Dr_SINBOONA_ARARSA_KENENI_SHORT_PEARLS_ON_MEDICAL_CASES_EDITION

19.Teenger with Cystic fibrosis presents with chest infection
treated with ceftazidime + tobramycin
20.Rapidly progressive fever + high volume of
purulent sputum uncontrolled bronchopneumonia
weight
loss septicaemia by Burkholderia cepacia
treated by Ceftazidime+aminoglycosides
21.Lab of cystic fibrosis :
Sweat test :sweat chloride more than 60mmol/L
Decreased chloride secretion
increased sodium absorption
CFTR gene Genetic test is confirmatory
F508(DF508)mutation on chromosome 7
22.Treatment of cystic fibrosis :
Chest physiotherapy postural drainage
High calorie + high fat Vitamin D
Pancreatic enzymes
Supplement N- Acetylcystein
Heart lung transplant
Gene therapy Human Recombinant DNASE