Reifung des Stirnhirns
Reifung des Stirnhirns
Reifung des Stirnhirns
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Facit<br />
Results demonstrate the way an anatomical disconnection<br />
syndrom in psychosis will develop by graded processes<br />
depending on the severity of trauma:<br />
• In a first step (non-invasive challenge of dopamine) the degraded<br />
glutamatergic efflux from the malfunctional developing prefrontal<br />
cortex suppresses maturation of both LIII and LV pyramids<br />
• In a second step (more severe challenge) the degraded efflux from the<br />
prefrontal cortex induces a suppressive LIII collateralisation and an<br />
oversprouting of exclusively LV collaterals<br />
• Presumably, this dissoziation may result from the preservation of<br />
transient LV fibre surplus values which characterise the postnatal<br />
pyramidal development
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