JM ActiCare for Antimicrobial Rinse-Off Formulations
JM ActiCare for Antimicrobial Rinse-Off Formulations
JM ActiCare for Antimicrobial Rinse-Off Formulations
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“Silver inside”- the new trend• Apart from the use in creams and lotions, antimicrobial silver-ingredients arenowadays also used in shower gels, AP/ DEO and shaving products to providebetter protection against body odour and antimicrobial protection <strong>for</strong> shavingstressedskin• <strong>JM</strong>AC TM is a silver-based antimicrobial ingredientIngredients Deo Shower:Aqua, Sodium Laureth Sulfate, Cocamidopropyl Betaine, PEG-7 Glyceryl Cocoate,Parfum, Butyl Acrylate/Ethyltrimonium Chloride Methacrylate/Styrene Copolymer,Silver Citrate, Sodium Chloride, Glycerin, PEG-200 Hydrogenated GlycerylPalmate, PEG-40 Hydrogenated Castor Oil, Polyquaternium-7, Glycol Distearate,Citric Acid, Laureth-4, Benzophenone-4, Sodium Benzoate, Sodium Salicylate,Methylparaben, Propylparaben, Linalool, Limonene, Coumarin,CI 61570, CI 16035, CI 10316Ingredients Deo Spray:Butane, Isobutane, Propane, Cyclomethicone, AluminumChlorohydrate, Tocopheryl Acetate, Persea Gratissima Oil,Silver Citrate, Aqua, Citric Acid, Dimethicone,Disteardimonium Hectorite, Octyldodecanol, Limonene,Butylphenyl Methylpropional, Coumarin, Eugenol, BenzylAlcohol, Parfum<strong>JM</strong>AC <strong>for</strong> <strong>Antimicrobial</strong> <strong>Formulations</strong>Peter Klug, Sonja Gehm BU Industrial & Consumer Specialties, Personal Care (Copyright Clariant. All rights reserved.) 28.05.2010Slide 2
“Silver inside”- the new trendIngredients: Dipropylene Glycol; Water;Propylene Glycol; Sodium Stearate;Poloxamine 1307; Fragrance;Aminomethylpropanol; Disodium EDTA;BHT; Diethylhexyl Sodium Sulfosuccinate;Silver Chloride; CI 77891; CI 42053Ingredients: Dipropylene Glycol;Water; Propylene Glycol; SodiumStearate; Poloxamine 1307; Fragrance;Aminomethylpropanol; Disodium EDTA;BHT; Diethylhexyl SodiumSulfosuccinate; Silver Chloride;Titanium Dioxide; CI 77891; Green 3;CI 42053Right Guard Anti-TranspirantDeospray Cool ImpactRight Guard Anti-TranspirantRoll-on Cool ImpactRight Guard Anti-TranspirantDeo Stick Cool ImpactRight Guard Anti-TranspirantShower Gel Cool ImpactClaims:• 24h extra protection againstsweat and foot odor• Antibacterial active-complexwith silver-Ions• Prevents athlete’s foot• Especially skin sensitive, noalcohol<strong>JM</strong>AC <strong>for</strong> <strong>Antimicrobial</strong> <strong>Formulations</strong>Peter Klug, Sonja Gehm BU Industrial & Consumer Specialties, Personal Care (Copyright Clariant. All rights reserved.) 28.05.2010Slide 3
<strong>JM</strong>AC TMJohnson Matthey <strong>Antimicrobial</strong> CompositeThe antimicrobial activity of silver has been known very long time.To take advantage of very powerful antimicrobial effect of the silver ion whilst keeping its reactivity under control, it is necessary toarrange <strong>for</strong> a method of „controlled release“ of silver ions, so that they are effectively released „on demand“. This is achieved bypreparing a structure known as a composite, of silver chloride and titanium dioxide – <strong>JM</strong>AC TM• The system works because an electron exchange occurs between the twocomponents, and this allows a slight degree of solubility of the silver ionsonce the composite is put into water. When this occurs, (see fig.) an ionicequilibrium is set up such that in deionised water some 20 to 40 parts perbillion of silver goes into solution, with all the rest of the silver stayingbound up in the composite. This equilibrium will remain in place indefinitely,until something occurs to remove silver ions from solution, whereuponfuther silver ions will be released from the composite to top up theequilibrium.• The <strong>JM</strong>AC TM range of biocides provides a release of silver ions ondemand. It can be seen that it will be possible to built into a <strong>for</strong>mulation avery large „ antimicrobial capacity“ without increasing the biological activityof system at any given time.Johnson Matthey <strong>Antimicrobial</strong> Composite.AgCl coating20% of particleweightTiO 2TiO+++ TiO 22+ ++++ + + + + ++++ + + + + +++ TiO 2TiO+ +2TiO+2Saturatedsolution of Ag +Cl -<strong>JM</strong>AC <strong>for</strong> <strong>Antimicrobial</strong> <strong>Formulations</strong>Peter Klug, Sonja Gehm BU Industrial & Consumer Specialties, Personal Care (Copyright Clariant. All rights reserved.)28.05.2010Slide 4
Deposition Study on HairStudy design• Hair tresses: European brown hair and European blond,bleached hair• Shampoo base: SLES : CAPB = 7:3,15 % active surfactant,containing the maximum allowed content of <strong>JM</strong> <strong>ActiCare</strong> (0.2 %)• The hair tresses were washed 1 or 3 times with the above shampoo base• After drying, the hair tresses were reduced to ashes and the silver content analyzed byETAAS (electro thermal atomic absorption method)<strong>JM</strong>AC <strong>for</strong> <strong>Antimicrobial</strong> <strong>Formulations</strong>Peter Klug, Sonja Gehm BU Industrial & Consumer Specialties, Personal Care (Copyright Clariant. All rights reserved.) 28.05.2010Slide 5
Deposition of silver after washing on hairShampoo base with 0.2 % <strong>JM</strong> <strong>ActiCare</strong>32.821.310.50.50brown hair, 1 washing brown hair, 3 washings blond, bleached hair, 1washingDeposition of silver in ppmblond, bleached hair, 3washings<strong>JM</strong>AC <strong>for</strong> <strong>Antimicrobial</strong> <strong>Formulations</strong>Peter Klug, Sonja Gehm BU Industrial & Consumer Specialties, Personal Care (Copyright Clariant. All rights reserved.) 28.05.2010Slide 6
Deposition of <strong>JM</strong> <strong>ActiCare</strong> TM afterwashing on hairShampoo base with 0.2 % <strong>JM</strong> <strong>ActiCare</strong>20018016014012010080604020030.0183.230.0brown hair, 1 washing brown hair, 3 washings blond, bleached hair, 1washingDeposition of <strong>JM</strong> <strong>ActiCare</strong> in ppm83.3blond, bleached hair, 3washings<strong>JM</strong>AC <strong>for</strong> <strong>Antimicrobial</strong> <strong>Formulations</strong>Peter Klug, Sonja Gehm BU Industrial & Consumer Specialties, Personal Care (Copyright Clariant. All rights reserved.) 28.05.2010Slide 7
Study results• The study shows a significant deposition of silver on the hair tresses• The deposition increases with increasing number of washings• MIC values <strong>for</strong> <strong>JM</strong> <strong>ActiCare</strong> TM :– Pseudomonas aeroginosa 8 ppm– Staphylococcus aureus 20 ppm– Candida albicans 500 ppm– Aspergillus brasiliensis 500 ppm• Based on the study results and taking the antimicrobial activity of <strong>JM</strong> <strong>ActiCare</strong> intoconsideration efficacy against gram-positive and gram-negative bacteria on hair (keratin) isexpected• As the deposition is superficial, that means the local concentration on the hair surface ishigher than average, activity against yeast & mould is expected as well<strong>JM</strong>AC <strong>for</strong> <strong>Antimicrobial</strong> <strong>Formulations</strong>Peter Klug, Sonja Gehm BU Industrial & Consumer Specialties, Personal Care (Copyright Clariant. All rights reserved.) 28.05.2010Slide 8
Silver – the new wave biocideSilver Citrate is permitted up to 0.0024 % Silver.Silver deposited on TiO 2 is permitted up to 0.004 % as AgCl which equals 0.0034 % SilverMore Silver can be incorporated into a cosmetic products by using <strong>JM</strong>AC TM instead of a Silver Citrate.Patented <strong>JM</strong>AC particles 0.5 to 2 microns in size
<strong>JM</strong>AC TM range• <strong>JM</strong>AC Composite PG – contain 15% Ag– INCI: Silver Chloride (and) Titanium Dioxide• <strong>JM</strong>AC P10 – contain 1.5% Ag– INCI: Silver Chloride (and) Titanium Dioxide• <strong>JM</strong> <strong>ActiCare</strong> – contain 1.5% Ag– INCI: Silver Chloride (and) Titanium Dioxide (and) Diethylhexyl Sodium Sulfosuccinate (and) PropyleneGlycol<strong>JM</strong>AC TM Silver inside<strong>for</strong> better protection against body odorand shaving-stressed skinas well as antimicrobial protection of your hair.•<strong>JM</strong>AC <strong>for</strong> <strong>Antimicrobial</strong> <strong>Formulations</strong>Peter Klug, Sonja Gehm BU Industrial & Consumer Specialties, Personal Care (Copyright Clariant. All rights reserved.)28.05.2010Slide 10
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