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AMBIGUOUS GENITALIA.pdf - Dr. Erfan & Bagedo General Hospital

AMBIGUOUS GENITALIA.pdf - Dr. Erfan & Bagedo General Hospital

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Male Pseudo-hermaphrodite<br />

• Complete newborn male differentiation requires:<br />

– SRY and downstream genes<br />

– Antimullerian hormone (AMH) &testosterone<br />

– Gonadotropin production (during the second and third trimester),<br />

– Conversion of testosterone to dihydrotestosterone (DHT) by 5 alphareductase<br />

– End organ response to androgens<br />

Copyright © 1982 - 2009 <strong>Dr</strong>. <strong>Erfan</strong> & <strong>Bagedo</strong> <strong>Hospital</strong>

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