Thyroid cytology - RCPA

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Parathyroid adenoma vs thyroid lesion: Parathyroid Hyperparathyroidism + Cells Usually smaller Nuclei 'Salt and pepper' coarse chromatin Intranuclear vacuoles Many naked nuclei Cytoplasm Fine, red (neurosecretory granules) Cytoplasmic vacuoles Colloid Absent Background Usually clean; no foamy macrophages; no calcium oxalate crystals under polarized light Immunostains PTH+ <strong>Thyroid</strong> - Usually larger Fine chromatin Fewer naked nuclei Coarse, blue Present Often degenerated; calcium oxalate crystals identified Thyroglobulin, TTF-1+
Fig 1. Colloid with a definite edge. Fig 2. Colloid with a cracked appearance.
Page 1 and 2: Thyroid cytology Dr Alpha Tsui Roya
Page 3 and 4: 4. Follicular neoplasm 5. Hurthle c
Page 5 and 6: -numerous neutrophils, degenerate d
Page 7 and 8: The diagnosis of follicular carcino
Page 9 and 10: Hyalinising trabecular tumour (aden
Page 11: phenomenon. Can be seen in treated
Page 15 and 16: Fig 5. Blood, serum and clumped pla
Page 17 and 18: Fig 9. Graves’ disease. Note: Occ
Page 19 and 20: Fig 13. Hyperplastic nodule. Sheets
Page 21 and 22: Fig 17. Occasional atypical cells i
Page 23 and 24: Fig 21. Follicular neoplasm with ro
Page 25 and 26: Fig 25. Hurthle cell neoplasm with
Page 27 and 28: Fig 29. Papillary carcinoma. Note n
Page 29 and 30: Fig 33. Follicular variant of papil
Page 31 and 32: Fig 37. Cyst-lining cells with intr
Page 33 and 34: Fig 41. Medullary carcinoma with a
Page 35 and 36: Fig 45. Non-Hodgkin lymphoma of the

Thyroid cytology - RCPA

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