Antonella Castellano - ADAM

Antonella
Castellano, MD
HOME ADDRESS
Via Friuli, 42
20135 Milan (Italy)
PHONE NUMBER
+39 02 2157103
MOBILE NUMBER
+39 3397589535
E-MAIL
castellano.antonella@hsr.it
Professional profile
High school diploma at the Liceo Scientifico "C. De Giorgi "- Lecce,
(full marks, 100/100 cum laude).
MD Degree at the University Vita-Salute San Raffaele in Milan (Italy)
on July 18, 2006 with a thesis entitled "Magnetic resonance
tractography in the study of neoplastic cerebral pathology” (full marks,
110/110 magna cum laude).
2007-2011: residency in Radiology at the Università degli Studi di
Milano and the Vita-Salute San Raffaele University, Milan; postgraduate
degree on August 1 st , 2011 with a thesis entitled "A novel
method to characterize structural features and extension of cerebral
gliomas using Diffusion Tensor MR Imaging and Texture Analysis”
(full marks, 70/70 magna cum laude).
Member of ISMRM (International Society for Magnetic Resonance in
Medicine)
Member of the ESR (European Society of Radiology)
Member of AINR (Associazione Italiana di Neuroradiologia)
Member of SIRM (Società Italiana di Radiologia Medica)
Member of the European Low-Grade Glioma Network
Clinical and research activities
2002-2003
Internship in the laboratory of Neuropharmacology of DIBIT-San
Raffaele Scientific Institute, Milan, directed by Prof. Jacopo Meldolesi.
2004-PRESENT
Internship in the Neuroradiology Unit and C.E.R.M.A.C. (Excellence
Center for High Field MR), Head and Neck Department, San Raffaele
Scientific Institute and Hospital, under the supervision of Prof.
Giuseppe Scotti and Prof. Andrea Falini.
2007-2009
Residency in Radiology, Università. W degli Studi di Milano,
Ospedale San Paolo, under the supervision of Prof. Gianpaolo
Cornalba.
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2010-2011
Residency in Radiology, Università Vita-Salute San Raffaele, directed
by Prof. Alessandro Del Maschio.
20-25 JANUARY 2011
Certification of the European Course of Pediatric Neuroradiology,
Marseille, France, directed by Dr. Andrea Rossi.
Research interests
Antonella Castellano is a neuroradiologist with a strong research
interest in the field of MR imaging. She is interested in the
development and clinical application of advanced MRI techniques
such as Diffusion Tensor Imaging (DTI) and Tractography, and
Perfusion MRI. Her studies were primarily focused on brain tumor
pathology. Since 2005 she actively collaborated with the
Neuroradiology Unit and CERMAC and participated in the
optimization and implementation on a 3 Tesla scanner of
tractography in the preoperative planning of brain tumors. In the
same year, she was involved in a project of in vivo validation of MR
Tractography by correlation with intraoperative subcortical stimulation
data, carried out with the Division of Neurosurgery, Dept. of
Neurological Sciences, Università di Milano, supervised by Prof.
Lorenzo Bello. The results of this study were the object of her degree
thesis, were published in 2008 (Bello et al, Neuroimage 39, 369-82)
and are currently highly cited (3-yrs C.Ind. 51). Tractography is now
part of clinical advanced preoperative MR studies in San Raffaele
Hospital, with more than 300 patients studied in the last four years.
Recently, the candidate has been interested in exploring diffusion
metrics with a quantitative approach, in order to better characterize
structural features of pathological tissue.
Refereed publications
1. Castellano A, Bello L, Michelozzi C, Gallucci M, Fava E, Iadanza
A, Riva M, Casaceli G and Falini A (2011). Role of Diffusion
Tensor MR Tractography in predicting the extent of
resection in glioma surgery. Accepted for publication in Neuro-
Oncology, corrected proofs. IF: 5.483
2. Papagno C, Gallucci M, Casarotti A, Castellano A, Falini A, Fava
E, Giussani C, Carrabba G, Bello L and Caramazza A (2011).
Connectivity constraints on cortical reorganization of neural
circuits involved in object naming. NeuroImage 55(3):1306-
1313. IF: 5.932
3. Papagno C, Miracapillo C, Casarotti A, Romero Lauro LJ,
Castellano A, Falini A, Casaceli G, Fava E and Bello L (2011).
What is the role of the uncinate fasciculus? Surgical removal
and proper name retrieval. Brain 134(Pt 2):405-414. IF: 9.230
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4. De Nunzio G, Pastore G, Donativi M, Castellano A and Falini A.
(2011) A CAD system for cerebral glioma based on texture
features in DT-MR images. Nuclear Instruments and Methods in
Physics Research A 2011, doi:10.1016/j.nima.2010.12.086. IF:
1.142
5. Bello L, Castellano A, Fava E, Casaceli G, Riva M, Scotti G,
Gaini SM and Falini A (2010). Intraoperative use of diffusion
tensor imaging fiber tractography and subcortical mapping
for resection of gliomas: Technical considerations.
Neurosurgical Focus 28(2):E6. IF: 2.348
6. Bertani G, Fava E, Casaceli G, Carrabba G, Casarotti A,
Papagno C, Castellano A, Falini A, Gaini SM and Bello L (2009).
Intraoperative mapping and monitoring of brain functions for
the resection of low-grade gliomas: Technical
considerations. Neurosurgical Focus 27(4):E4. IF: 2.348
7. Bello L, Gambini A, Castellano A, Carrabba G, Acerbi F, Fava E,
Giussani C, Cadioli M, Blasi V, Casarotti A, Papagno C, Gupta
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AK, Gaini S, Scotti G and Falini A (2008). Motor and language
DTI fiber tracking combined with intraoperative subcortical
mapping for surgical removal of gliomas. NeuroImage
39(1):369-382. IF: 5.932
Book chapters
1. Bello L, Castellano A, Fava E, Casaceli G, Riva M and Falini A
(2012). Preoperative diffusion tensor imaging: contribution
to surgical planning and validation by intraoperative
electrostimulation. In Brain Mapping. From Neural Basis of
Cognition to Surgical Applications. Duffau H (ed.), Springer Wien
New York: 263-275 (ISBN 978-3-7091-0722-5).
Invited seminars
1. Diffusion Tensor Imaging (DTI) & Fiber Tracking: technical
principles and clinical applications. - Invited @ University of
Turin, Department of Physics - Turin (Italy), December 17, 2008
2. Role of DTI Tractography in clinical neuroradiology. - Invited
@ Head and Neck Department, San Raffaele Scientific Institute -
Milan (Italy), December 9, 2008
3. DTI Tractography: Basics, pitfalls & tract identification clues.
Invited @ 5th European Low Grade Glioma Network Meeting,
Barcelona (Spain), January 30-31, 2009
4. Diffusion Tensor Imaging (DTI) & Fiber Tractography:
clinical applications. - Invited @ National Institute of Nuclear
Physics (INFN) - MAGIC-5 Workshop 2009 - Serralunga d’Alba
(Cuneo - Italy), May 5, 2009
5. Diffusion Tensor Magnetic Resonance Imaging and
Tractography: a walk-through of the virtual dissection of
human brain white matter pathways. Invited @ University of
Salento, Laboratory of Human Anatomy and Neuroscience -
Lecce (Italy), April 20, 2011

Meeting Proceedings
1. Studio mediante DTI e Fiber Tracking del coinvolgimento dei
fasci di sostanza bianca in pazienti affetti da glioma
cerebrale di differente tipo e grado istologico. Castellano A,
Gambini A, Falini A, Bello L, Cadioli M, Scotti G. Oral
presentation at XXII Congresso Nazionale AINR - Milano, 4-6
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Ottobre 2006. Atti del Congresso in “The Neuroradiology Journal
- Rivista di Neuroradiologia”, vol.19 suppl.1, Oct. 2006.
2. Corrispondenza tra Fiber Tracking e siti di
neurostimolazione sottocorticale intraoperatoria dei circuiti
motori e del linguaggio in pazienti affetti da tumore
cerebrale. Gambini A, Bello L, Falini A, Castellano A, Cadioli M,
Scotti G. . Best oral presentation award at XXII Congresso
Nazionale AINR - Milano, 4-6 Ottobre 2006. Atti del Congresso in
“The Neuroradiology Journal - Rivista di Neuroradiologia”, vol.19
suppl.1, Oct. 2006.
3. Exploring the connections of SMA in patients with cerebral
gliomas: a combined MR DTI tractography and
intraoperative subcortical mapping study. Castellano A, Bello
L, Falini A, Gambini A, Blasi V, Scotti G. Best oral presentation
award at XXIV Annual Meeting AINR (Italian Society of
Neuroradiology), Rome (Italy), October 1-3, 2008.
4. The anatomy of spatial neglect revealed by MR DTI
tractography and intraoperative subcortical mapping.
Castellano A, Bello L, Falini A, Iadanza A, Gambini A, Scotti G.
Presented at XXIV Annual Meeting AINR (Italian Society of
Neuroradiology), Rome (Italy), October 1-3, 2008.
5. MR-DTI: a Semi-Automated Algorithm to Identify Damaged
Brain Areas from Fractional Anisotropy Maps. De Nunzio G,
Ciraci C, Donativi M, Castellano A, Ricci F, Quarta S, et al. IEEE
Nuclear Science Symposium and Medical Imaging Conference,
Dresden, October 19-25, 2008; in ISI Web of Science, IEEE
Nuclear Science Symposium 2009; Jan 1(9): 3700-2.
6. Topographic organization of SMA connections as assessed
by MR DTI tractography and intraoperative subcortical
mapping. Castellano A, Bello L, Scifo P, Fava E, Carrabba G,
Bertani G, Scotti G, Falini A. Oral presentation at ISMRM 17th
Scientific Meeting and Exhibition, Honolulu, April 18-24, 2009.
7. Neural correlates of spatial awareness revealed by MR DTI
tractography and intraoperative subcortical mapping.
Castellano A, Bello L, Fava E, Casarotti A, Papagno C, Carrabba
G, Scotti G, Falini A. Presented at ISMRM 17th Scientific Meeting
and Exhibition, Honolulu, April 18-24, 2009.
8. DTI e Fiber Tractography: applicazioni cliniche nello studio
dei tumori cerebrali. Castellano A, Falini A. Presented at
“Tecniche Avanzate in RM: dai principi fisici al neuroimaging” -
Perugia, 26 Giugno 2009.

9. DTI-MR 3D Texture Analysis per la valutazione delle
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caratteristiche strutturali e dell’estensione dei gliomi
cerebrali. Castellano A, De Nunzio G, Donativi M, Pastore G,
Soffietti R, Cornalba GP, Scotti G, Bello L, Falini A. Presented at
XIV Congresso Nazionale AINO (Associazione Italiana Neuro-
Oncologia) - 6 Ottobre 2009.
10. Trattografia DTI per la determinazione preoperatoria
dell’estensione della resezione chirurgica di gliomi
sovratentoriali - Castellano A, Michelozzi M, Casaceli G, Bertani
G, Carrabba G, Gaini SM, Scotti G, Bello L, Falini A. Presented
at XIV Congresso Nazionale AINO (Associazione Italiana Neuro-
Oncologia) - 6 Ottobre 2009.
11. A semi-automated DTI-based approach to evaluate structural
characteristics and extension of cerebral gliomas. De Nunzio
G, Castellano A, Donativi M, Pastore G, Falini A. Presented at
European Congress of Radiology, ECR 2010 (poster No C-2926)
Vienna, March 4-8, 2010.
12. Changes in gliomas structural features after Temodal
treatment evaluated by DTI-MR texture analysis: a
preliminary study. Castellano A, Bello L, Fava E, Riva M,
Casaceli G, De Nunzio G, Donativi M, Pastore G, Rudà R,
Soffietti R, Falini A. Presented at 9th International Meeting
UPDATES IN NEURO-ONCOLOGY - Brain Tumor Symposium,
Cortona (AR), Italy July 2-4, 2010.
13. Automated evaluation of structural characteristics and
extension of cerebral gliomas using DTI-MR 3D Texture
Analysis. De Nunzio G, Castellano A, Pastore G, Donativi M,
Scotti G, Bello L, Falini A. Presented at ISMRM 18th Scientific
Meeting and Exhibition, Stockholm, 1-7 May 2010.
14. Exploring functional connections in the living human brain
with MR tractography and intraoperative subcortical
mapping. Castellano A, Bello L, Iadanza A, Fava E, Casarotti E,
Papagno C, Scotti G, Falini A. Oral presentation at XIX
Symposium Neuroradiologicum, Bologna, October 4-9, 2010.
15. Role of Diffusion Tensor MR Tractography in predicting
supratentorial gliomas resectability. Castellano A, Michelozzi
C, Bello L, Iadanza A, Scotti G, Falini A. Oral presentation at XIX
Symposium Neuroradiologicum, Bologna, October 4-9, 2010.
16. DTI-MR Functional Diffusion Maps per la valutazione delle
modificazioni delle caratteristiche strutturali dei gliomi
cerebrali dopo trattamento chemioterapico. Castellano A,
Donativi M, De Nunzio G, Bello L, Iadanza A, Pastore G, Riva M,
Rudà R, Soffietti R, Falini A. Presented at I Congresso Nazionale
di Neuroradiologia Funzionale AINR (Italian Society of
Neuroradiology), Milan (Italy), February 17-18, 2011.
17. Role of Diffusion Tensor MR Tractography in predicting
supratentorial gliomas resectability. Castellano A, Bello L,
Michelozzi C, Gallucci M, Fava E, Iadanza A, Casaceli G, Riva

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M, Falini A. Presented at the Annual European Low-Grade
Gliomas Network Meeting, London, UK, February 5 th -6 th 2011.
18. Evaluation of Changes in Gliomas Structural Features After
Chemotherapy using DTI-Based Functional Diffusion Maps
(FDMs): A Preliminary Study with Intraoperative Correlation.
Castellano A, Donativi M, Bello L, De Nunzio G, Riva M, Pastore
G, Casaceli G, Rudà R, Soffietti R, Scotti G, Falini A. Presented
at ISMRM 19th Scientific Meeting and Exhibition, Montreal, 7-13
May 2011.
19. A novel Diffusion Tensor MR based approach to evaluate
structural features of Low Grade Gliomas. Riva M, Castellano
A, Casaceli G, Fava E, Raneri F, Falini A, Bello L. Presented at
ISMRM Workshop “Mapping Functional Network for Brain
Surgery”, Milan, 6-9 September 2011.
Computer competence
Intermediate level of programming skills using MATLAB.
Advanced level of skill in using the most frequently used image
analysis software for neuroimaging research (SPM, FSL, MRIStudio)
Advanced level of skill in using Microsoft Office programs.
Additional informations
She received the "Alfiere del Lavoro" award - Medal of
the President of the Italian Republic Carlo Azeglio Ciampi on October
19, 2000.