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How does this sound: JAK2 is a gene that turns on a series of actions that controls the production of blood cells and fibrocytes When abnormal, control is lost and excessive numbers of cells are produced
The ball is in your court Under normal physiological circumstances when a ligand (for example - EPO) binds with a receptor, a conformational changes occurs. The JAK2 protein then makes contact with the cytoplasm domain of the receptor where it catalyzes tyrosine phosphorylation. This leads to the activation of signal transducers and transcription (STAT) molecules ????????
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