Efficacy and tolerability of Hypericum extract for the ... - Livar.net

Placebo as comparator in long-term trial
(Kasper et al., 2008b) DB, R
MC
Tricyclic as comparator
(Vorbach et al., 1994) DB, R,
MC
(Harrer et al., 1994) DB, R,
MC
(Wheatley, 1997) DB, R,
MC
Recurrent episode of moderate
major depression HAMD ≥20,
mean ~23
Depressive disorder according
to DSM-III-R; mean HAMD ~20
Moderate: ICD-10 F32.1; HAMD
16–24, mean HAMD ~21
(Bergmann et al., 1993) DB Mild to moderate: mean
HAMD 15.6
(Woelk, 2000) DB, R, Mild to moderate: mean
MC HAMD 22.4 (mild N=189;
moderate N=135)
(Philipp et al., 1999) DB, R, Moderate: ICD-10 F32.1
MC and F33.1
SSRI as comparator
(Brenner et al., 2000) DB, R Mild to moderate: HAMD ≥17,
mean HAMD ~21
(Hypericum Depression
Trial Study Group, 2002)
DB, R,
MC
(Harrer et al., 1999) DB, R,
MC
(Schrader, 2000) DB, R,
MC
WS 5570 (900) Placebo PP 426 Relapse rates
51/282 (18.1%)
LI 160 (900) Imipramine
(75)
LI 160 (900) Maprotiline
(75)
Mild to moderate: HAMD 17–24 LI 160 (900) Amitriptyline
(75)
Mild, moderate and severe:
HAMD ≥20, mean ~23 (77.6%
mild to moderate; data are
shown for the whole cohort
since separate data for the mild
to moderate subgroup were not
provided)
Mild to moderate: ICD-10 F32.0
and F32.1; mean HAMD ~17
(mild N=72, moderate N=77)
Mild to moderate: HAMD 16–24,
mean HAMD ~20
Esbericum (dose not stated) Amitriptyline
(30)
ZE 117 (500) Imipramine
(150)
STEI 300 (1050) Imipramine
(100)
LI 160 (900) Sertraline
(75)
LI 160 (900) Sertraline
(50)
LoHyp-57 (800) Fluoxetine
(20)
ZE 117 (500) Fluoxetine
(20)
Relapse rates
37/144 (25.7%)
ITT 135 42/67 (62.7) 37/68 (54.4)
PP 130 54/66 (81.8) 40/64 (62.5)
EP 102 27/51 (53) 28/51 (55)
PP 86 27/44 (61) 28/42 (67)
ITT 156 40/87 (46) 42/78 (53.9)
PP 121 40/67 (59.7) 42/54 (77.8)
EP 80 32/40 (80) c
28/40 (70)
EP 324 e
68/157 (43.2) 67/167 (40.1)
ITT 205 67/100 (67) 66/105 (62.9)
EP 216 76/106 (71.7) 70/110 (63.6)
ITT 28 7/13 (54) 6/15 (40)
EP 30 7/15 (46.7) 6/15 (40)
ITT 222 43/113 (38.1) 53/109 (48.6)
EP 224 46/113 (40.7) 55/111 (49.5)
PP 161 39/82 (47.6) 48/79 (61)
ITT 149 (all) 50/70 (71.4) 57/79 (72.2)
72 (mild) 27/33 (81.8) 30/39 (76.9)
77 (moderate) 23/37 (62.2) 27/40 (67.5)
EP 161 (all) 50/77 (64.9) 57/84 (67.8)
ITT 240 f
75/126 (60) 45/114 (40)
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Efficacy and tolerability of Hypericum extract for the treatment of mild to moderate depression
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