Cyberknife SBRS for the treatment of Pancreatic Cancer

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Importance of Continuous Intra-fraction Tracking • 20 pancreatic cancer patients treated with 25Gy in a single fraction • Comparing assessment of motion between 4D-CT and CyberKnife® Synchrony® tracking • Conclusions: • 4D-CT predicted motion well in SI direction but not in AP and LR directions as compared to Synchrony • “A single 4D-CT may not be sufficient to predict organ movement caused by pt. respiratory motion during an actual course of treatment.” • “Clinical implications of this error may be decreased tumor control rates and increased normal tissue toxicity.” Minn et al (2009)
Targeting Tumors That Move with Respiration Conventional Radiotherapy Systems • Respiratory-induced motion of tumors causes significant targeting uncertainty • Conventional respiratory compensation techniques demand large planning margins – Respiratory Gating
Page 1 and 2: SBRT for the treatment of Pancreati
Page 3 and 4: SBRT for the treatment of Pancreati
Page 5 and 6: CyberKnife Robotic Radiosurgery Sys
Page 7 and 8: CyberKnife ® Target Tracking Syste
Page 11 and 12: Cyberknife SBRT at the JCC • 160
Page 13 and 14: Pancreatic Cancer: Overview • 400
Page 15 and 16: Loco-regional - Chemo-Radiation Pan
Page 17 and 18: Pancreatic Cancer: SBRT
Page 19 and 20: Pancreatic Cancer: Benefits of SBRT
Page 23 and 24: Respiratory Induced Motion Challeng
Page 25: Importance of Continuous Intra-frac
Page 29 and 30: Targeting Tumors That Move with Res
Page 31 and 32: How It Works… (2) • Prior to tr
Page 33 and 34: How It Works… (3) • This proces
Page 35 and 36: Linac Based Radiotherapy vs. CyberK
Page 37 and 38: Pancreatic Cancer: Cyberknife Case
Page 39: X-sight lung to track stent in head
Page 42 and 43: Pancreatic Cancer: Cyberknife SBRT
Page 44: References • Murphy, J. D et al (

Cyberknife SBRS for the treatment of Pancreatic Cancer

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