antibacterial potential of some herbal preparation - International ...
antibacterial potential of some herbal preparation - International ...
antibacterial potential of some herbal preparation - International ...
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contents three medicinal plants; Piper longum, Piper nigrum,<br />
Zingiber <strong>of</strong>ficinale (fig.1). Trikatu churna possess wide range <strong>of</strong><br />
<strong>antibacterial</strong> properties against S. epidermidis, S. aureus, P. vulgaris,<br />
B. subtilis, P. aeruginosa and K. pneumoniae. Avipattikar is<br />
<strong>preparation</strong> <strong>of</strong> Zingiber <strong>of</strong>ficinale, Piper nigrum, Piper longum,<br />
Terminalia chebula etc. It was proved potent <strong>antibacterial</strong> agent<br />
against S. epidermidis, S. aureus, P. vulgaris, K. pneumoniae, S. typhi, S.<br />
typhimurium. Chandanadi churna and Pushyanug churna was potent<br />
<strong>antibacterial</strong> against P. vulgaris, K. pneumoniae, E. coli, P. aeruginosa<br />
and S. aureus. Santalum album and Holarrhena antidysenterica are<br />
important ingredients <strong>of</strong> Chandanadi churna and Pushyanug churna<br />
and reported as <strong>antibacterial</strong> against B. subtilis, S. epidermidis P.<br />
pseudoalcaligenes, P. vulgaris and S. typhimurium 20,10.<br />
Tambekar et al.<br />
Int J Pharm Pharm Sci, Vol 2, Suppl 4, 176179<br />
From the study it was also observed that the compound <strong>herbal</strong><br />
<strong>preparation</strong> was more <strong>antibacterial</strong> while single <strong>herbal</strong> <strong>preparation</strong><br />
least <strong>antibacterial</strong> against bacterial pathogens this may be due to its<br />
synergistic or combine effects <strong>of</strong> medicinal plants. Chandanadi<br />
churna, Bilba churna, Amla churna and Pushyanug churna were<br />
strong <strong>antibacterial</strong> against Staphylococcus epidermidis, Proteus<br />
vulgaris, Staphylococcus aureus, Escherichia coli, Pseudomonas<br />
aeruginosa and Salmonella typhi which are associated with different<br />
type <strong>of</strong> infections including urinary tract infection, wound infection,<br />
otitis media, gastroenteritis, and meningitis. Study proved its<br />
traditional applications are safe as ayurvedic medicine and therefore<br />
may be useful to prevent or control the enteric infections.<br />
Table 3: Antibacterial activity <strong>of</strong> <strong>herbal</strong> <strong>preparation</strong>s against various bacterial pathogens at 5 mg/disc (Zone <strong>of</strong> inhibition <strong>of</strong> growth in<br />
mm average <strong>of</strong> 3 reading)<br />
Herbal <strong>preparation</strong>s Solvent extracts<br />
P. vulgaris<br />
(MTCC426)<br />
S. epidermidis<br />
(MTCC435)<br />
Panchasakar churna Aqueous 15 24 30 12 16 22 13 15 16 13<br />
Ethanol 16 25 28 11 15 18 18 17 13 19<br />
Methanol 18 27 32 19 20 20 17 21 15 15<br />
Acetone 16 25 32 11 16 18 22 22 14 21<br />
Pushyanug churna Aqueous 18 29 18 14 15 13 12 ‐ 13 12<br />
Ethanol 16 25 24 13 16 13 ‐ ‐ 15 12<br />
Methanol 18 27 27 12 15 15 11 ‐ 19 15<br />
Acetone 20 26 25 14 16 15 12 ‐ 16 15<br />
Pashanbhed churna Aqueous 17 28 22 16 16 12 ‐ ‐ 16 12<br />
Ethanol 17 29 19 16 16 12 ‐ ‐ 15 12<br />
Methanol 20 29 22 13 16 14 ‐ ‐ 17 14<br />
Acetone 19 31 20 17 16 16 ‐ ‐ 18 13<br />
Gokharu churna Aqueous 22 22 21 18 14 ‐ 14 15 13 13<br />
Ethanol 21 21 22 18 16 13 15 16 14 13<br />
Methanol 20 24 21 20 17 14 16 15 14 16<br />
Acetone 21 20 21 22 16 14 17 18 16 15<br />
Trikatu churna Aqueous 17 14 15 13 17 18 13 ‐ ‐ ‐<br />
Ethanol 17 19 17 12 16 17 12 ‐ ‐ ‐<br />
Methanol 16 18 17 12 16 16 13 ‐ ‐ ‐<br />
Acetone 16 18 19 14 16 17 14 ‐ ‐ ‐<br />
Amla churna Aqueous 17 20 24 20 18 17 15 16 15 18<br />
Ethanol 20 20 28 19 18 16 16 19 17 18<br />
Methanol 22 23 29 22 18 20 21 19 16 20<br />
Acetone 19 24 29 21 19 21 16 20 15 21<br />
Avipattikar churna Aqueous 17 22 20 15 ‐ 12 14 15 12 17<br />
Ethanol 15 18 18 14 ‐ 14 17 16 12 14<br />
Methanol 22 20 17 13 13 16 18 17 12 15<br />
Acetone 18 23 20 14 13 15 16 15 13 16<br />
Bilba churna Aqueous 17 22 24 19 18 15 23 19 14 19<br />
Ethanol 18 23 25 17 16 18 23 16 15 17<br />
Methanol 20 25 26 22 16 19 23 18 16 20<br />
Acetone 21 24 23 22 17 17 24 16 17 18<br />
Arjuna churna Aqueous 19 23 24 16 17 16 19 18 17 15<br />
Ethanol 21 25 23 20 19 18 20 19 17 15<br />
Methanol 21 25 26 23 21 18 21 21 20 17<br />
Acetone 20 25 27 22 19 20 22 17 16 15<br />
Chandanadi churna Aqueous 20 26 24 21 13 17 20 20 13 20<br />
Ethanol 20 28 25 20 14 20 21 21 17 18<br />
Methanol 21 28 27 22 20 23 20 21 21 19<br />
Acetone 22 30 24 21 19 19 20 20 20 22<br />
Negative control Water ‐ ‐ ‐ ‐ ‐ ‐ ‐ ‐ ‐ ‐<br />
Ethanol ‐ ‐ ‐ ‐ ‐ ‐ ‐ ‐ ‐ ‐<br />
Methanol ‐ ‐ ‐ ‐ ‐ ‐ ‐ ‐ ‐ ‐<br />
Acetone ‐ ‐ ‐ ‐ ‐ ‐ ‐ ‐ ‐ ‐<br />
Positive control Ampicillin<br />
(10mcg/disc)<br />
16 25 24 11 16 18 30 18 14 19<br />
S. aureus<br />
(MTCC96)<br />
E. coli<br />
(MTCCi739)<br />
P. aeruginosa<br />
(MTCC424)<br />
B. subtilis<br />
(MTCC441)<br />
K. pneumoniae<br />
(MTCC 109)<br />
S. typhi<br />
(MTCC i733)<br />
E. aerogenes<br />
(MTCC 111)<br />
S. typhimurium<br />
(MTCC 98)<br />
178