Ivica Đilović STRUCTURAL STUDIES OF BOVINE 3 ...

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For Ivana who lives with me every day and Roko who makes it all worthwhile.
Contents Acknowledgments iii Abstract vii Sažetak (in Croatian) viii Prošireni sažetak (in Croatian) ix 1 Introduction 1 2 Literature review 4 2.1 Non-heme iron-dependent dioxygenases . . . . . . . . . . . . . . 4 2.2 Occurence within catabolic pathways . . . . . . . . . . . . . . . 7 2.2.1 Aromatic amino acid degradation pathways in bacteria . 7 2.2.2 Mammalian aromatic amino acid degradation pathways . 7 2.3 Classification of ring-cleaving dioxygenases . . . . . . . . . . . . 12 2.3.1 Vicinal Oxygen Chelate superfamily . . . . . . . . . . . . 12 2.3.2 Cupin superfamily . . . . . . . . . . . . . . . . . . . . . 15 2.4 Recent X-ray structures of dioxygenases . . . . . . . . . . . . . 19 2.4.1 Intradiol dioxygenases . . . . . . . . . . . . . . . . . . . 19 2.4.2 Extradiol dioxygenases . . . . . . . . . . . . . . . . . . . 20 2.4.3 What controls intradiol versus extradiol specificity? . . . 27 2.5 3-Hydroxyanthranilate 3,4-dioxygenase . . . . . . . . . . . . . . 29 2.5.1 Structural aspects . . . . . . . . . . . . . . . . . . . . . . 30 2.5.2 The mechanism of inactivation of 3-hydroxyanthranilate- 3,4-dioxygenase by 4-chloro-3-hydroxyanthranilate . . . . 37 v
Page 1 and 2: text Ivica Ðilović STRUCTURAL STU
Page 3: Acknowledgments This work certainly
Page 7 and 8: University of Zagreb Faculty of Sci
Page 9 and 10: Prošireni sažetak Aromatski spoje
Page 11 and 12: CONTENTS xi Biochem. Soc. Trans. 21
Page 13: CONTENTS xiii Ovaj enzim (3HAO) je

Ivica Đilović STRUCTURAL STUDIES OF BOVINE 3 ...

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