Influence of ethanolic extract of Borassus flabellifer L. male flowers ...

Mahesh S Paschapur et al /Int.J. PharmTech Res.2009,1(3) 554
Table1: Effect of ethanololic extract of Borassus flabellifer male flowers on nystatin-induced rat paw oedema
Groups Dose
(mg/kg)
Mean change in Paw Volume (ml)
2h 4h 6h 24h 48h 72h
Control 1% CMC 2.63±0.06 2.88±0.04 2.65±0.02 2.17±0.02 2.01±0.03 1.93±0.02
Standard 100 1.51±0.04 c
Alc 200 200 2.35±0.05 b
Alc 400 400 1.79±0.04 c
1.33±0.02 c 1.24±0.01 c 1.30±0.02 c 1.18±0.01 c 1.03±0.01 c
2.21±0.03 c 2.11±0.03 c 2.21±0.02 2.10±0.02 a 1.96±0.02
1.63±0.02 c 1.51±0.01 c 1.68±0.03 c 1.5±0.01 c 1.38±0.01 c
Standard: Diclofenac sodium (100mg/kg b.w.), Alc 200: Ethanolic extract at dose 200mg/kg b.w.,
Alc 400: Ethanolic extract at dose 400mg/kg b.w.
Each value is the Mean ± S.E.M. for 6 rats
a P < 0.05; b P < 0.01; c P < 0.0001 compared with control
Table 2: Effect of ethanololic extract of Borassus flabellifer male flowers on various biochemical
changes in nystatin-induced paw oedema in rats
Groups Dose
SGOT
SGPT Lipid peroxidation Alkaline
(mg/kg)
(U/ml)
(U/ml)
Phosphate
(U/ml)
Control 1% CMC 99.17±3.4 58.17±1.77 100 80.00±2.20
Standard 100 58.33±2.18 c
Alc 200 200 83.83±1.85 c
Alc 400 400 73.17±1.92 c
22.33±1.28 c
42.17±1.13 c
29.17±1.16 c
48.50±1.47 c
78.83±1.77 c
66.50±1.58 c
Standard: Diclofenac sodium (100mg/kg b.w.), Alc 200: Ethanolic extract at dose 200mg/kg b.w.,
Alc 400: Ethanolic extract at dose 400mg/kg b.w.
Each value is the Mean ± S.E.M. for 6 rats
a P < 0.05; b P < 0.01; c P < 0.0001 compared with control
48.50±1.47 c
65.67±1.22 c
54.50±1.33 c
Table 3: Effect of ethanololic extract of Borassus flabellifer male flowers on FCA induced poly arthritis in
rats
Groups Dose
Mean change in Paw Volume (ml)
(mg/kg)
Day 0 Day 5 Day 10 Day 15 Day 21
Control 1% CMC 1.07±0.02 1.43±0.02 1.76±0.02 1.88±0.02 1.90±0.02
Standard 100 1.02±0.02 1.23±0.03 c
1.34±0.02 c
Alc 200 200 1.02±0.02 1.36±0.02 1.49±0.02 c
Alc 400 400 1.02±0.03 1.29±0.02 b
1.41±0.02 c
Standard: Diclofenac sodium (100mg/kg b.w.), Alc 200: Ethanolic extract at dose 200mg/kg b.w.,
Alc 400: Ethanolic extract at dose 400mg/kg b.w.
Each value is the Mean ± S.E.M. for 6 rats
a P < 0.05; b P < 0.01; c P < 0.0001 compared with control
1.39±0.03 c
1.53±0.01 c
1.46±0.01 c
1.31±0.02 c
1.48±0.01 c
1.42±0.00 c