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Notice of Hearing on the Application to Use Sodium Fluoroacetate ...

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l 4<br />

3 6<br />

fai 1 ure as cne c3rmi nal ?vent 3r r~s3i r2~3ry zrrls? fc? 1 ~,vi ns 52var2<br />

c<strong>on</strong>vulsi<strong>on</strong>s. Seatn in szrnivzres is c>,ou~b,c ts Se che resul Xf cmtral nervous sysxm a'sorders,<br />

56. Tests with rats treated with fluorocitraze have dem<strong>on</strong>scrated zarked<br />

kidney damage. ~ests with rats wherein il uoroci trate was admini s tered<br />

in drinking water in c<strong>on</strong>centrati<strong>on</strong>s as low as 5 ppm for seven days<br />

have also shcwn mor?nologicaT damage <strong>to</strong> tssces. This t2st snowed<br />

that chere was some regeneraticn , a 1 chough recovery was not cmpl st?,<br />

after 21 days. Rars given sub-lethal doses <str<strong>on</strong>g>of</str<strong>on</strong>g> fluoroc~tra~: have<br />

Seen shown LO grow ncm,al?y for seven c<strong>on</strong>chs acd hen <strong>to</strong> survive an<br />

i ntraperi :<strong>on</strong>edl 4082-<str<strong>on</strong>g>of</str<strong>on</strong>g> 71 uoroci trat? hi ch would normal ?y have been<br />

fatal . This i ndi catzs that a certain <strong>to</strong>lsrance for fl uoroci tracs<br />

nay be develosed. O~her studies '~ave shown rhac re?eaxi sub-;e:ha!<br />

doses <str<strong>on</strong>g>of</str<strong>on</strong>g> ~<strong>on</strong><str<strong>on</strong>g>of</str<strong>on</strong>g>luor~acc~ac~ have increas2d :he cclerance <str<strong>on</strong>g>of</str<strong>on</strong>g> scme<br />

speci 2s , e. g . , go1 den 2agl2s , rats, nice 5nd pcssi bl;/ rhes~s -n<strong>on</strong>A?ys.<br />

gepea<strong>to</strong>d sub-lethal doses <str<strong>on</strong>g>of</str<strong>on</strong>g> in<strong>on</strong><str<strong>on</strong>g>of</str<strong>on</strong>g>luorccitraie airninis~~rob <strong>to</strong> dogs,<br />

guinea pigs, rabbirs and mallard ducks, however, have accumulated :o<br />

lethal levels. The reas<strong>on</strong> more data isn't available <strong>on</strong> whe<strong>the</strong>r<br />

fluoroacetate accumuia-ies in an animal is because it is so <strong>to</strong>xic.<br />

Issue 6 - Human Safety<br />

57. Sodi urn m<strong>on</strong>oil uorcscetate i s a white, odor1 ess, pcwaery , fl uoro-crsanj c<br />

salt similar in appearance <strong>to</strong> flour, powdered sugar or baking powder..<br />

It is essentially tasteless having <strong>on</strong>ly a mild, salty, sour or vinegar<br />

taste <strong>to</strong> indi,vidu;ls. 1: is highly so:.~b:z in l&:t:r, but reiicivsly

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