M. tuberculosis, 1208, 1441<br />

Isoprinosine<br />

combinations<br />

3'-azido-3'-deoxythymidine, 1784<br />

AZT, 1784<br />

human immunodeficiency virus type 1,<br />

1984<br />

human immunodeficiency virus type 1,<br />

1984<br />

Itraconazole<br />

high-performance liquid chromatography,<br />

1310<br />

pharmacokinetics, 1310, 1595<br />

renal dysfunction, 1595<br />

S. schenckii, 1619<br />

sporotrichosis, 1619

xxii SUBJECT INDEX<br />

Jasplakinolide<br />

antifungal agents, 1154<br />

C. albicans, 1154<br />

C<strong>and</strong>ida spp., 1154<br />

comparative activity<br />

clotrimazole <strong>and</strong> miconazole, 1154<br />

Josamycin<br />

Arthrobacter spp., 420<br />

C. trachomatis, 1350<br />

comparative activity, 1710<br />

R. conorii, 255<br />

R. rickettsii, 255<br />

Staphylococcus spp., 420<br />

Kanamycin<br />

B. bronchiseptica, 1891<br />

C. coli resistance, 1170<br />

C. jejuni resistance, 1170<br />

Campylobacter resistance, 945<br />

E. coli<br />

lipopolysaccharide, 1247<br />

fecal flora resistance, 1801<br />

H. ducreyi, 1458<br />

hyperbilirubinemia<br />

centrifugal ultrafiltration, 1571<br />

K. pneumoniae resistance, 1379<br />

M. avium, 1131<br />

N. asteroides, 1776<br />

S. aureus resistance, 932<br />

S. marcescens resistance, 1379<br />

Shigella spp., 20<br />

Keratitis<br />

P. aeruginosa, 978<br />

tobramycin, 978<br />

Ketoconazole<br />

C. albicans, 209<br />

combinations<br />

SF 86-327, 1237<br />

T. (S.) cruzi, 1237<br />

comparative activity<br />

fluconazole, 209<br />

pharmacokinetics, 209<br />

T. (S.) cruzi, 1237<br />

T. vaginalis, 1323<br />

testosterone, 646<br />

Kingella denitrificans<br />

R plasmid, 765<br />

tetracycline resistance, 765<br />

Klebsiella aerogenes<br />

YTR 830, 925<br />

Klebsiella pneumoniae<br />

amikacin resistance, 1379<br />

transposon mediated, 1416<br />

P-lactam resistance, 1660<br />

,-lactamases, 626, 1660<br />

cephaloridine, 364<br />

cephalosporin resistance, 1660<br />

CGP 17520, 364<br />

cystitis, 636<br />

E-3846, 636<br />

etoposide, 1456<br />

gentamicin resistance, 1379<br />

kanamycin resistance, 1379<br />

lomefloxacin, 656<br />

meningitis, 1705<br />

netilmicin resistance, 1379<br />

plasmids, 1660<br />

pyelonephritis, 636<br />

R-3746, 671<br />

R plasmid, 9, 626, 1379, 1416<br />

surface protein antigens, 364<br />

temocillin, 1705<br />

tobramycin resistance, 1379<br />

Klebsiella spp.<br />

CS-807, 1082<br />

PD 117,596, 1450<br />

tigemonam, 84<br />

U-76,252, 1082<br />

Labyrinthitis<br />

cytomegalovirus, 865<br />

ganciclovir, 865<br />

Lactobacillus reuteri<br />

production <strong>and</strong> isolation of reuterin,<br />

1854<br />

Lactobacillus spp.<br />

daptomycin, 788<br />

paldimycin, 788<br />

Legionella pneumophila<br />

A-61827, 27<br />

azithromycin, 752<br />

carumonam, 1593<br />

PD 117,596, 1450<br />

Legionella spp.<br />

NY-198, 1427<br />

Legionnaires disease<br />

NY-198, 1427<br />

Letters to the editor<br />

antacids<br />

ciprofloxacin pharmacokinetics, 949<br />

B. subtilis<br />

streptomycin adenylyltransferase, 949<br />

ciprofloxacin<br />

antacids, 949<br />

pharmacokinetics, 949<br />

common cold therapy, 605, 606, 608<br />

Cryptosporidium sp., 1907<br />

fleroxacin, 791<br />

in vitro simulation of serious infections,<br />

1600<br />

M. tuberculosis, 287<br />

N. gonorrhoeae<br />

P-lactamase, 158<br />

R plasmid, 158<br />

tetracycline resistance, 951<br />

pharmacokinetics<br />

ciprofloxacin, 949<br />

puerperal infections, 407<br />

pyrazinamide, 287<br />

S. aureus, 1464<br />

S. typhimurium, 791<br />

streptomycin<br />

B. subtilis adenylyltransferase, 949<br />

sulfadimethoxine, 1907<br />

susceptibility testing, 1464<br />

tetracycline<br />

N. gonorrhoeae resistance, 951<br />

ticarcillin-clavulanic acid, 407<br />

zinc for common cold, 605, 606, 608<br />

pH <strong>and</strong> free ion concentration, 608<br />

stability constants, 606<br />

Lidocaine<br />

ceftriaxone reconstitution, 1439<br />

Lincomycin<br />

Arthrobacter spp., 420<br />

Staphylococcus spp., 420<br />

Lincosamides<br />

Arthrobacter resistance, 420<br />

Staphylococcus resistance, 420<br />

Lipid X<br />

pharmacokinetics, 37<br />

Lipopolysaccharides<br />

E. coli<br />

amikacin, 1247<br />

ANTIMICROB. AGENTS CHEMOTHER.<br />

gentamicin, 1247<br />

kanamycin, 1247<br />

spectinomycin, 1247<br />

tobramycin, 1247<br />

Liposomes<br />

amikacin<br />

M. avium-M. intracellulare, 1404<br />

ampicillin, 1560<br />

enviroxime, 890<br />

L. monocytogenes, 1560<br />

lipid composition, 1560<br />

phosphonoacetate, 858<br />

phosphonoformate, 858<br />

stearylamine-phosphatidylcholine, 966<br />

T. b. gambiense, 966<br />

Liposome-swelling assay<br />

P. aeruginosa, 1267<br />

Listeria monocytogenes<br />

ampicillin, 1204<br />

nanoparticle polyisohexylcyanoacrylate-bound,<br />

1204<br />

ampicillin, liposome entrapped<br />

lipid composition, 1560<br />

azithromycin, 752<br />

DuP 105, 150, 580<br />

DuP 721, 150, 580<br />

Listeria spp.<br />

tigemonam, 84<br />

Lomefloxacin<br />

B. fragilis, 617<br />

Branhamella spp., 656<br />

comparative activity<br />

amoxicillin, ciprofloxacin, cefuroxime,<br />

fleroxacin, ofloxacin, <strong>and</strong> trimethoprim,<br />

617<br />

ciprofloxacin, enoxacin, norfloxacin,<br />

<strong>and</strong> ofloxacin, 656<br />

E. coli, 656<br />

Enterobacter spp., 656<br />

Enterobacteriaceae, 617<br />

H. influenzae, 617, 656<br />

high-performance liquid chromatography,<br />

1503, 1508<br />

K. pneumoniae, 656<br />

Neisseria spp., 617<br />

P. aeruginosa, 617<br />

pharmacokinetics, 1503, 1508<br />

Pseudomonas spp., 656<br />

Salmonella spp., 656<br />

Shigella spp., 656<br />

Staphylococcus spp., 617, 656<br />

Streptococcus spp., 617<br />

tolerance, 1503<br />

LY163892<br />

B. catarrhalis, 268<br />

chemical stability in storage, 1477<br />

comparative activity<br />

amoxicillin, amoxicillin-clavulanic<br />

acid, <strong>and</strong> cefaclor, 268<br />

cefaclor <strong>and</strong> cefuroxime, 131<br />

cefaclor, cephalexin, cephalothin, <strong>and</strong><br />

cefuroxime, 1477<br />

E. coli, 268<br />

H. influenzae, 131, 268<br />

pediatric infections, 268<br />

pharmacokinetics, 1738<br />

S. aureus, 131<br />

Streptococcus spp., 268<br />

susceptibility test conditions, 1477<br />

M14659<br />

comparative activity

VOL. 32, 1988<br />

ceftazidime <strong>and</strong> ceftriaxone, 1648<br />

E. coli, 1648<br />

low-iron environment, 1648<br />

Macrolides<br />

comparative activity, 1710<br />

T. vaginalis, 144<br />

Malachite green<br />

E. coli<br />

heat treatment, 1680<br />

Malaria<br />

antimalarial agents<br />

mechanisms of action, 793<br />

minireview, 793<br />

chemoprophylaxis, 953<br />

chloroquine resistance, 799<br />

minireviews, 793, 799, 953, 957<br />

treatment, 957<br />

Marrow transplantation<br />

ganciclovir, 271<br />

Massularia accuminata<br />

B. gingivalis, 598<br />

B. melaninogenicus, 598<br />

ME1207<br />

,-lactamases, 1421<br />

comparative activity<br />

cefaclor, cefixime, <strong>and</strong> T-2525, 1421<br />

E. coli, 1421<br />

H. influenzae, 1421<br />

N. gonorrhoeae, 1421<br />

P. cepacia, 1421<br />

P. rettgeri, 1421<br />

S. pneumoniae, 1421<br />

Staphylococcus spp., 1421<br />

Measles virus<br />

P-536, 1257<br />

Mebendazole<br />

T. vaginalis, 144<br />

Mefloquine<br />

polymorphonuclear neutrophils, 1124<br />

Meningitis<br />

coccidioidal<br />

fluconazole, 369<br />

gentamicin<br />

cerebrospinal fluid penetration,<br />

1034<br />

H. influenzae, 1034<br />

K. pneumoniae, 1705<br />

temocillin, 1705<br />

Methicillin<br />

dysgonic fermenter 2, 78<br />

Methylenepenams<br />

antibacterial properties, 1005<br />

Methylglyoxal bis(guanylhydrazone)<br />

P. carinii, 896<br />

3-Methylhypoxanthine<br />

influenza viruses, 906<br />

5-Methylthioribose analogs<br />

G. lamblia, 1904<br />

0. malhamensis, 1904<br />

P. falciparum, 1904<br />

3'-C-Methyluridine<br />

influenza viruses, 906<br />

Metronidazole<br />

combinations<br />

enterococci, 1769<br />

streptomycin, 1769<br />

enterococci, 1769<br />

T. vaginalis, 144, 1323<br />

Mezlocillin<br />

B. catarrhalis, 259<br />

Bacillus spp., 642<br />

combinations<br />

ciprofloxacin, 782<br />

P. maltophilia, 782<br />

hyperbilirubinemia<br />

centrifugal ultrafiltration, 1571<br />

M. morganii, 1385<br />

P. maltophilia, 782<br />

P. vulgaris, 1385<br />

pharmacokinetics, 777<br />

Miconazole<br />

comparative activity<br />

amphotericin B, 1864<br />

polymorphonuclear leukocytes, 1864<br />

T. vaginalis, 1323<br />

Microsporum spp.<br />

G2, 1586<br />

Minireviews<br />

antibiotic biosynthetic genes, 1472<br />

antifungal agents, 1<br />

antimalarial agents<br />

mechanisms of action, 793<br />

azoles, I<br />

B. catarrhalis<br />

susceptibility testing, 1747<br />

bacterial adhesion, 1603, 1609<br />

biosynthetic genes, 1472<br />

C. trachomatis<br />

antibodies, monoclonal, 1295<br />

susceptibility testing, 1295<br />

Campylobacter spp.<br />

resistance mechanisms, 1107<br />

chloroquine<br />

mechanism of resistance, 799<br />

H. influenzae<br />

susceptibility testing, 1747<br />

malaria, 793, 799<br />

chemoprophylaxis, 953<br />

treatment, 957<br />

mixed aerobic-anaerobic infections, 611<br />

N. gonorrhoeae<br />

susceptibility testing, 1747<br />

P. falciparum, 799<br />

pharmacokinetics<br />

outcome of infections, 289<br />

Plasmodium spp., 793<br />

rhinovirus colds chemotherapy, 409<br />

Streptomyces spp.<br />

cloned genes, 1465, 1472<br />

recombinant DNA systems, 1465<br />

susceptibility testing<br />

B. catarrhalis, 1747<br />

H. influenzae, 1747<br />

N. gonorrhoeae, 1747<br />

triazoles, I<br />

Minocycline<br />

C. trachomatis, 1080, 1350<br />

comparative activity<br />

demeclocycline, doxycycline, erythromycin,<br />

nalidixic acid, oxytetracycline,<br />

rifampin, <strong>and</strong> tetracycline,<br />

986<br />

E. risticii, 986<br />

H. ducreyi, 1458<br />

N. asteroides, 1776<br />

P. multocida, 213<br />

Miocamycin<br />

comparative activity, 1710<br />

Mixed infections<br />

aerobic-anaerobic, 611<br />

minireview, 611<br />

Morganella morganii<br />

ampicillin, 1385<br />

P-lactam resistance, 1385<br />

P-lactamase, 1385<br />

carbenicillin, 1385<br />

SUBJECT INDEX xxiii<br />

cefotaxime, 1385<br />

cefoxitin, 1385<br />

ceftriaxone, 1385<br />

cephaloridine, 1385<br />

imipenem, 1385<br />

mezlocillin, 1385<br />

Morganella spp.<br />

E-1040, 1666<br />

R-3746, 671<br />

tigemonam, 84<br />

Moxalactam<br />

B. catarrhalis, 259<br />

comparative activity<br />

clindamycin-gentamicin, 853<br />

cost analysis, 853<br />

endomyometritis, 853<br />

hyperbilirubinemia<br />

centrifugal ultrafiltration, 1571<br />

P. aeruginosa filamentous forms<br />

human granulocytes, 1565<br />

P. vulgaris, 1073<br />

Shigella spp., 20<br />

Mtr phenotype<br />

N. gonorrhoeae, 971<br />

Mucor racemosus<br />

cycloheximide efflux, 341<br />

trichodermin, 341<br />

Mupirocin<br />

comparative activity<br />

erythromycin, 1780<br />

impetigo, 1780<br />

Mycobacterium avium<br />

amikacin, 1131<br />

capreomycin, 1131<br />

ethionamide, 1131<br />

isoniazid, 1131<br />

kanamycin, 1131<br />

rifampin, 1131<br />

streptomycin, 1131<br />

susceptibility testing, 1131<br />

Mycobacterium avium complex<br />

acquired immune deficiency syndrome,<br />

1392<br />

amikacin, 886, 1149, 1400<br />

amikacin-clofazimine, 1400<br />

amikacin-clofazimine-rifabutin, 1400<br />

amikacin-rifabutin, 1400<br />

amikacin-tumor necrosis factor, 1149<br />

azithromycin, 1149<br />

azithromycin-tumor necrosis factor,<br />

1149<br />

clofazime-ethambutol, 1392<br />

clofazimine-ciprofloxacin, 1392<br />

ethambutol-ciprofloxacin, 1392<br />

ethambutol-erythromycin, 1392<br />

ethambutol-rifampin, 1392<br />

ethambutol-rifampin-ciprofloxacin, 1392<br />

ethambutol-rifampin-ciprofloxacin-erythromycin,<br />

1392<br />

ethambutol-rifampin-erythromycin, 1392<br />

fatty acids, 400<br />

model man, 886<br />

rifabutin-ciprofloxacin, 1392<br />

rifabutin-clofazimine, 1392<br />

rifabutin-ethambutol, 1392<br />

rifampin-ciprofloxacin, 1392<br />

rifampin-erythromycin, 1392<br />

roxithromycin, 1149<br />

roxithromycin-tumor necrosis factor,<br />

1149<br />

Mycobacterium avium-M. intracellulare<br />

amikacin, 1404<br />

liposome encapsulated, 1404

xxiv SUBJECT INDEX<br />

Mycobacterium leprae<br />

clarithromycin, 1758<br />

clofazimine, 1583<br />

erythromycin, 1758<br />

phenazines, 1583<br />

roxithromycin, 1758<br />

Mycobacterium smegmatis<br />

cyclohexane triones, 814<br />

Mycobacterium spp.<br />

dihydromycoplanecin A, 110<br />

Mycobacterium tuberculosis<br />

A-56620, 1441<br />

ATP bioluminescence assay, 1208<br />

cefonicid, 1441<br />

ceforanide, 1441<br />

cefotaxime, 1441<br />

cefpirome, 1441<br />

ceftizoxime, 1441<br />

cephapirin, 1441<br />

difloxacin, 1441<br />

ethambutol, 1208, 1441<br />

imipenem, 1441<br />

isoniazid, 1208, 1441<br />

letter to the editor, 287<br />

PD 127,391, 1251<br />

pyrazinamide, 125, 287<br />

pHs, different, 1002<br />

radiometric method, 1002<br />

rifampin, 1208, 1441<br />

SK&F 88070, 1441<br />

streptomycin, 1208, 1441<br />

susceptibility testing, 125<br />

Mycoplasma hominis<br />

A-63075, 1500<br />

clarithromycin, 1500<br />

difloxacin, 1500<br />

erythromycin, 1500<br />

temafloxacin, 1500<br />

Mycoplasma pneumoniae<br />

A-63075, 1500<br />

clarithromycin, 1500<br />

difloxacin, 1500<br />

erythromycin, 1500<br />

temafloxacin, 1500<br />

Naegleria fowleri<br />

acrolein, 962<br />

cyclophosphamide, 962<br />

Nafcillin<br />

hyperbilirubinemia<br />

centrifugal ultrafiltration, 1571<br />

Nalidixic acid<br />

B. bronchiseptica, 1891<br />

cleavable-complex assay, 1086<br />

comparative activity<br />

ciprofloxacin, enoxacin, norfloxacin,<br />

<strong>and</strong> ofloxacin, 1285<br />

demeclocycline, doxycycline, erythromycin,<br />

minocycline, oxytetracycline,<br />

rifampin, <strong>and</strong> tetracycline,<br />

986<br />

E. faecalis resistance, 1285<br />

E. risticii, 986<br />

Enterobacteriaceae resistance, 1285<br />

fecal flora resistance, 1801<br />

GABA receptor, 1624<br />

P. aeruginosa resistance, 1285<br />

P. falciparum, 1182<br />

S. aureus, 1192<br />

resistance, 1285<br />

Shigella spp., 20<br />

Nauclea latifolia<br />

B. gingivalis, 598<br />

B. melaninogenicus, 598<br />

Neisseria gonorrhoeae<br />

A-61827, 27<br />

azithromycin, 752<br />

,B-lactamases, 158, 1430<br />

cefodizime, 426<br />

cefotaxime, 426<br />

DNA gyrase inhibitors, 1788<br />

genetic transformation, 1788<br />

imipenem-cilastatin, 773<br />

letters to the editor, 158, 951<br />

ME1207, 1421<br />

minireview, 1747<br />

Mtr phenotype, 971<br />

PD 117,596, 1450<br />

R-3746, 671<br />

R plasmids, 158, 488<br />

transfer to Neisseria spp., 1430<br />

susceptibility testing, 1747<br />

T-3262, 663<br />

tetracycline resistance, 488, 951<br />

trospectomycin, 216<br />

Neisseria meningitidis<br />

azithromycin, 752<br />

cefixime, 1896<br />

cefpodoxime, 1896<br />

ceftriaxone, 18%<br />

ciprofloxacin, 1740<br />

penicillin resistance, 706<br />

R plasmid<br />

transfer from N. gonorrhoeae, 1430<br />

Neisseria perflava-N. sicca<br />

tetracycline<br />

resistance, 1271<br />

Neisseria spp.<br />

ceftibuten, 1576<br />

E-1040, 1666<br />

lomefloxacin, 617<br />

PD 127,391, 1251<br />

R plasmid, 488, 765<br />

transfer from N. gonorrhoeae, 1430<br />

tetracycline resistance, 488, 765<br />

tigemonam, 84<br />

U-76,253A, 443<br />

Neomycin<br />

B. bronchiseptica, 1891<br />

Nephrotoxicity<br />

apalcillin, 942<br />

cefazolin, 314<br />

cefoperazone, 314<br />

ceftazidime, 314<br />

cephaloglycin, 314<br />

cephaloridine, 314, 912<br />

cephalothin, 314<br />

gentamicin, 912<br />

hydrocortisone, influence of, 992<br />

Neplanocin A<br />

influenza viruses, 906<br />

Neplanocin C<br />

influenza viruses, 906<br />

Netilmicin<br />

A. denitrificans subsp. xylosoxidans,<br />

276<br />

B. catarrhalis, 259<br />

cardiopulmonary bypass, 631<br />

K. pneumoniae resistance, 1379<br />

pharmacokinetics, 631<br />

S. marcescens resistance, 1379<br />

Neutrophils<br />

clindamycin<br />

periodontal bacteria, 1521<br />

ANTIMICROB. AGENTS CHEMOTHER.<br />

Nifurtimox<br />

immune response, effect on, 241<br />

T. cruzi, 241<br />

Nigerian chewing sticks<br />

B. gingivalis, 598<br />

B. melaninogenicus, 598<br />

Nitrosoureas<br />

amphQtericin B<br />

C. albicans, 327<br />

Nocardia asteroides<br />

amikacin, 1776<br />

ampicillin, 1776<br />

1-lactamase, 1776<br />

carbenicillin, 1776<br />

cefotaxime, 1776<br />

ceftriaxone, 1776<br />

ciprofloxacin, 1776<br />

erythromycin, 1776<br />

gentamicin, 1776<br />

imipenem, 1776<br />

kanamycin, 1776<br />

minocycline, 1776<br />

sulfamethoxazole, 1776<br />

susceptibility patterns, 1776<br />

Nocardia spp.<br />

A-56620, 1078<br />

A-62254, 1078<br />

amifloxacin, 1078<br />

cefepime, 1078<br />

cefpirome, 1078<br />

ciprofloxacin, 1078<br />

difloxacin, 1078<br />

enoxacin, 1078<br />

imipenem, 1078<br />

PD-1 17558, 1078<br />

RO 23-6240, 1078<br />

S-25930, 1078<br />

S-25932, 1078<br />

Nonoxynol-9<br />

T. vaginalis, 1323<br />

Norfloxacin<br />

A. denitrificans subsp. xylosoxidans, 276<br />

B.fragilis, 1437, 1869<br />

binding to feces, 1869<br />

Bordetella spp., 137<br />

C. trachomatis, 1080, 1350, 1735<br />

C. freundii resistance, 922<br />

cleavable-complex assay, 1086<br />

comparative activity<br />

amifloxacin, ciprofloxacin, enoxacin,<br />

<strong>and</strong> ofloxacin, 928<br />

doxycycline <strong>and</strong> minocycline, 1735<br />

tobramycin, 1820<br />

conjunctivitis, 1820<br />

E. coli, 1292<br />

endogenous active efflux, 1187<br />

E. faecium, 1869<br />

fecal binding, 1869<br />

gram-negative bacteria, 1292<br />

gram-positive bacteria, 1292<br />

H. influenzae, 1820<br />

Haemophilus spp., 147<br />

ocular infections, 1820<br />

P. aeruginosa, 1292<br />

P. falciparum, 1182<br />

P. maltophilia, 782<br />

P. pseudomallei, 928, 1435<br />

S. aureus, 1192, 1820<br />

S. pneumoniae, 1820<br />

Shigella spp., 20<br />

Staphylococcus spp., 1820<br />

streptococci, alpha-hemolytic, 1820<br />

theophylline pharmacokinetics, 510

VOL. 32, 1988<br />

urinary tract infections, 1292<br />

L-Norvalyl-L-chlorovinylglycine<br />

comparative activity, 319<br />

gram-positive bacteria, 319<br />

Staphylococcus spp., 319<br />

Nosocomial infections<br />

Staphylococcus spp., 202<br />

Novobiocin<br />

A. lignieresii, 1354<br />

B. bronchiseptica, 1891<br />

P. falciparum, 1182<br />

P. multocida, 1354<br />

Nucleic acid synthesis<br />

bacterial adhesion, 1609<br />

minireview, 1609<br />

NY-198<br />

B. fragilis, 1437<br />

C. trachomatis, 1080, 1735<br />

comparative activity<br />

ciprofloxacin, 1427<br />

doxycycline <strong>and</strong> minocycline, 1735<br />

Legionella spp., 1427<br />

Legionnaires disease, 1427<br />

pharmacokinetics, 156, 1427<br />

Ochromonas malhamensis<br />

5-methylthioribose analogs, 1904<br />

Ocular infections<br />

H. influenzae, 1820<br />

norfloxacin, 1820<br />

S. aureus, 1820<br />

S. pneumoniae, 1820<br />

Staphylococcus spp., 1820<br />

streptococci, alpha-hemolytic, 1820<br />

tobramycin, 1820<br />

Ofloxacin<br />

A. denitrificans subsp. xylosoxidans,<br />

276<br />

B. fragilis, 1437<br />

bite wound bacteria, 1143<br />

Bordetella spp., 137<br />

C. trachomatis, 1080, 1350, 1735<br />

C. freundii resistance, 922<br />

cleavable-complex assay, 1086<br />

comparative activity<br />

amifloxacin, ciprofloxacin, enoxacin,<br />

<strong>and</strong> norfloxacin, 928<br />

doxycycline <strong>and</strong> minocycline, 1735<br />

cystitis, 1640<br />

cytogenetic effects, 936<br />

DR-3355 isomer, 1336<br />

E. coli, 1640<br />

GABA receptor, 1624<br />

Haemophilus spp., 147<br />

P. falciparum, 1182<br />

P. pseudomallei, 928<br />

pharmacokinetics, 1590, 1640<br />

S. aureus, 1192<br />

Shigella spp., 20<br />

Ole<strong>and</strong>omycin<br />

Arthrobacter spp., 420<br />

Staphylococcus spp., 420<br />

Oligonucleotide probes<br />

,3-lactamases, 397<br />

comparative studies, 397<br />

Open-heart surgery<br />

flucloxacillin, 930<br />

Oral bacteria<br />

tetracycline resistance, 1271<br />

Ornithine decarboxylase inhibitors<br />

T. gondii, 303<br />

Osteomyelitis<br />

enoxacin, 834<br />

vancomycin bone concentrations, 1320<br />

Outer membrane<br />

permeability<br />

P. aeruginosa, 1267<br />

P. cepacia, 1636<br />

proteins<br />

E. coli, 1879<br />

iron regulated, 1879<br />

Oxacillin<br />

Bacillus spp., 642<br />

bactericidal testing, 1614<br />

coagulase-negative staphylococcal susceptibility,<br />

1754<br />

P. multocida, 213<br />

S. aureus, 1614<br />

MBCs, 374<br />

susceptibility, 1754<br />

Oxetanocin G<br />

cytomegalovirus, 1053<br />

Oxolinic acid<br />

B. bronchiseptica, 1891<br />

cleavable-complex assay, 1086<br />

P. falciparum, 1182<br />

Oxyimino-cephalosporins<br />

,B-lactamase, 1243<br />

E. coli, 1243<br />

Oxytetracycline<br />

B. bronchiseptica, 1891<br />

comparative activity<br />

demeclocycline, doxycycline, erythromycin,<br />

minocycline, nalidixic<br />

acid, rifampin, <strong>and</strong> tetracycline,<br />

986<br />

E. risticii, 986<br />

P-536<br />

encephalomyocarditis virus, 1257<br />

influenza virus, 1257<br />

measles virus, 1257<br />

poliovirus type 1, 1257<br />

T. cruzi, 1412<br />

type 5, 1257<br />

herpes simplex virus type 1, 1257<br />

UDP-glucose analog, 1257<br />

vaccinia virus, 1257<br />

vesicular stomatitis virus, 1257<br />

PADAC<br />

P-lactamase assay, 1040<br />

Paldimycin<br />

Actinomyces spp., 788<br />

Bifidobacterium spp., 788<br />

Clostridium spp., 788<br />

comparative activity<br />

daptomycin, penicillin, <strong>and</strong> vancomycin,<br />

788<br />

Eubacterium spp., 788<br />

Lactobacillus spp., 788<br />

Peptostreptococcus spp., 788<br />

Propionibacterium spp., 788<br />

Pap fimbrial adhesion<br />

berberine sulfate, 1274<br />

Paradoxical effect<br />

P-lactams, 1073<br />

P. vulgaris, 1073<br />

Parainfluenza virus<br />

sulfated polysaccharides, 1742<br />

Pasteurella multocida<br />

actinomycin D, 1354<br />

amoxicillin-clavulanic acid, 213<br />

ampicillin, 213<br />

SUBJECT INDEX xxv<br />

cefaclor, 213<br />

cefadroxil, 213<br />

cefuroxime, 213<br />

cephalexin, 213<br />

chloramphenicol, 213<br />

clindamycin, 213<br />

daptomycin, 1354<br />

erythromycin, 213<br />

minocycline, 213<br />

novobiocin, 1354<br />

oxacillin, 213<br />

penicillin, 213<br />

phospholipid composition, 1354<br />

polymyxin, 1354<br />

rifamycin, 1354<br />

tetracycline, 213<br />

trimethoprim-sulfamethoxazole, 213<br />

Pasteurella spp.<br />

P-lactamase, 1282<br />

R plasmid, 1282<br />

PD-1 17558<br />

Nocardia spp., 1078<br />

PD 117,596<br />

Acinetobacter spp., 1450<br />

B. catarrhalis, 1450<br />

C. jejuni, 1450<br />

comparative activity<br />

amikacin, aztreonam, cephalothin, CI<br />

934, ciprofloxacin, imipenem, <strong>and</strong><br />

piperacillin, 1450<br />

Corynebacterium spp., 1450<br />

E. coli, 1450<br />

Enterobacter spp., 1450<br />

Enterococcus spp., 1450<br />

Haemophilus spp., 1450<br />

Klebsiella spp., 1450<br />

L. pneumophila, 1450<br />

N. gonorrhoeae, 1450<br />

P. mirabilis, 1450<br />

Pseudomonas spp., 1450<br />

S. aureus, 1450<br />

S. marcescens, 1450<br />

Streptococcus spp., 1450<br />

PD 127,391<br />

B. fragilis, 1251<br />

C. trachomatis, 1251<br />

comparative activity<br />

ceftazidime, ciprofloxacin, gentamicin,<br />

<strong>and</strong> imipenem, 1278<br />

cefuroxime, ciprofloxacin, gentamicin,<br />

nalidixic acid, <strong>and</strong> ofloxacin, 1251<br />

Enterobacteriaceae, 1251<br />

gram-negative aerobes, 1278<br />

gram-positive aerobes, 1278<br />

H. influenzae, 1251<br />

M. tuberculosis, 1251<br />

Neisseria spp., 1251<br />

P. aeruginosa, 1251, 1278<br />

Pseudomonas spp., 1278<br />

S. pneumoniae, 1251<br />

Staphylococcus spp., 1251<br />

Pediatric infections<br />

LY163892, 268<br />

Pefloxacin<br />

A. denitrificans subsp. xylosoxidans,<br />

276<br />

B. catarrhalis, 259<br />

C. trachomatis, 1350<br />

combinations<br />

endocarditis, 919<br />

fosfomycin, 919<br />

S. aureus, 919<br />

comparative activity

xxvi SUBJECT INDEX<br />

amikacin-ceftazidime, 231<br />

ceftazidime-amikacin, 231<br />

endocarditis, 231, 919<br />

GABA receptor, 1624<br />

Haemophilus spp., 147<br />

P. aeruginosa, 231<br />

resistance, development of, 231<br />

P. falciparum, 1182<br />

S. aureus, 919<br />

Shigella spp., 20<br />

Penems<br />

protein binding, 159<br />

spectrophotometric assay, 159<br />

Penicillin<br />

B. catarrhalis, 259<br />

Bacillus spp., 642<br />

biosynthesis<br />

P. chrysogenum glucokinase-deficient<br />

mutant, 1061<br />

Chlamydia sp. strain TWAR, 257<br />

dysgonic fermenter 2, 78<br />

H. ducreyi, 1458<br />

H. influenzae, 498<br />

N. meningitidis resistance, 706<br />

P. multocida, 213<br />

S. aureus resistance, 1164<br />

T. vaginalis, 1323<br />

Penicillin G<br />

bite wound bacteria, 1143<br />

methylene analogs<br />

antibacterial properties, 1005<br />

Penicillinase<br />

P. cepacia, 838<br />

Penicillin-binding proteins<br />

B. fragilis, 1848<br />

H. influenzae, 498<br />

Penicillium chrysogenum<br />

P-galactosidase activity, 1061<br />

glucokinase-deficient mutant, 1061<br />

penicillin biosynthesis, 1061<br />

Pentamidine<br />

comparative activity<br />

dapsone, trimethoprim-dapsone, <strong>and</strong><br />

trimethoprim-sulfamethoxazole,<br />

623<br />

P. carinii, 623, 896, 1490<br />

pharmacokinetics, 1490<br />

pneumonia, 623, 1490<br />

Pentosan polysulfate<br />

cytomegalovirus, 1742<br />

herpes simplex virus, 1742<br />

human immunodeficiency virus, 1742<br />

vesicular stomatitis virus, 1742<br />

Pentostam<br />

P. carinii, 896<br />

Pentylenetetrazole<br />

BMY-26225, 758<br />

cefazolin, 758<br />

convulsive threshold, 758<br />

imipenem-cilastatin, 758<br />

rat model, 758<br />

Peptidoglycan synthesis<br />

bacterial adhesion, 1609<br />

minireview, 1609<br />

Peptococcus spp.<br />

DR-3355, 1336<br />

Peptostreptococcus anaerobius<br />

tetracycline<br />

resistance, 1271<br />

Peptostreptococcus spp.<br />

daptomycin, 788<br />

paldimycin, 788<br />

Percutaneous transhepatic biliary drainage<br />

cefotiam, 726<br />

sulbenicillin, 726<br />

ursodeoxycholate, 726<br />

Periodontal disease<br />

A. actinomycetemcomitans, 1521<br />

C. ochracea, 1521<br />

clindamycin, 1521<br />

E. corrodens, 1521<br />

tetracycline resistance, 1271<br />

Pharmacokinetics<br />

A40926, 246<br />

amdinocillin pivoxil<br />

influence of food, 592<br />

amikacin, 236<br />

amopyroquin, 568<br />

apalcillin, 942<br />

calcium fosfomycin, 938<br />

carumonam, 354<br />

cefazolin, 33<br />

cefetamet, 573<br />

cefetamet pivoxil, 573<br />

cefonicid, 485<br />

protein binding, 128<br />

cefoperazone, 42<br />

cefoperazone-sulbactam, 42, 503, 730<br />

continuous ambulatory peritoneal dialysis,<br />

51<br />

cefotaxime<br />

protein binding, 128<br />

cefpiramide, 33, 1360<br />

cefpirome, 13%<br />

ceftazidime, 1845<br />

ceftazidime-vancomycin, 92<br />

ceftizoxime<br />

protein binding, 128<br />

ciprofloxacin, 949, 982, 1537<br />

clindamycin, 1825<br />

dihydromycoplanecin A, 110<br />

erythromycin estolate, 561<br />

erythromycin ethylsuccinate, 561<br />

fleroxacin, 1515<br />

fluconazole, 209, 369<br />

flurithromycin, 1875<br />

ganciclovir, 1899<br />

gentamicin, 467, 736<br />

±2HM-HBG, 1807<br />

(R,S)-9-[4-hydroxy-2(hydroxymethyl)<br />

butyl]guanine, 1807<br />

imipenem-cilastatin, 530<br />

itraconazole, 1310<br />

renal dysfunction, 1595<br />

ketoconazole, 209<br />

letter to the editor, 949<br />

lipid X, 37<br />

lomefloxacin, 1503, 1508<br />

LY163892, 1738<br />

mezlocillin, 777<br />

minireview, 289<br />

monoclonal anti-lipid A antibody, 710<br />

netilmicin, 631<br />

NY-198, 156, 1427<br />

ofloxacin, 1590, 1640<br />

outcome of infections, 289<br />

pentamidine, 1490<br />

ribavirin aerosol, 117<br />

rimantadine, 1699, 1813<br />

roxithromycin, 1461<br />

sulbactam, 42<br />

teicoplanin, 1223<br />

temocillin, 1705<br />

theophylline<br />

ciprofloxacin, effect of, 75<br />

ANTIMICROB. AGENTS CHEMOTHER.<br />

norfloxacin, 510<br />

tobramycin<br />

charcoal, effect of, 274<br />

trimethoprim-sulfamethoxazole, 1640<br />

trimetrexate, 324<br />

tromethamine fosfomycin, 938<br />

vancomycin, 92, 631, 848<br />

vancomycin-ceftazidime, 92<br />

PhastSystem<br />

13-lactamases, 1730<br />

Phenazines<br />

M. leprae, 1583<br />

structure-activity relationships, 1583<br />

Pheromones<br />

S. faecalis, 547<br />

Phlebovirus<br />

ribavirin, 331<br />

Phosphatidylcholine<br />

liposomes, 966<br />

T. b. gambiense, 966<br />

Phospholipids<br />

A. lignieresii, 1354<br />

P. multocida, 1354<br />

Phosphonoacetate<br />

herpes simplex virus type 2, 858<br />

liposomes, 858<br />

Phosphonoformate<br />

herpes simplex virus type 2, 858<br />

liposomes, 858<br />

Phosphonylmethoxyethyl purines<br />

human immunodeficiency virus, 1025<br />

Pipemidic acid<br />

C. trachomatis, 1080<br />

Piperacillin<br />

A. denitrificans subsp. xylosoxidans, 276<br />

B. catarrhalis, 259<br />

cephaloridine nephrotoxicity, 912<br />

combinations<br />

ciprofloxacin, 782<br />

P. maltophilia, 782<br />

dysgonic fermenter 2, 78<br />

gentamicin nephrotoxicity, 912<br />

P. maltophilia, 782<br />

P. pseudomallei, 1435<br />

P. vulgaris, 1073<br />

Piritrexim<br />

P. carinii, 430<br />

T. gondii, 430<br />

Plasma bactericidal activity<br />

erythromycin estolate, 1227<br />

erythromycin ethylsuccinate, 1227<br />

Plasmids<br />

1-lactamases, 175, 1730<br />

DNA probes, 175<br />

resistance<br />

Acinetobacter spp., 15<br />

C. coli, 1170<br />

C. difficile, 1213<br />

C. freundii, 9<br />

C. jejuni, 1170<br />

E. aerogenes, 9<br />

E. coli, 9, 1243, 1552<br />

E. corrodens, 765<br />

Enterobacteriaceae, 1289<br />

Enterococcus spp., 1793<br />

K. denitrificans, 765<br />

K. pneumoniae, 9, 626, 1379, 1416,<br />

1660<br />

letter to the editor, 158<br />

N. gonorrhoeae, 158, 488, 1430<br />

Neisseria spp., 488, 765<br />

P. morganii, 9<br />

Pasteurella spp., 1282

VOL. 32, 1988<br />

S. aureus, 932, 1164, 1174<br />

S. faecalis, 547, 1528<br />

S. marcescens, 9, 1289, 1379, 1834<br />

S. sonnei, 1598<br />

S. wien, 1262<br />

Staphylococcus spp., 1494<br />

Streptococcus spp., 1793<br />

sulfonamides, 1684<br />

Plasmodium berghei<br />

cyclosporine, 462<br />

stage-selective inhibition, 462<br />

Plasmodium falciparum<br />

amifloxacin, 1182<br />

amopyroquin, 568<br />

B. javanica, 1725<br />

2-bromo-L-histidine, 1655<br />

2-chloro-L-histidine, 1655<br />

chloroquine resistance, 799<br />

cinchonidine, 250<br />

cinchonine, 250<br />

ciprofloxacin, 1182<br />

coumermycin A, 1182<br />

enoxacin, 1182<br />

2-fluoro-L-histidine, 1655<br />

histidine analogs, 1655<br />

inositol hexaphosphate, 391<br />

2-iodo-L-histidine, 1655<br />

5-methylthioribose analogs, 1904<br />

minireview, 799<br />

nalidixic acid, 1182<br />

norfloxacin, 1182<br />

novobiocin, 1182<br />

ofloxacin, 1182<br />

oxolinic acid, 1182<br />

pefloxacin, 1182<br />

quassinoids, 1725<br />

quinidine, 250<br />

quinine, 250<br />

S. amara, 1725<br />

WR 194,965 phosphate, 540<br />

Plasmodium spp.<br />

antimalarial agents<br />

mechanisms of action, 793<br />

minireview, 793<br />

minireview, 793<br />

Pneumococci<br />

U-76,253A, 443<br />

Pneumocystis carinii<br />

acquired immunodeficiency syndrome,<br />

1057<br />

amicarbalide, 896<br />

ampicillin, 896<br />

Astiban, 896<br />

chloramphenicol, 896<br />

chlorpromazine, 896<br />

clind4mycin, 807<br />

clindamycin-primaquine, 807<br />

dapsone, 96, 623, 1057, 1158<br />

dapsone-trimethoprim, 623<br />

dehydroemetine, 896<br />

diaveridine, 96<br />

difluoromethylornithine, 896<br />

DL-a-difluoromethylornithine, 1158<br />

diminazene, 896<br />

aceturate, 1158<br />

ethidium, 896<br />

gentamicin, 896<br />

imidocarb, 896<br />

isom.etamidium, 896<br />

methylglyoxal bis(guanylhydrazone), 896<br />

pentamidine, 623, 896, 1490<br />

Pentostam, 896<br />

piritrexim, 430<br />

pneumonia, 623, 896, 1057, 1490<br />

primaquine, 807<br />

primaquine-clindamycin, 807<br />

pyrimethamine, 96<br />

quinacrine, 896<br />

quinapyramine, 896<br />

quinidine, 896<br />

quinine, 896<br />

spectinomycin, 896<br />

spiramycin, 896<br />

sulfadiazine, 96<br />

sulfadoxine, 96<br />

sulfamethoxazole, 96<br />

suramin, 1158<br />

trimethoprim, 96<br />

trimethoprim-dapsone, 623<br />

trimethoprimn-sulfamethoxazole, 623,<br />

1158<br />

trimetrexate, 324<br />

Pneumonia<br />

dapsone, 1057<br />

P. carinii, 1057, 1490<br />

dosages <strong>and</strong> intervals, 623<br />

pentamidine, 1490<br />

Poliovirus<br />

sulfated polysaccharides, 1742<br />

type I<br />

P-536, 1257<br />

Polycystic kidney disease<br />

ciprofloxacin, 844<br />

Polyisohexylcyanoacrylate<br />

ampicillin binding<br />

L. monocytogenes, 1204<br />

Polymorphonuclear leukocytes<br />

amphotericin B, 1864<br />

miconazole, 1864<br />

P. aeruginosa<br />

moxalactam-induced filamentous<br />

forms, 1565<br />

Polymorphonuclear neutrophils<br />

amodiaquine, 1124<br />

chloroquine, 1124<br />

mefloquine, 1124<br />

Polymyxin<br />

A. lignieresii, 1354<br />

E. coli, 308<br />

P. multocida, 1354<br />

Polymyxin B<br />

B. bronchiseptica, 1891<br />

Polyvinylpyrrolidone<br />

Enterobacteriaceae, 873<br />

Porins<br />

P. cepacia, 1636<br />

Postantibiotic effect<br />

ampicillin, 450<br />

ciprofloxarin, 450<br />

E. coli, 450<br />

tobramycin, 450<br />

Primaquine<br />

combinations<br />

clindamycin, 807<br />

P. carinii, 807<br />

P. carinii, 807<br />

Pristinamycin<br />

aerobic bacteria, 1094<br />

comparative activity<br />

cefoxitin, chloramphenicol, clindamycin,<br />

metronidazole, penicillin,<br />

pristinamnycin group IA, <strong>and</strong><br />

pristinamycin group IIA, 1094<br />

Procaine<br />

E. coli permeability, 153<br />

SUBJECT INDEX xxvii<br />

Propionibacterium spp.<br />

daptomycin, 788<br />

paldimycin, 788<br />

Prostatic tissue<br />

enoxacin concentrations, 1433<br />

Protein synthesis<br />

bacterial adhesion, 1603<br />

minireyiew, 1603<br />

Proteus mirabilis<br />

CS-807, 1082<br />

cystitis, 636<br />

E-3846, 636<br />

PD 117,596, 1450<br />

pyelonephritis, 636<br />

R-3746, 671<br />

U-76,252, 1082<br />

YTR 830, 925<br />

Proteus morganii<br />

R plasmids, 9<br />

Proteus spp.<br />

tigenionam, 84<br />

trospectomycin, 216<br />

Proteus vulgaris<br />

ampicillin, 1385<br />

f-lactamases, 1073, 1385<br />

1-lactams<br />

paradoxical effect, 1073<br />

resistance, 1385<br />

carbenicillin, 1385<br />

cefbuperazone, 1073<br />

cefmenoxime, 1073<br />

cefmetazole, 1073<br />

cefoperazone, 1073<br />

cefotaxime, 1073, 1385<br />

cefotiam, 1073<br />

cefoxitin, 1385<br />

ceftazidime, 1073<br />

ceftizoxime, 1073<br />

ceftriaxone, 1073, 1385<br />

cefuroxime, 1073<br />

cefuzonam, 1073<br />

cephaloridine, 1073, 1385<br />

cephalothin, 1073<br />

imipenem, 1385<br />

mezlocillin, 1385<br />

moxalactam, 1073<br />

piperacillin, 1073<br />

R-3746, 671<br />

Prothrombin<br />

cefotetan effect, 1446<br />

cefoxitin effect, 1446<br />

Providencia rettgeri<br />

ME1207, 1421<br />

Providencia spp.<br />

R-3746, 671<br />

tigemonam, 84<br />

PSE-2<br />

sequence, 134<br />

Pseudomonas aeruginosa<br />

A-61827, 27<br />

amikacin-ceftazidime, 231<br />

resistance, development of, 231<br />

aminoglycoside resistance, 689<br />

ampicillin, 552<br />

antibodies<br />

monoclonal, 649<br />

aztreonam, 552<br />

P-lactamases, 1443<br />

heterogeneity, 1893<br />

carumonam, 1593<br />

cefepime resistance, 1443<br />

cefixime, 1896<br />

cefoperazone-ceftazidime, 298

xxviii SUBJECT INDEX<br />

cefotaxime resistance, 1443<br />

cefpirome, 1396<br />

cefpodoxime, 1896<br />

ceftazidime resistance, 1443<br />

ceftazidime-amikacin, 231<br />

resistance, development of, 231<br />

ceftazidime-cefoperazone, 298<br />

ceftriaxone, 552, 1896<br />

ciprofloxacin resistance, 535<br />

CS-807, 1082<br />

cystitis, 636<br />

DuP 105, 580<br />

DuP 721, 580<br />

E1040, 693, 1666<br />

E-3846, 636<br />

endocarditis, 231<br />

enhanced antibiotic binding, 649<br />

etoposide, 1456<br />

fluoroquinolone resistance, 1285<br />

gentamicin, 552<br />

imipenem resistance, 1267<br />

immunoblotting, 649<br />

in vitro simulation of serious infections,<br />

552<br />

keratitis, 978<br />

liposome-swelling assay, 1267<br />

lomefloxacin, 617<br />

moxalactam-induced filamentous forms<br />

human granulocytes, 1565<br />

norfloxacin, 1292<br />

outer membrane<br />

permeability, 1267<br />

proteins, 785<br />

PD 127,391, 1251, 1278<br />

pefloxacin, 231<br />

pyelonephritis, 636<br />

quinolone resistance, 785<br />

T-3262, 663, 827<br />

tobramycin, 978<br />

binding to alginate, 518<br />

tolA mutant, 649<br />

U-76,252, 1082<br />

Pseudomonas cepacia<br />

,B-lactam resistance, 1636<br />

P-lactamase, 838<br />

cystic fibrosis, 1636<br />

E-1040, 1666<br />

ME1207, 1421<br />

outer membrane permeability, 1636<br />

penicillinase, 838<br />

porins, 1636<br />

T-3262, 663<br />

Pseudomonas maltophilia<br />

A-56620, 782<br />

amikacin, 782<br />

aztreonam, 782<br />

P-lactamase<br />

cloning of operon on E. coli, 819<br />

carbenicillin, 782<br />

cefoperazone, 782<br />

cefsulodin, 782<br />

ceftazidime, 782<br />

ciprofloxacin, 782<br />

ciprofloxacin-amikacin, 782<br />

ciprofloxacin-aztreonam, 782<br />

ciprofloxacin-cefoperazone, 782<br />

ciprofloxacin-cefsulodin, 782<br />

ciprofloxacin-ceftazidime, 782<br />

ciprofloxacin-gentamicin, 782<br />

ciprofloxacin-imipenem, 782<br />

ciprofloxacin-mezlocillin, 782<br />

ciprofloxacin-piperacillin, 782<br />

ciprofloxacin-tobramycin, 782<br />

difloxacin, 782<br />

gentamicin, 782<br />

imipenem, 782<br />

mezlocillin, 782<br />

norfloxacin, 782<br />

piperacillin, 782<br />

Sch 34343, 782<br />

T-3262, 663<br />

ticarcillin, 782<br />

tobramycin, 782<br />

Pseudomonas pseudomallei<br />

amifloxacin, 928<br />

amoxicillin, 1435<br />

amoxicillin-clavulanic acid, 1435<br />

carumonam, 1435<br />

cefotaxime, 1435<br />

ceftazidime, 1435<br />

ceftriaxone, 1435<br />

ciprofloxacin, 928, 1435<br />

enoxacin, 928<br />

imipenem, 1435<br />

norfloxacin, 928, 1435<br />

ofloxacin, 928<br />

piperacillin, 1435<br />

ticarcillin, 1435<br />

ticarcillin-clavulanic acid, 1435<br />

Pseudomonas spp.<br />

amiloride, 395<br />

cystic fibrosis, 395<br />

E-1040, 1666<br />

lomefloxacin, 656<br />

PD 117,5%, 1450<br />

PD 127,391, 1278<br />

R-3746, 671<br />

tigemonam, 84, 346<br />

tobramycin, 395<br />

U-76,253A, 443<br />

Puerperal infections<br />

letter to the editor, 407<br />

ticarcillin-clavulanic acid, 407<br />

Pulmonary aspergillosis<br />

amphotericin B, 1676<br />

Punta Toro virus<br />

ribavirin, 331<br />

Pyelonephritis<br />

daptomycin, 81<br />

daptomycin-gentamicin, 81<br />

E-3846, 636<br />

gentamicin, 81, 736<br />

gentamicin-daptomycin, 81<br />

S. faecalis, 81<br />

Pyrazinamide<br />

letter to the editor, 285<br />

M. tuberculosis, 125, 285<br />

pHs, different, 1002<br />

radiometric method, 1002<br />

susceptibility testing, 125<br />

Pyrazofurin<br />

influenza viruses, 906<br />

Pyridinium-2-azo-p-dimethylaniline chromophore<br />

P-lactamase assay, 1040<br />

Pyrimethamine<br />

P. carinii, 96<br />

T. gondii, 303<br />

Pyrimidine deoxynucleotide metabolism<br />

herpes simplex virus type 1, 1100<br />

Quassinoids<br />

E. histolytica, 1725<br />

P. falciparum, 1725<br />

ANTIMICROB. AGENTS CHEMOTHER.<br />

Quinacrine<br />

P. carinii, 896<br />

Quinapyramine<br />

P. carinii, 896<br />

Quinidine<br />

P. carinii, 8%<br />

P. falciparum, 250<br />

Quinine<br />

E. coli permeability, 153<br />

P. carinii, 896<br />

P. falciparum, 250<br />

Quinolones<br />

C. freundii resistance, 922<br />

cleavable-complex assay, 1086<br />

DNA gyrase resistance, 104<br />

DNA synthesis, 1113<br />

E. coli, 1113<br />

permeation, 438<br />

fecal binding, 1869<br />

GABA receptor, 1624<br />

y-aminobutyric acid receptor, 1624<br />

inhibition of y-aminobutyric acid binding<br />

to receptor sites, 190<br />

P. aeruginosa resistance, 785<br />

R-3746<br />

Bacteroides spp., 671<br />

Branhamella spp., 671<br />

C. diversus, 671<br />

C. freundii, 671<br />

Clostridium spp., 671<br />

comparative activity<br />

amoxicillin-clavulanic acid, cefaclor,<br />

cefixime, cephalexin, <strong>and</strong> trimethoprim-sulfamethoxazole,<br />

671<br />

E. aerogenes, 671<br />

E. cloacae, 671<br />

E. coli, 671<br />

Enterococcus spp., 671<br />

H. influenzae, 671<br />

K. pneumoniae, 671<br />

Morganella spp., 671<br />

N. gonorrhoeae, 671<br />

P. mirabilis, 671<br />

P. vulgaris, 671<br />

Providencia spp., 671<br />

Pseudomonas spp., 671<br />

S. marcescens, 671<br />

S. pneumoniae, 671<br />

Salmonella spp., 671<br />

Shigella spp., 671<br />

streptococci, 671<br />

Yersinia spp., 671<br />

Radiochemical method<br />

E. coli biofilms, 770<br />

Radiometric method<br />

M. tuberculosis, 125<br />

pyrazinamide, 125<br />

Rat granuloma pouch<br />

cefpirome, 1396<br />

Recombinant DNA<br />

minireview, 1465<br />

Streptomyces spp., 1465<br />

Renal cyst infection<br />

ciprofloxacin, 844<br />

Reovirus<br />

sulfated polysaccharides, 1742<br />

Respiratory syncytial virus<br />

immunoglobulin, intravenous, 1269<br />

interferon alpha-2a, recombinant, 589<br />

intravenous immunoglobulin, 1269

VOL. 32, 1988<br />

Reuterin<br />

high-performance liquid chromatography,<br />

1854<br />

isolation, 1854<br />

production, 1854<br />

Reverse transcriptases<br />

human immunodeficiency virus, 1887<br />

human immunodeficiency virus type 1,<br />

684, 1733<br />

human immunodeficiency virus type 2,<br />

1733<br />

simian immunodeficiency virus, 1733,<br />

1887<br />

Rhinovirus<br />

alpha-2b interferon, 47<br />

colds chemotherapy, 409<br />

enviroxime, 890<br />

interferon, recombinant alfa-2b, 224<br />

ipratropium bromide, 1644<br />

minireview, 409<br />

Ribavirin<br />

aerosol<br />

pharmacokinetics, 117<br />

Argentine hemorrhagic fever, 1304<br />

influenza B virus, 761<br />

influenza viruses, 906<br />

Phlebovirus, 331<br />

Punta Toro virus, 331<br />

small-particle aerosol, 761<br />

vesicular stomatitis virus transcription,<br />

492<br />

Ribonucleotide reductase<br />

herpes simplex virus type 1, 1100<br />

Rickettsia conorii<br />

erythromycin, 255<br />

josamycin, 255<br />

spiramycin, 255<br />

Rickettsia rickettsii<br />

erythromycin, 255<br />

josamycin, 255<br />

spiramycin, 255<br />

Rifabutin<br />

combinations<br />

amikacin, 1400<br />

ciprofloxacin, 1392<br />

clofazimine, 1392<br />

ethambutol, 1392<br />

M. avium complex, 1392, 1400<br />

human immunodeficiency virus type 1,<br />

684<br />

Rifampin<br />

B. bronchiseptica, 1891<br />

B. catarrhalis, 259<br />

Bordetella spp., 137<br />

C. trachomatis, 1350<br />

combinations<br />

ciprofloxacin, 1392<br />

erythromycin, 1392<br />

ethambutol, 1392<br />

M. avium complex, 1392<br />

trimethoprim, 802<br />

urinary tract infections, 802<br />

comparative activity<br />

demeclocycline, doxycycline, erythromycin,<br />

minocycline, nalidixic<br />

acid, oxytetracycline, <strong>and</strong> tetracycline,<br />

986<br />

dysgonic fermenter 2, 78<br />

E. coli<br />

heat treatment, 1680<br />

E. risticii, 986<br />

H. ducreyi, 1458<br />

H. influenzae, 180<br />

M. avium, 1131<br />

M. tuberculosis, 1208, 1441<br />

Rifampin-trimethoprim<br />

comparative activity<br />

sulfamethoxazole-trimethoprim, 802<br />

urinary tract infections, 802<br />

Rifamycin<br />

A. lignieresii, 1354<br />

P. multocida, 1354<br />

Rikamycin<br />

C. trachomatis, 1350<br />

Rimantadine<br />

metabolism, 1699<br />

pharmacokinetics, 1699, 1813<br />

RO 23-6240<br />

C. trachomatis, 1080<br />

Nocardia spp., 1078<br />

Rokitamycin<br />

comparative activity, 1710<br />

Rosaramicin<br />

Arthrobacter spp., 420<br />

Staphylococcus spp., 420<br />

Rosoxacin<br />

C. trachomatis, 1350<br />

H. ducreyi, 1458<br />

Roxithromycin<br />

Bordetella spp., 137<br />

C. trachomatis, 1350<br />

combinations<br />

M. avium complex, 1149<br />

tumor necrosis factor, 1149<br />

comparative activity, 1710<br />

clarithromycin <strong>and</strong> erythromycin, 1758<br />

M. avium complex, 1149<br />

M. leprae, 1758<br />

pharmacokinetics, 1461<br />

T. gondii, 524<br />

T. pallidum, resistant, 164<br />

tonsillectomy, 1461<br />

toxicity, 1541<br />

uptake <strong>and</strong> distribution, 1541<br />

S-6123<br />

comparative activity<br />

ampicillin, ciprofloxacin, clindamycin,<br />

tetracycline, <strong>and</strong> trimethoprimsulfamethoxazole,<br />

1341<br />

E. coli, 1341<br />

Enterococcus spp., 1341<br />

gram-negative bacteria, 1341<br />

H. influenzae, 1341<br />

mechanism of action, 1341<br />

Staphylococcus spp., 1341<br />

Streptococcus spp., 1341<br />

S-25930<br />

Nocardia spp., 1078<br />

S-25932<br />

Nocardia spp., 1078<br />

S26308<br />

cytomegalovirus, 678<br />

interferon, 678<br />

Saccharomyces cerevisiae<br />

cilofungin, 1331<br />

Salmonella paratyphi A<br />

ampicillin resistance, 195<br />

cross-resistant mutant, 195<br />

mutation, pleiotropic, 195<br />

Salmonella spp.<br />

lomefloxacin, 656<br />

R-3746, 671<br />

tigemonam, 84<br />

SUBJECT INDEX xxix<br />

Salmonella typhimurium<br />

A-61827, 27<br />

allicin, 1763<br />

ampicillin, 57<br />

chloramphenicol, 57<br />

ciprofloxacin, 57<br />

diallyl thiosulfinate, 1763<br />

fleroxacin, 791<br />

letter to the editor, 791<br />

Salmonella wien<br />

FIme plasmid, 1262<br />

R plasmid, 1262<br />

tetracycline resistance, class B, 1262<br />

TnJO-like transposon, 1262<br />

Sarcina lutea<br />

etoposide, 1456<br />

Scrub typhus<br />

chloramphenicol, 285<br />

ciprofloxacin, 285<br />

gentamicin, 285<br />

SDZ 89-485<br />

S. schenckii, 1619<br />

sporotrichosis, 1619<br />

Sedecamycin<br />

comparative activity<br />

carbadox, lincomycin, <strong>and</strong> tiamulin,<br />

458<br />

T. hyodysenteriae, 458<br />

Serindeia werneckei<br />

B. gingivalis, 598<br />

B. melaninogenicus, 598<br />

Serratia marcescens<br />

6'-N-acetyltransferase type 4, 1289<br />

amikacin resistance, 1289, 1379<br />

gentamicin resistance, 1379<br />

kanamycin resistance, 1379<br />

netilmicin resistance, 1379<br />

PD 117,596, 1450<br />

R-3746, 671<br />

R plasmid, 9, 1289, 1379, 1834<br />

tigemonam, 84<br />

tobramycin resistance, 1379<br />

Serratia spp.<br />

E-1040, 1666<br />

Serum bactericidal activity<br />

cefoxitin, 1511<br />

ceftizoxime, 1511<br />

SF 86-327<br />

combinations<br />

ketoconazole, 1237<br />

T. (S.) cruzi, 1237<br />

T. (S.) cruzi, 1237<br />

Shigella sonnei<br />

R plasmids, 1598<br />

trimethoprim resistance, 1598<br />

Shigella spp.<br />

amikacin, 20<br />

ampicillin, 20<br />

ampicillin-sulbactam, 20<br />

cefam<strong>and</strong>ole, 20<br />

cefoperazone, 20<br />

cefotaxime, 20<br />

ceftazidime, 20<br />

ceftriaxone, 20<br />

cefuroxime, 20<br />

cephalothin, 20<br />

chloramphenicol, 20<br />

ciprofloxacin, 20<br />

enoxacin, 20<br />

gentamicin, 20<br />

kanamycin, 20<br />

lomefloxacin, 656<br />

moxalactam, 20

xxx SUBJECT INDEX<br />

nalidixic acid, 20<br />

norfloxacin, 20<br />

ofloxacin, 20<br />

pefloxacin, 20<br />

R-3746, 671<br />

streptomycin, 20<br />

sulfanmethoxazole, 20<br />

tetracycline, 20<br />

tigemonam, 84<br />

trimethoprimn, 20<br />

trimethoprim-sulfamethoxazole,<br />

20<br />

Simarouba amara<br />

E. histolytica, 1725<br />

P. falciparum, 1725<br />

quassinoids, 1725<br />

Simian immunodeficiency virus<br />

3'-azido-3'-deoxythyiidine triphosphate,<br />

1733<br />

AZT triphosphate, 1733<br />

foscarnet, 1733<br />

reverse transcriptase, 1733, 1887<br />

Simian varicella-zoster virus<br />

+2HM-HBG, 1807<br />

(R,S)-9-[4-hydroxy-2(hydroxymethyl)<br />

butyl]guanite, 1807<br />

Sindbis virus<br />

carrageenans, 1742<br />

dextran sulfate, 1742<br />

fucoidan, 1742<br />

pentosan polysulfate, 1742<br />

sulfated polysaccharides, 1742<br />

SK&F 88070<br />

M. tuberculosis, 1441<br />

Skin infections<br />

cefonicid, 485<br />

cephalexin hydrochloride, 882<br />

cephalexin monohydrate, 882<br />

Skin structure infections<br />

cefonicid, 485<br />

Sodium hydroxide digestion method<br />

gentamicin, 595<br />

SodiUim hypochlorite<br />

Enterobacteriaceae, 873<br />

Soft tissue infections<br />

cephalexin hydrochloride, 882<br />

cephalexin monohydrate, 882<br />

Spectinomycin<br />

E. coli<br />

lipopolysaccharide, 1247<br />

gonorrhea<br />

disk zone diameter as predictor of outcome,<br />

775<br />

f. ducreyi, 1458<br />

P. carinii, 896<br />

Spectrophotometric assay<br />

protein binding of penems, 159<br />

Spermine<br />

E. coli, 308<br />

Spiramycin<br />

Arthrobacter spp., 420<br />

comparative activity, 1710<br />

P. carinii, 896<br />

R. conorii, 255<br />

R. rickettsii, 255<br />

Staphylococcus spp., 420<br />

T. gondii, 303, 524<br />

Sporothrix schenckii<br />

amphotericin B, 1619<br />

itraconazole, 1619<br />

SDZ 89-485, 1619<br />

terbinafine, 1619<br />

Sporotrichosis<br />

amphotericin B, 1619<br />

itraconazole, 1619<br />

SDZ 89-485, 1619<br />

terbinafine, 1619<br />

Staphylococcus aureus<br />

A-61827, 27<br />

acriflavin resistance, 932<br />

acrinol resistance, 932<br />

amikacin resistance, 932<br />

bactericidal testing, 1614<br />

benzalkonium chloride resistance, 932<br />

,-lactamase, 1614, 1754<br />

transposon, 1164<br />

cefazolin, 262<br />

cefotaxime-chloramphenicol, 1375<br />

cefpirome, 13%<br />

ceftriaxone-chloramphenicol, 1375<br />

cephalexin hydrochloride, 882<br />

cephalexin monohydrate, 882<br />

cephalosporins, 170<br />

cephalothin, 374<br />

chlorhexidine resistance, 932<br />

cinoxacin, 1192<br />

ciprofloxacin, 747, 1192<br />

conjunctivitis, 1820<br />

daptomycin, 279, 454<br />

difloxacin, 262<br />

DNA gyrase, 1192<br />

DuP 105, 580<br />

DuP 721, 580<br />

endocarditis, 262, 747, 919<br />

enoxacin, 262<br />

ethidium bromide resistance, 932<br />

etoposide, 1456<br />

fluoroquinolone resistance, 1285<br />

fosfomycin, 919<br />

fosfomycin-pefloxacin, 919<br />

gentamicin resistance, 932, 1174<br />

imipenem sub-MICs<br />

killing, 1012<br />

phagocytosis, 1012<br />

serum sensitivity, 1012<br />

kanamycin resistance, 932<br />

letter to the editor, 1464<br />

LY163892, 131<br />

MBC reproducibility, 374<br />

nalidixic acid, 1192<br />

norfloxacin, 1192, 1820<br />

ocular infections, 1820<br />

ofloxacin, 1192<br />

oxacillin, 374, 1614<br />

susceptibility, 1754<br />

PD 117,596, 1450<br />

pefloxacin, 919<br />

pefloxacin-fosfomycin, 919<br />

penicillin resistance, 1164<br />

R plasmids, 932, 1164, 1174<br />

resistance phenotype, 170<br />

susceptibility testing, 1464<br />

T-3262, 663<br />

tobramycin, 1820<br />

resistance, 932<br />

U-76,253A, 443<br />

vancomycin, 374, 454<br />

Staphylococcus carnosus<br />

methicillin resistance.<br />

cloning from S. epidermidis,<br />

1494<br />

Staphylococcus epidermidis<br />

catheters, 1627<br />

cefam<strong>and</strong>ole, 63<br />

cefazolin, 63<br />

ANTIMICROB. AGENTS CHEMOTHER.<br />

daptomycin, 63, 279<br />

disodium EDTA, 1627<br />

DuP 105, 580<br />

DuP 721, 580<br />

endocarditis, 63<br />

methicillin resistance<br />

cloning in S. carnosus, 1494<br />

R plasmid, 1494<br />

T-3262, 661<br />

vancomycin, 63, 1627<br />

Staphylococcus spp.<br />

A-61827, 27<br />

carbomycin, 420<br />

cefixime, 18%<br />

cefpodoxime, 18%<br />

ceftriaxone, 1896<br />

celesticetin, 420<br />

cephalexin hydrochloride, 882<br />

cephalexin monohydrate, 882<br />

clindamycin, 420<br />

coagulase negative<br />

P-lactamase, 1754<br />

oxacillin susceptibility, 1754<br />

conjunctivitis, 1820<br />

CS-807, 1082<br />

daptomycin, 24, 279<br />

DR-3355, 1336<br />

DuP 105, 150<br />

DuP 721, 150<br />

E-1040, 1666<br />

E-3846, 636<br />

erythromycin, 420<br />

halovinylglycine compounds, 319<br />

L-norvalyl peptide derivatives,<br />

319<br />

josamycin, 420<br />

lincomycin, 420<br />

resistance, 420<br />

lomefloxacin, 617, 656<br />

ME1207, 1421<br />

norfloxacin, 1820<br />

nosocomial infections<br />

cardiac surgery, 202<br />

coronary angioplasty, 202<br />

ocular infections, 1820<br />

ole<strong>and</strong>omycin, 420<br />

PD 127,391, 1251<br />

rosaramicin, 420<br />

S-6123, 1341<br />

spiramycin, 420<br />

T-3262, 827<br />

tobramycin, 1820<br />

trospectomycin, 216<br />

tylosin, 420<br />

U-76,252, 1082<br />

U-76,253A, 443<br />

vernamycin B, 420<br />

Stearylamine<br />

liposomes, %6<br />

T. b. gambiense, 966<br />

Stomatitis, denture<br />

C. albicans, 1859<br />

fluconazole, 1859<br />

Streptococci<br />

alpha-hemolytic<br />

conjunctivitis, 1820<br />

norfloxacin, 1820<br />

ocular infections, 1820<br />

tobramycin, 1820<br />

group B<br />

cefotaxime-chloramphenicol, 1375<br />

ceftriaxone-chloramphenicol, 1375

VOL . 32, 1988<br />

Streptococcus faecalis<br />

P-lactamase, 122, 547, 768<br />

cystitis, 636<br />

daptomycin, 81, 877<br />

effect on translocation, 337<br />

daptomycin-gentamicin, 81, 877<br />

E-3846, 636<br />

endocarditis, 877<br />

erythromycin resistance, 547<br />

gentamicin, 81, 736<br />

resistance, 547<br />

gentamicin-daptomycin, 81, 877<br />

gentamicin-penicillin G procaine, 877<br />

gentamicin-vancomycin, 877<br />

penicillin G procaine, 877<br />

penicillin G procaine-gentamicin, 877<br />

pheromones, 547<br />

pyelonephritis, 81, 636<br />

R plasmid, 547<br />

vancomycin, 877<br />

vancomycin-gentamicin, 877<br />

Streptococcus faecium<br />

aminoglycoside resistance, 1528<br />

gentamicin resistance, 1528<br />

R plasmids, 1528<br />

Streptococcus pneumoniae<br />

ampicillin, 552<br />

aztreonam, 552<br />

ceftriaxone, 552<br />

conjunctivitis, 1820<br />

daptomycin, 24<br />

gentamicin, 552<br />

in vitro simulation of serious infections,<br />

552<br />

ME1207, 1421<br />

norfloxacin, 1820<br />

ocular infections, 1820<br />

PD 127,391, 1251<br />

R-3746, 671<br />

tigemonam, 84<br />

tobramycin, 1820<br />

Streptococcus pyogenes<br />

A-61827, 27<br />

berberine sulfate<br />

fibronectin, 1370<br />

hexadecane, 1370<br />

host cell adherence, 1370<br />

cephalexin hydrochloride, 882<br />

cephalexin monohydrate, 882<br />

Streptococcus sanguis<br />

etoposide, 1456<br />

Streptococcus sobrinus<br />

C31G, 350<br />

Streptococcus spp.<br />

A-61827, 27<br />

C31G, 350<br />

Campylobacter resistance gene, 1793<br />

ceftibuten, 1576<br />

CS-807, 1082<br />

daptomycin, 141<br />

DuP 105, 150, 580<br />

DuP 721, 150, 580<br />

E-1040, 1666<br />

endocarditis, 141<br />

erythromycin estolate, 1227<br />

erythromycin ethylsuccinate, 1227<br />

lomefloxacin, 617<br />

LY163892, 268<br />

PD 117,596, 1450<br />

penicillin G, 141<br />

R-3746, 671<br />

R plasmids, 1793<br />

S-6123, 1341<br />

T-3262, 827<br />

tetracycline<br />

resistance, 1271<br />

tigemonam, 84, 346<br />

trospectomycin, 216<br />

U-76,252, 1082<br />

U-76,253A, 443<br />

Streptomyces avermitilis<br />

avermectin production<br />

glucose metabolism, 282<br />

Streptomyces spp.<br />

antibiotic biosynthetic genes, 1472<br />

biosynthetic genes, 1472<br />

cloned genes, 1465, 1472<br />

minireviews, 1465, 1472<br />

recombinant DNA, 1465<br />

Streptomycin<br />

adenylyltransferase<br />

B. subtilis, 949<br />

letter to the editor, 949<br />

combinations<br />

enterococci, 1769<br />

streptomycin, 1769<br />

enterococci, 1769<br />

fecal flora resistance, 1801<br />

M. avium, 1131<br />

M. tuberculosis, 1208, 1441<br />

Shigella spp., 20<br />

Sulbactam<br />

bioassay, 1347<br />

combinations<br />

ampicillin, 1830<br />

B. fragilis, 403<br />

B. fragilis-E. coli, 1830<br />

cefoperazone, 403<br />

pharmacokinetics, 42<br />

Sulbenicillin<br />

biliary excretion<br />

ursodeoxycholate, 726<br />

percutaneous transhepatic biliary drainage,<br />

726<br />

Sulfadiazine<br />

P. carinii, 96<br />

Sulfadimethoxine<br />

B. bronchiseptica, 1891<br />

Cryptosporidium sp., 1907<br />

letter to the editor, 1907<br />

Sulfadoxine<br />

P. carinii, 96<br />

T. gondii, 303<br />

Sulfamethoxazole<br />

C. trachomatis, 1350<br />

combinations<br />

trimethoprim, 802<br />

urinary tract infections, 802<br />

H. ducreyi, 1458<br />

hyperbilirubinemia<br />

centrifugal ultrafiltration, 1571<br />

N. asteroides, 1776<br />

P. carinii, 96<br />

Shigella spp., 20<br />

Sulfamethoxazole-trimethoprim<br />

Bordetella spp., 137<br />

comparative activity<br />

rifampin-trimethoprim, 802<br />

urinary tract infections, 802<br />

Sulfamonomethoxine<br />

B. bronchiseptica, 1891<br />

Sulfated polysaccharides<br />

adenovirus, 1742<br />

coxsackievirus, 1742<br />

cytomegalovirus, 1742<br />

herpes simplex virus, 1742<br />

SUBJECT INDEX xxxi<br />

human immunodeficiency virus, 1742<br />

parainfluenza virus, 1742<br />

poliovirus, 1742<br />

reovirus, 1742<br />

Sindbis virus, 1742<br />

vaccinia virus, 1742<br />

vesicular stomatitis virus, 1742<br />

Sulfisoxazole<br />

B. catarrhalis, 259<br />

Chlamydia sp. strain TWAR, 257<br />

H. influenzae, 180<br />

hyperbilirubinemia<br />

centrifugal ultrafiltration, 1571<br />

Sulfonamides<br />

dihydropteroate synthase (sullI) gene,<br />

1684<br />

resistance plasmids, 1684<br />

sulII gene<br />

nucleotide sequence, 1684<br />

Suramin<br />

P. carinii, 1158<br />

Susceptibility testing<br />

B. catarrhalis, 1747<br />

C. trachomatis, 1350<br />

minireview, 1295<br />

monoclonal antibodies, 1295<br />

ceftibuten, 1576<br />

Enterobacteriaceae, 1365<br />

gram-negative bacteria, 385<br />

H. influenzae, 1747<br />

chloramphenicol, 1484<br />

letter to the editor, 1464<br />

LY163892, 1477<br />

M. avium, 1131<br />

M. tuberculosis, 125<br />

minireview, 1747<br />

N. gonorrhoeae, 1747<br />

pyrazinamide, 125<br />

S. aureus, 1464<br />

T. pallidum subsp. pallidum, 68<br />

T-25<br />

influenza viruses, 906<br />

T-26<br />

influenza viruses, 906<br />

T-3262<br />

B. catarrhalis, 663<br />

B. fragilis, 663, 1437<br />

C. trachomatis, 1080<br />

comparative activity<br />

ceftazidime, ciprofloxacin, gentamicin,<br />

imipenem, <strong>and</strong> ofloxacin, 663<br />

ciprofloxacin, ofloxacin, norfloxacin,<br />

<strong>and</strong> pipemidic acid, 827<br />

E. coli, 663, 827<br />

E. faecalis, 663<br />

Enterobacteriaceae, 663, 827<br />

Enterococcus spp., 827<br />

H. influenzae, 663<br />

N. gonorrhoeae, 663<br />

P. aeruginosa, 663, 827<br />

P. cepacia, 663<br />

P. maltophilia, 663<br />

S. aureus, 663<br />

S. epidermidis, 663<br />

Staphylococcus spp., 827<br />

Streptococcus spp., 827<br />

Talampicillin<br />

dental granuloma, 566<br />

Teicoplanin<br />

combinations<br />

Corynebacterium group JK, 434

xxxii SUBJECT INDEX<br />

gentamicin <strong>and</strong> tobramycin, 434<br />

Corynebacterium group JK, 434<br />

pharmacokinetics, 1223<br />

Temafloxacin<br />

comparative activity<br />

erythromycin, 1500<br />

M. hominis, 1500<br />

M. pneumoniae, 1500<br />

U. urealyticum, 1500<br />

Temocillin<br />

A. denitrificans subsp. xylosoxidans,<br />

276<br />

infusion system, 1705<br />

K. pneumoniae, 1705<br />

meningitis, 1705<br />

pharmacokinetics, 1705<br />

Terbinafine<br />

Aspergillus spp., 780<br />

comparative activity<br />

amphotericin B <strong>and</strong> ketoconazole, 780<br />

S. schenckii, 1619<br />

sporotrichosis, 1619<br />

Terminalia glaucescens<br />

B. gingivalis, 598<br />

B. melaninogenicus, 598<br />

Testosterone<br />

fluconazole, 646<br />

ketoconazole, 646<br />

Tetracaine<br />

E. coli permeability, 153<br />

Tetracycline<br />

B. bronchiseptica, 1891<br />

B. catarrhalis, 259<br />

B. fragilis resistance, 1271<br />

Bacillus spp., 642<br />

bite wound bacteria, 1143<br />

Bordetella spp., 137<br />

C. trachomatis, 1350<br />

Campylobacter resistance, 1793<br />

Chlamydia sp. strain TWAR, 257<br />

comparative activity<br />

demeclocycline, doxycycline, erythromycin,<br />

minocycline, nalidixic<br />

acid, oxytetracycline, <strong>and</strong> rifampin,<br />

986<br />

cryptic resistance determinant on<br />

Tn4400, 1797<br />

detoxification, 1797<br />

E. risticii, 986<br />

efflux, 1797<br />

Eubacterium spp. resistance, 1271<br />

F. nucleatum resistance, 1271<br />

fecal flora resistance, 1801<br />

H. ducreyi, 1458<br />

H. influenzae, 180<br />

letter to the editor, 951<br />

N. gonorrhoeae resistance, 488, 951<br />

N. perflava-N. sicca resistance, 1271<br />

Neisseria resistance, 488<br />

oral bacteria, 1271<br />

P. anaerobius resistance, 1271<br />

P. multocida, 213<br />

periodontal disease, 1271<br />

resistance<br />

degradation, 1797<br />

E. corrodens, 765<br />

efflux, 1797<br />

K. denitrificans, 765<br />

Neisseria spp., 765<br />

S. wien resistance, 1262<br />

Shigella spp., 20<br />

Streptococcus spp. resistance, 1271<br />

V. parvula resistance, 1271<br />

Theophylline<br />

GABA receptor, 1624<br />

y-aminobutyric acid receptor, 1624<br />

pharmacokinetics<br />

ciprofloxacin, effect of, 75<br />

norfloxacin, 510<br />

Thiamphenicol<br />

H. ducreyi, 1458<br />

Ticarcillin<br />

B. catarrhalis, 259<br />

dysgonic fermenter 2, 78<br />

Enterobacteriaceae, 873<br />

P. maltophilia, 782<br />

P. pseudomallei, 1435<br />

Ticarcillin-clavulanic acid<br />

A. denitrificans subsp. xylosoxidans, 276<br />

B. catarrhalis, 259<br />

Bacillus spp., 642<br />

comparative activity<br />

clindamycin-amikacin, 1557<br />

head <strong>and</strong> neck surgery in cancer<br />

patients, 1557<br />

letter to the editor, 407<br />

P. pseudomallei, 1435<br />

puerperal infections, 407<br />

wound infections, 1557<br />

Ticarcillin-potassium clavulanate<br />

Enterobacteriaceae resistance, 1365<br />

Tigemonam<br />

A. hydrophila, 84<br />

Acinetobacter spp., 84<br />

B. catarrhalis, 84<br />

Bacteroides spp., 84<br />

C. diversus, 84<br />

comparative activity<br />

aztreonam, cefaclor, <strong>and</strong> trimethoprim-sulfamethoxazole,<br />

346<br />

E. aerogenes, 84<br />

E. cloacae, 84<br />

E. coli, 84, 346<br />

Enterobacter spp., 84<br />

Enterobacteriaceae, 84<br />

Enterococcus spp., 84<br />

Haemophilus spp., 84<br />

Klebsiella spp., 84<br />

Listeria spp., 84<br />

Morganella spp., 84<br />

Neisseria spp., 84<br />

Proteus spp., 84<br />

Providencia spp., 84<br />

Pseudomonas spp., 84, 346<br />

S. marcescens, 84<br />

S. pneumoniae, 84<br />

Salmonella spp., 84<br />

Shigella spp., 84<br />

Streptococcus spp., 84, 346<br />

Y. enterocolitica, 84<br />

Tinidazole<br />

T. vaginalis, 144<br />

Tobramycin<br />

A. denitrificans subsp. xylosoxidans,<br />

276<br />

B. catarrhalis, 259<br />

combinations<br />

amiloride, 395<br />

ampicillin, 1231<br />

biliary tract infections, 1231<br />

ciprofloxacin, 782<br />

P. maltophilia, 782<br />

Pseudomonas spp., 395<br />

comparative activity<br />

norfloxacin, 1820<br />

conjunctivitis, 1820<br />

ANTIMICROB. AGENTS CHEMOTHER.<br />

E. coli, 450<br />

lipopolysaccharide, 1247<br />

Enterobacteriaceae, 873<br />

H. influenzae, 1820<br />

iontophoretic application, 978<br />

K. pneumoniae resistance, 1379<br />

keratitis, 978<br />

ocular infections, 1820<br />

P. aeruginosa, 978<br />

alginate binding, 518<br />

P. maltophilia, 782<br />

pharmacokinetics<br />

charcoal, effect of, 274<br />

postantibiotic effect, 450<br />

Pseudomonas spp., 395<br />

S. aureus, 1820<br />

resistance, 932<br />

S. marcescens resistance, 1379<br />

S. pneumoniae, 1820<br />

Staphylococcus spp., 1820<br />

streptococci, alpha-hemolytic, 1820<br />

Tobramycin-ampicillin<br />

biliary tract infections, 1231<br />

comparative activity<br />

cefoperazone, 1231<br />

Tonsillectomy<br />

erythromycin<br />

acistrate, 1019<br />

stearate, 1019<br />

tissue <strong>and</strong> plasma concentrations,<br />

1019<br />

roxithromycin, 1461<br />

Torulopsis glabrata<br />

cilofungin, 1331<br />

Total hip arthroplasty<br />

vancomycin bone concentrations, 1320<br />

Toxoplasma gondii<br />

A-56268, 524<br />

azithromycin, 524, 755<br />

enzyme-linked immunosorbent assay,<br />

303<br />

ornithine decarboxylase inhibitors, 303<br />

piritrexim, 430<br />

pyrimethamine, 303<br />

roxithromycin, 524<br />

spiramycin, 303, 524<br />

sulfadoxine, 303<br />

Translocation<br />

enterococci, 1769<br />

Treponema hyodysenteriae<br />

sedecamycin, 458<br />

Treponema pallidum<br />

erythromycin resistance, 164<br />

roxithromycin resistance, 164<br />

Treponema pallidum subsp. pallidum<br />

susceptibility testing, 68<br />

Triazoles<br />

minireview, 1<br />

Trichodermin<br />

M. racemosus, 341<br />

Trichomonas vaginalis<br />

aminoglycosides, 144<br />

amphotericin B, 1323<br />

anisomycin, 144<br />

antifungal agents, 144<br />

P-lactams, 144<br />

chemotaxis, 1323<br />

folic acid antagonists, 144<br />

furazolidone, 144<br />

gentamicin, 1323<br />

imidazoles, 1323<br />

ketoconazole, 1323<br />

macrolides, 144

VOL. 32, 1988<br />

mebendazole, i44<br />

metronidazole, 144, 1323<br />

miconazole, 1323<br />

Nonoxynol-9, 1323<br />

penicillin, 1323<br />

tinidazole, 144<br />

Trichophyton spp.<br />

G2, 1586<br />

Trimethoprim<br />

combinations<br />

dapsone, 623<br />

P. carinii, 623<br />

pneumonia, 623<br />

rifampin <strong>and</strong> sulfamethoxazole, 802<br />

urinary tract infections, 802<br />

Enterobacteriaceae, 873<br />

H. ducreyi, 1458<br />

H. influenzae resistance, 477<br />

P. carinii, 96<br />

S. sonnei resistance, 1598<br />

Shigella spp., 20<br />

Trimethoprim-sulfamnethoxazole<br />

A. denitrificans subsp. xylosoxidans,<br />

276<br />

B. catarrhalis, 259<br />

Bacillus spp., 642<br />

comparative activity<br />

ciprofloxacin, 1327<br />

dapsone, pentamidine, <strong>and</strong> trimethoprim-dapsone,<br />

623<br />

cystitis, 1640<br />

dysgonic fermenter 2, 78<br />

E. coli, 1640<br />

Enterobacteriaceae, 1327<br />

H. ducreyi, 1458<br />

H. influenzae, 180<br />

P. carinii, 623, 1158<br />

P. multocida, 213<br />

pharmacokinetics, 1640<br />

pneumonia, 623<br />

Shigella spp., 20<br />

urinary tract infections, 1327<br />

Trimetrexate<br />

high-pressure liquid chromatography,<br />

324<br />

P. carinii, 324<br />

pharmacokinetics, 324<br />

Tromethamine fosfomycin<br />

pharmacokinetics, 938<br />

young <strong>and</strong> elderly adults, 938<br />

Trospectomycin<br />

B. catarrhalis, 216<br />

B. fragilis, 584<br />

Bacteroides spp., 216, 584<br />

C. trachomatis, 216<br />

C. difficile, 216<br />

Chlamydia sp. strain TWAR, 257<br />

Clostridium spp., 216<br />

comparatiVe activity<br />

ampicillin, cefaclor, cefoxitin, clindamycin,<br />

<strong>and</strong> doxycycline, 584<br />

ampicillin, gentamicin, <strong>and</strong><br />

spectinomycin, 216<br />

Enterobacteriaceae, 216<br />

H. influenzae, 216<br />

N. gonorrhoeae, 216<br />

Proteus spp., 216<br />

Staphylococcus spp., 216<br />

Streptococcus spp., 216<br />

Trypanosoma brucei gambiense<br />

stearylamine- <strong>and</strong> phosphatidylcholineliposomes,<br />

966<br />

Trypanosoma cruzi<br />

nifurtimox, 241<br />

immune response, effect on, 241<br />

P536, 1412<br />

UDP-glucose analog, 1412<br />

Trypanosoma (Schizotrypanum) cruzi<br />

ketoconazole, 1237<br />

ketoconazole-SF 86-327, 1237<br />

SF 86-327, 1237<br />

Tubercidin<br />

influenza viruses, 906<br />

Tumor necrosis factor<br />

combinations<br />

amikacin, azithronycin, <strong>and</strong><br />

roxithromycin, 1149<br />

M. avium complex, 1149<br />

Tylosin<br />

Arthrobacter spp., 420<br />

E. coli<br />

heat treatment, 1680<br />

Staphylococcus spp., 420<br />

U-76,252<br />

A. hydrophila, 1082<br />

B. catarrhalis, 1082<br />

C. diversus, 1082<br />

comparative activity<br />

amoxicillin, amoxicillin-clavulanic<br />

acid, cefaclor, cefuroxime, cephalexin,<br />

<strong>and</strong> erythromycin, 1082<br />

E. coli, 1082<br />

E. faecalis, 1082<br />

Enterobacteriaceae; 1082<br />

H. influenzae, 1082<br />

Klebsiella spp., 1082<br />

P. aeruginosa, 1082<br />

P. mirabilis, 1082<br />

Staphylococcus spp., 1082<br />

Streptococcus spp., 1082<br />

U-76,253A<br />

Acinetobacter spp., 443<br />

B. catarrhalis, 443<br />

comparative activity<br />

amoxicillin, amoxicillin-clavulanic<br />

acid, cefaclor, cefixime, <strong>and</strong> cefuroxime,<br />

443<br />

Enterobacteriaceae, 443<br />

enterococci, 443<br />

H. influenzae, 443<br />

Neisseria spp., 443<br />

pneumococci, 443<br />

Pseudomonas spp., 443<br />

S. aareus, 443<br />

Staphylococcus spp., 443<br />

Streptococcus spp., 443<br />

UDP-glucose analogs<br />

herpes simplex virus type 1, 1257<br />

P-536, 1257, 1412<br />

T. cruzi, 1412<br />

Ureaplasma urealyticum<br />

A-63075, 1500<br />

clarithromycin, 1500<br />

difloxacin; 1500<br />

erythromycin, 1500<br />

temafloxacin, 1500<br />

Uridine<br />

3'-azido-3'-deoxythymidine toxicity,<br />

997<br />

AZT toxicity, 997<br />

Urinary tract infections<br />

berberine sulfate, 1274<br />

carumonam, 473, 1031<br />

SUBJECT INDEX xxxiii<br />

ceftazidime, 1031<br />

ciprofloxacin, 1327<br />

Enterobacteriaceae, 1327<br />

gentamicin, 473<br />

norfloxacin, 1292<br />

rifampin-trimethoprim, 802<br />

sulfamethoxazole-trimethoprim, 802<br />

trimethoprim-sulfamethoxazole, 1327<br />

Ursodeoxycholate<br />

biliary excretion<br />

cefotiam, 726<br />

sulbenicillin, 726<br />

Vaccinia virus<br />

P-536, 1257<br />

sulfated polysaccharides, 1742<br />

Vancomycin<br />

Bacillus spp., 642<br />

bone concentrations<br />

osteomyelitis, 1320<br />

total hip arthroplasty, 1320<br />

cardiopulmonary bypass, 631<br />

catheters, 1627<br />

combinations<br />

Corynebacterium group JK, 434<br />

gentamicin <strong>and</strong> tobramycin, 434<br />

comparative activity<br />

cefam<strong>and</strong>ole, cefazolin, <strong>and</strong> daptomycin,<br />

63<br />

daptomycin, 454<br />

Corynebacterium group JK, 434<br />

dysgonic fermenter 2, 78<br />

E. coli<br />

heat treatment, 1680<br />

endocarditis, 63<br />

pharmacokinetics, 92, 631, 848<br />

S. aureus, 454<br />

MBCs, 374<br />

S. epidermidis, 63, 1627<br />

Vancomycin-ceftazidime<br />

pharmacokinetics, 92<br />

Varicella-zoster virus<br />

acyclovir triphosphate, 1137<br />

3'-azido-3'-deoxythymidine, 265<br />

AZT, 265<br />

B-220, 1720<br />

buciclovir triphosphate, 1137<br />

9-(3,4-dihydroxybutyl)guanine triphosphate,<br />

1137<br />

DNA polymerases, 1137<br />

9-[4-hydroxy-2(hydroxymethyl)butyl]<br />

guanine triphosphate, 1137<br />

9-(2-hydroxyethoxymethyl)guanine triphosphate,<br />

1137<br />

Veillonella parvula<br />

tetracycline<br />

resistance, 1271<br />

Vernamycin B<br />

Arthrobacter spp., 420<br />

Staphylococcus spp., 420<br />

Vernonia amygdalina<br />

B. gingivalis, 598<br />

B. melaninogenicus, 598<br />

Vesicular stomatitis virus<br />

carrageenans, 1742<br />

dextran sulfate, 1742<br />

fucoidan, 1742<br />

P-536, 1257<br />

pentosan polysulfate, 1742<br />

ribavirin, phosphorylated, 492<br />

sulfated polysaccharides, 1742<br />

transcription, 492

xxxiv SUBJECT INDEX ANTIMICROB. AGENTS CHEMOTHER.<br />

Virus-antigen assays<br />

human immunodeficiency virus type 1,<br />

684<br />

Vitamin K<br />

cefotetan effect on metabolism, 1446<br />

cefoxitin effect on metabolism, 1446<br />

Wound infections<br />

clindamycin-amikacin, 1557<br />

ticarcillin-clavulanic acid, 1557<br />

WR 194,965 phosphate<br />

crystal <strong>and</strong> molecular structure, 540<br />

Xanthomonas maltophilia<br />

E-1040, 1666<br />

Xylotubercidin<br />

influenza viruses, 906<br />

Yersinia enterocolitica<br />

tigemonam, 84<br />

Yersinia spp.<br />

R-3746, 671<br />

YTR 830<br />

1-lactamases, 925<br />

C. freundii, 925<br />

comparative activity<br />

clavulanic acid <strong>and</strong> sulbactam,<br />

925<br />

E. cloacae, 925<br />

E. coli, 925<br />

K. aerogenes, 925<br />

mechanisms of action, 925<br />

P. mirabilis, 925<br />

Zinc<br />

common cold, 605, 606, 608<br />

letters to the editor, 605, 606, 608

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