Nuchal Translucency in First-Trimester Ultrasound Screening for ...
Nuchal Translucency in First-Trimester Ultrasound Screening for ...
Nuchal Translucency in First-Trimester Ultrasound Screening for ...
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Compar<strong>in</strong>g Screen<strong>in</strong>g Methods <strong>for</strong> T21<br />
<strong>Nuchal</strong> <strong>Translucency</strong> +<br />
Maternal Age<br />
Comb<strong>in</strong>ed Test: Age +<br />
NT + PAPP-A PAPP A + Beta- Beta<br />
hCG<br />
Full Integrated Test:<br />
Comb<strong>in</strong>ed Test + Quad<br />
Screen<br />
Serum Integrated Test:<br />
PAPP-A PAPP A + Quad<br />
Screen (No U/S)<br />
Quad Screen: serum<br />
AFP, uE3,<br />
hCG, <strong>in</strong>hib<strong>in</strong> A<br />
Gestational Age<br />
Detection<br />
Rate/Sensitivity<br />
False Positive<br />
Rate<br />
11-14 11 14 weeks 72-77% 72 77% 4.2-5% 4.2 5%<br />
11-14 11 14 weeks 85% 4.8<br />
11-14 11 14 weeks +<br />
15-18 15 18 weeks<br />
11-14 11 14 weeks +<br />
15-18 15 18 weeks<br />
85%<br />
90-95% 90 95%<br />
1%<br />
2.6-5% 2.6 5%<br />
85% 3.5%<br />
15-18 15 18 weeks 85% 6.8%<br />
*All data from FASTER (<strong>First</strong> and Second <strong>Trimester</strong> Evaluation of Risk) and SURUSS (Serum, Ur<strong>in</strong>e and <strong>Ultrasound</strong><br />
Screen<strong>in</strong>g Study) Trials.<br />
Barss VA et al. “Overview of prenatal screen<strong>in</strong>g <strong>for</strong> Down syndrome.” UpToDate 16.1.
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