(Statins) and Fixed-dose Combination Products Containing a Statin

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Final Report Update 5 Drug Effectiveness Review Project the fixed-dose combination product had a significantly greater decrease in low-density lipoprotein cholesterol compared to those taking the statin alone. In the niacin extended release fixed-dose trials, there was no significant difference in low-density lipoprotein cholesterol reduction compared to the statins except in the Bays 2003 trial 102 which obtained 42% reduction with niacin ER/lovastatin 1000/40 mg compared to simvastatin 20 mg (34%, P
Final Report Update 5 Drug Effectiveness Review Project Table 7. Achieving target low-density lipoprotein cholesterol goals Baseline low-density lipoprotein cholesterol 130 160 190 220 _____(Percent Reduction to Achieve Target Goals)_____ Target LDL-C < 70 mg/dL 43% 56% 63% 68% Target LDL-C < 100 mg/dL 23% 38% 47% 55% Target LDL-C < 130 19% 32% 41% Target LDL-C < 160 16% 27% Based on the Adult Treatment Panel III. Table VI-3-1. Page VI-19. 3 Abbreviations: LDL-C, low-density lipoprotein cholesterol. Statins Fifty-one reports measured the percentage of patients meeting their National Cholesterol 15-17, 19-22, 29, 86, 87, 113, 114 Education Program low-density lipoprotein cholesterol treatment goals. Additionally, 1 study reported only on the European guidelines goal attainment, 113 1 study reported on the Japanese goal attainment, 22 and 3 reported on attainment of both the Adult Treatment Panel III and the 2003 European goals. 17, 20, 29 Many of the studies compared the efficacy of the usual starting doses of the compared drugs rather than the efficacy and adverse events when the drugs were tailored over time. Problems in dosing limited the validity of many of these trials. Many compared only the low, starting doses of several statins and no study evaluated the Adult Treatment Panel III guideline achievement efficacy of rosuvastatin 5 mg. The percentage of patients achieving Adult Treatment Panel III low-density lipoprotein cholesterol
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(Statins) and Fixed-dose Combination Products Containing a Statin

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