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Daflon 500 mg - cacvs

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Author,<br />

year<br />

Shadid N,<br />

2012<br />

Rass K,<br />

2012<br />

Nordon<br />

IM, 2011<br />

Liu X,<br />

2011<br />

Rasmussen<br />

LH, 2011<br />

Disselhoff<br />

BC, 2011<br />

Chan<br />

CY,2011<br />

Jia X,<br />

2011<br />

Blo<strong>mg</strong>ren<br />

L, 2011<br />

Schul<br />

MW, 2011<br />

Carradice<br />

D, 2011<br />

Carradice<br />

D, 2011<br />

Christenson<br />

JT, 2010<br />

Dimension Procedure Follow-up<br />

430 patients UGFS vs. HL/S<br />

Baseline, month 3, year 1<br />

and 2<br />

QoL<br />

questionnaire<br />

EQ-5D<br />

400 patients EVLA vs. HL/S Year 2 CIVIQ<br />

159 patients EVLA vs. RFA<br />

60 patients<br />

<strong>500</strong> patients<br />

(580 legs)<br />

120 patients<br />

UGFS + SFJ ligation vs.<br />

conventional stripping<br />

EVLA vs. RFA vs. UGFS<br />

vs. Stripping<br />

EVLA<br />

vs. Cryostripping<br />

82 patients EVLA vs. CHIVA<br />

60 patients<br />

227 patients<br />

58 patients<br />

280 patients<br />

280 patients<br />

Comparative studies (1/2)<br />

Foam sclerotherapy +<br />

SFJ ligation vs.<br />

conventional stripping<br />

Preoperative duplex<br />

examination + Surgery<br />

vs. Only surgery<br />

Sclerotherapy vs.<br />

Stocking (crossover to<br />

sclerotherapy)<br />

EVLA<br />

vs. Surgery*<br />

EVLA<br />

vs. Surgery*<br />

Pre-operative and<br />

month 3<br />

AVVQ+ EQ-5D<br />

Conclusion<br />

At year 2 follow-up, UGFS was not inferior to<br />

surgery.<br />

Both EVLT and HLS are comparably safe and<br />

effective procedures to treat GSV incompetence.<br />

Changes in the AVVQ and<br />

EQ-5D at 3 months were similar in both groups.<br />

Month 3 and 6 AVVQ -<br />

Pre-operative, day 3,<br />

month 1 and year 1<br />

EQ-5D<br />

+SF36<br />

Year 5 AVVSS<br />

Week 1 and month 1, 3, 6<br />

and 12<br />

AVVQ<br />

Months 3 and 6 -<br />

Year 7 (late follow-up<br />

study)<br />

T0, after compression trial,<br />

after sclerotherapy and month<br />

3 and 12 after sclerotherapy,<br />

SF36<br />

AVVQ<br />

Week 1, 6, 12 and 52 AVVQ<br />

- AVVQ + SF36<br />

Disease-specific quality-of-life and SF-36 scores had<br />

improved in all groups by 1 year follow-up.<br />

AVVSS improved significantly after treatment in both<br />

groups, with no significant difference between them.<br />

Both groups benefited significantly from surgery in<br />

disease-specific perceptions.<br />

Foam sclerotherapy + SFJ ligation involves a less<br />

postoperative discomfort<br />

QoL was similar in both groups, but routine<br />

preoperative duplex imaging improved the results of<br />

surgery for primary varicose veins for at least 7 year<br />

Sclerotherapy offers a statistically superior broad<br />

spectrum relief of symptoms.<br />

Clinical recurrence was associated with worse AVVQ<br />

scores<br />

EVLA had a less negative impact on early<br />

postintervention QoL<br />

204 legs EVLA vs. HL/S Day 12, year 1, year 2 AVVSS + SF36 Similar QoL improvement after HL/S and EVLA

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