Polyurethane Amine Catalysts - Polyurethanes - American ...

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Table 1 - Acute Oral and Dermal Toxicity Classification*
Classification Acute Oral LD50 Acute Dermal LD50
Skin Contact
Skin contact with amine catalysts can cause moderate to severe irritation and burns,
from redness and swelling to painful blistering, ulceration, and chemical burns.
Repeated or prolonged exposure may also result in severe contact dermatitis. In most
instances, it will be irritant contact dermatitis, but dermal sensitization leading to
allergic contact dermatitis has been associated with one amine catalyst (see Table 1)
(Foti,2003, Hervella, 2006).
Systemic effects resulting from the absorption of selected amines through the skin
may include headaches, nausea, faintness, anxiety, decrease in blood pressure,
reddening of the skin, hives, and facial swelling. These symptoms are related to
histamine release and they are generally transient in nature.
Eye Contact
(rat mg/kg) (rabbit, mg/kg)
Practically Nontoxic >5000 >5000
Slightly Toxic 2000-5000 2000-5000
Moderately Toxic 300-2000 1000-2000
Toxic 50-300 200-1000
Highly Toxic