Drug Design 2 - Applied Bioinformatics Group
Drug Design 2 - Applied Bioinformatics Group
Drug Design 2 - Applied Bioinformatics Group
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Reduce AZriDon Rate<br />
• „Fail early, fail cheap“<br />
The earlier unsuitable candidates are removed from the<br />
pipeline, the more money can be saved.<br />
• If drugs with unsuitable proper%es can be removed in an earlier<br />
development phase, the a"ri%on rate in the late (expensive)<br />
development phases can be reduced<br />
• Which properDes does a good drug need?<br />
• How to predict these proper%es?<br />
Overview of the Different Areas<br />
Pharmaceutical Phase<br />
Pharmacokinetic<br />
Phase<br />
Pharmacodynamic<br />
Phase<br />
Storage<br />
Application<br />
Dissolution<br />
Absorption<br />
Distribution<br />
Place of Action<br />
(Receptors)<br />
Pharmacological<br />
Effect<br />
Clinical Effect Toxic Effect<br />
AbsorpDon and EliminaDon<br />
Absorption<br />
Elimination<br />
Parenteral<br />
Gehirn<br />
Central<br />
Biliary Renal<br />
Compartment<br />
Enteral<br />
Biotransformation<br />
Excretion<br />
Blood-Brain Barrier<br />
Membranes<br />
of the GI Tract<br />
After: Mut, p. 5
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