PRODUCT MONOGRAPH

Drug-Food Interactions
Andriol ® must be taken with meal since fat enhances its absorption. 1
Drug-Herb Interactions
It was found that some herbal products (e.g. St. John’s Wort) which are available as over-thecounter
(OTC) products might interfere with steroid metabolism and therefore may decrease
plasma testosterone levels 3 .
Drug-Laboratory Interactions
Testosterone products may decrease levels of thyroxine-binding globulin, resulting in decreased
total T4 serum levels and increased resin uptake of T3 and T4. Free thyroid hormone levels
remain unchanged, however, and there is no clinical evidence of thyroid dysfunction.
DOSAGE AND ADMINISTRATION
Recommended Dose and Dosage Adjustment
Usually, a daily dosage of 120-160 mg divided in two doses, taken once in the morning and once
in the evening for 2-3 weeks is adequate. Subsequent dosage (40-120mg daily) should be based
on the subsequent testosterone levels and/or clinical effect obtained during therapy.
Missed Dose
Should you forget a dose, take your dose at the next scheduled time. Do not take a double dose
of this medicine.
Administration
To ensure adequate absorption, Andriol ® (testosterone undecanoate capsules) must be taken with
a meal and swallowed without chewing.
OVERDOSAGE
For management of a suspected drug overdose, contact your regional Poison Control Centre.
No experience with overdosage has been reported. No specific antidote is available.
ANDRIOL ® (testosterone undecanoate capsules) Page 10 of 26