Micronised Purified Flavonoid Fraction - QUONIA
Micronised Purified Flavonoid Fraction - QUONIA
Micronised Purified Flavonoid Fraction - QUONIA
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72 Lyseng-Williamson & Perry<br />
4. Therapeutic Efficacy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 83<br />
4.1 In Patients with Chronic Venous Insufficiency (CVI) . . . . . . . . . . . . . . . . . . . . . . . . 83<br />
4.1.1 Comparative Trials . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 84<br />
4.1.2 Long-Term Treatment . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 85<br />
4.2 In Patients with Venous Ulcers . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 86<br />
4.2.1 Effects on Venous Ulcer Healing . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 87<br />
4.2.2 Cost-Effectiveness . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 88<br />
4.3 In Patients with Haemorrhoids . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 88<br />
4.3.1 Comparison with Placebo . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 89<br />
4.3.2 MPFF plus Fibre in Comparative Trials . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 89<br />
4.3.3 In Pregnant Patients . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 89<br />
4.3.4 To Reduce Bleeding After Haemorrhoidectomy . . . . . . . . . . . . . . . . . . . . . . . 90<br />
5. Tolerability . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 91<br />
6. Dosage and Administration . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 92<br />
7. Place of <strong>Micronised</strong> <strong>Purified</strong> <strong>Flavonoid</strong> <strong>Fraction</strong> in the Management of CVI,<br />
Venous Ulcers and Haemorrhoids . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 92<br />
7.1 CVI . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 92<br />
7.2 Venous Ulcers . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 94<br />
7.3 Haemorrhoids . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 95<br />
7.4 Conclusions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 97<br />
Summary<br />
Abstract <strong>Micronised</strong> purified flavonoid fraction (MPFF) [Daflon ® 500mg 1], an oral<br />
phlebotropic drug consisting of 90% micronised diosmin and 10% flavonoids<br />
expressed as hesperidin, improves venous tone and lymphatic drainage, and reduces<br />
capillary hyperpermeability by protecting the microcirculation from inflammatory<br />
processes. The absorption of diosmin is improved by its<br />
micronisation to particles with a diameter