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aNNEx 3<br />

Standard GRADE criteria for grading of evidence<br />

See references 19–23.<br />

Domain Grade Characteristic<br />

Study design 0 All randomized controlled trials<br />

–1 All observational studies<br />

Study design 0 Most of the pooled effect provided by studies, with low risk of bias<br />

limitations<br />

–1 Most of the pooled effect provided by studies with moderate risk of bias<br />

–2 Most of the pooled effect provided by studies with high risk of bias<br />

Note: Low risk of bias: no limitations or minor limitations<br />

Moderate risk of bias: serious limitations or potentially very serious limitations including unclear concealment<br />

of allocation or serious limitations, excluding limitations on randomization or concealment<br />

of allocation<br />

High risk of bias: limitations for randomization, concealment of allocation, including small blocked<br />

randomization (

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