Indium-111 Leukocyte Scintigraphy - Lieberman's eRadiology ...

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Kinzya B. Grant, Year IV Gillian Lieberman, MD Nuclear Medicine Background Information What is oxine? oxine Oxine (8-hydroxyquinolone) (8 hydroxyquinolone) is a lipid-soluble lipid soluble complex that chelates metal ions Leukocytes are removed from plasma for labeling How is it taken up? Indium-111 Indium 111 oxine complex diffuses through cell membranes Once intracellular, the complex dissociates Indium-111 Indium 111 binds nuclear and cytoplasmic proteins Oxine diffuses back out of the cell 6
Kinzya B. Grant, Year IV Gillian Lieberman, MD Nuclear Medicine Background Information How are Indium-111 Indium 111 oxine-labeled oxine labeled leukocytes distributed? After infusion, radiolabeled leukocytes are distributed to the blood pool, lungs, liver, and spleen Imaging is done 18-24 18 24 hrs after injection when lung and blood pool activity are not normally seen 7
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Page 3 and 4: 61yo male Recent history Kinzya B.
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Page 21 and 22: sternum Kinzya B. Grant, Year IV Gi
Page 29 and 30: HPI Kinzya B. Grant, Year IV Gillia
Page 31 and 32: Imaging Kinzya B. Grant, Year IV Gi
Page 33 and 34: CT shoulder coronal Kinzya B. Grant
Page 39 and 40: Axial STIR Kinzya B. Grant, Year IV
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Indium-111 Leukocyte Scintigraphy - Lieberman's eRadiology ...

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