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Analytica Chimica Acta Volume 751, Pages 1-188 (2 November 2012)

Analytica Chimica Acta Volume 751, Pages 1-188 (2 November 2012)

Analytica Chimica Acta Volume 751, Pages 1-188 (2 November 2012)

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Highlights<br />

► Visual detection based gold and silver nanoparticles aggregation. ► Functionalized and nonfunctionalized<br />

nanoparticles. ► High selectivity and sensitivity. ► No complex instrumentation is<br />

required/chemical creativity for analyte detection.<br />

Chemometrics<br />

Validation of analytical methods involved in dissolution assays:<br />

Acceptance limits and decision methodologies<br />

Original Research Article<br />

<strong>Pages</strong> 44-51<br />

E. Rozet, E. Ziemons, R.D. Marini, B. Boulanger, Ph. Hubert<br />

Graphical abstract<br />

Highlights<br />

► Novel methodology to validate analytical methods involved in dissolution tests. ► Valid methods<br />

will ensure to make the correct decisions with high probability. ► A Quality by Design compliant<br />

validation methodology for dissolution assays. ► <strong>Analytica</strong>l Target Profile is defined for dissolution<br />

assays. ► Application to the validation of a HPLC–UV analytical method.<br />

Electrochemistry<br />

Nanoplatinum-enclosed gold nanocores as catalytically promoted<br />

nanolabels for sensitive electrochemical immunoassay

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