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Hybrid Parallel Programming for Massive Graph Analysis

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Steps in the de Bruijn graph‐based<br />

assembly y scheme<br />

1 Preprocessing<br />

FASTQ input data<br />

Sequences after<br />

error resolution<br />

2 Kmer spectrum<br />

Determine<br />

appropriate pp p<br />

value of k to use<br />

6<br />

5<br />

4<br />

Compute and<br />

memory-intensive<br />

y<br />

3<br />

Scaffolding<br />

Error resolution + further<br />

graph compaction<br />

Vertex/edge compaction<br />

(lossless trans<strong>for</strong>mations)<br />

Preliminary de Bruijn graph<br />

construction

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