Forsknings- og Innovationsberetning 2011 - Forskningens Hus

infektionsmedicinsk afdeling
Forskningsansvarlig
Professor, overlæge Henrik Nielsen
Telefon: 99 32 65 25
E-mail: henrik.nielsen@rn.dk
Afdelingsledelse
Ledende overlæge Henrik Nielsen
Oversygeplejerske Jytta Højsleth
Igangværende forsknings-
projekter
• Epidemiologi og klinik ved Campylobacter
concisus infektion
• Langtidsfølger efter bakteriæmi
• Epidemiologi og klinik ved influenza A på
hospital
• Gonorré i Region Nordjylland
• Hantavirus infektion i Danmark
• Betydning af diabetes ved bakteriæmi
med Staphylococcus aureus
• Epidemiologi og klinik af purulent meningtis
i 10-års periode
• Kliniske aspekter af HIV infektion i Danmark
• Kliniske aspekter af viral hepatitis i Danmark
Videnskabeligt personale
Professor, dr.med.: Henrik Nielsen
Overlæger: Gitte Pedersen og Ulla Hjort
Læger: Hans Linde Nielsen, Michael Dalager-
Pedersen, Iben Ørsted, Line Ø Sørensen,
Shakil Shakar, Jesper Smit og Jacob Bodilsen
Forskningsårsværk: 2,5
Antal ansatte med dr.med.-grad: 1
Antal ansatte med ph.d.-grad: 3
Ph.d.-studerende
• Ph.d.-studerende Hans Linde Nielsen,
indskrevet Århus Universitet
• Ph.d.-studerende Michael Dalager-Pedersen,
indskrevet Århus Universitet
Vejlederfunktioner
• Professor Henrik Nielsen vejleder Hans
Linde Nielsen og Michael dalager-Pedersen
Bedømmelsesarbejde
Dr.med. / ph.d.:
• Bedømmelse af ph.d.-afhandling ved Århus
Universitet og ved Helsinki Universitet
Innovation og samarbejde
Indleverede patentansøgninger: 0
Indberettede opfindelser: 0
Samarbejdsaftaler med andre vidensinstitutioner
og medikotekniske virksomheder: 0
42
Økonomi
Bevillinger fra fonde i kr.: 600.000
Bevillinger fra offentlige puljer i kr.: 0
Bevillinger fra internationale fonde / puljer
(herunder EU-midler) i EUR: 0
Publikationer
Forskning
Artikel, peer-reviewed
1. Martin-Iguacel R, Bresil P, Teglbjærg
PS, Huremovic J. Acute Myositis With
Prolonged Hyperthermia After Severe Influenza
A (H1N1) Pneumonia in 2 Obese
Patients. Infect Dis Clin Pract (Baltim
Md) 2011;19(3):223-5.
2. Petersen TS, Andersen SE, Gerstoft J,
Thorsteinsson K, Larsen CS, Pedersen
G, Pedersen C, Obel N. Adherence to
national guidelines for initiation of antiretroviral
regimens in HIV patients: a Danish
nationwide study. Br J Clin Pharmacol
2011;72(1):116-24.
3. Larsen IK, Pedersen G, Schønheyder
HC. Bacteraemia with an unknown focus: is
the focus de facto absent or merely unreported?
A one-year hospital-based cohort
study. APMIS 2011;119(4-5):275-9.
4. Gradel KO, Thomsen RW, Lundbye-
Christensen S, Nielsen HI, Schønheyder
HC. Baseline C-reactive protein level as a
predictor of mortality in bacteraemia patients:
a population-based cohort study. Clin
Microbiol Infect 2011;17(4):627-32.
5. Hansen A, Obel N, Nielsen HI, Pedersen
C, Gerstoft J. Bone mineral density
changes in protease inhibitor-sparing vs.
nucleoside reverse transcriptase inhibitorsparing
highly active antiretroviral therapy:
data from a randomized trial. HIV Med
2011;12(3):157-65.
6. Janum SH, Søvsø M, Gradel KO,
Schønheyder HC, Nielsen H. C-reactive
protein level as a predictor of mortality in
liver disease patients with bacteremia.
Scand J Gastroenterol
2011;46(12):1478-83.
7. Lohse N, Gerstoft J, Kronborg G, Larsen
CS, Pedersen C, Pedersen G, Nielsen
L, Sørensen HT, Obel N. Comorbidity
Acquired before HIV Diagnosis and Mortality
in HIV-infected and Uninfected Persons:
A Danish population-based cohort study. J
Acquir Immune Defic Syndr
2011;57(4):334-9.
8. Hansen N, Obel N, Christensen PB,
Kjær M, Laursen AL, Krarup HB, Møller
A, Schlichting P, Bukh J, Weis N,
[the Danish Database for Hepatitis B
and C (DANHEP)- group] . Effectiveness
of treatment with pegylated interferon and
ribavirin in an unselected population of
patients with chronic hepatitis C: A Danish
nationwide cohort study. BMC Infect Dis
2011;11(1):177-e8.
9. Andersen RM, Bjørn-Præst SO, Gradel
KO, Nielsen C, Nielsen HI. Epidemiology,
diagnostic delay and outcome of tuberculosis
in North Jutland, Denmark. Dan Med Bull
2011;58(3):A4256-e5.
10. Krarup H, Andersen S, Madsen PH,
Christensen PB, Laursen AL, Bentzen-
Petersen A, Møller JM, Weis N, [the
DANHEP group] . HBeAg and not genotypes
predicts viral load in patients with hepatitis
B in Denmark: A nationwide cohort
study. Scand J Gastroenterol
2011;46(12):1484-91.
11. Engsig FN, Gerstoft J, Kronborg G,
Larsen CS, Pedersen G, Pedersen C,
Obel N. Head and neck cancer in HIV
patients and their parents: a Danish cohort
study. Clin Epidemiol 2011;3:217-27.
12. Rasmussen L, Dybdal M, Gerstoft J,
Kronborg G, Larsen CS, Pedersen C,
Pedersen G, Jensen J, Pedersen L, Sørensen
HT, Obel N. HIV and risk of
venous thromboembolism: a Danish nationwide
population-based cohort study. HIV
Med 2011;12(4):202-10.
13. Obel N, Omland LH, Kronborg G,
Larsen CS, Pedersen C, Pedersen G,
Sørensen HT, Gerstoft J. Impact of Non-
HIV and HIV Risk Factors on Survival in
HIV-Infected Patients on HAART: A Population-Based
Nationwide Cohort Study. PLoS
One 2011;6(7):e22698-6.
14. Engsig FN, Kronborg G, Larsen CS,
Pedersen G, Pedersen C, Gerstoft J,
Obel N. Lung cancer in HIV patients and
their parents: a Danish cohort study. BMC
Cancer 2011;11:272-e10.
15. Audelin AM, Gerstoft J, Obel N, Mathiesen
L, Laursen A, Pedersen C,
Nielsen HI, Jensen J, Nielsen L, Nielsen
C, Jørgensen LB. Molecular phylogenetics
of transmitted drug resistance in newly
diagnosed HIV Type 1 individuals in Denmark:
a nation-wide study. AIDS Res Hum
Retroviruses 2011;27(12):1283-90.
16. Larsen IK, Gradel KO, Helms M, Hornstrup
MK, Jürgens G, Mens H, Rosager
CL, Clausen TH, Kronborg G, Nielsen
HI. Non-typhoidal Salmonella and Campylobacter
infections among HIV-positive patients
in Denmark. Scand J Infect Dis
2011;43(1):3-7.
17. Nielsen HL, Nielsen H, Ejlertsen T,
Engberg J, Günzel D, Zeitz M, Hering
NA, Fromm M, Schulzke JD, Bücker R.
Oral and Fecal Campylobacter concisus
Strains Perturb Barrier Function by Apoptosis
Induction in HT-29/B6 Intestinal Epithelial
Cells. PLoS One 2011;6(8):e23858-
8.
18. Pett SL, Carey C, Lin E, Wentworth D,
Lazovski J, Miro JM, Gordin F, Angus B,
Rodriguez-Barradas M, Rubio R, Tambussi
G, Cooper DA, Emery S, [for the
INSIGHT-ESPRIT Study Group] . Predictors
of bacterial pneumonia in Evaluation of
Subcutaneous Interleukin-2 in a Randomized
International Trial (ESPRIT). HIV Med
2011;12(4):219-7.
19. Spanggaard MH, Hønge B, Schønheyder
HC, Nielsen H. Short-term gentamicin